7,18876 % | Samsara BioCapital, LLC | 5 161 888 | 0 | 31.12.2022 |
6,05189 % | Frazier Healthcare Partners | 4 345 559 | 80 000 | 31.12.2022 |
4,94397 % | BlackRock Institutional Trust Company, N.A. | 3 550 018 | 273 697 | 31.12.2022 |
4,22701 % | Versant Ventures | 3 035 207 | -400 000 | 01.03.2023 |
4,17798 % | Deep Track Capital LP | 3 000 000 | 0 | 31.12.2022 |
3,87812 % | The Vanguard Group, Inc. | 2 784 681 | 392 808 | 31.12.2022 |
3,70302 % | State Street Global Advisors (US) | 2 658 956 | 193 237 | 31.12.2022 |
3,55366 % | Octagon Capital Advisors LP | 2 551 703 | 0 | 31.12.2022 |
3,52914 % | Baker Bros. Advisors LP | 2 534 102 | 0 | 31.12.2022 |
2,82613 % | OrbiMed Advisors, LLC | 2 029 300 | 0 | 31.12.2022 |
2,01216 % | Suvretta Capital Management, LLC | 1 444 830 | 54 830 | 31.12.2022 |
1,76542 % | Point72 Asset Management, L.P. | 1 267 660 | -1 173 094 | 31.12.2022 |
1,72423 % | Dimensional Fund Advisors, L.P. | 1 238 080 | 124 336 | 31.12.2022 |
1,62407 % | Pictet Asset Management Ltd. | 1 166 164 | 484 052 | 31.12.2022 |
1,62001 % | Victory Capital Management Inc. | 1 163 245 | 136 182 | 31.12.2022 |
1,28982 % | Candriam Luxembourg S.A. | 926 155 | 0 | 31.01.2023 |
1,28982 % | Candriam Belgium S.A. | 926 155 | 55 000 | 31.12.2022 |
1,27674 % | Nuveen LLC | 916 765 | -44 493 | 31.12.2022 |
1,27321 % | Geode Capital Management, L.L.C. | 914 226 | 39 669 | 31.12.2022 |
1,23703 % | Assenagon Asset Management S.A. | 888 249 | -543 145 | 31.12.2022 |
1,21461 % | Vivo Capital, LLC | 872 151 | 0 | 31.12.2022 |
1,20869 % | Federated Hermes Global Investment Management Corp. | 867 900 | 867 900 | 31.12.2022 |
1,15556 % | Laurion Capital Management LP | 829 750 | 643 | 31.12.2022 |
1,14223 % | Adage Capital Management, L.P. | 820 178 | 720 178 | 31.12.2022 |
1,13925 % | Affinity Asset Advisors LLC | 818 035 | 4 037 | 31.12.2022 |
1,12312 % | Sofinnova Investments, Inc | 806 459 | 518 558 | 31.12.2022 |
1,07611 % | Driehaus Capital Management, LLC | 772 700 | -108 984 | 31.12.2022 |
1,02925 % | Davis (Jerel C) | 739 051 | 1 646 | 22.12.2022 |
1,00245 % | Rubric Capital Management LP | 719 809 | -229 357 | 31.12.2022 |
0,96094 % | EcoR1 Capital, LLC | 690 000 | 0 | 31.12.2022 |
0,89509 % | Nicholas Investment Partners, L.P. | 642 720 | 75 305 | 31.12.2022 |
0,71188 % | Citadel Advisors LLC | 511 167 | 290 148 | 31.12.2022 |
0,70679 % | Rock Springs Capital Management LP | 507 512 | 0 | 31.12.2022 |
0,68200 % | Baillie Gifford & Co. | 489 708 | 25 394 | 31.12.2022 |
0,61380 % | Millennium Management LLC | 440 738 | 41 769 | 31.12.2022 |
0,58934 % | Saturn V Capital Management LLC | 423 177 | 423 177 | 31.12.2022 |
0,53916 % | Northern Trust Investments, Inc. | 387 144 | 11 216 | 31.12.2022 |
0,53617 % | Altium Capital Management LP | 385 000 | -140 000 | 31.12.2022 |
0,53438 % | Charles Schwab Investment Management, Inc. | 383 712 | 9 225 | 31.12.2022 |
0,52309 % | Two Sigma Investments, LP | 375 608 | -90 517 | 31.12.2022 |
0,51363 % | Eventide Asset Management, LLC | 368 811 | 368 811 | 31.12.2022 |
0,50392 % | Ensign Peak Advisors, Inc. | 361 838 | 124 933 | 31.12.2022 |
0,50106 % | D. E. Shaw & Co., L.P. | 359 785 | -119 742 | 31.12.2022 |
0,47405 % | International Biotechnology Trust PLC | 340 389 | 0 | 31.12.2022 |
0,42728 % | Fidelity Management & Research Company LLC | 306 810 | -22 429 | 31.12.2022 |
0,42382 % | Norges Bank Investment Management (NBIM) | 304 326 | 304 326 | 31.12.2022 |
0,41938 % | Dobmeier (Eric L. J.D.) | 301 138 | 12 151 | 10.02.2023 |
0,39477 % | Ikarian Capital LLC | 283 464 | 0 | 31.12.2022 |
0,32841 % | Connor, Clark & Lunn Investment Management Ltd. | 235 816 | -51 468 | 31.12.2022 |
0,26934 % | Invesco Capital Management LLC | 193 400 | 13 264 | 31.12.2022 |
0,25533 % | Putnam Investment Management, L.L.C. | 183 343 | -7 200 | 31.12.2022 |
0,25299 % | Renaissance Technologies LLC | 181 662 | -37 680 | 31.12.2022 |
0,24375 % | BofA Global Research (US) | 175 023 | 35 910 | 31.12.2022 |
0,24372 % | Integral Health Asset Management, LLC | 175 000 | 175 000 | 31.12.2022 |
0,24234 % | Rafferty Asset Management LLC | 174 011 | 30 893 | 31.12.2022 |
0,22989 % | BlackRock Financial Management, Inc. | 165 075 | 1 760 | 31.12.2022 |
0,22798 % | Goldman Sachs & Company, Inc. | 163 702 | -182 336 | 31.12.2022 |
0,21260 % | BlackRock Investment Management, LLC | 152 658 | 6 369 | 31.12.2022 |
0,20998 % | Frohlich (Tom) | 150 777 | 3 103 | 10.02.2023 |
0,20834 % | Polar Asset Management Partners Inc. | 149 600 | 0 | 31.12.2022 |
0,19854 % | Woodline Partners LP | 142 563 | -166 821 | 31.12.2022 |
0,19166 % | Northern Trust Global Investments | 137 619 | 98 593 | 31.12.2022 |
0,19113 % | BNY Mellon Asset Management | 137 243 | 2 292 | 31.12.2022 |
0,19083 % | Morgan Stanley & Co. LLC | 137 025 | 5 694 | 31.12.2022 |
0,18303 % | Algert Global LLC | 131 427 | -1 430 | 31.12.2022 |
0,18296 % | Walleye Capital LLC | 131 375 | -166 009 | 31.12.2022 |
0,17959 % | ExodusPoint Capital Management, LP | 128 955 | -41 701 | 31.12.2022 |
0,17715 % | Sphera Funds Management Ltd. | 127 200 | -407 158 | 31.12.2022 |
0,15869 % | Nan Fung Group Holdings Ltd | 113 950 | 0 | 31.12.2022 |
0,14570 % | JP Morgan Asset Management | 104 622 | 15 119 | 31.12.2022 |
0,14206 % | EAM Investors, LLC | 102 007 | -21 903 | 31.12.2022 |
0,14197 % | Barclays Bank PLC | 101 941 | 9 670 | 31.12.2022 |
0,13746 % | Schweizerische Nationalbank | 98 700 | 5 200 | 31.12.2022 |
0,13620 % | UBS Asset Management (Americas), Inc. | 97 801 | -3 870 | 31.01.2023 |
0,12553 % | Balyasny Asset Management LP | 90 140 | -190 147 | 31.12.2022 |
0,12534 % | Pura Vida Investments, LLC | 90 000 | 90 000 | 31.12.2022 |
0,11379 % | Parametric Portfolio Associates LLC | 81 705 | -5 203 | 31.12.2022 |
0,11294 % | Rhumbline Advisers Ltd. Partnership | 81 093 | 4 382 | 31.12.2022 |
0,11141 % | BioImpact Capital LLC | 80 000 | 80 000 | 31.12.2022 |
0,10918 % | Nomura Asset Management Co., Ltd. | 78 400 | 78 400 | 30.11.2022 |
0,10890 % | Citi Investment Research (US) | 78 195 | -53 812 | 31.12.2022 |
0,10863 % | Soleus Capital Management, L.P. | 78 000 | 0 | 31.12.2022 |
0,09765 % | New York State Common Retirement Fund | 70 116 | 7 241 | 31.12.2022 |
0,09576 % | UBS Financial Services, Inc. | 68 764 | 45 316 | 31.12.2022 |
0,09301 % | EAM Global Investors LLC | 66 787 | -17 559 | 31.12.2022 |
0,08862 % | BlackRock Advisors (UK) Limited | 63 636 | 2 432 | 28.02.2023 |
0,08356 % | HealthCor Management, L.P. | 60 000 | -206 830 | 31.12.2022 |
0,08211 % | Baillie Gifford Overseas Ltd. | 58 957 | 0 | 31.01.2023 |
0,08168 % | Mellon Investments Corporation | 58 648 | 21 230 | 31.12.2022 |
0,08021 % | Wellington Management Company, LLP | 57 593 | 12 503 | 31.12.2022 |
0,07773 % | California State Teachers Retirement System | 55 811 | 1 952 | 31.12.2022 |
0,07584 % | BlackRock Asset Management Ireland Limited | 54 454 | 15 710 | 31.12.2022 |
0,07314 % | AllianceBernstein L.P. | 52 520 | 17 400 | 31.12.2022 |
0,06893 % | HighVista Strategies LLC | 49 495 | -34 056 | 31.12.2022 |
0,06751 % | Goldman Sachs Asset Management, L.P. | 48 474 | -8 078 | 31.12.2022 |
0,06605 % | FundLogic SAS | 47 430 | 0 | 31.12.2022 |
0,06388 % | Jump Financial, LLC | 45 868 | 2 234 | 31.12.2022 |
0,06383 % | Dimensional Fund Advisors, Ltd. | 45 833 | 0 | 31.01.2023 |
0,06341 % | Martingale Asset Management, L.P. | 45 533 | 206 | 31.12.2022 |
0,06128 % | Fisher Investments | 44 003 | -7 004 | 31.12.2022 |