16,51664 % | BlackRock Institutional Trust Company, N.A. | 10 742 640 | −230 826 | |
15,00741 % | PRIMECAP Management Company | 9 761 012 | 776 580 | |
12,12092 % | The Vanguard Group, Inc. | 7 883 601 | −118 900 | |
9,44748 % | EcoR1 Capital, LLC | 6 144 767 | 0 | |
5,88833 % | T. Rowe Price Associates, Inc. | 3 829 848 | −108 253 | |
5,66366 % | State Street Global Advisors (US) | 3 683 715 | 482 802 | |
4,21292 % | BVF Partners L.P. | 2 740 141 | 451 381 | |
3,77012 % | TCG Crossover Management, LLC | 2 452 138 | 0 | |
3,69440 % | RTW Investments L.P. | 2 402 883 | 0 | |
2,67121 % | Dimensional Fund Advisors, L.P. | 1 737 388 | 235 856 | |
2,57428 % | Geode Capital Management, L.L.C. | 1 674 348 | 39 472 | |
2,54560 % | Braidwell LP | 1 655 690 | 1 040 159 | |
1,64474 % | Loomis, Sayles & Company, L.P. | 1 069 762 | −22 584 | |
1,57388 % | Point72 Asset Management, L.P. | 1 023 673 | −1 153 408 | |
1,44807 % | UBS Financial Services, Inc. | 941 842 | 67 666 | |
1,39063 % | Jacobs Levy Equity Management, Inc. | 904 485 | 384 509 | |
1,29655 % | Woodline Partners LP | 843 296 | −2 620 | |
1,15013 % | Johnson & Johnson Innovation-JJDC, Inc. | 748 062 | 0 | |
1,08151 % | Two Sigma Investments, LP | 703 431 | −35 792 | |
1,05620 % | Goldman Sachs & Company, Inc. | 686 969 | 364 603 | |
1,03078 % | Baker Bros. Advisors LP | 670 431 | 0 | |
0,98737 % | Finepoint Capital LP | 642 200 | −17 800 | |
0,98076 % | Morgan Stanley & Co. LLC | 637 901 | 209 600 | |
0,97885 % | Charles Schwab Investment Management, Inc. | 636 656 | 6 016 | |
0,94019 % | Invesco Capital Management LLC | 611 515 | 201 691 | |
0,93314 % | Northern Trust Investments, Inc. | 606 924 | −72 923 | |
0,88405 % | RA Capital Management, LP | 575 000 | 0 | |
0,86664 % | BlackRock Financial Management, Inc. | 563 673 | 2 124 | |
0,84475 % | Deep Track Capital LP | 549 439 | 49 439 | |
0,74213 % | BofA Global Research (US) | 482 691 | 449 184 | |
0,70861 % | Hudson Bay Capital Management LP | 460 890 | 460 890 | |
0,70223 % | Nantahala Capital Management, LLC | 456 741 | 456 741 | |
0,61857 % | Dahiyat (Bassil Ishmael) | 402 326 | 90 029 | |
0,61215 % | Adar1 Capital Management LLC | 398 152 | 163 545 | |
0,58455 % | Erste Asset Management GmbH | 380 200 | 28 000 | |
0,57980 % | abrdn Inc. | 377 112 | 201 592 | |
0,53616 % | Principal Global Investors (Equity) | 348 726 | 8 581 | |
0,48543 % | BlackRock Asset Management Ireland Limited | 315 731 | −9 250 | |
0,47502 % | Columbia Threadneedle Investments (US) | 308 958 | 16 959 | |
0,46262 % | BlackRock Advisors (UK) Limited | 300 895 | −1 387 | |
0,44637 % | PanAgora Asset Management Inc. | 290 328 | 260 124 | |
0,39985 % | Mellon Investments Corporation | 260 069 | −22 083 | |
0,34128 % | PSP Investments | 221 971 | 47 662 | |
0,32963 % | Parametric Portfolio Associates LLC | 214 393 | −91 672 | |
0,32743 % | Desjarlais (John R) | 212 963 | 20 154 | |
0,31662 % | BlackRock Investment Management, LLC | 205 932 | −151 | |
0,31083 % | DCF Advisers, LLC | 202 167 | −1 000 | |
0,30750 % | Macquarie Investment Management | 200 000 | 0 | |
0,30096 % | Rhenman & Partners Asset Management AB | 195 750 | 0 | |
0,28232 % | Legal & General Investment Management Ltd. | 183 627 | −7 887 | |
0,27075 % | Barclays Bank PLC | 176 102 | −154 643 | |
0,25628 % | ExodusPoint Capital Management, LP | 166 689 | 166 689 | |
0,25396 % | Citi Investment Research (US) | 165 179 | 47 191 | |
0,25193 % | Rhumbline Advisers Ltd. Partnership | 163 857 | −6 143 | |
0,24556 % | Nuveen LLC | 159 716 | −674 650 | |
0,23920 % | Cubist Systematic Strategies, LLC | 155 580 | 155 580 | |
0,23431 % | Renaissance Technologies LLC | 152 400 | 152 400 | |
0,22728 % | Norges Bank Investment Management (NBIM) | 147 823 | −72 070 | |
0,21973 % | Silvercrest Asset Management Group LLC | 142 917 | −826 | |
0,21408 % | American Century Investment Management, Inc. | 139 242 | 25 011 | |
0,20504 % | Trexquant Investment LP | 133 360 | 50 119 | |
0,19874 % | BNY Mellon Asset Management | 129 265 | 1 947 | |
0,19854 % | Kuch John J | 129 136 | 36 542 | |
0,18895 % | Thrivent Asset Management, LLC | 122 897 | 6 528 | |
0,17727 % | Schweizerische Nationalbank | 115 300 | −8 300 | |
0,16860 % | Essex LLC | 109 661 | −4 000 | |
0,15640 % | TD Asset Management Inc. | 101 722 | −11 000 | |
0,15591 % | Manulife Investment Management (North America) Limited | 101 407 | 1 034 | |
0,15589 % | Susquehanna Fundamental Investments, LLC | 101 392 | 101 392 | |
0,15498 % | T. Rowe Price International Ltd | 100 799 | 2 488 | |
0,15310 % | Susquehanna International Group, LLP | 99 578 | 58 675 | |
0,14370 % | Dimensional Fund Advisors, Ltd. | 93 464 | 0 | |
0,13336 % | Rafferty Asset Management LLC | 86 741 | 34 765 | |
0,13218 % | Winton Capital Management Ltd. | 85 970 | 32 265 | |
0,12765 % | UBS Asset Management (Switzerland) | 83 023 | −14 714 | |
0,12030 % | JP Morgan Asset Management | 78 247 | −900 | |
0,11891 % | Campbell & Company, Inc. | 77 341 | 77 341 | |
0,11785 % | Fidelity Management & Research Company LLC | 76 652 | 72 419 | |
0,11126 % | UBS Fund Management (Switzerland) AG | 72 362 | −856 | |
0,11084 % | AllianceBernstein L.P. | 72 090 | 0 | |
0,10554 % | Polen Capital Management, LLC | 68 646 | 0 | |
0,10497 % | PGIM Quantitative Solutions LLC | 68 275 | −2 440 | |
0,10418 % | Canada Life Asset Management Limited | 67 759 | −15 776 | |
0,09945 % | INTECH Investment Management LLC | 64 681 | 30 709 | |
0,09295 % | Irish Life Investment Managers Ltd. | 60 453 | 8 290 | |
0,09130 % | Millennium Management LLC | 59 383 | 59 383 | |
0,09121 % | New York State Teachers' Retirement System | 59 326 | 1 200 | |
0,09091 % | California State Teachers Retirement System | 59 130 | 0 | |
0,08992 % | Citadel Advisors LLC | 58 484 | −61 037 | |
0,08949 % | BlackRock Investment Management (UK) Ltd. | 58 208 | 5 895 | |
0,08335 % | XTX Markets LLC | 54 209 | 35 627 | |
0,08291 % | Northern Trust Global Investments Limited | 53 923 | −1 012 | |
0,07969 % | Ohio Public Employees Retirement System | 51 832 | −1 565 | |
0,07912 % | Alps Advisors, Inc. | 51 459 | −5 126 | |
0,07792 % | Eckert (Celia E) | 50 682 | 16 209 | |
0,07760 % | Jump Financial, LLC | 50 473 | 50 473 | |
0,07627 % | Y-Intercept (Hong Kong) Ltd | 49 605 | 49 605 | |
0,07592 % | Aperio Group, LLC | 49 380 | −21 826 | |
0,07575 % | DWS Investments UK Limited | 49 269 | −5 609 | |
0,07149 % | Fubon Asset Management Company Ltd. | 46 499 | −335 | |