7,94972 % | Fidelity Management & Research Company LLC | 6 084 718 | 454 406 | 31. 12. 2024 |
7,40354 % | Avoro Capital Advisors LLC | 5 666 666 | 0 | 31. 12. 2024 |
5,90619 % | Driehaus Capital Management, LLC | 4 520 595 | -75 126 | 31. 12. 2024 |
4,93547 % | Wellington Management Company, LLP | 3 777 611 | -65 836 | 31. 12. 2024 |
3,80711 % | Braidwell LP | 2 913 964 | 206 709 | 31. 12. 2024 |
3,74543 % | Janus Henderson Investors | 2 866 755 | 314 363 | 31. 12. 2024 |
3,57983 % | Commodore Capital LP | 2 740 000 | 40 000 | 31. 12. 2024 |
3,52451 % | Polar Capital LLP | 2 697 657 | 253 012 | 31. 12. 2024 |
3,32795 % | Capital International Investors | 2 547 210 | -33 962 | 31. 12. 2024 |
2,99783 % | Capital World Investors | 2 294 537 | -387 000 | 31. 12. 2024 |
2,43464 % | Adage Capital Management, L.P. | 1 863 473 | -220 499 | 31. 12. 2024 |
1,95520 % | Pictet Asset Management Ltd. | 1 496 511 | -32 303 | 31. 12. 2024 |
1,88552 % | AllianceBernstein L.P. | 1 443 180 | 18 445 | 31. 12. 2024 |
1,88212 % | Fidelity Institutional Asset Management | 1 440 572 | 153 200 | 31. 12. 2024 |
1,87854 % | T. Rowe Price Investment Management, Inc. | 1 437 831 | -65 977 | 31. 12. 2024 |
1,63556 % | Rock Springs Capital Management LP | 1 251 859 | -64 618 | 31. 12. 2024 |
1,51716 % | Affinity Asset Advisors LLC | 1 161 237 | 17 216 | 31. 12. 2024 |
1,51631 % | First Light Asset Management, LLC | 1 160 580 | -21 082 | 31. 12. 2024 |
1,51187 % | Westfield Capital Management Company, L.P. | 1 157 189 | 487 589 | 31. 12. 2024 |
1,32981 % | Samlyn Capital, LLC | 1 017 838 | -2 368 | 31. 12. 2024 |
1,31351 % | BlackRock Financial Management, Inc. | 1 005 363 | 0 | 31. 12. 2024 |
1,29825 % | Baker Bros. Advisors LP | 993 679 | 0 | 31. 12. 2024 |
1,23841 % | OrbiMed Advisors, LLC | 947 877 | 36 457 | 31. 12. 2024 |
1,19678 % | JP Morgan Asset Management | 916 013 | 67 835 | 31. 12. 2024 |
1,17549 % | Marshall Wace LLP | 899 718 | -295 762 | 31. 12. 2024 |
1,10903 % | TimesSquare Capital Management, LLC | 848 850 | 70 557 | 31. 12. 2024 |
1,05827 % | Vestal Point Capital, LP | 810 000 | -15 000 | 31. 12. 2024 |
1,04723 % | Jennison Associates LLC | 801 553 | 224 892 | 31. 12. 2024 |
0,97174 % | Invus Public Equities Advisors, LLC | 743 769 | 0 | 31. 12. 2024 |
0,89776 % | Loomis, Sayles & Company, L.P. | 687 145 | -20 077 | 31. 12. 2024 |
0,89494 % | First Turn Management, LLC | 684 986 | 359 768 | 31. 12. 2024 |
0,84971 % | BlackRock Institutional Trust Company, N.A. | 650 365 | -49 513 | 31. 12. 2024 |
0,80929 % | BNP Paribas Asset Management USA, Inc. | 619 431 | 217 815 | 31. 12. 2024 |
0,78390 % | Boxer Capital Management, LLC | 600 000 | 600 000 | 31. 12. 2024 |
0,74739 % | Two Sigma Investments, LP | 572 052 | 54 773 | 31. 12. 2024 |
0,72968 % | Federated Hermes Global Investment Management Corp. | 558 500 | -177 700 | 31. 12. 2024 |
0,68267 % | Fiera Capital Inc. | 522 514 | -19 478 | 31. 12. 2024 |
0,64304 % | Candriam Belgium S.A. | 492 181 | 28 320 | 31. 12. 2024 |
0,64304 % | Candriam Luxembourg S.A. | 492 181 | 0 | 31. 12. 2024 |
0,61928 % | Avidity Partners Management LP | 474 000 | -344 000 | 31. 12. 2024 |
0,53362 % | JPMorgan Asset Management U.K. Limited | 408 431 | 311 581 | 31. 12. 2024 |
0,49104 % | StemPoint Capital LP | 375 845 | 375 845 | 31. 12. 2024 |
0,45210 % | Millennium Management LLC | 346 040 | 137 014 | 31. 12. 2024 |
0,42880 % | The Vanguard Group, Inc. | 328 202 | -3 154 | 31. 12. 2024 |
0,42762 % | Citadel Advisors LLC | 327 303 | -395 201 | 31. 12. 2024 |
0,42504 % | Perceptive Advisors LLC | 325 324 | -199 606 | 31. 12. 2024 |
0,42131 % | Saturn V Capital Management LP | 322 470 | 322 470 | 31. 12. 2024 |
0,41359 % | Putnam Investment Management, L.L.C. | 316 565 | 9 675 | 31. 12. 2024 |
0,38305 % | JPMorgan Asset Management (Europe) S.à.r.l. | 293 187 | -3 832 | 31. 12. 2024 |
0,37738 % | Alyeska Investment Group, L.P. | 288 843 | 0 | 31. 12. 2024 |
0,37722 % | State Street Global Advisors (US) | 288 722 | 9 209 | 31. 12. 2024 |
0,37627 % | Altium Capital Management LP | 288 000 | -72 600 | 31. 12. 2024 |
0,37615 % | MFS Investment Management | 287 903 | 205 216 | 31. 12. 2024 |
0,37092 % | abrdn Inc. | 283 899 | 35 588 | 31. 12. 2024 |
0,36502 % | Goldman Sachs & Company, Inc. | 279 388 | -34 365 | 31. 12. 2024 |
0,35764 % | Dafna Capital Management, LLC | 273 739 | 0 | 31. 12. 2024 |
0,33965 % | Dimensional Fund Advisors, L.P. | 259 970 | -39 895 | 31. 12. 2024 |
0,33842 % | Franklin Advisers, Inc. | 259 025 | 0 | 31. 12. 2024 |
0,32045 % | Great Point Partners, LLC | 245 272 | 245 272 | 31. 12. 2024 |
0,31541 % | Algert Global LLC | 241 417 | 21 772 | 31. 12. 2024 |
0,31163 % | Assenagon Asset Management S.A. | 238 522 | 26 235 | 31. 12. 2024 |
0,29053 % | Medical Strategy GmbH | 222 372 | 0 | 31. 8. 2024 |
0,29002 % | Walleye Capital LLC | 221 982 | 117 022 | 31. 12. 2024 |
0,28606 % | Russell Investments Trust Company | 218 949 | 60 764 | 30. 9. 2024 |
0,27185 % | BlackRock Advisors (UK) Limited | 208 074 | 2 706 | 31. 1. 2025 |
0,26554 % | DNB Asset Management AS | 203 243 | 12 620 | 31. 12. 2024 |
0,25766 % | MPM BioImpact LLC | 197 212 | 31 412 | 31. 12. 2024 |
0,25473 % | Lord, Abbett & Co. LLC | 194 971 | 20 986 | 31. 12. 2024 |
0,25216 % | Parkman Healthcare Partners LLC | 193 004 | 1 346 | 31. 12. 2024 |
0,25213 % | BlackRock Asset Management Ireland Limited | 192 981 | 44 245 | 31. 12. 2024 |
0,24536 % | AXA Investment Managers UK Ltd. | 187 796 | -294 | 31. 12. 2024 |
0,24115 % | Balyasny Asset Management LP | 184 580 | 100 382 | 31. 12. 2024 |
0,23822 % | Granahan Investment Management, LLC | 182 333 | -18 544 | 31. 12. 2024 |
0,23083 % | Schroder Investment Management Ltd. (SIM) | 176 674 | 0 | 31. 12. 2024 |
0,22804 % | BlackRock Investment Management (UK) Ltd. | 174 538 | -5 423 | 31. 12. 2024 |
0,22097 % | Deep Track Capital LP | 169 132 | 169 132 | 31. 12. 2024 |
0,20321 % | Eversept Partners, LP | 155 540 | 155 540 | 31. 12. 2024 |
0,19728 % | Nomura Asset Management Co., Ltd. | 151 000 | -34 400 | 30. 11. 2023 |
0,19180 % | Bridger Management, LLC | 146 800 | 0 | 31. 12. 2024 |
0,17314 % | New York State Common Retirement Fund | 132 521 | 0 | 31. 12. 2024 |
0,17097 % | Goldman Sachs Asset Management, L.P. | 130 858 | -2 279 | 31. 12. 2024 |
0,16892 % | Ally Bridge Group NY LLC | 129 291 | -82 500 | 31. 12. 2024 |
0,16540 % | Schweizerische Nationalbank | 126 600 | 1 300 | 31. 12. 2024 |
0,15669 % | Invesco Advisers, Inc. | 119 933 | -172 | 31. 12. 2024 |
0,15319 % | Victory Capital Management Inc. | 117 251 | 49 237 | 31. 12. 2024 |
0,15286 % | PFM Health Sciences, LP | 116 998 | -62 880 | 31. 12. 2024 |
0,14378 % | Tenax Capital Ltd. | 110 047 | 0 | 31. 5. 2023 |
0,13938 % | Nan Fung Life Sciences | 106 680 | 0 | 31. 12. 2024 |
0,13078 % | Baron Capital Management, Inc. | 100 100 | 0 | 31. 12. 2024 |
0,12619 % | State of Wisconsin Investment Board | 96 584 | -4 398 | 31. 12. 2024 |
0,12224 % | Principal Global Investors (Equity) | 93 562 | 0 | 31. 12. 2024 |
0,12145 % | Neuberger Berman, LLC | 92 961 | -32 675 | 31. 12. 2024 |
0,12066 % | Columbia Threadneedle Investments (US) | 92 350 | 25 967 | 31. 12. 2024 |
0,11955 % | International Biotechnology Trust PLC | 91 500 | 66 000 | 30. 9. 2023 |
0,11763 % | New Jersey Division of Investment | 90 033 | 5 460 | 31. 12. 2024 |
0,11363 % | D. E. Shaw & Co., L.P. | 86 973 | -117 919 | 31. 12. 2024 |
0,10238 % | Polen Capital Management, LLC | 78 361 | 9 746 | 30. 11. 2024 |
0,09863 % | UBS Asset Management (Switzerland) | 75 488 | 20 923 | 31. 12. 2024 |
0,09698 % | Azab (Mohammad) | 74 225 | 0 | 5. 4. 2024 |
0,09485 % | Atika Capital Management LLC | 72 600 | -53 400 | 31. 12. 2024 |