13,81252 % | Janus Henderson Investors | 13 297 317 | 382 157 | |
6,81460 % | Polar Capital LLP | 6 560 415 | −193 257 | |
5,96255 % | Tontine Asset Management, LLC | 5 740 143 | 32 025 | |
4,44896 % | BlackRock Institutional Trust Company, N.A. | 4 283 011 | 4 276 921 | |
4,12600 % | Vivo Capital, LLC | 3 972 099 | 0 | |
3,86023 % | Kotler (Kevin) | 3 716 242 | −1 010 094 | |
3,83439 % | The Vanguard Group, Inc. | 3 691 363 | 3 691 363 | |
3,01095 % | Braidwell LP | 2 898 639 | 230 090 | |
2,32812 % | Citadel Advisors LLC | 2 241 281 | 677 391 | |
2,32032 % | Wealth Effects LLC | 2 233 771 | −34 084 | |
2,19724 % | Two Seas Capital LP | 2 115 279 | 1 797 039 | |
1,56283 % | Woodline Partners LP | 1 504 532 | 4 008 | |
1,54092 % | Brandes Investment Partners, L.P. | 1 483 439 | 21 214 | |
1,27766 % | Tang Capital Management, LLC | 1 230 000 | 182 725 | |
1,23561 % | Tri Locum Partners LP | 1 189 518 | 7 | |
1,20580 % | Geode Capital Management, L.L.C. | 1 160 820 | 1 056 593 | |
1,18367 % | State Street Global Advisors (US) | 1 139 515 | 1 102 671 | |
1,18228 % | Checkpoint Capital L.P. | 1 138 178 | 436 791 | |
1,03328 % | Adage Capital Management, L.P. | 994 738 | −916 245 | |
1,00501 % | Samsara BioCapital, LLC | 967 527 | 0 | |
0,81359 % | MPM BioImpact LLC | 783 242 | −87 907 | |
0,76140 % | Cutter Capital Management, LP | 733 001 | 191 075 | |
0,73039 % | Medical Strategy GmbH | 703 144 | 14 400 | |
0,68737 % | BofA Global Research (US) | 661 729 | 656 868 | |
0,67946 % | Kennedy Capital Management LLC | 654 116 | 969 | |
0,64994 % | SEB Investment Management AB | 625 695 | −210 | |
0,63363 % | Altium Capital Management LP | 610 000 | 56 943 | |
0,62737 % | Modera Wealth Management, LLC | 603 966 | 1 358 | |
0,62325 % | Knoll Capital Management, LLC | 600 000 | 0 | |
0,54251 % | Hudson Bay Capital Management LP | 522 277 | 273 117 | |
0,52872 % | Soleus Capital Management, L.P. | 509 000 | 509 000 | |
0,48856 % | Driehaus Capital Management, LLC | 470 341 | −5 096 | |
0,44691 % | Ally Bridge Group NY LLC | 430 245 | −116 791 | |
0,44418 % | Morgan Stanley & Co. LLC | 427 613 | 128 462 | |
0,44366 % | DWS Investment Management Americas, Inc. | 427 116 | 2 116 | |
0,43706 % | New York State Common Retirement Fund | 420 755 | 383 355 | |
0,41013 % | Lord, Abbett & Co. LLC | 394 834 | 201 601 | |
0,39295 % | Parkman Healthcare Partners LLC | 378 289 | −9 481 | |
0,36356 % | Nantahala Capital Management, LLC | 350 000 | 350 000 | |
0,34590 % | Knott Partners Management, LLC | 333 000 | 0 | |
0,33244 % | UBS Asset Management (Switzerland) | 320 040 | 0 | |
0,31260 % | Columbia Threadneedle Investments (US) | 300 940 | 9 666 | |
0,29825 % | Morgan Stanley Smith Barney LLC | 287 129 | −3 610 | |
0,29531 % | Balyasny Asset Management LP | 284 299 | −25 413 | |
0,27969 % | Barclays Bank PLC | 269 261 | 269 261 | |
0,27350 % | UBS Switzerland AG | 263 297 | 0 | |
0,25596 % | Nuveen LLC | 246 410 | 246 410 | |
0,24342 % | UBS Financial Services, Inc. | 234 342 | 220 812 | |
0,24122 % | BlackRock Financial Management, Inc. | 232 227 | 232 227 | |
0,24065 % | Arctic Fund Management AS | 231 675 | −15 000 | |
0,23756 % | BlackRock Investment Management, LLC | 228 702 | 195 672 | |
0,22925 % | Charles Schwab Investment Management, Inc. | 220 701 | 220 701 | |
0,21719 % | Exome Asset Management LLC | 209 092 | 209 092 | |
0,21717 % | BNY Mellon Asset Management | 209 066 | 209 066 | |
0,21201 % | Obermeyer Wood Investment Counsel, LLLP | 204 105 | −75 389 | |
0,18583 % | Ende (Eric J) | 178 900 | 11 000 | |
0,18173 % | J. Goldman & Co., L.P. | 174 952 | 174 952 | |
0,17420 % | Iridian Asset Management LLC | 167 700 | 50 000 | |
0,16526 % | Divis (Gregory J. Jr.) | 159 100 | 0 | |
0,15581 % | Troluce Capital Advisors LLC | 150 000 | 150 000 | |
0,14542 % | DWS Investment GmbH | 140 000 | 0 | |
0,14231 % | Schulhoff & Company, Inc. | 137 000 | 0 | |
0,14096 % | Glass (Geoffrey Michael) | 135 700 | 11 000 | |
0,13078 % | Dorsey, Wright & Associates, LLC | 125 905 | −1 735 | |
0,12743 % | Rhumbline Advisers Ltd. Partnership | 122 675 | 121 130 | |
0,12450 % | MML Investors Services, LLC | 119 856 | 17 925 | |
0,12040 % | Mellon Investments Corporation | 115 909 | 115 909 | |
0,11328 % | Morgan Stanley AIP GP LP | 109 050 | 34 692 | |
0,11196 % | Cetera Investment Advisers LLC | 107 787 | −6 191 | |
0,11063 % | MAI Capital Management, LLC | 106 502 | −5 103 | |
0,10387 % | Silverback Asset Management, LLC | 100 000 | 100 000 | |
0,10291 % | Investors Asset Management of Georgia, Inc. | 99 075 | 9 600 | |
0,10024 % | BlackRock Advisors (UK) Limited | 96 500 | 1 797 | |
0,09976 % | Capula Investment Management LLP | 96 043 | 96 043 | |
0,09770 % | Thornton (Peter J) | 94 055 | 11 000 | |
0,09558 % | Cetera Advisors LLC | 92 017 | 7 531 | |
0,09126 % | RBC Capital Markets Wealth Management | 87 860 | −32 089 | |
0,09059 % | AllianceBernstein L.P. | 87 210 | −273 | |
0,08704 % | Avantax Advisory Services, Inc. | 83 792 | 28 036 | |
0,08570 % | Lion Point Capital, L.P. | 82 500 | 0 | |
0,08362 % | McHugh (Thomas S) | 80 500 | 0 | |
0,08105 % | McCamish (Mark Anthony) | 78 025 | 11 000 | |
0,08015 % | Polen Capital Management, LLC | 77 165 | 0 | |
0,07478 % | Prelude Capital Management, LLC | 71 994 | 71 994 | |
0,07271 % | Gendell (Jeffrey L) | 70 000 | 0 | |
0,07244 % | Schonfeld Strategic Advisors LLC | 69 742 | −252 258 | |
0,07117 % | Jane Street Capital, L.L.C. | 68 518 | 11 913 | |
0,06961 % | Azimut Capital Management Sgr SpA | 67 014 | −911 | |
0,06689 % | Renaissance Technologies LLC | 64 396 | −341 610 | |
0,06586 % | Palczuk (Linda S) | 63 400 | 11 000 | |
0,06560 % | Envestnet Asset Management, Inc. | 63 151 | 47 822 | |
0,05681 % | BlackRock Asset Management Ireland Limited | 54 693 | 7 363 | |
0,05538 % | GTS Securities LLC | 53 315 | −12 502 | |
0,05165 % | SunAmerica Asset Management, LLC | 49 723 | 0 | |
0,05165 % | Corebridge Financial Inc | 49 723 | 49 723 | |
0,04809 % | Jump Financial, LLC | 46 300 | −79 700 | |
0,04569 % | Commonwealth Financial Network | 43 988 | −779 | |
0,04563 % | JPMorgan Private Bank (United States) | 43 932 | 39 045 | |
0,04455 % | Invesco Advisers, Inc. | 42 889 | 42 889 | |
0,04361 % | Manulife Investment Management (North America) Limited | 41 979 | 41 979 | |