| 6,90 % | Maverick Capital, Ltd. | 8 447 804 | 1 853 485 | 2023-12-31 |
| 6,02 % | M28 Capital Management LP | 7 373 413 | 328 913 | 2023-12-31 |
| 4,89 % | Adage Capital Management, L.P. | 5 987 730 | 2 200 000 | 2023-12-31 |
| 4,66 % | Shin Nippon Biomedical Laboratories Ltd | 5 705 060 | 0 | 2023-06-12 |
| 4,57 % | 683 Capital Management LLC | 5 600 000 | −250 000 | 2023-12-31 |
| 4,00 % | BlackRock Institutional Trust Company, N.A. | 4 903 231 | 431 425 | 2023-12-31 |
| 3,67 % | Bellevue Asset Management AG | 4 494 458 | 0 | 2023-12-31 |
| 3,21 % | Kynam Capital Management LP | 3 932 082 | 0 | 2023-12-31 |
| 3,07 % | PRIMECAP Management Company | 3 759 408 | −21 100 | 2023-12-31 |
| 2,62 % | Point72 Asset Management, L.P. | 3 213 500 | 3 213 500 | 2023-12-31 |
| 2,46 % | Invus Public Equities Advisors, LLC | 3 007 400 | 1 007 400 | 2023-12-31 |
| 14,86 % | RA Capital Management, LP | 18 202 009 | 1 000 000 | 2023-12-31 |
| 11,42 % | GSK plc | 13 983 761 | 3 300 000 | 2023-12-31 |
| 1,65 % | Kagoshima Shinsangyo Sousei Investment, L. P. | 2 019 873 | 2 019 873 | 2022-07-19 |
| 1,62 % | Citadel Advisors LLC | 1 982 252 | 1 982 252 | 2023-12-31 |
| 1,28 % | T. Rowe Price Associates, Inc. | 1 569 395 | 356 463 | 2023-12-31 |
| 1,19 % | Geode Capital Management, L.L.C. | 1 459 764 | 64 627 | 2023-12-31 |
| 1,19 % | Maven Investment Partners US Ltd. | 1 452 778 | 1 452 778 | 2023-12-31 |
| 1,14 % | Woodline Partners LP | 1 391 561 | 162 878 | 2023-12-31 |
| 1,06 % | The Vanguard Group, Inc. | 1 298 677 | 116 075 | 2023-12-31 |
| 1,03 % | State Street Global Advisors (US) | 1 263 729 | 68 982 | 2023-12-31 |
| 0,98 % | Fidelity Management & Research Company LLC | 1 202 215 | 541 790 | 2023-12-31 |
| 0,87 % | Laurion Capital Management LP | 1 071 500 | 200 000 | 2023-12-31 |
| 0,54 % | Platinum Asset Management | 655 331 | 200 000 | 2023-12-31 |
| 0,48 % | Driehaus Capital Management, LLC | 587 575 | 587 575 | 2023-12-31 |
| 0,44 % | Northern Trust Investments, Inc. | 535 041 | 69 023 | 2023-12-31 |
| 0,42 % | Millennium Management LLC | 514 581 | 259 687 | 2023-12-31 |
| 0,42 % | Newtyn Management, LLC | 510 000 | 0 | 2023-12-31 |
| 0,41 % | Marshall Wace LLP | 500 209 | 318 571 | 2023-12-31 |
| 0,35 % | Walleye Capital LLC | 432 933 | 283 973 | 2023-12-31 |
| 0,33 % | Bolno (Paul B. M.D.) | 407 425 | 0 | 2023-06-12 |
| 0,33 % | JPMorgan Asset Management U.K. Limited | 401 551 | 0 | 2023-12-31 |
| 0,27 % | Goldman Sachs & Company, Inc. | 334 175 | 41 655 | 2023-12-31 |
| 0,22 % | Wellington Management Company, LLP | 274 093 | 9 208 | 2023-12-31 |
| 0,17 % | Jacobs Levy Equity Management, Inc. | 212 377 | 212 377 | 2023-12-31 |
| 0,17 % | Nuveen LLC | 207 771 | −5 067 | 2023-12-31 |
| 0,17 % | TD Asset Management Inc. | 205 746 | 43 054 | 2023-12-31 |
| 0,16 % | Water Street Capital, Inc. | 192 722 | 0 | 2023-12-31 |
| 0,15 % | BlackRock Financial Management, Inc. | 185 031 | 28 315 | 2023-12-31 |
| 0,15 % | Morgan Stanley & Co. LLC | 177 832 | 107 906 | 2023-12-31 |
| 0,14 % | BlackRock Investment Management, LLC | 173 523 | −200 | 2023-12-31 |
| 0,14 % | Charles Schwab Investment Management, Inc. | 169 693 | 0 | 2023-12-31 |
| 0,12 % | Schweizerische Nationalbank | 152 400 | 152 400 | 2023-12-31 |
| 0,12 % | BNY Mellon Asset Management | 143 067 | −1 177 | 2023-12-31 |
| 0,11 % | Manulife Investment Management (North America) Limited | 133 406 | 51 087 | 2023-12-31 |
| 0,10 % | Barclays Bank PLC | 122 928 | 105 401 | 2023-12-31 |
| 0,09 % | Rhumbline Advisers Ltd. Partnership | 114 595 | 3 084 | 2023-12-31 |
| 0,09 % | Credit Suisse Funds AG | 111 931 | 94 461 | 2023-12-31 |
| 0,08 % | Monashee Investment Management, LLC | 103 300 | 103 300 | 2023-12-31 |
| 0,08 % | BlackRock Advisors (UK) Limited | 100 257 | 4 241 | 2024-03-31 |
| 0,08 % | Vargeese (Chandra) | 96 346 | 0 | 2023-06-12 |
| 0,07 % | Balyasny Asset Management LP | 88 970 | 52 618 | 2023-12-31 |
| 0,07 % | Macquarie Investment Management | 81 955 | 0 | 2023-12-31 |
| 0,07 % | UBS Financial Services, Inc. | 81 584 | 56 701 | 2023-12-31 |
| 0,07 % | Assenagon Asset Management S.A. | 80 624 | 5 873 | 2024-02-29 |
| 0,06 % | Jane Street Capital, L.L.C. | 79 438 | 79 438 | 2023-12-31 |
| 0,06 % | California State Teachers Retirement System | 78 661 | 65 614 | 2023-12-31 |
| 0,06 % | a16z Perennial Management, L.P. | 77 619 | 77 619 | 2023-12-31 |
| 0,06 % | State Teachers Retirement System of Ohio | 75 800 | 75 800 | 2023-12-31 |
| 0,06 % | Martingale Asset Management, L.P. | 68 807 | 25 190 | 2023-12-31 |
| 0,05 % | J. J. Burns & Company, LLC | 65 049 | 32 000 | 2023-12-31 |
| 0,05 % | BofA Global Research (US) | 62 226 | 17 247 | 2023-12-31 |
| 0,05 % | Barclays Capital Inc. | 58 339 | 58 339 | 2023-12-31 |
| 0,05 % | T. Rowe Price International Ltd | 57 968 | 1 738 | 2023-12-31 |
| 0,05 % | UBS Asset Management (Switzerland) | 57 026 | 50 287 | 2023-12-31 |
| 0,05 % | Goldman Sachs Asset Management, L.P. | 56 957 | 7 683 | 2023-12-31 |
| 0,04 % | Francis (Christopher John) | 51 564 | −10 258 | 2023-02-16 |
| 0,04 % | BlackRock Asset Management Ireland Limited | 50 923 | 8 721 | 2023-12-31 |
| 0,04 % | Capstone Investment Advisors, LLC | 50 000 | 50 000 | 2023-12-31 |
| 0,04 % | Legal & General Investment Management Ltd. | 49 356 | 44 618 | 2023-12-31 |
| 0,04 % | Northern Trust Global Investments | 48 884 | −8 | 2023-12-31 |
| 0,04 % | Kraematon Investment Advisors, Inc | 47 000 | 47 000 | 2023-12-31 |
| 0,04 % | ACCI Capital Investments SGIIC, SA | 45 000 | 45 000 | 2023-12-31 |
| 0,04 % | UBS Asset Management (UK) Ltd. | 44 341 | 0 | 2024-02-29 |
| 0,03 % | Putnam Investment Management, L.L.C. | 42 537 | 42 537 | 2023-12-31 |
| 0,03 % | Northern Trust Global Investments Limited | 42 525 | 42 525 | 2023-12-31 |
| 0,03 % | BNP Paribas Securities Corp. North America | 41 234 | 30 858 | 2023-12-31 |
| 0,03 % | Birchview Capital, LP | 40 000 | 40 000 | 2023-12-31 |
| 0,03 % | JPMorgan Private Bank (United States) | 39 111 | 39 111 | 2023-12-31 |
| 0,03 % | Tudor Investment Corporation | 36 580 | 36 580 | 2023-12-31 |
| 0,03 % | Mellon Investments Corporation | 36 491 | 3 981 | 2023-12-31 |
| 0,03 % | Mirae Asset Global Investments (USA) LLC | 35 523 | −51 130 | 2023-12-31 |
| 0,03 % | Deka Investment GmbH | 35 000 | 35 000 | 2022-12-31 |
| 0,03 % | SG Americas Securities, L.L.C. | 34 562 | 8 694 | 2023-12-31 |
| 0,03 % | Virtu Americas LLC | 34 432 | 34 432 | 2023-12-31 |
| 0,03 % | Zürcher Kantonalbank (Asset Management) | 32 250 | 30 250 | 2023-12-31 |
| 0,03 % | Trexquant Investment LP | 32 119 | 32 119 | 2023-12-31 |
| 0,03 % | MetLife Investment Management, LLC | 31 423 | 0 | 2023-12-31 |
| 0,03 % | Aperio Group, LLC | 31 347 | 12 028 | 2023-12-31 |
| 0,02 % | Verdine Gregory L | 30 000 | 0 | 2023-06-12 |
| 0,02 % | SunAmerica Asset Management, LLC | 29 390 | −119 | 2023-12-31 |
| 0,02 % | SEI Investments Management Corporation | 29 000 | 0 | 2023-12-31 |
| 0,02 % | Invesco Advisers, Inc. | 28 919 | 7 151 | 2023-12-31 |
| 0,02 % | DWS Investments UK Limited | 27 457 | −714 | 2023-12-31 |
| 0,02 % | Engineers Gate Manager, L.P. | 26 820 | 26 820 | 2023-12-31 |
| 0,02 % | Two Sigma Investments, LP | 26 543 | 26 543 | 2023-12-31 |
| 0,02 % | Columbia Threadneedle Investments (US) | 25 999 | 25 999 | 2023-12-31 |
| 0,02 % | Conestoga Capital Advisors, LLC | 25 994 | 0 | 2024-02-29 |
| 0,02 % | Vaughan Nelson Investment Management, L.P. | 25 203 | 0 | 2023-12-31 |
| 0,02 % | Cinctive Capital Management LP | 25 000 | 25 000 | 2023-12-31 |
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