7,28952 % | BlackRock Institutional Trust Company, N.A. | 44 065 123 | 1 167 858 | |
5,52770 % | The Vanguard Group, Inc. | 33 414 934 | 1 066 847 | |
4,96436 % | RA Capital Management, LP | 30 009 536 | −2 276 219 | |
4,50377 % | Vivo Capital, LLC | 27 225 292 | 0 | |
4,49267 % | State Street Global Advisors (US) | 27 158 191 | −1 803 480 | |
4,48014 % | Janus Henderson Investors | 27 082 461 | 4 516 615 | |
3,67178 % | Holocene Advisors, LP | 22 195 909 | 4 024 559 | |
3,60629 % | Adage Capital Management, L.P. | 21 800 000 | −7 075 000 | |
2,37073 % | Fidelity Management & Research Company LLC | 14 331 054 | −637 372 | |
2,23492 % | Wellington Management Company, LLP | 13 510 114 | 847 710 | |
2,17395 % | Geode Capital Management, L.L.C. | 13 141 514 | 73 515 | |
2,15848 % | Goldman Sachs & Company, Inc. | 13 047 997 | −4 308 662 | |
1,91685 % | Woodline Partners LP | 11 587 344 | 4 549 031 | |
1,81969 % | Vestal Point Capital, LP | 11 000 000 | 9 950 000 | |
1,58310 % | Darwin Global Management Ltd | 9 569 835 | −12 468 938 | |
1,49963 % | Morgan Stanley Investment Management Inc. (US) | 9 065 290 | 9 065 132 | |
1,23181 % | Segall Bryant & Hamill, LLC | 7 446 275 | 3 369 196 | |
1,16989 % | Eventide Asset Management, LLC | 7 072 000 | 0 | |
1,16371 % | Millennium Management LLC | 7 034 632 | 2 914 427 | |
1,15903 % | Braidwell LP | 7 006 315 | 7 006 315 | |
1,07173 % | UBS Financial Services, Inc. | 6 478 618 | 3 318 902 | |
0,99256 % | Boxer Capital Management, LLC | 6 000 000 | 6 000 000 | |
0,84458 % | Northern Trust Investments, Inc. | 5 105 476 | 587 027 | |
0,74836 % | Charles Schwab Investment Management, Inc. | 4 523 864 | 73 482 | |
0,69217 % | Citadel Advisors LLC | 4 184 145 | −500 187 | |
0,66357 % | Deep Track Capital LP | 4 011 287 | −3 563 762 | |
0,64406 % | First Turn Management, LLC | 3 893 327 | 768 360 | |
0,64147 % | BofA Global Research (US) | 3 877 702 | 1 266 306 | |
0,58791 % | T. Rowe Price Associates, Inc. | 3 553 943 | −3 140 198 | |
0,48510 % | Columbia Threadneedle Investments (US) | 2 932 442 | 265 103 | |
0,45929 % | New Enterprise Associates (NEA) | 2 776 409 | 0 | |
0,41179 % | Russell Investments Trust Company | 2 489 261 | 346 342 | |
0,40907 % | Tri Locum Partners LP | 2 472 836 | 2 472 836 | |
0,40743 % | Jefferies LLC | 2 462 941 | −7 233 594 | |
0,37221 % | Affinity Asset Advisors LLC | 2 250 000 | 750 000 | |
0,36443 % | Marshall Wace LLP | 2 202 995 | 930 412 | |
0,35864 % | OrbiMed Advisors, LLC | 2 168 000 | 2 168 000 | |
0,35709 % | Morgan Stanley & Co. LLC | 2 158 620 | 99 716 | |
0,33085 % | Logos Global Management LLC | 2 000 000 | 2 000 000 | |
0,32682 % | BlackRock Advisors (UK) Limited | 1 975 632 | 6 896 | |
0,32447 % | Nuveen LLC | 1 961 399 | 14 657 | |
0,32081 % | Norges Bank Investment Management (NBIM) | 1 939 300 | 1 423 000 | |
0,31280 % | BlackRock Asset Management Ireland Limited | 1 890 870 | 183 466 | |
0,31096 % | Invesco Capital Management LLC | 1 879 725 | −186 007 | |
0,30604 % | Edmond de Rothschild Asset Management (France) S.A. | 1 850 000 | 150 000 | |
0,30559 % | abrdn Inc. | 1 847 285 | 360 027 | |
0,27621 % | J. Goldman & Co., L.P. | 1 669 684 | 1 493 445 | |
0,26073 % | BlackRock Financial Management, Inc. | 1 576 091 | −128 156 | |
0,25826 % | Exome Asset Management LLC | 1 561 152 | 656 026 | |
0,25299 % | Qube Research & Technologies Ltd | 1 529 298 | 1 529 298 | |
0,25250 % | Walleye Capital LLC | 1 526 335 | −130 294 | |
0,24973 % | Barclays Bank PLC | 1 509 588 | 209 904 | |
0,24630 % | Point72 Asset Management, L.P. | 1 488 892 | 1 488 892 | |
0,24600 % | BlackRock Investment Management, LLC | 1 487 047 | −12 764 | |
0,24031 % | Renaissance Technologies LLC | 1 452 700 | 1 452 700 | |
0,22722 % | Nan Fung Life Sciences | 1 373 550 | 0 | |
0,22135 % | Bridger Management, LLC | 1 338 084 | 0 | |
0,21857 % | Patient Square Capital, LP | 1 321 268 | 1 321 268 | |
0,20045 % | Ostrum Asset Management | 1 211 700 | 1 211 700 | |
0,19910 % | Rafferty Asset Management LLC | 1 203 583 | −220 421 | |
0,17805 % | First Trust Advisors L.P. | 1 076 323 | −51 750 | |
0,17780 % | Ally Bridge Group NY LLC | 1 074 824 | −256 229 | |
0,17059 % | BNY Mellon Asset Management | 1 031 203 | −17 928 | |
0,17031 % | Pensionmark Financial Group, LLC | 1 029 553 | 0 | |
0,16672 % | Schweizerische Nationalbank | 1 007 800 | 136 400 | |
0,16553 % | Citi Investment Research (US) | 1 000 601 | 567 054 | |
0,16543 % | Rhenman & Partners Asset Management AB | 1 000 000 | 0 | |
0,15220 % | SilverArc Capital Management, LLC | 920 022 | −881 539 | |
0,14588 % | DWS Investments UK Limited | 881 816 | 174 156 | |
0,13810 % | Rhumbline Advisers Ltd. Partnership | 834 844 | 12 070 | |
0,13030 % | Susquehanna International Group, LLP | 787 667 | 559 241 | |
0,12757 % | Polen Capital Management, LLC | 771 151 | 0 | |
0,10367 % | William Blair Investment Management, LLC | 626 684 | 109 256 | |
0,10344 % | AllianceBernstein L.P. | 625 291 | −604 491 | |
0,09797 % | State of Wisconsin Investment Board | 592 213 | 273 687 | |
0,09649 % | Mellon Investments Corporation | 583 275 | 7 092 | |
0,09201 % | UBS Asset Management (Switzerland) | 556 181 | 231 713 | |
0,09118 % | MML Investors Services, LLC | 551 168 | 0 | |
0,08746 % | Algert Global LLC | 528 686 | 133 615 | |
0,08695 % | Medical Strategy GmbH | 525 625 | −1 509 301 | |
0,08423 % | Goldman Sachs Asset Management, L.P. | 509 175 | −20 033 | |
0,08418 % | Legal & General Investment Management Ltd. | 508 872 | 12 540 | |
0,08271 % | Lion Point Capital, L.P. | 500 000 | −130 000 | |
0,08023 % | California State Teachers Retirement System | 484 962 | 52 846 | |
0,07891 % | Prelude Capital Management, LLC | 476 994 | 128 932 | |
0,07426 % | Manulife Investment Management (North America) Limited | 448 886 | −246 649 | |
0,07235 % | UBS Fund Management (Switzerland) AG | 437 342 | −20 124 | |
0,06924 % | Aquatic Capital Management LLC | 418 541 | 418 541 | |
0,06798 % | BlackRock Investment Management (UK) Ltd. | 410 924 | 7 029 | |
0,06692 % | Mirae Asset Global Investments (USA) LLC | 404 555 | 9 994 | |
0,06678 % | Hennion & Walsh Asset Management, Inc. | 403 703 | 61 819 | |
0,06672 % | Northern Trust Global Investments Limited | 403 337 | 282 108 | |
0,06608 % | Jane Street Capital, L.L.C. | 399 434 | −551 232 | |
0,06404 % | T. Rowe Price International Ltd | 387 092 | 44 615 | |
0,06335 % | Summit Wealth Strategies | 382 972 | −2 084 | |
0,05818 % | INTECH Investment Management LLC | 351 724 | 108 905 | |
0,05755 % | MetLife Investment Management, LLC | 347 919 | 24 260 | |
0,05721 % | LPL Financial LLC | 345 836 | 61 778 | |
0,05586 % | Adar1 Capital Management LLC | 337 676 | −219 483 | |
0,05474 % | Polar Asset Management Partners Inc. | 330 911 | 80 200 | |