11,93418 % | RA Capital Management, LP | 18 202 009 | −16 115 | |
10,99901 % | GSK plc | 16 775 691 | 2 791 930 | |
5,02843 % | Maverick Capital, Ltd. | 7 669 361 | −18 718 | |
4,04180 % | M28 Capital Management LP | 6 164 548 | −835 452 | |
4,00138 % | BlackRock Institutional Trust Company, N.A. | 6 102 901 | 301 813 | |
3,74053 % | Shin Nippon Biomedical Laboratories Ltd | 5 705 060 | 0 | |
3,51280 % | Adage Capital Management, L.P. | 5 357 719 | 156 330 | |
3,49135 % | 683 Capital Management LLC | 5 325 000 | −25 000 | |
3,28152 % | Emerald Advisers LLC | 5 004 976 | 690 808 | |
2,99387 % | Invus Public Equities Advisors, LLC | 4 566 251 | 514 851 | |
2,68454 % | Bellevue Asset Management AG | 4 094 458 | 0 | |
2,60656 % | Kynam Capital Management LP | 3 975 521 | 43 439 | |
1,74680 % | PRIMECAP Management Company | 2 664 216 | −212 224 | |
1,57615 % | The Vanguard Group, Inc. | 2 403 942 | 583 600 | |
1,48402 % | State Street Global Advisors (US) | 2 263 426 | 749 007 | |
1,30228 % | Geode Capital Management, L.L.C. | 1 986 245 | 73 503 | |
1,09120 % | Millennium Management LLC | 1 664 300 | 28 690 | |
0,89188 % | T. Rowe Price Associates, Inc. | 1 360 291 | −425 323 | |
0,59539 % | Driehaus Capital Management, LLC | 908 096 | 348 300 | |
0,42025 % | Northern Trust Investments, Inc. | 640 971 | −3 753 | |
0,40114 % | Morgan Stanley & Co. LLC | 611 818 | 28 178 | |
0,37706 % | Ikarian Capital LLC | 575 088 | −15 000 | |
0,36787 % | Fidelity Management & Research Company LLC | 561 080 | −607 693 | |
0,35231 % | Platinum Asset Management | 537 345 | −62 810 | |
0,33863 % | Laurion Capital Management LP | 516 473 | −355 027 | |
0,32486 % | SilverArc Capital Management, LLC | 495 471 | 0 | |
0,32005 % | Exome Asset Management LLC | 488 135 | 488 135 | |
0,31143 % | Newtyn Management, LLC | 475 000 | −25 000 | |
0,28082 % | Wellington Management Company, LLP | 428 311 | 29 212 | |
0,26487 % | AllianceBernstein L.P. | 403 984 | 67 395 | |
0,24587 % | Affinity Asset Advisors LLC | 375 000 | 88 415 | |
0,24036 % | Jacobs Levy Equity Management, Inc. | 366 601 | 124 741 | |
0,22948 % | Avidity Partners Management LP | 350 000 | 350 000 | |
0,22276 % | Connor, Clark & Lunn Investment Management Ltd. | 339 749 | −122 833 | |
0,21752 % | JPMorgan Asset Management U.K. Limited | 331 768 | −63 798 | |
0,21022 % | Nuveen LLC | 320 620 | 97 270 | |
0,19870 % | Moody Aldrich Partners, LLC | 303 062 | 123 703 | |
0,18428 % | Trexquant Investment LP | 281 060 | 168 428 | |
0,17917 % | Charles Schwab Investment Management, Inc. | 273 272 | −160 305 | |
0,17610 % | Bolno (Paul B. M.D.) | 268 585 | −90 474 | |
0,16747 % | MFS Investment Management | 255 426 | 0 | |
0,16409 % | BlackRock Financial Management, Inc. | 250 268 | 8 825 | |
0,14160 % | Parametric Portfolio Associates LLC | 215 966 | −139 736 | |
0,13667 % | BlackRock Investment Management, LLC | 208 456 | 22 572 | |
0,13113 % | Ghost Tree Capital, LLC | 200 000 | 200 000 | |
0,12912 % | Goldman Sachs & Company, Inc. | 196 939 | −103 348 | |
0,12060 % | TD Asset Management Inc. | 183 946 | −68 000 | |
0,11057 % | BNY Mellon Asset Management | 168 647 | 22 439 | |
0,10986 % | Boothbay Fund Management, LLC | 167 556 | −4 370 | |
0,10789 % | Vargeese (Chandra) | 164 556 | 68 210 | |
0,10261 % | Schweizerische Nationalbank | 156 500 | 0 | |
0,10056 % | Two Sigma Investments, LP | 153 379 | −349 446 | |
0,09165 % | Manulife Investment Management (North America) Limited | 139 790 | 4 914 | |
0,08864 % | Prelude Capital Management, LLC | 135 200 | −9 100 | |
0,08250 % | Rhumbline Advisers Ltd. Partnership | 125 834 | 4 092 | |
0,07942 % | BlackRock Advisors (UK) Limited | 121 132 | 1 538 | |
0,07862 % | UBS Financial Services, Inc. | 119 913 | 37 592 | |
0,07810 % | BlackRock Asset Management Ireland Limited | 119 116 | 18 859 | |
0,07571 % | Point72 Asset Management, L.P. | 115 478 | −1 859 259 | |
0,07118 % | D. E. Shaw & Co., L.P. | 108 567 | −176 525 | |
0,06985 % | Jane Street Capital, L.L.C. | 106 542 | 69 207 | |
0,06729 % | Schonfeld Strategic Advisors LLC | 102 635 | 102 635 | |
0,06700 % | New York State Common Retirement Fund | 102 184 | 83 364 | |
0,06567 % | Cinctive Capital Management LP | 100 162 | 31 756 | |
0,06230 % | Putnam Investment Management, L.L.C. | 95 019 | −1 787 | |
0,05901 % | J. J. Burns & Company, LLC | 90 000 | 90 000 | |
0,05901 % | ACCI Capital Investments SGIIC, SA | 90 000 | 0 | |
0,05853 % | PDT Partners, LLC | 89 267 | 75 967 | |
0,05840 % | Legal & General Investment Management Ltd. | 89 076 | 17 924 | |
0,05806 % | Martingale Asset Management, L.P. | 88 547 | 19 643 | |
0,05593 % | State Teachers Retirement System of Ohio | 85 300 | 14 000 | |
0,05373 % | Macquarie Investment Management | 81 955 | 0 | |
0,05178 % | T. Rowe Price International Ltd | 78 980 | 3 340 | |
0,05117 % | Susquehanna International Group, LLP | 78 048 | 78 048 | |
0,05099 % | California State Teachers Retirement System | 77 768 | −907 | |
0,05089 % | a16z Perennial Management, L.P. | 77 619 | 0 | |
0,05026 % | Adar1 Capital Management LLC | 76 651 | 46 651 | |
0,04922 % | BofA Global Research (US) | 75 073 | −18 413 | |
0,04594 % | Engineers Gate Manager, L.P. | 70 071 | 19 903 | |
0,04566 % | Northern Trust Global Investments | 69 638 | −1 369 | |
0,04511 % | Y-Intercept (Hong Kong) Ltd | 68 803 | 68 803 | |
0,04072 % | Marshall Wace LLP | 62 102 | −251 303 | |
0,03851 % | Barclays Bank PLC | 58 743 | −35 051 | |
0,03671 % | Mellon Investments Corporation | 55 985 | 5 175 | |
0,03623 % | GSA Capital Partners LLP | 55 258 | −39 779 | |
0,03390 % | Janus Henderson Investors | 51 700 | 51 700 | |
0,03381 % | Francis (Christopher John) | 51 564 | −10 258 | |
0,03380 % | Bessemer Trust Company, N.A. (US) | 51 549 | 51 549 | |
0,03140 % | Assenagon Asset Management S.A. | 47 888 | 530 | |
0,03024 % | Verdine Gregory L | 46 115 | 16 115 | |
0,02987 % | Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 45 557 | 45 557 | |
0,02859 % | MetLife Investment Management, LLC | 43 601 | 5 533 | |
0,02731 % | Corebridge Financial Inc | 41 656 | 41 656 | |
0,02696 % | Northern Trust Global Investments Limited | 41 116 | −444 | |
0,02693 % | Mirae Asset Global Investments (USA) LLC | 41 077 | 41 077 | |
0,02623 % | Birchview Capital, LP | 40 000 | 0 | |
0,02491 % | Goldman Sachs Asset Management, L.P. | 37 992 | −2 399 | |
0,02397 % | SG Americas Securities, L.L.C. | 36 563 | −97 264 | |
0,02376 % | SunAmerica Asset Management, LLC | 36 241 | 6 851 | |
0,02345 % | Aperio Group, LLC | 35 761 | 11 416 | |