47,36823 % | Artal International S.C.A. | 171.231.426 | -351.744 | 25.07.2024 |
10,70213 % | Fidelity Management & Research Company LLC | 38.687.123 | 24.793.061 | 30.06.2024 |
2,48210 % | BlackRock Institutional Trust Company, N.A. | 8.972.550 | 1.982.903 | 30.06.2024 |
2,29466 % | Braidwell LP | 8.294.950 | 8.294.950 | 30.06.2024 |
2,12319 % | The Vanguard Group, Inc. | 7.675.125 | 1.273.900 | 30.06.2024 |
1,61722 % | OrbiMed Advisors, LLC | 5.846.100 | 2.304.100 | 30.06.2024 |
1,50798 % | Ulys, L.L.C. | 5.451.204 | 0 | 25.07.2024 |
1,14006 % | Point72 Asset Management, L.P. | 4.121.191 | 3.536.805 | 30.06.2024 |
0,97270 % | Invus Public Equities Advisors, LLC | 3.516.214 | 0 | 25.07.2024 |
0,89920 % | Geode Capital Management, L.L.C. | 3.250.535 | 861.398 | 30.06.2024 |
0,66653 % | Citadel Advisors LLC | 2.409.456 | 2.274.979 | 30.06.2024 |
0,65902 % | New Enterprise Associates (NEA) | 2.382.286 | 0 | 30.06.2024 |
0,63998 % | State Street Global Advisors (US) | 2.313.477 | 325.967 | 30.06.2024 |
0,63740 % | Nantahala Capital Management, LLC | 2.304.150 | 2.304.150 | 30.06.2024 |
0,57891 % | Columbia Threadneedle Investments (US) | 2.092.710 | 674.760 | 30.06.2024 |
0,51869 % | Opaleye Management Inc. | 1.875.000 | 1.875.000 | 30.06.2024 |
0,47466 % | Pinnacle Associates Ltd. | 1.715.831 | -31.999 | 30.06.2024 |
0,37598 % | Charles Schwab Investment Management, Inc. | 1.359.148 | 478.025 | 30.06.2024 |
0,37314 % | Debbane (Raymond) | 1.348.879 | 0 | 25.07.2024 |
0,34930 % | Medical Strategy GmbH | 1.262.672 | -2.030.863 | 31.12.2023 |
0,32932 % | Marshall Wace LLP | 1.190.448 | 691.276 | 30.06.2024 |
0,30376 % | Coats (Lonnel) | 1.098.068 | 0 | 18.03.2024 |
0,25407 % | Northern Trust Investments, Inc. | 918.455 | 127.543 | 30.06.2024 |
0,20433 % | Wellington Management Company, LLP | 738.628 | 52.210 | 30.06.2024 |
0,20226 % | Hennion & Walsh Asset Management, Inc. | 731.138 | 188.239 | 30.09.2024 |
0,16524 % | Millennium Management LLC | 597.321 | 63.137 | 30.06.2024 |
0,15809 % | Schonfeld Strategic Advisors LLC | 571.492 | -388.658 | 30.06.2024 |
0,09356 % | BlackRock Investment Management, LLC | 338.198 | 89.151 | 30.06.2024 |
0,08969 % | Wade (Jeffrey L) | 324.214 | 0 | 18.03.2024 |
0,08536 % | BlackRock Financial Management, Inc. | 308.581 | 55.948 | 30.06.2024 |
0,07795 % | Goldman Sachs & Company, Inc. | 281.772 | 200.893 | 30.06.2024 |
0,07553 % | AllianceBernstein L.P. | 273.041 | 53.100 | 30.06.2024 |
0,07469 % | BBR Partners LLC | 270.000 | 240.000 | 30.06.2024 |
0,07433 % | BNY Mellon Asset Management | 268.692 | 53.050 | 30.06.2024 |
0,07074 % | Main (Alan J) | 255.724 | 0 | 18.03.2024 |
0,06941 % | LifeSci Index Partners, LLC | 250.923 | 125.063 | 31.12.2023 |
0,06871 % | Amouyal (Philippe J) | 248.364 | 0 | 25.07.2024 |
0,05931 % | Nuveen LLC | 214.399 | -307.911 | 30.06.2024 |
0,05690 % | BlackRock Asset Management Ireland Limited | 205.696 | 72.496 | 30.06.2024 |
0,05690 % | BlackRock Advisors (UK) Limited | 205.688 | 4.547 | 30.09.2024 |
0,05533 % | ACCI Capital Investments SGIIC, SA | 200.000 | 20.000 | 31.07.2024 |
0,04979 % | Virtus Etf Advisers LLC | 179.972 | -113.120 | 30.06.2024 |
0,04910 % | Crum (Brian T) | 177.497 | 0 | 18.03.2024 |
0,04796 % | Morgan Stanley & Co. LLC | 173.383 | -12.196 | 30.06.2024 |
0,04621 % | Sobecki (Christopher J) | 167.055 | 0 | 25.07.2024 |
0,04500 % | Kassler-Taub (Kenneth B) | 162.672 | 43.047 | 28.02.2024 |
0,04227 % | Rhumbline Advisers Ltd. Partnership | 152.785 | 17.940 | 30.06.2024 |
0,04070 % | UBS Financial Services, Inc. | 147.111 | -19.850 | 30.06.2024 |
0,03625 % | Assenagon Asset Management S.A. | 131.042 | -720 | 30.09.2024 |
0,03592 % | Jane Street Capital, L.L.C. | 129.856 | -151.732 | 30.06.2024 |
0,03545 % | Mellon Investments Corporation | 128.156 | 56.852 | 30.06.2024 |
0,03375 % | Caspar Asset Management S.A. | 122.000 | 122.000 | 31.12.2023 |
0,03375 % | Altium Capital Management LP | 121.986 | 121.986 | 30.06.2024 |
0,03242 % | T. Rowe Price International Ltd | 117.179 | 11.864 | 30.06.2024 |
0,03157 % | Susquehanna International Group, LLP | 114.126 | 103.283 | 30.06.2024 |
0,03008 % | Commonwealth Financial Network | 108.734 | 7.600 | 30.09.2024 |
0,02766 % | Compagnie Lombard Odier SCmA | 100.000 | 6.000 | 30.09.2024 |
0,02536 % | Goldman Sachs Asset Management, L.P. | 91.659 | 16.324 | 30.06.2024 |
0,02527 % | Parametric Portfolio Associates LLC | 91.351 | 77.491 | 30.06.2024 |
0,02442 % | Morgan Stanley Smith Barney LLC | 88.290 | 44.572 | 30.06.2024 |
0,02425 % | Barker (Samuel L) | 87.649 | 8.032 | 28.04.2024 |
0,02412 % | BofA Global Research (US) | 87.185 | 1.313 | 30.06.2024 |
0,02341 % | Simplex Trading, LLC | 84.637 | 84.637 | 30.06.2024 |
0,02187 % | Northern Trust Global Investments | 79.073 | 3.429 | 30.06.2024 |
0,02143 % | UBS Fund Management (Switzerland) AG | 77.466 | 0 | 30.09.2024 |
0,02105 % | Dimensional Fund Advisors, L.P. | 76.086 | 26.143 | 30.06.2024 |
0,01936 % | BMO Private Investment Counsel Inc. | 70.000 | 30.000 | 30.06.2024 |
0,01923 % | China Universal Asset Management Co., Ltd. | 69.527 | 27.058 | 30.09.2024 |
0,01777 % | Aperio Group, LLC | 64.230 | -3.622 | 30.06.2024 |
0,01709 % | Corebridge Financial Inc | 61.770 | 61.770 | 30.06.2024 |
0,01690 % | LPL Financial LLC | 61.085 | -28.878 | 30.06.2024 |
0,01661 % | Pathstone | 60.038 | -2.687 | 30.06.2024 |
0,01604 % | Mirae Asset Global Investments (USA) LLC | 57.975 | 57.974 | 30.06.2024 |
0,01527 % | MetLife Investment Management, LLC | 55.182 | 22.320 | 30.06.2024 |
0,01470 % | Seth (Kiernan) | 53.136 | 31.269 | 28.02.2023 |
0,01468 % | Russell Investments Trust Company | 53.080 | 3.980 | 30.06.2024 |
0,01458 % | McDermott (Wendy) | 52.694 | 24.216 | 28.02.2024 |
0,01423 % | Stifel, Nicolaus & Company, Incorporated | 51.451 | -723 | 30.06.2024 |
0,01382 % | Manulife Investment Management (North America) Limited | 49.957 | 14.411 | 30.06.2024 |
0,01354 % | JPMorgan Private Bank (United States) | 48.931 | 12.608 | 30.06.2024 |
0,01338 % | Swain (Judith L) | 48.364 | 8.032 | 28.04.2024 |
0,01338 % | Lefkowitz (Robert J) | 48.364 | 8.032 | 28.04.2024 |
0,01328 % | Vanguard Investments Australia Ltd. | 47.993 | 47.993 | 31.08.2024 |
0,01322 % | Alexander (Kristen) | 47.800 | 17.450 | 28.02.2024 |
0,01317 % | Granowitz (Craig B. M.D., Ph.D.) | 47.626 | 0 | 18.03.2024 |
0,01281 % | T. Rowe Price Associates, Inc. | 46.297 | 0 | 30.06.2024 |
0,01275 % | SG Americas Securities, L.L.C. | 46.090 | 23.893 | 30.09.2024 |
0,01263 % | SunAmerica Asset Management, LLC | 45.658 | -391 | 31.03.2024 |
0,01254 % | Victory Capital Management Inc. | 45.341 | 13.972 | 30.06.2024 |
0,01253 % | Wells Fargo Bank, N.A. | 45.301 | 14.587 | 30.06.2024 |
0,01162 % | LUNIS Verm¿gensmanagement AG | 42.000 | 0 | 31.03.2024 |
0,01148 % | J.P. Morgan Securities plc | 41.487 | -12.326 | 30.06.2024 |
0,01135 % | Nies (Alan S) | 41.046 | 9.302 | 21.05.2023 |
0,01130 % | Wedbush Securities, Inc. | 40.850 | -800 | 30.06.2024 |
0,01124 % | KWB Wealth | 40.640 | 0 | 30.09.2024 |
0,01116 % | Palantoni (Frank P) | 40.332 | 9.302 | 21.05.2023 |
0,01097 % | Voya Investment Management LLC | 39.646 | 10.677 | 30.06.2024 |
0,01091 % | Barclays Bank PLC | 39.437 | -25.182 | 30.06.2024 |
0,01022 % | Two Sigma Investments, LP | 36.927 | -152.504 | 30.06.2024 |
0,01004 % | Invesco Capital Management LLC | 36.278 | 11.874 | 30.06.2024 |