7,60022 % | Fidelity Management & Research Company LLC | 5 203 110 | 3 540 565 | 30.06.2024 |
6,09026 % | RTW Investments L.P. | 4 169 393 | 60 000 | 30.06.2024 |
4,67426 % | Commodore Capital LP | 3 200 000 | -1 160 000 | 30.06.2024 |
4,01607 % | Deerfield Management Company, L.P. | 2 749 401 | 100 000 | 30.06.2024 |
3,50394 % | Federated Hermes Global Investment Management Corp. | 2 398 800 | 150 000 | 30.06.2024 |
3,39497 % | Samlyn Capital, LLC | 2 324 195 | 247 605 | 30.06.2024 |
3,07649 % | Franklin Advisers, Inc. | 2 106 163 | 241 915 | 30.06.2024 |
2,95036 % | Paradigm BioCapital Advisors LP | 2 019 814 | 2 019 814 | 30.06.2024 |
2,77534 % | Boxer Capital, L.L.C. | 1 900 000 | 0 | 30.06.2024 |
2,42907 % | Wellington Management Company, LLP | 1 662 941 | 414 301 | 30.06.2024 |
2,29896 % | Holocene Advisors, LP | 1 573 866 | 634 290 | 30.06.2024 |
2,26411 % | Driehaus Capital Management, LLC | 1 550 009 | 323 518 | 30.06.2024 |
2,16928 % | Morgan Stanley & Co. LLC | 1 485 092 | 556 281 | 30.06.2024 |
2,11953 % | Two Sigma Investments, LP | 1 451 027 | 20 418 | 30.06.2024 |
2,02339 % | T. Rowe Price Associates, Inc. | 1 385 216 | 199 862 | 30.06.2024 |
1,97926 % | Avoro Capital Advisors LLC | 1 355 000 | 466 112 | 30.06.2024 |
1,86832 % | BVF Partners L.P. | 1 279 049 | 106 800 | 30.06.2024 |
1,85079 % | Polar Capital LLP | 1 267 052 | 1 267 052 | 30.06.2024 |
1,84519 % | VR Adviser, LLC | 1 263 214 | -527 000 | 30.06.2024 |
1,76265 % | Lynx1 Capital Advisors LLC | 1 206 707 | -302 300 | 30.06.2024 |
1,49258 % | Fidelity Institutional Asset Management | 1 021 822 | 1 021 822 | 30.06.2024 |
1,48555 % | Janus Henderson Investors | 1 017 007 | 474 427 | 30.06.2024 |
1,47250 % | Incyte Corp | 1 008 076 | -2 996 468 | 30.06.2024 |
1,46227 % | Rock Springs Capital Management LP | 1 001 073 | -145 487 | 30.06.2024 |
1,40048 % | Woodline Partners LP | 958 769 | 287 970 | 30.06.2024 |
1,39929 % | Marshall Wace LLP | 957 952 | 853 060 | 30.06.2024 |
1,24160 % | Logos Global Management LLC | 850 000 | 850 000 | 30.06.2024 |
1,23353 % | Pictet Asset Management Ltd. | 844 474 | 214 799 | 30.06.2024 |
1,22699 % | Cormorant Asset Management, LP | 840 000 | 125 000 | 30.06.2024 |
1,12474 % | Adage Capital Management, L.P. | 770 000 | 445 000 | 30.06.2024 |
1,11066 % | Invus Public Equities Advisors, LLC | 760 355 | 305 274 | 30.06.2024 |
1,08417 % | BlackRock Financial Management, Inc. | 742 225 | 3 033 | 30.06.2024 |
1,05270 % | T. Rowe Price Investment Management, Inc. | 720 676 | -8 339 | 30.06.2024 |
1,02249 % | Novo Holdings A/S | 700 000 | 25 000 | 30.09.2024 |
1,01957 % | Candriam Luxembourg S.A. | 697 997 | 0 | 30.09.2024 |
0,99039 % | AllianceBernstein L.P. | 678 021 | 594 761 | 30.06.2024 |
0,91094 % | SilverArc Capital Management, LLC | 623 628 | 57 341 | 30.06.2024 |
0,85455 % | Balyasny Asset Management LP | 585 024 | 585 024 | 30.06.2024 |
0,84716 % | Invesco Advisers, Inc. | 579 967 | 578 811 | 30.06.2024 |
0,76437 % | Great Point Partners, LLC | 523 288 | 300 000 | 30.06.2024 |
0,76152 % | D. E. Shaw & Co., L.P. | 521 339 | 247 813 | 30.06.2024 |
0,62583 % | BlackRock Institutional Trust Company, N.A. | 428 443 | 26 103 | 30.06.2024 |
0,59808 % | Dafna Capital Management, LLC | 409 445 | 30 450 | 30.06.2024 |
0,57796 % | Lord, Abbett & Co. LLC | 395 672 | 71 042 | 30.06.2024 |
0,54969 % | Soleus Capital Management, L.P. | 376 321 | 180 744 | 30.06.2024 |
0,54499 % | Frazier Life Sciences Management, L.P. | 373 100 | -373 379 | 30.06.2024 |
0,49009 % | Tri Locum Partners LP | 335 514 | 49 192 | 30.06.2024 |
0,48134 % | Medical Strategy GmbH | 329 522 | 18 321 | 30.06.2024 |
0,47021 % | First Turn Management, LLC | 321 906 | 321 906 | 30.06.2024 |
0,43821 % | Perceptive Advisors LLC | 300 000 | 300 000 | 30.06.2024 |
0,43821 % | Baker Bros. Advisors LP | 300 000 | 300 000 | 30.06.2024 |
0,42166 % | StemPoint Capital LP | 288 668 | 54 797 | 30.06.2024 |
0,38690 % | State Street Global Advisors (US) | 264 873 | 20 197 | 30.06.2024 |
0,35533 % | Millennium Management LLC | 243 257 | 92 987 | 30.06.2024 |
0,31382 % | Voloridge Investment Management, LLC | 214 838 | 149 137 | 30.06.2024 |
0,30514 % | Handelsbanken Kapitalf¿rvaltning AB | 208 900 | 34 200 | 30.09.2024 |
0,30267 % | Goldman Sachs & Company, Inc. | 207 209 | 102 495 | 30.06.2024 |
0,29666 % | BlackRock Advisors (UK) Limited | 203 092 | 675 | 30.09.2024 |
0,28104 % | BlackRock Asset Management Ireland Limited | 192 397 | -7 721 | 30.06.2024 |
0,26617 % | TimesSquare Capital Management, LLC | 182 220 | 174 216 | 30.06.2024 |
0,26563 % | Citadel Advisors LLC | 181 853 | -170 355 | 30.06.2024 |
0,26161 % | Decheng Capital LLC | 179 098 | 77 300 | 30.06.2024 |
0,25540 % | Ally Bridge Group NY LLC | 174 844 | -81 084 | 30.06.2024 |
0,24955 % | BNP Paribas Securities Corp. North America | 170 844 | 67 959 | 30.06.2024 |
0,24069 % | Saturn V Capital Management LP | 164 773 | -211 856 | 30.06.2024 |
0,22802 % | OrbiMed Advisors, LLC | 156 100 | 156 100 | 30.06.2024 |
0,22789 % | Liu (Hui) | 156 016 | 98 085 | 15.03.2024 |
0,22678 % | The Vanguard Group, Inc. | 155 257 | 8 232 | 30.06.2024 |
0,22354 % | State of Wisconsin Investment Board | 153 038 | 130 307 | 30.06.2024 |
0,22213 % | Lundberg (Sven Ante) | 152 071 | 0 | 15.03.2024 |
0,21634 % | Aquilo Capital Management, LLC | 148 109 | -107 000 | 30.06.2024 |
0,21565 % | Sphera Funds Management Ltd. | 147 633 | -1 700 | 30.06.2024 |
0,19475 % | Algert Global LLC | 133 323 | 35 549 | 30.06.2024 |
0,18632 % | TD Asset Management Inc. | 127 554 | -23 620 | 30.06.2024 |
0,18469 % | BlackRock Investment Management (UK) Ltd. | 126 442 | 40 537 | 30.06.2024 |
0,18259 % | Affinity Asset Advisors LLC | 125 000 | 125 000 | 30.06.2024 |
0,17752 % | Invesco Capital Management LLC | 121 529 | -5 564 | 30.06.2024 |
0,17534 % | Nan Fung Life Sciences | 120 038 | 30 522 | 30.06.2024 |
0,17049 % | HighVista Strategies LLC | 116 718 | -4 962 | 30.06.2024 |
0,16652 % | Ensign Peak Advisors, Inc. | 114 000 | 114 000 | 30.06.2024 |
0,16068 % | DWS Investment GmbH | 110 000 | 0 | 30.06.2024 |
0,14607 % | Integral Health Asset Management, LLC | 100 000 | -65 000 | 30.06.2024 |
0,14607 % | Tang Capital Management, LLC | 100 000 | 100 000 | 30.06.2024 |
0,13219 % | Rhenman & Partners Asset Management AB | 90 500 | 90 500 | 30.06.2024 |
0,13043 % | Wellington Management Singapore Pte. Ltd. | 89 295 | 89 295 | 31.03.2024 |
0,13043 % | Wellington Management Japan Pte Ltd | 89 295 | -61 818 | 30.06.2023 |
0,12740 % | abrdn Inc. | 87 215 | 87 215 | 30.09.2024 |
0,12708 % | Nomura Asset Management Co., Ltd. | 87 000 | 87 000 | 30.11.2023 |
0,12278 % | Voya Investment Management LLC | 84 055 | 54 205 | 30.06.2024 |
0,11813 % | BofA Global Research (US) | 80 873 | 25 690 | 30.06.2024 |
0,11759 % | Nicholas Investment Partners, L.P. | 80 503 | 62 818 | 30.06.2024 |
0,11431 % | Schweizerische Nationalbank | 78 254 | 4 200 | 30.06.2024 |
0,11291 % | First Trust Advisors L.P. | 77 296 | 26 233 | 30.06.2024 |
0,10888 % | Jane Street Capital, L.L.C. | 74 542 | 61 764 | 30.06.2024 |
0,10769 % | Platinum Asset Management | 73 722 | -25 768 | 30.06.2024 |
0,10747 % | Iwicki (Mark T.) | 73 576 | 73 576 | 15.03.2024 |
0,10594 % | Principal Global Investors (Equity) | 72 526 | 3 740 | 31.08.2024 |
0,10320 % | J.P. Morgan Securities LLC | 70 652 | -26 024 | 30.06.2024 |
0,09710 % | Eversept Partners, LP | 66 474 | -53 008 | 30.06.2024 |
0,09176 % | Fred Alger Management, LLC | 62 816 | 42 219 | 30.06.2024 |