8,97078 % | RTW Investments L.P. | 3 412 486 | 140 145 | |
7,15054 % | BlackRock Institutional Trust Company, N.A. | 2 720 065 | 480 432 | |
6,40225 % | Paradigm BioCapital Advisors LP | 2 435 416 | −427 990 | |
5,92744 % | Tang Capital Management, LLC | 2 254 797 | 0 | |
5,77651 % | TD Cowen (Research) | 2 197 385 | 74 855 | |
5,29838 % | Horowitz Management, Inc. | 2 015 503 | 2 015 503 | |
5,21800 % | The Vanguard Group, Inc. | 1 984 926 | 163 061 | |
4,74304 % | Morgan Stanley & Co. LLC | 1 804 254 | −41 324 | |
4,17331 % | Frazier Life Sciences Management, L.P. | 1 587 527 | −200 000 | |
3,89029 % | Jennison Associates LLC | 1 479 868 | 148 930 | |
3,40803 % | Perceptive Advisors LLC | 1 296 416 | 0 | |
3,00012 % | Assenagon Asset Management S.A. | 1 141 247 | 77 825 | |
2,43333 % | State Street Global Advisors (US) | 925 639 | 208 549 | |
2,25174 % | Azamian (Bobak R) | 856 562 | −232 571 | |
2,10378 % | Ikarian Capital LLC | 800 277 | 90 000 | |
2,03269 % | Geode Capital Management, L.L.C. | 773 235 | 143 543 | |
1,95043 % | Two Sigma Investments, LP | 741 942 | 520 216 | |
1,76251 % | ExodusPoint Capital Management, LP | 670 459 | 454 501 | |
1,64978 % | Artisan Partners Limited Partnership | 627 578 | 148 | |
1,56237 % | Ensign Peak Advisors, Inc. | 594 325 | −133 566 | |
1,55100 % | Integral Health Asset Management, LLC | 590 000 | 0 | |
1,48672 % | Vivo Capital, LLC | 565 550 | 0 | |
1,46245 % | TCG Crossover Management, LLC | 556 317 | −237 512 | |
1,31441 % | Polygon Management Ltd. | 500 000 | 50 000 | |
1,31441 % | Cormorant Asset Management, LP | 500 000 | −1 639 102 | |
1,21777 % | Lord, Abbett & Co. LLC | 463 240 | 381 014 | |
1,19609 % | Macquarie Investment Management | 454 991 | 304 991 | |
1,10609 % | Jefferies LLC | 420 758 | 150 000 | |
1,06966 % | Dimensional Fund Advisors, L.P. | 406 899 | −17 931 | |
1,02518 % | Invesco Advisers, Inc. | 389 977 | 167 722 | |
1,02419 % | HOOPP Investment Management | 389 600 | −508 400 | |
1,01777 % | J. Goldman & Co., L.P. | 387 161 | 223 814 | |
0,99080 % | Medical Strategy GmbH | 376 899 | 58 824 | |
0,98858 % | Nuveen LLC | 376 055 | 219 538 | |
0,95810 % | Driehaus Capital Management, LLC | 364 463 | 203 300 | |
0,91637 % | Millennium Management LLC | 348 586 | 322 942 | |
0,72085 % | T. Rowe Price Associates, Inc. | 274 211 | −59 877 | |
0,70924 % | D. E. Shaw & Co., L.P. | 269 793 | 73 281 | |
0,70899 % | BlackRock Financial Management, Inc. | 269 701 | 74 372 | |
0,68843 % | Charles Schwab Investment Management, Inc. | 261 879 | 39 882 | |
0,67295 % | Emerald Advisers LLC | 255 990 | 226 886 | |
0,63910 % | BofA Global Research (US) | 243 112 | 13 620 | |
0,61777 % | Ghost Tree Capital, LLC | 235 000 | −65 000 | |
0,60854 % | Northern Trust Investments, Inc. | 231 490 | 5 784 | |
0,59642 % | Qube Research & Technologies Ltd | 226 879 | 193 516 | |
0,56795 % | Boone Capital Management LLC | 216 047 | −393 057 | |
0,55345 % | Allspring Global Investments, LLC | 210 531 | 29 465 | |
0,54545 % | Citadel Advisors LLC | 207 489 | −11 789 | |
0,52601 % | Boothbay Fund Management, LLC | 200 094 | 24 582 | |
0,47676 % | Goldman Sachs & Company, Inc. | 181 360 | 2 603 | |
0,44690 % | Sands Capital Ventures LLC | 170 000 | 0 | |
0,43927 % | Link (William J) | 167 098 | 27 116 | |
0,33472 % | Wellington Management Company, LLP | 127 328 | 15 906 | |
0,32539 % | Robert W. Baird & Co. Inc. | 123 778 | −4 494 | |
0,28889 % | Flying L Investments Xi, L.L.C. | 109 892 | −105 684 | |
0,28695 % | Essex Investment Management Company, LLC | 109 156 | 87 948 | |
0,26960 % | abrdn Inc. | 102 555 | 0 | |
0,25984 % | BlackRock Investment Management, LLC | 98 842 | 20 118 | |
0,24571 % | BlackRock Advisors (UK) Limited | 93 467 | 704 | |
0,23461 % | BNY Mellon Asset Management | 89 244 | 27 604 | |
0,22430 % | Connor, Clark & Lunn Investment Management Ltd. | 85 323 | −11 724 | |
0,22355 % | Bessemer Trust Company, N.A. (US) | 85 038 | 0 | |
0,22345 % | Hudson Bay Capital Management LP | 85 000 | 85 000 | |
0,20811 % | BlackRock Asset Management Ireland Limited | 79 165 | 14 654 | |
0,20727 % | Jane Street Capital, L.L.C. | 78 847 | 40 572 | |
0,20242 % | PGIM Securities Investment Trust Enterprise | 77 000 | 77 000 | |
0,19871 % | Walleye Capital LLC | 75 588 | −196 910 | |
0,19591 % | Baird Investment Management | 74 526 | −3 222 | |
0,18732 % | Parametric Portfolio Associates LLC | 71 255 | 8 386 | |
0,17734 % | Russell Investments Trust Company | 67 461 | 47 214 | |
0,17026 % | Neervannan (Seshadri) | 64 767 | 12 044 | |
0,14236 % | TwinBeech Capital LP | 54 152 | 54 152 | |
0,14098 % | GGM Wealth Advisors | 53 630 | 30 | |
0,13778 % | BlackRock Investment Management (UK) Ltd. | 52 413 | 23 044 | |
0,13733 % | Mottiwala (Aziz) | 52 242 | 8 172 | |
0,13055 % | Rhumbline Advisers Ltd. Partnership | 49 660 | 6 070 | |
0,12657 % | Columbia Threadneedle Investments (US) | 48 148 | −10 219 | |
0,12443 % | Schweizerische Nationalbank | 47 333 | 4 900 | |
0,12373 % | State of Wisconsin Investment Board | 47 065 | 24 227 | |
0,12350 % | Lannebo Kapitalförvaltning AB | 46 981 | 0 | |
0,12350 % | E. Ohman J:or Asset Management AB | 46 981 | 8 000 | |
0,11726 % | New York State Common Retirement Fund | 44 604 | 5 105 | |
0,10515 % | SilverArc Capital Management, LLC | 40 000 | 40 000 | |
0,10402 % | Wahl (Bryan) | 39 568 | 7 602 | |
0,10069 % | Graham Capital Management, L.P. | 38 301 | 38 301 | |
0,09940 % | Advisory Services Network, LLC | 37 811 | 37 811 | |
0,09303 % | TD Asset Management Inc. | 35 388 | −13 200 | |
0,09232 % | AllianceBernstein L.P. | 35 120 | 7 820 | |
0,09175 % | Trexquant Investment LP | 34 903 | −6 135 | |
0,08778 % | Mellon Investments Corporation | 33 390 | 1 223 | |
0,08749 % | Manulife Investment Management (North America) Limited | 33 282 | 3 112 | |
0,08467 % | Whitfield (Dianne C) | 32 208 | 7 397 | |
0,08212 % | Aperio Group, LLC | 31 240 | 1 419 | |
0,07862 % | Yeu-lin (Elizabeth M.D.) | 29 906 | 11 506 | |
0,07761 % | Jackson Creek Investment Advisors LLC | 29 524 | −53 | |
0,07747 % | Alps Advisors, Inc. | 29 468 | 3 020 | |
0,07397 % | Schonfeld Strategic Advisors LLC | 28 137 | 12 606 | |
0,07354 % | UBS Financial Services, Inc. | 27 973 | −10 367 | |
0,07315 % | Voloridge Investment Management, LLC | 27 827 | 27 827 | |
0,07114 % | Legal & General Investment Management Ltd. | 27 062 | 4 231 | |