8,54 % | EcoR1 Capital, LLC | 5 282 516 | 0 | |
5,43 % | T. Rowe Price Associates, Inc. | 3 360 443 | 295 961 | |
5,38 % | State Street Global Advisors (US) | 3 326 856 | 348 255 | |
4,14 % | Fidelity Management & Research Company LLC | 2 562 691 | −528 990 | |
2,43 % | Armistice Capital LLC | 1 500 000 | 22 000 | |
2,19 % | T. Rowe Price Investment Management, Inc. | 1 351 367 | −2 426 996 | |
2,13 % | Geode Capital Management, L.L.C. | 1 314 943 | 54 991 | |
2,07 % | Dimensional Fund Advisors, L.P. | 1 279 077 | −172 270 | |
16,29 % | BlackRock Institutional Trust Company, N.A. | 10 073 333 | 637 886 | |
14,40 % | PRIMECAP Management Company | 8 901 607 | 717 401 | |
10,93 % | The Vanguard Group, Inc. | 6 755 536 | 115 886 | |
1,60 % | Loomis, Sayles & Company, L.P. | 988 244 | −518 308 | |
1,21 % | Johnson & Johnson Innovation-JJDC, Inc. | 748 062 | 0 | |
1,19 % | BlackRock Financial Management, Inc. | 736 235 | 191 124 | |
1,16 % | Two Sigma Investments, LP | 714 927 | 255 151 | |
1,15 % | Candriam Belgium S.A. | 707 984 | 55 000 | |
1,15 % | Candriam Luxembourg S.A. | 707 965 | 0 | |
0,95 % | Northern Trust Investments, Inc. | 585 429 | 47 872 | |
0,84 % | Charles Schwab Investment Management, Inc. | 520 698 | 32 251 | |
0,73 % | Morgan Stanley & Co. LLC | 453 846 | 60 518 | |
0,68 % | JP Morgan Asset Management | 420 670 | −45 579 | |
0,57 % | Millennium Management LLC | 350 214 | −377 254 | |
0,56 % | Goldman Sachs & Company, Inc. | 348 529 | 232 128 | |
0,55 % | Principal Global Investors (Equity) | 342 010 | −4 107 | |
0,53 % | Norges Bank Investment Management (NBIM) | 325 439 | −213 506 | |
0,49 % | Mellon Investments Corporation | 300 376 | −2 407 | |
0,47 % | Parametric Portfolio Associates LLC | 289 030 | 133 602 | |
0,45 % | ExodusPoint Capital Management, LP | 280 813 | −14 125 | |
0,44 % | Dahiyat (Bassil Ishmael) | 270 508 | 39 269 | |
0,40 % | Baker Bros. Advisors LP | 245 431 | 122 304 | |
0,40 % | Hudson Bay Capital Management LP | 245 000 | 12 500 | |
0,38 % | DCF Advisers, LLC | 237 107 | −9 193 | |
0,37 % | Columbia Threadneedle Investments (US) | 226 602 | −67 191 | |
0,36 % | Rhenman & Partners Asset Management AB | 225 000 | 0 | |
0,35 % | PanAgora Asset Management Inc. | 218 288 | 65 568 | |
0,31 % | BlackRock Investment Management, LLC | 189 471 | −571 | |
0,30 % | Rhumbline Advisers Ltd. Partnership | 184 831 | 4 862 | |
0,30 % | Invesco Capital Management LLC | 183 194 | −328 953 | |
0,29 % | Renaissance Technologies LLC | 180 300 | 136 000 | |
0,29 % | BlackRock Advisors (UK) Limited | 177 066 | 8 982 | |
0,28 % | abrdn Inc. | 175 520 | 175 520 | |
0,28 % | UBS Asset Management (Americas), Inc. | 171 972 | −2 394 | |
0,27 % | Legal & General Investment Management Ltd. | 170 021 | 2 357 | |
0,27 % | Citadel Advisors LLC | 169 476 | 141 151 | |
0,27 % | Barclays Bank PLC | 168 499 | 63 582 | |
0,27 % | Schonfeld Strategic Advisors LLC | 166 111 | 166 111 | |
0,27 % | BNY Mellon Asset Management | 165 049 | 6 600 | |
0,27 % | Nuveen LLC | 164 881 | 14 789 | |
0,25 % | Russell Investments Trust Company | 156 618 | 23 892 | |
0,25 % | Segall Bryant & Hamill, LLC | 154 824 | 504 | |
0,25 % | BlackRock Asset Management Ireland Limited | 152 613 | 9 465 | |
0,24 % | Qube Research & Technologies Ltd | 145 846 | 110 360 | |
0,22 % | Silvercrest Asset Management Group LLC | 137 941 | 0 | |
0,22 % | Cubist Systematic Strategies, LLC | 137 089 | 113 533 | |
0,22 % | Desjarlais (John R) | 135 201 | 12 815 | |
0,22 % | New Jersey Division of Investment | 133 752 | 23 399 | |
0,21 % | Macquarie Investment Management | 129 191 | 0 | |
0,20 % | PSP Investments | 126 331 | 51 414 | |
0,20 % | Putnam Investment Management, L.L.C. | 125 833 | −3 000 | |
0,20 % | T. Rowe Price International Ltd | 123 332 | 2 880 | |
0,20 % | TD Asset Management Inc. | 123 250 | −56 914 | |
0,19 % | Rafferty Asset Management LLC | 119 818 | 9 131 | |
0,19 % | BofA Global Research (US) | 119 372 | 30 360 | |
0,17 % | Schweizerische Nationalbank | 107 500 | −12 000 | |
0,16 % | Dimensional Fund Advisors, Ltd. | 100 374 | 1 436 | |
0,16 % | Barclays Capital Inc. | 100 000 | 100 000 | |
0,16 % | Northern Trust Global Investments | 99 456 | −921 | |
0,16 % | Mutual of America Capital Management LLC | 99 335 | 42 364 | |
0,16 % | Credit Suisse Funds AG | 96 110 | 10 957 | |
0,15 % | Trexquant Investment LP | 93 759 | 58 672 | |
0,15 % | Engineers Gate Manager, L.P. | 89 805 | 78 923 | |
0,14 % | Goldman Sachs Asset Management, L.P. | 89 371 | 22 409 | |
0,14 % | Kuch John J | 87 719 | −5 323 | |
0,14 % | Jump Financial, LLC | 84 689 | 61 574 | |
0,14 % | Manulife Investment Management (North America) Limited | 83 591 | −553 | |
0,13 % | BNP Paribas Securities Corp. North America | 82 488 | 42 403 | |
0,13 % | Citi Investment Research (US) | 82 157 | 11 868 | |
0,13 % | BlackRock Investment Management (UK) Ltd. | 81 665 | 15 721 | |
0,13 % | AllianceBernstein L.P. | 77 700 | 0 | |
0,12 % | GWL Investment Management Ltd. | 75 215 | −2 037 | |
0,11 % | Avantis Investors | 70 271 | 21 002 | |
0,11 % | PGIM Quantitative Solutions LLC | 69 955 | −638 | |
0,11 % | JPMorgan Private Bank (United States) | 68 264 | 41 196 | |
0,11 % | UBS Asset Management (Switzerland) | 65 492 | −317 | |
0,10 % | American Century Investment Management, Inc. | 62 290 | 16 772 | |
0,10 % | Valente (Nancy M.D.) | 58 930 | 19 634 | |
0,09 % | New York State Teachers' Retirement System | 58 526 | −300 | |
0,09 % | California State Teachers Retirement System | 58 086 | −2 758 | |
0,09 % | Tekla Capital Management LLC_NLE | 56 675 | 56 675 | |
0,09 % | Aperio Group, LLC | 56 519 | 19 359 | |
0,09 % | NFJ Investment Group, LLC | 55 538 | 991 | |
0,09 % | Thrivent Asset Management, LLC | 54 244 | −1 205 | |
0,09 % | Texas Permanent School Fund | 52 587 | 1 109 | |
0,08 % | Polen Capital Management, LLC | 52 117 | −9 142 | |
0,08 % | Irish Life Investment Managers Ltd. | 48 972 | −2 003 | |
0,08 % | Brown Advisory | 48 365 | −752 | |
0,08 % | Aigen Investment Management, LP | 47 666 | 37 128 | |
0,08 % | State of Wisconsin Investment Board | 46 887 | −349 | |
0,07 % | Capula Investment Management LLP | 45 849 | 3 029 | |
0,07 % | Invesco Advisers, Inc. | 44 252 | 595 | |