7.60022 % | Fidelity Management & Research Company LLC | 5,203,110 | 3,540,565 | 6/30/2024 |
6.09026 % | RTW Investments L.P. | 4,169,393 | 60,000 | 6/30/2024 |
4.67426 % | Commodore Capital LP | 3,200,000 | -1,160,000 | 6/30/2024 |
4.01607 % | Deerfield Management Company, L.P. | 2,749,401 | 100,000 | 6/30/2024 |
3.50394 % | Federated Hermes Global Investment Management Corp. | 2,398,800 | 150,000 | 6/30/2024 |
3.39497 % | Samlyn Capital, LLC | 2,324,195 | 247,605 | 6/30/2024 |
3.07649 % | Franklin Advisers, Inc. | 2,106,163 | 241,915 | 6/30/2024 |
2.95036 % | Paradigm BioCapital Advisors LP | 2,019,814 | 2,019,814 | 6/30/2024 |
2.77534 % | Boxer Capital, L.L.C. | 1,900,000 | 0 | 6/30/2024 |
2.42907 % | Wellington Management Company, LLP | 1,662,941 | 414,301 | 6/30/2024 |
2.29896 % | Holocene Advisors, LP | 1,573,866 | 634,290 | 6/30/2024 |
2.26411 % | Driehaus Capital Management, LLC | 1,550,009 | 323,518 | 6/30/2024 |
2.16928 % | Morgan Stanley & Co. LLC | 1,485,092 | 556,281 | 6/30/2024 |
2.11953 % | Two Sigma Investments, LP | 1,451,027 | 20,418 | 6/30/2024 |
2.02339 % | T. Rowe Price Associates, Inc. | 1,385,216 | 199,862 | 6/30/2024 |
1.97926 % | Avoro Capital Advisors LLC | 1,355,000 | 466,112 | 6/30/2024 |
1.86832 % | BVF Partners L.P. | 1,279,049 | 106,800 | 6/30/2024 |
1.85079 % | Polar Capital LLP | 1,267,052 | 1,267,052 | 6/30/2024 |
1.84519 % | VR Adviser, LLC | 1,263,214 | -527,000 | 6/30/2024 |
1.76265 % | Lynx1 Capital Advisors LLC | 1,206,707 | -302,300 | 6/30/2024 |
1.49258 % | Fidelity Institutional Asset Management | 1,021,822 | 1,021,822 | 6/30/2024 |
1.48555 % | Janus Henderson Investors | 1,017,007 | 474,427 | 6/30/2024 |
1.47250 % | Incyte Corp | 1,008,076 | -2,996,468 | 6/30/2024 |
1.46227 % | Rock Springs Capital Management LP | 1,001,073 | -145,487 | 6/30/2024 |
1.40048 % | Woodline Partners LP | 958,769 | 287,970 | 6/30/2024 |
1.39929 % | Marshall Wace LLP | 957,952 | 853,060 | 6/30/2024 |
1.24160 % | Logos Global Management LLC | 850,000 | 850,000 | 6/30/2024 |
1.23353 % | Pictet Asset Management Ltd. | 844,474 | 214,799 | 6/30/2024 |
1.22699 % | Cormorant Asset Management, LP | 840,000 | 125,000 | 6/30/2024 |
1.12474 % | Adage Capital Management, L.P. | 770,000 | 445,000 | 6/30/2024 |
1.11066 % | Invus Public Equities Advisors, LLC | 760,355 | 305,274 | 6/30/2024 |
1.08417 % | BlackRock Financial Management, Inc. | 742,225 | 3,033 | 6/30/2024 |
1.05270 % | T. Rowe Price Investment Management, Inc. | 720,676 | -8,339 | 6/30/2024 |
1.02249 % | Novo Holdings A/S | 700,000 | 25,000 | 9/30/2024 |
1.01957 % | Candriam Luxembourg S.A. | 697,997 | 0 | 9/30/2024 |
0.99039 % | AllianceBernstein L.P. | 678,021 | 594,761 | 6/30/2024 |
0.91094 % | SilverArc Capital Management, LLC | 623,628 | 57,341 | 6/30/2024 |
0.85455 % | Balyasny Asset Management LP | 585,024 | 585,024 | 6/30/2024 |
0.84716 % | Invesco Advisers, Inc. | 579,967 | 578,811 | 6/30/2024 |
0.76437 % | Great Point Partners, LLC | 523,288 | 300,000 | 6/30/2024 |
0.76152 % | D. E. Shaw & Co., L.P. | 521,339 | 247,813 | 6/30/2024 |
0.62583 % | BlackRock Institutional Trust Company, N.A. | 428,443 | 26,103 | 6/30/2024 |
0.59808 % | Dafna Capital Management, LLC | 409,445 | 30,450 | 6/30/2024 |
0.57796 % | Lord, Abbett & Co. LLC | 395,672 | 71,042 | 6/30/2024 |
0.54969 % | Soleus Capital Management, L.P. | 376,321 | 180,744 | 6/30/2024 |
0.54499 % | Frazier Life Sciences Management, L.P. | 373,100 | -373,379 | 6/30/2024 |
0.49009 % | Tri Locum Partners LP | 335,514 | 49,192 | 6/30/2024 |
0.48134 % | Medical Strategy GmbH | 329,522 | 18,321 | 6/30/2024 |
0.47021 % | First Turn Management, LLC | 321,906 | 321,906 | 6/30/2024 |
0.43821 % | Perceptive Advisors LLC | 300,000 | 300,000 | 6/30/2024 |
0.43821 % | Baker Bros. Advisors LP | 300,000 | 300,000 | 6/30/2024 |
0.42166 % | StemPoint Capital LP | 288,668 | 54,797 | 6/30/2024 |
0.38690 % | State Street Global Advisors (US) | 264,873 | 20,197 | 6/30/2024 |
0.35533 % | Millennium Management LLC | 243,257 | 92,987 | 6/30/2024 |
0.31382 % | Voloridge Investment Management, LLC | 214,838 | 149,137 | 6/30/2024 |
0.30514 % | Handelsbanken Kapitalf¿rvaltning AB | 208,900 | 34,200 | 9/30/2024 |
0.30267 % | Goldman Sachs & Company, Inc. | 207,209 | 102,495 | 6/30/2024 |
0.29666 % | BlackRock Advisors (UK) Limited | 203,092 | 675 | 9/30/2024 |
0.28104 % | BlackRock Asset Management Ireland Limited | 192,397 | -7,721 | 6/30/2024 |
0.26617 % | TimesSquare Capital Management, LLC | 182,220 | 174,216 | 6/30/2024 |
0.26563 % | Citadel Advisors LLC | 181,853 | -170,355 | 6/30/2024 |
0.26161 % | Decheng Capital LLC | 179,098 | 77,300 | 6/30/2024 |
0.25540 % | Ally Bridge Group NY LLC | 174,844 | -81,084 | 6/30/2024 |
0.24955 % | BNP Paribas Securities Corp. North America | 170,844 | 67,959 | 6/30/2024 |
0.24069 % | Saturn V Capital Management LP | 164,773 | -211,856 | 6/30/2024 |
0.22802 % | OrbiMed Advisors, LLC | 156,100 | 156,100 | 6/30/2024 |
0.22789 % | Liu (Hui) | 156,016 | 98,085 | 3/15/2024 |
0.22678 % | The Vanguard Group, Inc. | 155,257 | 8,232 | 6/30/2024 |
0.22354 % | State of Wisconsin Investment Board | 153,038 | 130,307 | 6/30/2024 |
0.22213 % | Lundberg (Sven Ante) | 152,071 | 0 | 3/15/2024 |
0.21634 % | Aquilo Capital Management, LLC | 148,109 | -107,000 | 6/30/2024 |
0.21565 % | Sphera Funds Management Ltd. | 147,633 | -1,700 | 6/30/2024 |
0.19475 % | Algert Global LLC | 133,323 | 35,549 | 6/30/2024 |
0.18632 % | TD Asset Management Inc. | 127,554 | -23,620 | 6/30/2024 |
0.18469 % | BlackRock Investment Management (UK) Ltd. | 126,442 | 40,537 | 6/30/2024 |
0.18259 % | Affinity Asset Advisors LLC | 125,000 | 125,000 | 6/30/2024 |
0.17752 % | Invesco Capital Management LLC | 121,529 | -5,564 | 6/30/2024 |
0.17534 % | Nan Fung Life Sciences | 120,038 | 30,522 | 6/30/2024 |
0.17049 % | HighVista Strategies LLC | 116,718 | -4,962 | 6/30/2024 |
0.16652 % | Ensign Peak Advisors, Inc. | 114,000 | 114,000 | 6/30/2024 |
0.16068 % | DWS Investment GmbH | 110,000 | 0 | 6/30/2024 |
0.14607 % | Integral Health Asset Management, LLC | 100,000 | -65,000 | 6/30/2024 |
0.14607 % | Tang Capital Management, LLC | 100,000 | 100,000 | 6/30/2024 |
0.13219 % | Rhenman & Partners Asset Management AB | 90,500 | 90,500 | 6/30/2024 |
0.13043 % | Wellington Management Singapore Pte. Ltd. | 89,295 | 89,295 | 3/31/2024 |
0.13043 % | Wellington Management Japan Pte Ltd | 89,295 | -61,818 | 6/30/2023 |
0.12740 % | abrdn Inc. | 87,215 | 87,215 | 9/30/2024 |
0.12708 % | Nomura Asset Management Co., Ltd. | 87,000 | 87,000 | 11/30/2023 |
0.12278 % | Voya Investment Management LLC | 84,055 | 54,205 | 6/30/2024 |
0.11813 % | BofA Global Research (US) | 80,873 | 25,690 | 6/30/2024 |
0.11759 % | Nicholas Investment Partners, L.P. | 80,503 | 62,818 | 6/30/2024 |
0.11431 % | Schweizerische Nationalbank | 78,254 | 4,200 | 6/30/2024 |
0.11291 % | First Trust Advisors L.P. | 77,296 | 26,233 | 6/30/2024 |
0.10888 % | Jane Street Capital, L.L.C. | 74,542 | 61,764 | 6/30/2024 |
0.10769 % | Platinum Asset Management | 73,722 | -25,768 | 6/30/2024 |
0.10747 % | Iwicki (Mark T.) | 73,576 | 73,576 | 3/15/2024 |
0.10594 % | Principal Global Investors (Equity) | 72,526 | 3,740 | 8/31/2024 |
0.10320 % | J.P. Morgan Securities LLC | 70,652 | -26,024 | 6/30/2024 |
0.09710 % | Eversept Partners, LP | 66,474 | -53,008 | 6/30/2024 |
0.09176 % | Fred Alger Management, LLC | 62,816 | 42,219 | 6/30/2024 |