14,96499 % | Fidelity Management & Research Company LLC | 10.678.612 | 48.951 | 30.6.2022 |
8,13684 % | The Vanguard Group, Inc. | 5.806.227 | 686.912 | 30.6.2022 |
7,27898 % | Vifor (International), Ltd | 5.194.085 | 0 | 13.9.2022 |
5,73376 % | BlackRock Institutional Trust Company, N.A. | 4.091.453 | 306.603 | 30.6.2022 |
5,67001 % | State Street Global Advisors (US) | 4.045.964 | 404.301 | 30.6.2022 |
3,35404 % | Schall (Thomas J) | 2.393.352 | 0 | 13.9.2022 |
3,32502 % | Pictet Asset Management Ltd. | 2.372.645 | 532.478 | 30.6.2022 |
2,94707 % | Wasatch Global Investors Inc | 2.102.953 | 1.027.231 | 30.6.2022 |
2,51223 % | Baker Bros. Advisors LP | 1.792.657 | 875.795 | 30.6.2022 |
2,15378 % | GW&K Investment Management, LLC | 1.536.877 | 375.530 | 30.6.2022 |
1,99699 % | Cormorant Asset Management, LP | 1.425.000 | 560.000 | 30.6.2022 |
1,96820 % | Invesco Advisers, Inc. | 1.404.451 | 34.143 | 30.6.2022 |
1,87336 % | Hood River Capital Management LLC | 1.336.776 | 1.336.776 | 30.6.2022 |
1,65218 % | Marshall Wace LLP | 1.178.948 | -219.635 | 30.6.2022 |
1,54129 % | Norges Bank Investment Management (NBIM) | 1.099.824 | 661.000 | 31.12.2021 |
1,53785 % | HealthCor Management, L.P. | 1.097.370 | 140.630 | 30.6.2022 |
1,41112 % | Geode Capital Management, L.L.C. | 1.006.934 | 6.519 | 30.6.2022 |
1,18123 % | Nuveen LLC | 842.891 | 340.858 | 30.6.2022 |
1,02076 % | Eventide Asset Management, LLC | 728.385 | 0 | 30.6.2022 |
0,92914 % | Morgan Stanley & Co. LLC | 663.007 | 262.249 | 30.6.2022 |
0,89221 % | Sofinnova Investments, Inc | 636.659 | 62.975 | 30.6.2022 |
0,84084 % | Logos Global Management LLC | 600.000 | 600.000 | 30.6.2022 |
0,81428 % | Wellington Management Company, LLP | 581.050 | -64.783 | 30.6.2022 |
0,80444 % | Integral Health Asset Management, LLC | 574.029 | 174.029 | 30.6.2022 |
0,77680 % | Principal Global Investors (Equity) | 554.300 | 249.434 | 30.6.2022 |
0,76524 % | Barclays Bank PLC | 546.057 | 505.367 | 30.6.2022 |
0,76451 % | Tri Locum Partners LP | 545.532 | 249.205 | 30.6.2022 |
0,69025 % | Northern Trust Investments, Inc. | 492.544 | 46.115 | 30.6.2022 |
0,68038 % | APG Asset Management N.V. | 485.501 | 485.501 | 31.3.2022 |
0,61897 % | Perceptive Advisors LLC | 441.680 | -1.213.399 | 30.6.2022 |
0,53568 % | Charles Schwab Investment Management, Inc. | 382.244 | 14.545 | 30.6.2022 |
0,51949 % | Millennium Management LLC | 370.692 | -930.257 | 30.6.2022 |
0,50771 % | Voloridge Investment Management, LLC | 362.291 | -301.944 | 30.6.2022 |
0,44388 % | Invesco Capital Management LLC | 316.743 | 76.060 | 30.6.2022 |
0,43899 % | Goldman Sachs & Company, Inc. | 313.253 | 62.366 | 30.6.2022 |
0,43461 % | T. Rowe Price Associates, Inc. | 310.129 | -55.505 | 30.6.2022 |
0,42662 % | Citadel Advisors LLC | 304.424 | -1.906 | 30.6.2022 |
0,39746 % | Raymond James & Associates, Inc. | 283.620 | -11.213 | 30.6.2022 |
0,36369 % | Raymond James Financial Services Advisors, Inc. | 259.519 | 12.347 | 30.6.2022 |
0,32452 % | PGIM Quantitative Solutions LLC | 231.570 | 231.570 | 30.6.2022 |
0,32154 % | Parametric Portfolio Associates LLC | 229.439 | -14.171 | 30.6.2022 |
0,31396 % | Kanaya (Susan M) | 224.034 | 0 | 13.9.2022 |
0,30925 % | Thornburg Investment Management, Inc. | 220.675 | -25.602 | 30.6.2022 |
0,27396 % | Dimensional Fund Advisors, L.P. | 195.488 | -124.852 | 30.6.2022 |
0,25918 % | Lisanti Capital Growth, LLC | 184.946 | -136.623 | 30.6.2022 |
0,25265 % | Lord, Abbett & Co. LLC | 180.285 | 169.409 | 30.6.2022 |
0,25259 % | BNY Mellon Asset Management | 180.238 | 21.793 | 30.6.2022 |
0,24858 % | BlackRock Investment Management, LLC | 177.382 | 7.809 | 30.6.2022 |
0,23596 % | BlackRock Financial Management, Inc. | 168.375 | 22.142 | 30.6.2022 |
0,23578 % | Granahan Investment Management, Inc. | 168.245 | 45.478 | 30.6.2022 |
0,23563 % | Two Sigma Investments, LP | 168.141 | -833.794 | 30.6.2022 |
0,23097 % | Goldman Sachs Asset Management, L.P. | 164.816 | 39.130 | 30.6.2022 |
0,22422 % | Altium Capital Management LP | 160.000 | 160.000 | 30.6.2022 |
0,22342 % | Citi Investment Research (US) | 159.427 | 117.029 | 30.6.2022 |
0,21638 % | Soleus Capital Management, L.P. | 154.400 | 154.400 | 30.6.2022 |
0,21603 % | Susquehanna International Group, LLP | 154.151 | -18.198 | 30.6.2022 |
0,21353 % | Rafferty Asset Management LLC | 152.368 | -73.036 | 30.6.2022 |
0,20758 % | Feczko (Joseph M) | 148.127 | 0 | 13.9.2022 |
0,20083 % | Edwards (Thomas A) | 143.306 | 0 | 13.9.2022 |
0,20007 % | Parker (Geoffrey M) | 142.763 | 0 | 13.9.2022 |
0,19510 % | Assenagon Asset Management S.A. | 139.219 | -22.556 | 30.6.2022 |
0,19176 % | Northern Trust Global Investments | 136.838 | 38.823 | 30.6.2022 |
0,19157 % | Nomura Asset Management Co., Ltd. | 136.700 | -59.499 | 30.11.2021 |
0,18952 % | BofA Global Research (US) | 135.237 | -111.166 | 30.6.2022 |
0,18919 % | BZ Bank AG (Asset Management) | 135.000 | 0 | 31.5.2022 |
0,18498 % | Schweizerische Nationalbank | 132.000 | 16.100 | 30.6.2022 |
0,17251 % | Medical Strategy GmbH | 123.100 | 7.500 | 31.5.2022 |
0,16971 % | International Biotechnology Trust PLC | 121.100 | 85.000 | 30.6.2022 |
0,16641 % | Allspring Global Investments, LLC | 118.744 | 39.199 | 30.6.2022 |
0,15954 % | Capital Fund Management S.A. | 113.844 | 113.844 | 30.6.2022 |
0,14732 % | ExodusPoint Capital Management, LP | 105.124 | 11.155 | 30.6.2022 |
0,13558 % | Ensign Peak Advisors, Inc. | 96.746 | 23.783 | 30.6.2022 |
0,13236 % | Mutual of America Capital Management LLC | 94.450 | -41.248 | 30.6.2022 |
0,13220 % | UBS Financial Services, Inc. | 94.337 | -73.833 | 30.6.2022 |
0,12468 % | Aperio Group, LLC | 88.969 | -6.250 | 30.6.2022 |
0,12284 % | Cappel (Markus J) | 87.658 | 0 | 13.9.2022 |
0,12018 % | BlackRock Advisors (UK) Limited | 85.759 | 5.091 | 31.8.2022 |
0,12003 % | Mirabella Financial Services LLP | 85.653 | 85.653 | 30.6.2022 |
0,11562 % | Rhumbline Advisers Ltd. Partnership | 82.501 | 8.950 | 30.6.2022 |
0,11300 % | Group One Trading, L.P. | 80.635 | 80.635 | 30.6.2022 |
0,10959 % | Tekla Capital Management LLC | 78.197 | 0 | 30.6.2022 |
0,10581 % | AllianceBernstein L.P. | 75.500 | 13.100 | 30.6.2022 |
0,10479 % | California State Teachers Retirement System | 74.776 | 9.871 | 30.6.2022 |
0,10427 % | BlackRock Asset Management Ireland Limited | 74.403 | 9.221 | 30.6.2022 |
0,10216 % | Jane Street Capital, L.L.C. | 72.896 | -41.935 | 30.6.2022 |
0,10195 % | McKinnell (Henry A Jr) | 72.749 | 7.726 | 20.5.2022 |
0,10122 % | Allianz Global Investors U.S. LLC | 72.225 | 7.540 | 30.6.2022 |
0,09737 % | Jump Financial, LLC | 69.484 | 60.484 | 30.6.2022 |
0,09580 % | Cahill Wealth Management, LLC | 68.358 | 23.445 | 30.6.2022 |
0,09109 % | Hudson Bay Capital Management LP | 65.000 | 10.000 | 30.6.2022 |
0,08913 % | Cubist Systematic Strategies, LLC | 63.599 | 31.059 | 30.6.2022 |
0,08856 % | EFG Asset Management (UK) Limited | 63.195 | 11.721 | 31.5.2022 |
0,08696 % | EFG Asset Management (North America) Corp | 62.051 | 8.550 | 30.6.2022 |
0,08572 % | Ohio Public Employees Retirement System | 61.171 | 26.172 | 30.6.2022 |
0,08531 % | Algert Global LLC | 60.875 | 46.740 | 30.6.2022 |
0,08156 % | Jennison Associates LLC | 58.200 | 58.200 | 30.6.2022 |
0,07689 % | State of Wisconsin Investment Board | 54.866 | -11.834 | 30.6.2022 |
0,07367 % | SEI Investments Management Corporation | 52.572 | 52.572 | 30.6.2022 |
0,07277 % | PanAgora Asset Management Inc. | 51.929 | 23.495 | 30.6.2022 |
0,07146 % | Legal & General Investment Management Ltd. | 50.994 | 8.111 | 30.6.2022 |