14,96499 % | Fidelity Management & Research Company LLC | 10 678 612 | 48 951 | 30.06.2022 |
8,13684 % | The Vanguard Group, Inc. | 5 806 227 | 686 912 | 30.06.2022 |
7,27898 % | Vifor (International), Ltd | 5 194 085 | 0 | 13.09.2022 |
5,73376 % | BlackRock Institutional Trust Company, N.A. | 4 091 453 | 306 603 | 30.06.2022 |
5,67001 % | State Street Global Advisors (US) | 4 045 964 | 404 301 | 30.06.2022 |
3,35404 % | Schall (Thomas J) | 2 393 352 | 0 | 13.09.2022 |
3,32502 % | Pictet Asset Management Ltd. | 2 372 645 | 532 478 | 30.06.2022 |
2,94707 % | Wasatch Global Investors Inc | 2 102 953 | 1 027 231 | 30.06.2022 |
2,51223 % | Baker Bros. Advisors LP | 1 792 657 | 875 795 | 30.06.2022 |
2,15378 % | GW&K Investment Management, LLC | 1 536 877 | 375 530 | 30.06.2022 |
1,99699 % | Cormorant Asset Management, LP | 1 425 000 | 560 000 | 30.06.2022 |
1,96820 % | Invesco Advisers, Inc. | 1 404 451 | 34 143 | 30.06.2022 |
1,87336 % | Hood River Capital Management LLC | 1 336 776 | 1 336 776 | 30.06.2022 |
1,65218 % | Marshall Wace LLP | 1 178 948 | -219 635 | 30.06.2022 |
1,54129 % | Norges Bank Investment Management (NBIM) | 1 099 824 | 661 000 | 31.12.2021 |
1,53785 % | HealthCor Management, L.P. | 1 097 370 | 140 630 | 30.06.2022 |
1,41112 % | Geode Capital Management, L.L.C. | 1 006 934 | 6 519 | 30.06.2022 |
1,18123 % | Nuveen LLC | 842 891 | 340 858 | 30.06.2022 |
1,02076 % | Eventide Asset Management, LLC | 728 385 | 0 | 30.06.2022 |
0,92914 % | Morgan Stanley & Co. LLC | 663 007 | 262 249 | 30.06.2022 |
0,89221 % | Sofinnova Investments, Inc | 636 659 | 62 975 | 30.06.2022 |
0,84084 % | Logos Global Management LLC | 600 000 | 600 000 | 30.06.2022 |
0,81428 % | Wellington Management Company, LLP | 581 050 | -64 783 | 30.06.2022 |
0,80444 % | Integral Health Asset Management, LLC | 574 029 | 174 029 | 30.06.2022 |
0,77680 % | Principal Global Investors (Equity) | 554 300 | 249 434 | 30.06.2022 |
0,76524 % | Barclays Bank PLC | 546 057 | 505 367 | 30.06.2022 |
0,76451 % | Tri Locum Partners LP | 545 532 | 249 205 | 30.06.2022 |
0,69025 % | Northern Trust Investments, Inc. | 492 544 | 46 115 | 30.06.2022 |
0,68038 % | APG Asset Management N.V. | 485 501 | 485 501 | 31.03.2022 |
0,61897 % | Perceptive Advisors LLC | 441 680 | -1 213 399 | 30.06.2022 |
0,53568 % | Charles Schwab Investment Management, Inc. | 382 244 | 14 545 | 30.06.2022 |
0,51949 % | Millennium Management LLC | 370 692 | -930 257 | 30.06.2022 |
0,50771 % | Voloridge Investment Management, LLC | 362 291 | -301 944 | 30.06.2022 |
0,44388 % | Invesco Capital Management LLC | 316 743 | 76 060 | 30.06.2022 |
0,43899 % | Goldman Sachs & Company, Inc. | 313 253 | 62 366 | 30.06.2022 |
0,43461 % | T. Rowe Price Associates, Inc. | 310 129 | -55 505 | 30.06.2022 |
0,42662 % | Citadel Advisors LLC | 304 424 | -1 906 | 30.06.2022 |
0,39746 % | Raymond James & Associates, Inc. | 283 620 | -11 213 | 30.06.2022 |
0,36369 % | Raymond James Financial Services Advisors, Inc. | 259 519 | 12 347 | 30.06.2022 |
0,32452 % | PGIM Quantitative Solutions LLC | 231 570 | 231 570 | 30.06.2022 |
0,32154 % | Parametric Portfolio Associates LLC | 229 439 | -14 171 | 30.06.2022 |
0,31396 % | Kanaya (Susan M) | 224 034 | 0 | 13.09.2022 |
0,30925 % | Thornburg Investment Management, Inc. | 220 675 | -25 602 | 30.06.2022 |
0,27396 % | Dimensional Fund Advisors, L.P. | 195 488 | -124 852 | 30.06.2022 |
0,25918 % | Lisanti Capital Growth, LLC | 184 946 | -136 623 | 30.06.2022 |
0,25265 % | Lord, Abbett & Co. LLC | 180 285 | 169 409 | 30.06.2022 |
0,25259 % | BNY Mellon Asset Management | 180 238 | 21 793 | 30.06.2022 |
0,24858 % | BlackRock Investment Management, LLC | 177 382 | 7 809 | 30.06.2022 |
0,23596 % | BlackRock Financial Management, Inc. | 168 375 | 22 142 | 30.06.2022 |
0,23578 % | Granahan Investment Management, Inc. | 168 245 | 45 478 | 30.06.2022 |
0,23563 % | Two Sigma Investments, LP | 168 141 | -833 794 | 30.06.2022 |
0,23097 % | Goldman Sachs Asset Management, L.P. | 164 816 | 39 130 | 30.06.2022 |
0,22422 % | Altium Capital Management LP | 160 000 | 160 000 | 30.06.2022 |
0,22342 % | Citi Investment Research (US) | 159 427 | 117 029 | 30.06.2022 |
0,21638 % | Soleus Capital Management, L.P. | 154 400 | 154 400 | 30.06.2022 |
0,21603 % | Susquehanna International Group, LLP | 154 151 | -18 198 | 30.06.2022 |
0,21353 % | Rafferty Asset Management LLC | 152 368 | -73 036 | 30.06.2022 |
0,20758 % | Feczko (Joseph M) | 148 127 | 0 | 13.09.2022 |
0,20083 % | Edwards (Thomas A) | 143 306 | 0 | 13.09.2022 |
0,20007 % | Parker (Geoffrey M) | 142 763 | 0 | 13.09.2022 |
0,19510 % | Assenagon Asset Management S.A. | 139 219 | -22 556 | 30.06.2022 |
0,19176 % | Northern Trust Global Investments | 136 838 | 38 823 | 30.06.2022 |
0,19157 % | Nomura Asset Management Co., Ltd. | 136 700 | -59 499 | 30.11.2021 |
0,18952 % | BofA Global Research (US) | 135 237 | -111 166 | 30.06.2022 |
0,18919 % | BZ Bank AG (Asset Management) | 135 000 | 0 | 31.05.2022 |
0,18498 % | Schweizerische Nationalbank | 132 000 | 16 100 | 30.06.2022 |
0,17251 % | Medical Strategy GmbH | 123 100 | 7 500 | 31.05.2022 |
0,16971 % | International Biotechnology Trust PLC | 121 100 | 85 000 | 30.06.2022 |
0,16641 % | Allspring Global Investments, LLC | 118 744 | 39 199 | 30.06.2022 |
0,15954 % | Capital Fund Management S.A. | 113 844 | 113 844 | 30.06.2022 |
0,14732 % | ExodusPoint Capital Management, LP | 105 124 | 11 155 | 30.06.2022 |
0,13558 % | Ensign Peak Advisors, Inc. | 96 746 | 23 783 | 30.06.2022 |
0,13236 % | Mutual of America Capital Management LLC | 94 450 | -41 248 | 30.06.2022 |
0,13220 % | UBS Financial Services, Inc. | 94 337 | -73 833 | 30.06.2022 |
0,12468 % | Aperio Group, LLC | 88 969 | -6 250 | 30.06.2022 |
0,12284 % | Cappel (Markus J) | 87 658 | 0 | 13.09.2022 |
0,12018 % | BlackRock Advisors (UK) Limited | 85 759 | 5 091 | 31.08.2022 |
0,12003 % | Mirabella Financial Services LLP | 85 653 | 85 653 | 30.06.2022 |
0,11562 % | Rhumbline Advisers Ltd. Partnership | 82 501 | 8 950 | 30.06.2022 |
0,11300 % | Group One Trading, L.P. | 80 635 | 80 635 | 30.06.2022 |
0,10959 % | Tekla Capital Management LLC | 78 197 | 0 | 30.06.2022 |
0,10581 % | AllianceBernstein L.P. | 75 500 | 13 100 | 30.06.2022 |
0,10479 % | California State Teachers Retirement System | 74 776 | 9 871 | 30.06.2022 |
0,10427 % | BlackRock Asset Management Ireland Limited | 74 403 | 9 221 | 30.06.2022 |
0,10216 % | Jane Street Capital, L.L.C. | 72 896 | -41 935 | 30.06.2022 |
0,10195 % | McKinnell (Henry A Jr) | 72 749 | 7 726 | 20.05.2022 |
0,10122 % | Allianz Global Investors U.S. LLC | 72 225 | 7 540 | 30.06.2022 |
0,09737 % | Jump Financial, LLC | 69 484 | 60 484 | 30.06.2022 |
0,09580 % | Cahill Wealth Management, LLC | 68 358 | 23 445 | 30.06.2022 |
0,09109 % | Hudson Bay Capital Management LP | 65 000 | 10 000 | 30.06.2022 |
0,08913 % | Cubist Systematic Strategies, LLC | 63 599 | 31 059 | 30.06.2022 |
0,08856 % | EFG Asset Management (UK) Limited | 63 195 | 11 721 | 31.05.2022 |
0,08696 % | EFG Asset Management (North America) Corp | 62 051 | 8 550 | 30.06.2022 |
0,08572 % | Ohio Public Employees Retirement System | 61 171 | 26 172 | 30.06.2022 |
0,08531 % | Algert Global LLC | 60 875 | 46 740 | 30.06.2022 |
0,08156 % | Jennison Associates LLC | 58 200 | 58 200 | 30.06.2022 |
0,07689 % | State of Wisconsin Investment Board | 54 866 | -11 834 | 30.06.2022 |
0,07367 % | SEI Investments Management Corporation | 52 572 | 52 572 | 30.06.2022 |
0,07277 % | PanAgora Asset Management Inc. | 51 929 | 23 495 | 30.06.2022 |
0,07146 % | Legal & General Investment Management Ltd. | 50 994 | 8 111 | 30.06.2022 |