13,09729 % | Fidelity Management & Research Company LLC | 15.626.378 | 2.054.142 | 30.6.2024 |
9,04989 % | T. Rowe Price Associates, Inc. | 10.797.421 | 3.502.039 | 30.6.2024 |
6,94231 % | RTW Investments L.P. | 8.282.870 | -523.968 | 22.8.2024 |
5,98499 % | BlackRock Institutional Trust Company, N.A. | 7.140.692 | 1.669.713 | 30.6.2024 |
5,45218 % | Avoro Capital Advisors LLC | 6.505.000 | 680.000 | 30.6.2024 |
4,96703 % | The Vanguard Group, Inc. | 5.926.169 | 2.096.174 | 30.6.2024 |
4,52637 % | RA Capital Management, LP | 5.400.408 | 504.449 | 30.6.2024 |
4,29897 % | TD Cowen (Research) | 5.129.103 | -500.000 | 30.6.2024 |
4,25388 % | Bristol Myers Squibb | 5.075.304 | 5.075.304 | 27.11.2023 |
3,18668 % | Wellington Management Company, LLP | 3.802.026 | 2.573.028 | 30.6.2024 |
3,06499 % | Janus Henderson Investors | 3.656.843 | 2.414.010 | 30.6.2024 |
2,84719 % | Adage Capital Management, L.P. | 3.396.982 | 996.937 | 30.6.2024 |
2,78268 % | State Street Global Advisors (US) | 3.320.019 | -141.803 | 30.6.2024 |
1,89146 % | Geode Capital Management, L.L.C. | 2.256.697 | 657.023 | 30.6.2024 |
1,74742 % | Casdin Capital, LLC | 2.084.841 | 0 | 30.6.2024 |
1,59422 % | Artisan Partners Limited Partnership | 1.902.065 | -424.436 | 30.6.2024 |
1,44781 % | Boxer Capital, L.L.C. | 1.727.388 | 0 | 30.6.2024 |
1,00482 % | Nuveen LLC | 1.198.852 | 128.111 | 30.6.2024 |
0,93379 % | Polar Capital LLP | 1.114.101 | 1.114.101 | 30.6.2024 |
0,87855 % | Morgan Stanley & Co. LLC | 1.048.194 | -351.199 | 30.6.2024 |
0,70341 % | BlackRock Financial Management, Inc. | 839.235 | 600.535 | 30.6.2024 |
0,66475 % | Charles Schwab Investment Management, Inc. | 793.117 | 244.682 | 30.6.2024 |
0,63496 % | EcoR1 Capital, LLC | 757.576 | 0 | 30.6.2024 |
0,61943 % | D. E. Shaw & Co., L.P. | 739.039 | 707.773 | 30.6.2024 |
0,59213 % | OrbiMed Advisors, LLC | 706.475 | -287.625 | 30.6.2024 |
0,58090 % | Dimensional Fund Advisors, L.P. | 693.066 | -317.102 | 30.6.2024 |
0,57007 % | Northern Trust Investments, Inc. | 680.150 | 82.692 | 30.6.2024 |
0,54946 % | Invus Public Equities Advisors, LLC | 655.555 | 655.555 | 30.6.2024 |
0,54116 % | Woodline Partners LP | 645.658 | 59.320 | 30.6.2024 |
0,44646 % | Fidelity Institutional Asset Management | 532.669 | -136.731 | 30.6.2024 |
0,43394 % | SilverArc Capital Management, LLC | 517.734 | 28.431 | 30.6.2024 |
0,43026 % | TD Asset Management Inc. | 513.338 | 300.054 | 30.6.2024 |
0,42201 % | Alethea Capital Management, LLC | 503.504 | -257.193 | 30.6.2024 |
0,39824 % | Two Sigma Investments, LP | 475.146 | -226.054 | 30.6.2024 |
0,35621 % | Cormorant Asset Management, LP | 425.000 | 425.000 | 30.6.2024 |
0,35301 % | Goldman Sachs & Company, Inc. | 421.182 | 40.446 | 30.6.2024 |
0,34728 % | Lord, Abbett & Co. LLC | 414.340 | 414.340 | 30.6.2024 |
0,31833 % | Pictet Asset Management Ltd. | 379.802 | 368.930 | 30.6.2024 |
0,31632 % | Renaissance Technologies LLC | 377.400 | 377.400 | 30.6.2024 |
0,31508 % | Eventide Asset Management, LLC | 375.924 | 375.924 | 30.6.2024 |
0,30402 % | JPMorgan Asset Management U.K. Limited | 362.732 | -69.715 | 30.6.2024 |
0,27106 % | Candriam Luxembourg S.A. | 323.396 | 0 | 30.9.2024 |
0,26678 % | Invesco Capital Management LLC | 318.293 | -25.417 | 30.6.2024 |
0,24348 % | Norges Bank Investment Management (NBIM) | 290.500 | 205.400 | 31.3.2023 |
0,23586 % | BlackRock Investment Management, LLC | 281.410 | 75.900 | 30.6.2024 |
0,22862 % | Manulife Investment Management (North America) Limited | 272.762 | 42.636 | 30.6.2024 |
0,22521 % | Levin (Arthur A.) | 268.702 | 0 | 21.10.2024 |
0,21067 % | BNY Mellon Asset Management | 251.354 | 75.981 | 30.6.2024 |
0,18817 % | Voya Investment Management LLC | 224.503 | 199.982 | 30.6.2024 |
0,18123 % | AllianceBernstein L.P. | 216.228 | -112.298 | 30.6.2024 |
0,16777 % | UBS Asset Management (Americas), Inc. | 200.170 | 182.963 | 30.6.2024 |
0,16763 % | Darwin Global Management Ltd | 200.000 | 200.000 | 30.6.2024 |
0,16525 % | Boyce (Sarah) | 197.164 | 92.120 | 23.9.2024 |
0,16355 % | Parametric Portfolio Associates LLC | 195.131 | 59.706 | 30.6.2024 |
0,16055 % | Bessemer Trust Company, N.A. (US) | 191.553 | -123.181 | 31.7.2024 |
0,15665 % | Mirae Asset Global Investments (USA) LLC | 186.896 | 149.434 | 30.6.2024 |
0,15443 % | Mutual of America Capital Management LLC | 184.249 | 40.913 | 30.6.2024 |
0,15440 % | New York State Common Retirement Fund | 184.213 | 63.843 | 30.9.2024 |
0,15326 % | BofA Global Research (US) | 182.854 | 1.183 | 30.6.2024 |
0,14961 % | Propel Bio Management, LLC | 178.500 | 0 | 30.6.2024 |
0,13799 % | American Century Investment Management, Inc. | 164.631 | 25.663 | 30.6.2024 |
0,13581 % | Jane Street Capital, L.L.C. | 162.039 | 50.125 | 30.6.2024 |
0,13476 % | Citadel Advisors LLC | 160.777 | 57.644 | 30.6.2024 |
0,13208 % | BlackRock Advisors (UK) Limited | 157.588 | 13.939 | 30.9.2024 |
0,13139 % | Raymond James & Associates, Inc. | 156.763 | 3.131 | 30.9.2024 |
0,13109 % | Schweizerische Nationalbank | 156.400 | 15.600 | 30.6.2024 |
0,12572 % | Alyeska Investment Group, L.P. | 150.000 | 150.000 | 30.6.2024 |
0,11858 % | Rhumbline Advisers Ltd. Partnership | 141.481 | 22.604 | 30.6.2024 |
0,11067 % | Voloridge Investment Management, LLC | 132.041 | 132.041 | 30.6.2024 |
0,10508 % | Millennium Management LLC | 125.375 | -43.216 | 30.6.2024 |
0,10477 % | Simplify Asset Management Inc | 125.000 | 0 | 30.6.2024 |
0,10477 % | MPM BioImpact LLC | 125.000 | 125.000 | 30.6.2024 |
0,10402 % | BlackRock Asset Management Ireland Limited | 124.107 | 52.847 | 30.6.2024 |
0,10298 % | Goldman Sachs Asset Management, L.P. | 122.869 | -11.675 | 30.6.2024 |
0,10105 % | Rafferty Asset Management LLC | 120.557 | -146.575 | 30.6.2024 |
0,10034 % | Aperio Group, LLC | 119.720 | 3.647 | 30.6.2024 |
0,09991 % | T. Rowe Price International Ltd | 119.205 | -14.520 | 30.6.2024 |
0,09774 % | EAM Global Investors LLC | 116.615 | 116.615 | 30.6.2024 |
0,09723 % | Medical Strategy GmbH | 116.000 | -20.000 | 30.6.2024 |
0,09681 % | Squarepoint Capital LLP | 115.508 | 51.743 | 30.6.2024 |
0,09673 % | Raymond James Financial Services Advisors, Inc. | 115.403 | 3.370 | 30.9.2024 |
0,09368 % | Marshall Wace LLP | 111.770 | 9.906 | 30.6.2024 |
0,09227 % | Mellon Investments Corporation | 110.088 | 39.639 | 30.6.2024 |
0,08749 % | UBS Financial Services, Inc. | 104.383 | -91.063 | 30.6.2024 |
0,08650 % | Steward Partners Investment Advisory, LLC | 103.200 | 2.700 | 30.6.2024 |
0,08508 % | Wells Fargo Advisors | 101.512 | -30.375 | 30.6.2024 |
0,08503 % | Avantis Investors | 101.454 | 101.454 | 31.3.2024 |
0,08339 % | Driehaus Capital Management, LLC | 99.496 | 99.496 | 31.8.2024 |
0,08335 % | DWS Investment GmbH | 99.444 | 0 | 30.6.2024 |
0,08194 % | BlackRock Investment Management (UK) Ltd. | 97.768 | 35.235 | 30.6.2024 |
0,07993 % | Allianz Global Investors GmbH | 95.365 | 0 | 31.8.2024 |
0,07880 % | McCarthy (Teresa) | 94.018 | 0 | 16.10.2024 |
0,07743 % | Legal & General Investment Management Ltd. | 92.379 | 16.330 | 30.6.2024 |
0,07597 % | EAM Investors, LLC | 90.635 | 90.635 | 30.6.2024 |
0,07576 % | Barclays Bank PLC | 90.391 | -32.256 | 30.6.2024 |
0,07123 % | MacLean (Michael F.) | 84.980 | 38.490 | 23.9.2024 |
0,06987 % | Cinctive Capital Management LP | 83.362 | 83.362 | 30.6.2024 |
0,06616 % | California State Teachers Retirement System | 78.937 | 7.363 | 30.6.2024 |
0,06558 % | Hennion & Walsh Asset Management, Inc. | 78.238 | -975 | 30.9.2024 |
0,06407 % | Wilson (Troy Edward) | 76.444 | -550.000 | 15.4.2024 |