11,79559 % | Satter Management Co., L.P. | 5.621.835 | 0 | 31/03/2021 |
10,89780 % | OrbiMed Advisors, LLC | 5.193.946 | 0 | 31/03/2021 |
9,44178 % | Avoro Capital Advisors LLC | 4.500.000 | 4.500.000 | 03/06/2021 |
5,56245 % | Ikarian Capital LLC | 2.651.093 | 2.175.315 | 31/03/2021 |
4,34906 % | EcoR1 Capital, LLC | 2.072.782 | 2.072.782 | 31/03/2021 |
4,21511 % | BML Capital Management LLC | 2.008.942 | -131.289 | 31/12/2020 |
4,07368 % | Renaissance Technologies LLC | 1.941.538 | 142.494 | 31/03/2021 |
4,01061 % | Acadian Asset Management LLC | 1.911.478 | 401.968 | 31/03/2021 |
3,82917 % | Point72 Asset Management, L.P. | 1.825.000 | 1.825.000 | 17/05/2021 |
3,61978 % | The Vanguard Group, Inc. | 1.725.207 | -986.372 | 31/03/2021 |
3,30422 % | RA Capital Management, LP | 1.574.806 | 1.574.806 | 30/06/2021 |
2,10067 % | Parkman Healthcare Partners LLC | 1.001.189 | 736.807 | 31/03/2021 |
2,09817 % | Opaleye Management Inc. | 1.000.000 | 1.000.000 | 31/03/2021 |
2,09817 % | Scion Asset Management, LLC | 1.000.000 | 1.000.000 | 31/03/2021 |
1,33284 % | Novartis AG | 635.236 | -2.512.431 | 14/05/2020 |
1,26524 % | Gardner (Joseph H) | 603.019 | 0 | 14/06/2021 |
0,83927 % | Ally Bridge Group (HK) Limited | 400.000 | 0 | 31/03/2021 |
0,67254 % | Johnson Investment Counsel, Inc. | 320.536 | 0 | 31/03/2021 |
0,67254 % | Peters (Kevin G M.D.) | 320.536 | 0 | 14/06/2021 |
0,63564 % | Boothbay Fund Management, LLC | 302.949 | 252.755 | 31/03/2021 |
0,61983 % | Castelein (Caley M.) | 295.414 | 15.507 | 30/06/2021 |
0,54337 % | Geode Capital Management, L.L.C. | 258.974 | 107.136 | 31/03/2021 |
0,53231 % | T. Rowe Price Associates, Inc. | 253.700 | 253.700 | 31/03/2021 |
0,26305 % | BlackRock Institutional Trust Company, N.A. | 125.370 | 6.976 | 31/03/2021 |
0,25759 % | Citadel Advisors LLC | 122.770 | 40.661 | 31/03/2021 |
0,21192 % | Leonard (Braden Michael) | 101.000 | -49.000 | 31/12/2020 |
0,20982 % | Neville, Rodie & Shaw, Inc. | 100.000 | 0 | 30/06/2021 |
0,17269 % | Virtu Americas LLC | 82.306 | -88.783 | 31/03/2021 |
0,16385 % | Columbia Threadneedle Investments (US) | 78.092 | -5.502 | 31/03/2021 |
0,15002 % | Schonfeld Strategic Advisors LLC | 71.500 | 59.600 | 31/03/2021 |
0,11666 % | Northern Trust Investments, Inc. | 55.602 | 0 | 31/03/2021 |
0,10491 % | U.S. Bancorp Asset Management, Inc. | 50.000 | 0 | 31/03/2021 |
0,10491 % | CSS, LLC | 50.000 | 50.000 | 31/03/2021 |
0,05137 % | Prelack (Steven) | 24.485 | 24.485 | 30/06/2021 |
0,03571 % | Squarepoint Capital LLP | 17.019 | 17.019 | 31/03/2021 |
0,03558 % | Dalal Anupam | 16.959 | 14.690 | 30/06/2021 |
0,03391 % | Cohen (Cheryl L) | 16.160 | 16.160 | 30/06/2021 |
0,03269 % | Jane Street Capital, L.L.C. | 15.581 | -4.738 | 31/03/2021 |
0,03230 % | Dimensional Fund Advisors, L.P. | 15.393 | -8.719 | 31/03/2021 |
0,02693 % | Charles Schwab Investment Management, Inc. | 12.835 | 0 | 31/03/2021 |
0,02686 % | Two Sigma Investments, LP | 12.800 | 12.800 | 31/03/2021 |
0,02669 % | Lakeview Capital Partners, Llc | 12.722 | -4.778 | 31/03/2021 |
0,02637 % | Dugel (Pravin U) | 12.568 | 12.568 | 30/06/2021 |
0,02521 % | Qube Research & Technologies Ltd | 12.016 | -56.029 | 31/03/2021 |
0,02444 % | Barclays Bank PLC | 11.648 | 11.648 | 31/03/2021 |
0,02439 % | Marek (Regina) | 11.625 | 0 | 14/06/2021 |
0,02144 % | Truepoint Wealth Counsel LLC | 10.219 | 0 | 31/03/2021 |
0,02098 % | Ascent Wealth Partners, LLC | 10.000 | 0 | 31/03/2021 |
0,01049 % | Lindbrook Capital, LLC | 5.000 | 5.000 | 30/06/2021 |
0,00690 % | Tower Research Capital LLC | 3.288 | -117 | 31/03/2021 |
0,00664 % | UBS Financial Services, Inc. | 3.166 | -18.638 | 31/03/2021 |
0,00420 % | BofA Global Research (US) | 2.000 | 2.000 | 31/03/2021 |
0,00315 % | NEXT Financial Group, Inc. | 1.500 | 1.500 | 30/06/2021 |
0,00315 % | Advisor Group, Inc | 1.500 | 0 | 31/03/2021 |
0,00210 % | Wells Fargo Advisors | 1.000 | 0 | 31/03/2021 |
0,00076 % | O'Shaughnessy Asset Management, LLC | 363 | 135 | 31/03/2021 |
0,00045 % | Wells Fargo Bank, N.A. | 214 | -1 | 31/03/2021 |
0,00026 % | Parallel Advisors, LLC | 125 | 0 | 31/03/2021 |
0 % | Keudell Morrison Wealth Management, LLC | 0 | -30.694 | 30/06/2021 |
0 % | J.P. Morgan Securities LLC | 0 | -6.400 | 31/12/2020 |
0 % | PanAgora Asset Management Inc. | 0 | -44.630 | 31/03/2021 |
0 % | Tekla Capital Management LLC | 0 | -257.554 | 30/09/2020 |
0 % | Deutsche Asset Management Americas | 0 | -6.712 | 31/03/2020 |
0 % | Goldman Sachs & Company, Inc. | 0 | -29.407 | 30/09/2020 |
0 % | BlackRock Investment Management, LLC | 0 | -4.797 | 30/06/2020 |
0 % | Morgan Stanley & Co. LLC | 0 | -25.062 | 31/03/2021 |
0 % | Raymond James & Associates, Inc. | 0 | -12.000 | 31/03/2020 |
0 % | Arrowstreet Capital, Limited Partnership | 0 | -35.725 | 31/03/2021 |
0 % | Millennium Management LLC | 0 | -59.587 | 31/12/2020 |
0 % | GSA Capital Partners LLP | 0 | -17.895 | 31/03/2021 |
0 % | Hightower Advisors, LLC | 0 | -35.500 | 30/09/2020 |
0 % | Blackstone Alternative Investment Advisors LLC | 0 | -1.100 | 31/12/2020 |
0 % | Alambic Investment Management, L.P. | 0 | -35.264 | 31/12/2019 |
0 % | Susquehanna Fundamental Investments, LLC | 0 | -11.000 | 31/03/2021 |