5.13343 % | New Enterprise Associates (NEA) | 5,736,363 | -850,000 | 9/30/2021 |
5.10089 % | Avoro Capital Advisors LLC | 5,700,000 | 0 | 9/30/2021 |
4.67795 % | Eventide Asset Management, LLC | 5,227,376 | -4,282,624 | 9/30/2021 |
4.24143 % | BlackRock Institutional Trust Company, N.A. | 4,739,590 | 223,922 | 9/30/2021 |
2.92755 % | Magnetar Capital Partners LP | 3,271,390 | 3,271,390 | 9/30/2021 |
2.80997 % | Pentwater Capital Management LP | 3,140,000 | 3,140,000 | 9/30/2021 |
2.79485 % | Frazier Healthcare Partners | 3,123,107 | 0 | 9/30/2021 |
2.28814 % | Gabelli Funds, LLC | 2,556,885 | 2,229,785 | 9/30/2021 |
2.11806 % | Omni Partners US LLC | 2,366,824 | 2,366,824 | 9/30/2021 |
1.72129 % | ARP Americas LP | 1,923,455 | 1,923,455 | 9/30/2021 |
1.42928 % | Westchester Capital Management, LLC | 1,597,153 | 1,597,153 | 9/30/2021 |
1.27179 % | State Street Global Advisors (US) | 1,421,166 | 102,280 | 9/30/2021 |
1.25800 % | AQR Capital Management, LLC | 1,405,754 | 1,383,207 | 9/30/2021 |
1.19021 % | Spring Creek Capital, LLC | 1,330,000 | 1,330,000 | 9/30/2021 |
1.08246 % | AllianceBernstein L.P. | 1,209,595 | 1,109,295 | 9/30/2021 |
1.07703 % | Goldman Sachs & Company, Inc. | 1,203,525 | 749,719 | 9/30/2021 |
1.02938 % | Candriam Belgium S.A. | 1,150,280 | 360,182 | 9/30/2021 |
1.02018 % | Alpine Associates Management Inc. | 1,140,000 | 1,140,000 | 9/30/2021 |
1.01570 % | Segantii Capital Management Limited | 1,135,000 | 1,135,000 | 9/30/2021 |
0.99004 % | J.P. Morgan Securities LLC | 1,106,326 | 1,106,326 | 9/30/2021 |
0.80540 % | Carlson Capital, L.P. | 900,000 | 900,000 | 9/30/2021 |
0.79313 % | Fairmount Funds Management LLC | 886,281 | -10,000 | 9/30/2021 |
0.76084 % | Geode Capital Management, L.L.C. | 850,207 | 10,318 | 9/30/2021 |
0.71457 % | Citadel Advisors LLC | 798,500 | -3,368,259 | 9/30/2021 |
0.71318 % | Franklin Advisers, Inc. | 796,939 | -2,913,196 | 9/30/2021 |
0.68656 % | Morgan Stanley & Co. LLC | 767,192 | 715,868 | 9/30/2021 |
0.67692 % | Driehaus Capital Management, LLC | 756,426 | 500,000 | 9/30/2021 |
0.60869 % | Northern Trust Investments, Inc. | 680,183 | -34,383 | 9/30/2021 |
0.56244 % | Rock Springs Capital Management LP | 628,500 | 0 | 9/30/2021 |
0.52533 % | BlackRock Advisors (UK) Limited | 587,030 | -12,031 | 10/31/2021 |
0.51438 % | Brinker Capital Inc. | 574,793 | 371,800 | 8/31/2021 |
0.50949 % | QVT Financial LP | 569,333 | 569,333 | 9/30/2021 |
0.50449 % | BlackRock Asset Management Ireland Limited | 563,743 | 43,566 | 9/30/2021 |
0.49644 % | The Vanguard Group, Inc. | 554,749 | 155,450 | 9/30/2021 |
0.49549 % | Millennium Management LLC | 553,684 | 345,612 | 9/30/2021 |
0.49381 % | Norges Bank Investment Management (NBIM) | 551,812 | 551,812 | 12/31/2020 |
0.44661 % | Weiss Multi-Strategy Advisers LLC | 499,069 | 499,069 | 9/30/2021 |
0.42911 % | Nuveen LLC | 479,509 | 6,650 | 9/30/2021 |
0.42356 % | GLG Partners LP | 473,310 | 473,310 | 9/30/2021 |
0.41702 % | ACT Capital Management, L.L.C. | 466,000 | 1,000 | 9/30/2021 |
0.41460 % | Medical Strategy GmbH | 463,291 | 0 | 6/30/2021 |
0.39188 % | BlackRock Financial Management, Inc. | 437,910 | 194,160 | 9/30/2021 |
0.39113 % | Morgan Stanley Canada Limited | 437,068 | 328,768 | 9/30/2021 |
0.38800 % | Columbus Circle Investors | 433,574 | 431,017 | 12/31/2020 |
0.37898 % | Crabel Capital Management, L.L.C. | 423,490 | 423,490 | 9/30/2021 |
0.37880 % | Water Island Capital, LLC | 423,290 | 126,546 | 9/30/2021 |
0.33973 % | Susquehanna International Group, LLP | 379,627 | 277,635 | 9/30/2021 |
0.32867 % | JPMorgan Asset Management U.K. Limited | 367,278 | 367,278 | 9/30/2021 |
0.31310 % | Barclays Capital Inc. | 349,870 | 349,870 | 9/30/2021 |
0.30516 % | Hamblin Watsa Investment Counsel Ltd. | 341,000 | 341,000 | 9/30/2021 |
0.30251 % | Cowen Investment Management LLC | 338,042 | 338,042 | 9/30/2021 |
0.29709 % | Group One Trading, L.P. | 331,989 | 284,618 | 9/30/2021 |
0.29146 % | BlackRock Investment Management, LLC | 325,687 | -7,451 | 9/30/2021 |
0.28964 % | TIG Advisors, L.L.C. | 323,658 | 323,658 | 9/30/2021 |
0.27742 % | Mangrove Partners | 310,000 | 310,000 | 9/30/2021 |
0.27588 % | Candriam S.A. (France) | 308,285 | 308,285 | 9/30/2021 |
0.27073 % | LMR Partners LLP | 302,522 | 302,522 | 9/30/2021 |
0.26847 % | Picton Mahoney Asset Management | 300,000 | 300,000 | 9/30/2021 |
0.25676 % | BofA Global Research (US) | 286,918 | 63,117 | 9/30/2021 |
0.23746 % | Western Standard, LLC | 265,355 | 265,355 | 9/30/2021 |
0.20135 % | Balyasny Asset Management LP | 225,000 | 225,000 | 9/30/2021 |
0.19071 % | Charles Schwab Investment Management, Inc. | 213,112 | 5,759 | 9/30/2021 |
0.17898 % | Affinity Asset Advisors LLC | 200,000 | 200,000 | 9/30/2021 |
0.17781 % | Knott Partners Management, LLC | 198,699 | 0 | 9/30/2021 |
0.17468 % | Bardin Hill Investment Partners LP | 195,192 | 195,192 | 9/30/2021 |
0.17130 % | Marshall Wace LLP | 191,423 | -695,760 | 9/30/2021 |
0.17122 % | LPL Financial LLC | 191,328 | -53,145 | 9/30/2021 |
0.16306 % | BNY Mellon Asset Management | 182,210 | 10,476 | 9/30/2021 |
0.16059 % | Morgan Stanley Smith Barney LLC | 179,450 | 20,356 | 9/30/2021 |
0.15550 % | Jane Street Capital, L.L.C. | 173,761 | 162,463 | 9/30/2021 |
0.15409 % | Schweizerische Nationalbank | 172,190 | 4,400 | 9/30/2021 |
0.15007 % | Moore Capital Management, LP | 167,700 | 167,700 | 9/30/2021 |
0.14318 % | S. Muoio & Co. LLC | 160,000 | 160,000 | 9/30/2021 |
0.13818 % | Odey Asset Management LLP | 154,409 | 154,409 | 9/30/2021 |
0.13447 % | Vident Investment Advisory, LLC | 150,259 | -10,732 | 9/30/2021 |
0.13108 % | Credit Suisse Securities (USA) LLC | 146,474 | 144,556 | 9/30/2021 |
0.12520 % | Woodline Partners LP | 139,907 | -1,726,166 | 9/30/2021 |
0.12366 % | Vivaldi Asset Management, LLC | 138,187 | 138,187 | 9/30/2021 |
0.11850 % | Rhumbline Advisers Ltd. Partnership | 132,421 | 4,038 | 9/30/2021 |
0.11329 % | Equitec Proprietary Markets, LLC | 126,597 | 126,597 | 9/30/2021 |
0.11320 % | State of Wisconsin Investment Board | 126,500 | 1,758 | 9/30/2021 |
0.11186 % | Angelo, Gordon & Co., L.P. | 125,000 | 125,000 | 9/30/2021 |
0.10917 % | Mellon Investments Corporation | 121,993 | 25,825 | 9/30/2021 |
0.10395 % | CSS, LLC | 116,154 | 53,901 | 9/30/2021 |
0.10332 % | Capstone Investment Advisors, LLC | 115,451 | 115,451 | 9/30/2021 |
0.10202 % | HRT Financial LP | 113,999 | 113,999 | 9/30/2021 |
0.09791 % | Parametric Portfolio Associates LLC | 109,415 | 85,261 | 9/30/2021 |
0.09754 % | Havens Advisors, L.L.C. | 109,000 | 109,000 | 9/30/2021 |
0.09566 % | Stifel Nicolaus Investment Advisors | 106,900 | 25,250 | 9/30/2021 |
0.08990 % | Tudor Investment Corporation | 100,454 | 100,454 | 9/30/2021 |
0.08949 % | Polar Asset Management Partners Inc. | 100,000 | 100,000 | 9/30/2021 |
0.08786 % | Chartwell Investment Partners, LLC | 98,177 | 0 | 9/30/2021 |
0.08650 % | SG Americas Securities, L.L.C. | 96,664 | 96,664 | 9/30/2021 |
0.08540 % | TD Asset Management Inc. | 95,435 | -214,820 | 9/30/2021 |
0.08218 % | Northern Trust Global Investments | 91,836 | 2,773 | 9/30/2021 |
0.07607 % | Abaris Investment Management AG | 85,000 | 85,000 | 12/31/2020 |
0.07159 % | ERSTE-SPARINVEST Kapitalanlagegesellschaft mbH | 80,000 | 0 | 8/31/2021 |
0.07119 % | Knights of Columbus | 79,553 | 575 | 9/30/2021 |
0.06965 % | Credit Suisse Asset Management | 77,829 | 21,994 | 9/30/2021 |
0.06837 % | British Columbia Investment Management Corp. | 76,398 | -368,157 | 9/30/2021 |