9,09912 % | The Vanguard Group, Inc. | 25 418 388 | 979 857 | 31.12.2023 |
8,50209 % | RA Capital Management, LP | 23 750 601 | 10 428 313 | 31.12.2023 |
6,67502 % | BlackRock Institutional Trust Company, N.A. | 18 646 679 | 1 793 786 | 31.12.2023 |
5,87933 % | Redmile Group, LLC | 16 423 922 | -1 079 495 | 31.12.2023 |
3,95346 % | Janus Henderson Investors | 11 043 986 | -6 640 830 | 31.12.2023 |
2,89088 % | State Street Global Advisors (US) | 8 075 671 | -1 476 181 | 31.12.2023 |
2,12264 % | Fairmount Funds Management LLC | 5 929 592 | 0 | 31.12.2023 |
2,02703 % | Pentwater Capital Management LP | 5 662 500 | 5 662 500 | 31.12.2023 |
1,98294 % | Norges Bank Investment Management (NBIM) | 5 539 334 | 5 424 434 | 31.12.2023 |
1,92693 % | Geode Capital Management, L.L.C. | 5 382 875 | 482 900 | 31.12.2023 |
1,91874 % | Fidelity Investments Canada ULC | 5 360 000 | 5 360 000 | 31.12.2023 |
1,61904 % | D. E. Shaw & Co., L.P. | 4 522 797 | -2 472 442 | 31.12.2023 |
1,60153 % | Millennium Management LLC | 4 473 868 | 2 868 154 | 31.12.2023 |
1,15312 % | Voloridge Investment Management, LLC | 3 221 231 | 708 980 | 31.12.2023 |
1,05996 % | Boxer Capital, L.L.C. | 2 961 000 | 0 | 31.12.2023 |
1,05001 % | Emerald Advisers LLC | 2 933 190 | -344 179 | 31.12.2023 |
0,89251 % | Maverick Capital, Ltd. | 2 493 217 | -25 310 | 31.12.2023 |
0,82823 % | TIG Advisors, L.L.C. | 2 313 670 | 2 313 670 | 31.12.2023 |
0,79096 % | Morgan Stanley & Co. LLC | 2 209 536 | 64 583 | 31.12.2023 |
0,78723 % | Tang Capital Management, LLC | 2 199 137 | 699 137 | 31.12.2023 |
0,76133 % | Medical Strategy GmbH | 2 126 763 | 0 | 30.09.2023 |
0,74208 % | Northern Trust Investments, Inc. | 2 072 998 | 62 196 | 31.12.2023 |
0,73070 % | Nuveen LLC | 2 041 214 | -845 027 | 31.12.2023 |
0,72889 % | Kryger Capital Limited | 2 036 155 | 2 036 155 | 31.12.2023 |
0,69963 % | Wellington Management Company, LLP | 1 954 413 | -11 304 584 | 31.12.2023 |
0,67745 % | Charles Schwab Investment Management, Inc. | 1 892 446 | 61 871 | 31.12.2023 |
0,65481 % | Avidity Partners Management LP | 1 829 215 | -88 692 | 31.12.2023 |
0,63909 % | HOOPP Investment Management | 1 785 296 | 1 485 296 | 31.12.2023 |
0,63050 % | Alpine Associates Management Inc. | 1 761 300 | 1 749 300 | 31.12.2023 |
0,58394 % | Renaissance Technologies LLC | 1 631 240 | 896 600 | 31.12.2023 |
0,58324 % | Magnetar Capital Partners LP | 1 629 285 | 1 629 285 | 31.12.2023 |
0,55375 % | Sofinnova Investments, Inc | 1 546 902 | -498 300 | 31.12.2023 |
0,53976 % | AllianceBernstein L.P. | 1 507 809 | 1 207 295 | 31.12.2023 |
0,53932 % | AQR Capital Management, LLC | 1 506 601 | 1 380 964 | 31.12.2023 |
0,53580 % | Balyasny Asset Management LP | 1 496 758 | 1 484 838 | 31.12.2023 |
0,53238 % | Morgan Stanley Investment Management Inc. (US) | 1 487 210 | -544 787 | 31.12.2023 |
0,50933 % | Gabelli Funds, LLC | 1 422 804 | 1 422 804 | 31.12.2023 |
0,50922 % | Kynam Capital Management LP | 1 422 503 | 1 422 503 | 31.12.2023 |
0,50281 % | Affinity Asset Advisors LLC | 1 404 608 | 1 404 608 | 31.12.2023 |
0,49254 % | QVT Financial LP | 1 375 900 | 0 | 31.12.2023 |
0,48861 % | Westchester Capital Management, LLC | 1 364 927 | 1 364 927 | 31.12.2023 |
0,45296 % | J.P. Morgan Securities LLC | 1 265 347 | 28 617 | 31.12.2023 |
0,44501 % | BlackRock Financial Management, Inc. | 1 243 147 | -259 980 | 31.12.2023 |
0,42492 % | Marshall Wace LLP | 1 187 027 | 1 187 027 | 31.12.2023 |
0,41966 % | Artisan Partners Limited Partnership | 1 172 323 | -2 552 260 | 31.12.2023 |
0,40358 % | Principal Global Investors (Equity) | 1 127 402 | 142 738 | 31.12.2023 |
0,40186 % | Candriam Belgium S.A. | 1 122 598 | 10 | 31.12.2023 |
0,40185 % | Candriam Luxembourg S.A. | 1 122 557 | 0 | 31.12.2023 |
0,36220 % | Pinnacle Associates Ltd. | 1 011 792 | -4364 | 31.12.2023 |
0,34937 % | Pictet Asset Management Ltd. | 975 962 | -2 732 177 | 31.12.2023 |
0,34792 % | Adage Capital Management, L.P. | 971 928 | 771 928 | 31.12.2023 |
0,34762 % | BlackRock Advisors (UK) Limited | 971 070 | 19 799 | 31.01.2024 |
0,34495 % | T. Rowe Price Associates, Inc. | 963 620 | -2 811 554 | 31.12.2023 |
0,33918 % | Lombard Odier Asset Management (Europe) Ltd | 947 497 | -36 199 | 30.09.2022 |
0,32322 % | BlackRock Asset Management Ireland Limited | 902 926 | -16 784 | 31.12.2023 |
0,31994 % | Water Island Capital, LLC | 893 758 | 304 893 | 31.12.2023 |
0,31753 % | Two Sigma Investments, LP | 887 018 | -2 035 717 | 31.12.2023 |
0,31323 % | Avoro Capital Advisors LLC | 875 000 | 875 000 | 31.12.2023 |
0,30141 % | Farallon Capital Management, L.L.C. | 842 000 | 842 000 | 31.12.2023 |
0,29931 % | American Century Investment Management, Inc. | 836 134 | 137 018 | 31.12.2023 |
0,28969 % | Goldman Sachs & Company, Inc. | 809 254 | -64 684 | 31.12.2023 |
0,28475 % | Citadel Advisors LLC | 795 458 | -492 084 | 31.12.2023 |
0,27313 % | Eventide Asset Management, LLC | 763 000 | -537 000 | 31.12.2023 |
0,27183 % | Rock Springs Capital Management LP | 759 365 | 0 | 31.12.2023 |
0,27055 % | BofA Global Research (US) | 755 774 | 270 386 | 31.12.2023 |
0,26896 % | DWS Investments UK Limited | 751 326 | 630 590 | 31.12.2023 |
0,26810 % | Eversept Partners, LP | 748 950 | 748 950 | 31.12.2023 |
0,26348 % | Susquehanna International Group, LLP | 736 034 | -238 853 | 31.12.2023 |
0,25771 % | AQR Arbitrage, LLC | 719 919 | 719 919 | 31.12.2023 |
0,24428 % | IndexIQ Advisors LLC | 682 396 | 682 396 | 31.12.2023 |
0,23961 % | Voya Investment Management LLC | 669 351 | 154 215 | 31.12.2023 |
0,23692 % | BlackRock Investment Management, LLC | 661 835 | -13 096 | 31.12.2023 |
0,23624 % | Decheng Capital LLC | 659 928 | 244 048 | 31.12.2023 |
0,23620 % | BNY Mellon Asset Management | 659 833 | -30 822 | 31.12.2023 |
0,23067 % | Sio Capital Management, LLC | 644 366 | 411 615 | 31.12.2023 |
0,22938 % | Barclays Bank PLC | 640 777 | 302 253 | 31.12.2023 |
0,22708 % | Jane Street Capital, L.L.C. | 634 353 | -283 411 | 31.12.2023 |
0,21409 % | Superstring Capital Management LP | 598 072 | 598 072 | 31.12.2023 |
0,21361 % | First Trust Capital Management L.P. | 596 720 | 596 720 | 31.12.2023 |
0,21013 % | CPP Investment Board | 586 990 | 586 990 | 31.12.2023 |
0,20280 % | Baillie Gifford & Co. | 566 529 | 0 | 31.10.2023 |
0,19020 % | Melqart Asset Management (UK) Limited | 531 324 | 531 324 | 31.12.2023 |
0,18607 % | HSBC Global Asset Management (UK) Limited | 519 779 | 519 779 | 31.12.2023 |
0,18445 % | Invesco Capital Management LLC | 515 275 | 174 614 | 31.12.2023 |
0,17899 % | Picton Mahoney Asset Management | 500 000 | 500 000 | 31.12.2023 |
0,17899 % | CM Management, LLC | 500 000 | 0 | 31.12.2023 |
0,17290 % | JPMorgan Private Bank (United States) | 482 994 | -20 174 | 31.12.2023 |
0,17211 % | Schweizerische Nationalbank | 480 800 | 0 | 31.12.2023 |
0,16688 % | Carlson Capital, L.P. | 466 188 | 466 188 | 31.12.2023 |
0,16467 % | Slotnik Capital, LLC | 460 000 | 460 000 | 31.12.2023 |
0,16260 % | Dimensional Fund Advisors, L.P. | 454 213 | -726 531 | 31.12.2023 |
0,16222 % | Fidelity Management & Research Company LLC | 453 168 | -5 326 775 | 31.12.2023 |
0,14937 % | Credit Suisse Funds AG | 417 277 | 128 166 | 31.12.2023 |
0,14856 % | Segantii Capital Management Limited | 415 000 | 415 000 | 31.12.2023 |
0,14665 % | PanAgora Asset Management Inc. | 409 658 | -688 759 | 31.12.2023 |
0,14319 % | Woodline Partners LP | 400 000 | -2 033 161 | 31.12.2023 |
0,13893 % | GLG LLC | 388 103 | 374 005 | 31.12.2023 |
0,13696 % | Mellon Investments Corporation | 382 594 | -482 140 | 31.12.2023 |
0,13328 % | Pictet Asset Management (Japan) Ltd. | 372 310 | 372 310 | 31.10.2023 |
0,13247 % | Invesco Advisers, Inc. | 370 048 | -375 459 | 31.12.2023 |