| 9,45851 % | RA Capital Management, LP | 60 379 366 | 0 | |
| 6,79185 % | BlackRock Institutional Trust Company, N.A. | 43 356 429 | 300 243 | |
| 6,73601 % | Deep Track Capital LP | 43 000 000 | 4 823 749 | |
| 5,55961 % | The Vanguard Group, Inc. | 35 490 312 | 1 467 349 | |
| 4,26488 % | Vivo Capital, LLC | 27 225 292 | 0 | |
| 3,72439 % | Vestal Point Capital, LP | 23 775 000 | 1 769 660 | |
| 3,70197 % | State Street Investment Management (US) | 23 631 876 | -279 916 | |
| 2,52835 % | Soleus Capital Management, L.P. | 16 140 000 | 13 740 000 | |
| 2,25207 % | ClearBridge Investments, LLC | 14 376 311 | 5 689 169 | |
| 2,21694 % | Geode Capital Management, L.L.C. | 14 152 038 | 584 444 | |
| 2,02612 % | Morgan Stanley & Co. LLC | 12 933 955 | 6 114 874 | |
| 1,88544 % | Citadel Advisors LLC | 12 035 901 | 5 372 587 | |
| 1,83987 % | UBS Financial Services, Inc. | 11 745 012 | 6 772 529 | |
| 1,50483 % | Point72 Asset Management, L.P. | 9 606 217 | 2 479 399 | |
| 1,44794 % | Goldman Sachs & Company, Inc. | 9 243 099 | 1 599 684 | |
| 1,25293 % | Woodline Partners LP | 7 998 188 | 269 443 | |
| 1,14672 % | Eversept Partners, LP | 7 320 174 | 7 320 174 | |
| 1,12667 % | Segall Bryant & Hamill, LLC | 7 192 184 | -234 670 | |
| 1,09436 % | abrdn Inc. | 6 985 932 | 3 293 179 | |
| 1,04161 % | StemPoint Capital LP | 6 649 244 | 5 688 937 | |
| 0,95929 % | BofA Global Research (US) | 6 123 740 | -3 379 999 | |
| 0,94733 % | Millennium Management LLC | 6 047 354 | -4 759 271 | |
| 0,78312 % | Renaissance Technologies LLC | 4 999 100 | -602 000 | |
| 0,78037 % | Qube Research & Technologies Ltd | 4 981 598 | 186 043 | |
| 0,75755 % | Fidelity Management & Research Company LLC | 4 835 896 | -7 527 719 | |
| 0,73881 % | Northern Trust Investments, Inc. | 4 716 236 | -18 709 | |
| 0,73459 % | Charles Schwab Investment Management, Inc. | 4 689 314 | 238 283 | |
| 0,69688 % | Algert Global LLC | 4 448 600 | 1 187 666 | |
| 0,58007 % | DWS Investments UK Limited | 3 702 959 | -80 805 | |
| 0,56382 % | Squarepoint Capital LLP | 3 599 221 | 2 199 413 | |
| 0,54144 % | Kynam Capital Management LP | 3 456 318 | -203 208 | |
| 0,53487 % | Exome Asset Management LLC | 3 414 377 | 198 920 | |
| 0,50935 % | Ally Bridge Group NY LLC | 3 251 475 | 1 194 838 | |
| 0,48562 % | 683 Capital Management LLC | 3 100 000 | 250 000 | |
| 0,41943 % | Candriam Luxembourg S.A. | 2 677 461 | 23 698 | |
| 0,36500 % | Edmond de Rothschild Asset Management (France) S.A. | 2 330 000 | 200 000 | |
| 0,33461 % | Barclays Bank PLC | 2 136 011 | 1 004 495 | |
| 0,32600 % | Nuveen LLC | 2 081 071 | -725 596 | |
| 0,30018 % | BlackRock Advisors (UK) Limited | 1 916 200 | 29 682 | |
| 0,29699 % | Candriam Belgium S.A. | 1 895 892 | -118 | |
| 0,27555 % | BlackRock Investment Management, LLC | 1 759 000 | 274 705 | |
| 0,26871 % | BlackRock Asset Management Ireland Limited | 1 715 345 | -206 186 | |
| 0,25122 % | Susquehanna International Group, LLP | 1 603 685 | -268 815 | |
| 0,25064 % | Ikarian Capital LLC | 1 600 000 | 1 450 000 | |
| 0,24357 % | Balyasny Asset Management LP | 1 554 849 | -1 955 071 | |
| 0,24335 % | BlackRock Financial Management, Inc. | 1 553 442 | -72 543 | |
| 0,23498 % | Affinity Asset Advisors LLC | 1 500 000 | 0 | |
| 0,21517 % | Nan Fung Trinity (HK) Limited | 1 373 550 | 1 373 550 | |
| 0,18695 % | UBS Asset Management (Switzerland) | 1 193 385 | 596 614 | |
| 0,17202 % | BNY Mellon Asset Management | 1 098 122 | 57 132 | |
| 0,17003 % | Prelude Capital Management, LLC | 1 085 427 | 190 402 | |
| 0,16288 % | Pensionmark Financial Group, LLC | 1 039 779 | 7 376 | |
| 0,15665 % | Stonepine Capital Management, LLC | 1 000 000 | 500 000 | |
| 0,15250 % | Schweizerische Nationalbank | 973 500 | -22 000 | |
| 0,14800 % | Marshall Wace LLP | 944 790 | -4 195 674 | |
| 0,14109 % | Aperio Group, LLC | 900 659 | 545 519 | |
| 0,13990 % | Kodai Capital Management, L.P. | 893 091 | 893 091 | |
| 0,13690 % | Rhumbline Advisers Ltd. Partnership | 873 893 | 34 437 | |
| 0,12979 % | Rafferty Asset Management LLC | 828 509 | -53 098 | |
| 0,12532 % | Centiva Capital, LP | 800 001 | 0 | |
| 0,11216 % | Patient Square Capital, LP | 716 000 | 716 000 | |
| 0,10915 % | Columbia Threadneedle Investments (US) | 696 781 | -54 925 | |
| 0,10897 % | William Blair Investment Management, LLC | 695 620 | 0 | |
| 0,10642 % | GSA Capital Partners LLP | 679 331 | 444 725 | |
| 0,09795 % | AllianceBernstein L.P. | 625 291 | 0 | |
| 0,09736 % | Fubon Asset Management Company Ltd. | 621 525 | 21 027 | |
| 0,09030 % | Cantor Fitzgerald, L.P | 576 436 | 50 000 | |
| 0,08960 % | Boothbay Fund Management, LLC | 572 002 | 518 085 | |
| 0,08646 % | MML Investors Services, LLC | 551 915 | 800 | |
| 0,08629 % | Legal & General Investment Management Ltd. | 550 871 | 42 345 | |
| 0,08399 % | Mellon Investments Corporation | 536 178 | -27 112 | |
| 0,08007 % | Goldman Sachs Asset Management, L.P. | 511 103 | 72 984 | |
| 0,07833 % | Lion Point Capital, L.P. | 500 000 | 0 | |
| 0,07808 % | T. Rowe Price International Ltd | 498 445 | 65 038 | |
| 0,07792 % | HRT Financial LP | 497 407 | -911 867 | |
| 0,07751 % | Summit Wealth Strategies | 494 789 | -53 110 | |
| 0,07511 % | California State Teachers Retirement System | 479 503 | -5 459 | |
| 0,07430 % | UBS Fund Management (Switzerland) AG | 474 302 | -9 079 | |
| 0,07366 % | Invesco Advisers, Inc. | 470 190 | 9 059 | |
| 0,06911 % | Adar1 Capital Management LLC | 441 176 | 175 000 | |
| 0,06858 % | Schonfeld Strategic Advisors LLC | 437 795 | 152 189 | |
| 0,06755 % | BlackRock Investment Management (UK) Ltd. | 431 201 | 0 | |
| 0,06247 % | Citi Investment Research (US) | 398 775 | -721 553 | |
| 0,06221 % | Mirae Asset Global Investments (USA) LLC | 397 117 | -16 729 | |
| 0,06204 % | Northern Trust Global Investments Limited | 396 020 | 1 191 | |
| 0,06172 % | Graham Capital Management, L.P. | 393 990 | 17 230 | |
| 0,05894 % | Los Angeles Capital Management LLC | 376 272 | 342 098 | |
| 0,05708 % | Hennion & Walsh Asset Management, Inc. | 364 400 | -6 635 | |
| 0,05689 % | MetLife Investment Management, LLC | 363 137 | 57 829 | |
| 0,05687 % | UBS Asset Management (UK) Ltd. | 363 027 | 119 074 | |
| 0,05616 % | Harvest Fund Management Co., Ltd. | 358 506 | 41 612 | |
| 0,05599 % | Creative Planning, Inc. | 357 427 | 250 752 | |
| 0,05557 % | INTECH Investment Management LLC | 354 715 | -181 260 | |
| 0,05519 % | Group One Trading, L.P. | 352 342 | -91 522 | |
| 0,05443 % | Private Advisor Group LLC | 347 488 | 8 891 | |
| 0,05382 % | Alps Advisors, Inc. | 343 560 | 343 560 | |
| 0,05155 % | Inspire Investing | 329 051 | 44 327 | |
| 0,05046 % | Nvest Financial, LLC | 322 125 | 122 884 | |
| 0,05017 % | Invesco Capital Management LLC | 320 257 | -2 837 219 | |
| 0,04960 % | Manulife Investment Management (North America) Limited | 316 622 | 18 491 | |