10,25535 % | The Vanguard Group, Inc. | 7 052 605 | 56 561 | 2024-12-31 |
9,78114 % | EcoR1 Capital, LLC | 6 726 491 | 0 | 2024-12-31 |
7,68529 % | BlackRock Institutional Trust Company, N.A. | 5 285 175 | 152 309 | 2024-12-31 |
5,85132 % | T. Rowe Price Associates, Inc. | 4 023 951 | 289 365 | 2024-12-31 |
5,06053 % | Citadel Advisors LLC | 3 480 125 | 407 457 | 2025-01-30 |
5,02809 % | Pfizer Inc | 3 457 815 | 0 | 2024-12-31 |
4,84849 % | RTW Investments L.P. | 3 334 308 | 551 979 | 2024-12-31 |
3,47477 % | Bellevue Asset Management AG | 2 389 600 | 3 000 | 2024-12-31 |
3,21104 % | T. Rowe Price Investment Management, Inc. | 2 208 234 | 2 208 234 | 2024-12-31 |
2,92818 % | UBS Financial Services, Inc. | 2 013 709 | 1 544 844 | 2024-12-31 |
2,58333 % | ArrowMark Colorado Holdings, LLC | 1 776 555 | 532 105 | 2024-12-31 |
2,38047 % | State Street Global Advisors (US) | 1 637 050 | −6 677 | 2024-12-31 |
2,36295 % | Opaleye Management Inc. | 1 625 000 | 370 000 | 2024-12-31 |
2,30583 % | New Leaf Venture Partners LLC | 1 585 721 | 151 000 | 2024-12-31 |
2,19720 % | Geode Capital Management, L.L.C. | 1 511 014 | −8 320 | 2024-12-31 |
2,04798 % | Nextech Invest, Ltd. | 1 408 394 | 0 | 2024-12-31 |
1,97470 % | Avidity Partners Management LP | 1 358 000 | −139 000 | 2024-12-31 |
1,93799 % | JP Morgan Asset Management | 1 332 753 | −149 928 | 2024-12-31 |
1,80874 % | Norges Bank Investment Management (NBIM) | 1 243 868 | 165 622 | 2024-12-31 |
1,53935 % | Boxer Capital Management, LLC | 1 058 614 | 1 058 614 | 2024-12-31 |
1,25891 % | Houston (John G) | 865 750 | −188 441 | 2024-03-31 |
1,25277 % | Fidelity Institutional Asset Management | 861 530 | −587 912 | 2024-12-31 |
1,24783 % | Morgan Stanley & Co. LLC | 858 133 | 446 418 | 2024-12-31 |
1,22645 % | Dimensional Fund Advisors, L.P. | 843 430 | 186 254 | 2024-12-31 |
1,07714 % | Perceptive Advisors LLC | 740 749 | −287 000 | 2024-12-31 |
1,03792 % | Finepoint Capital LP | 713 778 | 139 400 | 2024-12-31 |
1,01789 % | Logos Global Management LLC | 700 000 | 300 000 | 2024-12-31 |
1,01396 % | Fidelity Management & Research Company LLC | 697 297 | −736 865 | 2024-12-31 |
1,00732 % | Woodline Partners LP | 692 733 | 194 996 | 2024-12-31 |
1,00080 % | BlackRock Financial Management, Inc. | 688 250 | −43 816 | 2024-12-31 |
0,98895 % | Two Sigma Investments, LP | 680 102 | 66 233 | 2024-12-31 |
0,95405 % | Schonfeld Strategic Advisors LLC | 656 100 | 300 295 | 2024-12-31 |
0,94925 % | Candriam Luxembourg S.A. | 652 801 | 0 | 2024-12-31 |
0,91610 % | Affinity Asset Advisors LLC | 630 000 | 405 000 | 2024-12-31 |
0,81866 % | Northern Trust Investments, Inc. | 562 995 | 55 788 | 2024-12-31 |
0,77957 % | Charles Schwab Investment Management, Inc. | 536 112 | 5 443 | 2024-12-31 |
0,73278 % | Candriam Belgium S.A. | 503 936 | −20 845 | 2024-12-31 |
0,63435 % | Wasatch Global Investors Inc | 436 241 | 298 | 2024-12-31 |
0,61269 % | RA Capital Management, LP | 421 348 | 0 | 2024-12-31 |
0,58976 % | Baker Bros. Advisors LP | 405 576 | 0 | 2024-12-31 |
0,53155 % | Goldman Sachs & Company, Inc. | 365 546 | −215 269 | 2024-12-31 |
0,47807 % | Aquilo Capital Management, LLC | 328 766 | −60 000 | 2024-12-31 |
0,45782 % | Millennium Management LLC | 314 843 | 106 218 | 2024-12-31 |
0,43214 % | PanAgora Asset Management Inc. | 297 186 | 35 475 | 2024-12-31 |
0,41491 % | Frazier Life Sciences Management, L.P. | 285 331 | 0 | 2024-09-30 |
0,38974 % | Marshall Wace LLP | 268 026 | 97 676 | 2024-12-31 |
0,38320 % | BIT Capital GmbH | 263 527 | 196 246 | 2024-12-31 |
0,36874 % | UBS Asset Management (Switzerland) | 253 584 | 208 703 | 2024-12-31 |
0,36743 % | American Century Investment Management, Inc. | 252 685 | −58 788 | 2024-12-31 |
0,36355 % | J.P. Morgan Securities LLC | 250 010 | 98 722 | 2024-12-31 |
0,33928 % | BlackRock Advisors (UK) Limited | 233 323 | 758 | 2025-01-31 |
0,33864 % | Nordea Funds Oy | 232 886 | 9 196 | 2024-12-31 |
0,32238 % | Nuveen LLC | 221 698 | −1 725 | 2024-12-31 |
0,32067 % | BlackRock Asset Management Ireland Limited | 220 528 | 17 495 | 2024-12-31 |
0,31802 % | Exome Asset Management LLC | 218 700 | 218 700 | 2024-12-31 |
0,30776 % | Nordea Investment Management AB (Denmark) | 211 644 | −3 141 | 2024-12-31 |
0,30390 % | Kennedy Capital Management LLC | 208 992 | 61 802 | 2024-12-31 |
0,30257 % | BlackRock Investment Management, LLC | 208 079 | −39 930 | 2024-12-31 |
0,30088 % | Caption Management, LLC | 206 915 | 206 915 | 2024-12-31 |
0,29953 % | Algert Global LLC | 205 988 | 37 927 | 2024-12-31 |
0,27133 % | Gilder Gagnon Howe & Co. LLC | 186 594 | −7 749 | 2024-12-31 |
0,26994 % | UBS Asset Management Switzerland AG | 185 641 | 0 | 2025-01-31 |
0,25450 % | Barclays Bank PLC | 175 019 | 53 320 | 2024-12-31 |
0,24367 % | Cassidy (Sean A) | 167 572 | −19 135 | 2024-03-31 |
0,23905 % | Neuberger Berman, LLC | 164 392 | 5 762 | 2024-12-31 |
0,23864 % | TwinBeech Capital LP | 164 112 | 164 112 | 2024-12-31 |
0,22612 % | Rhenman & Partners Asset Management AB | 155 500 | 25 000 | 2024-12-31 |
0,21085 % | Ghost Tree Capital, LLC | 145 000 | 70 000 | 2024-09-30 |
0,20594 % | JPMorgan Asset Management U.K. Limited | 141 626 | −478 697 | 2024-12-31 |
0,20433 % | Assenagon Asset Management S.A. | 140 518 | 777 | 2024-12-31 |
0,18723 % | BofA Global Research (US) | 128 755 | −315 298 | 2024-12-31 |
0,18598 % | SELECTRA Management Company S.A. | 127 900 | 1 900 | 2024-06-30 |
0,18510 % | Goldman Sachs Asset Management, L.P. | 127 292 | −46 019 | 2024-12-31 |
0,17791 % | TD Asset Management Inc. | 122 348 | 48 800 | 2024-12-31 |
0,17126 % | BNY Mellon Asset Management | 117 776 | −3 869 | 2024-12-31 |
0,16942 % | Columbia Threadneedle Investments (US) | 116 513 | 19 505 | 2024-12-31 |
0,16320 % | Parametric Portfolio Associates LLC | 112 231 | 8 666 | 2024-12-31 |
0,16100 % | Jane Street Capital, L.L.C. | 110 722 | −26 573 | 2024-12-31 |
0,16085 % | Banque Pictet & Cie S.A. | 110 619 | −10 205 | 2024-12-31 |
0,15540 % | Parkman Healthcare Partners LLC | 106 871 | 10 688 | 2024-12-31 |
0,14541 % | Saint Olive Gestion | 100 000 | 0 | 2024-12-31 |
0,14541 % | Wanjia Asset Management Co., Ltd. | 100 000 | −50 000 | 2024-06-30 |
0,14541 % | DWS Investment GmbH | 100 000 | 0 | 2024-12-31 |
0,14342 % | BlackRock Investment Management (UK) Ltd. | 98 629 | −9 752 | 2024-12-31 |
0,13669 % | Schweizerische Nationalbank | 94 000 | 0 | 2024-12-31 |
0,13665 % | UBS Asset Management (Americas), Inc. | 93 977 | −22 527 | 2024-12-31 |
0,13658 % | Taylor (Ian) | 93 928 | −56 279 | 2024-03-31 |
0,13214 % | Nomura Asset Management Taiwan Limited | 90 870 | 0 | 2024-12-31 |
0,13020 % | Manulife Investment Management (North America) Limited | 89 540 | −866 | 2024-12-31 |
0,12779 % | Graham Capital Management, L.P. | 87 879 | 24 303 | 2024-12-31 |
0,12778 % | Rhumbline Advisers Ltd. Partnership | 87 877 | 754 | 2024-12-31 |
0,12597 % | Patient Square Capital, LP | 86 627 | 86 627 | 2024-12-31 |
0,12571 % | Zacks Investment Management, Inc. | 86 448 | −3 379 | 2024-12-31 |
0,11724 % | DWS Investments UK Limited | 80 625 | −13 166 | 2024-12-31 |
0,11633 % | Edmond de Rothschild Asset Management (France) S.A. | 80 000 | 80 000 | 2024-12-31 |
0,11496 % | T. Rowe Price International Ltd | 79 060 | −40 070 | 2024-12-31 |
0,11427 % | abrdn Inc. | 78 585 | 0 | 2024-12-31 |
0,11080 % | Qube Research & Technologies Ltd | 76 198 | −133 711 | 2024-12-31 |
0,10855 % | Engineers Gate Manager, L.P. | 74 651 | 44 919 | 2024-12-31 |
0,10780 % | JPMorgan Private Bank (United States) | 74 133 | −878 | 2024-12-31 |