11,89781 % | PRIMECAP Management Company | 7 312 391 | −435 200 | |
10,41062 % | Baker Bros. Advisors LP | 6 398 365 | 0 | |
9,89979 % | RA Capital Management, LP | 6 084 412 | 754 000 | |
8,50647 % | Goldman Sachs & Company, Inc. | 5 228 074 | 223 252 | |
6,41041 % | BlackRock Institutional Trust Company, N.A. | 3 939 837 | 44 398 | |
5,60784 % | Perceptive Advisors LLC | 3 446 579 | 178 001 | |
5,45234 % | The Vanguard Group, Inc. | 3 351 010 | 56 549 | |
4,73472 % | New Enterprise Associates (NEA) | 2 909 956 | 0 | |
3,85829 % | Frazier Life Sciences Management, L.P. | 2 371 304 | 181 125 | |
3,26047 % | State Street Global Advisors (US) | 2 003 882 | −1 009 956 | |
2,70661 % | BlackRock Financial Management, Inc. | 1 663 485 | 48 190 | |
2,70221 % | Federated Hermes Global Investment Management Corp. | 1 660 780 | −220 | |
2,44061 % | Polar Capital LLP | 1 500 000 | 0 | |
2,08346 % | Rock Springs Capital Management LP | 1 280 493 | −242 400 | |
2,03822 % | Geode Capital Management, L.L.C. | 1 252 689 | 71 984 | |
1,99317 % | Commodore Capital LP | 1 225 000 | 175 000 | |
1,92380 % | Driehaus Capital Management, LLC | 1 182 370 | 326 865 | |
1,57378 % | HOOPP Investment Management | 967 243 | 236 600 | |
1,50033 % | Checkpoint Capital L.P. | 922 100 | 96 600 | |
1,35163 % | Alkeon Capital Management LLC | 830 712 | 830 712 | |
1,30458 % | Pictet Asset Management Ltd. | 801 796 | −409 883 | |
1,28904 % | BlackRock Investment Management (UK) Ltd. | 792 244 | 39 968 | |
1,14683 % | OrbiMed Advisors, LLC | 704 842 | 0 | |
0,96590 % | Janus Henderson Investors | 593 642 | −27 785 | |
0,83794 % | Opaleye Management Inc. | 515 000 | 0 | |
0,80163 % | T. Rowe Price Associates, Inc. | 492 682 | 42 212 | |
0,77286 % | Cormorant Asset Management, LP | 475 000 | −75 000 | |
0,75201 % | Voloridge Investment Management, LLC | 462 188 | −11 267 | |
0,70078 % | Northern Trust Investments, Inc. | 430 698 | −14 534 | |
0,69841 % | Morgan Stanley & Co. LLC | 429 244 | 285 267 | |
0,69632 % | Charles Schwab Investment Management, Inc. | 427 958 | 21 213 | |
0,67849 % | CPP Investment Board | 417 000 | −160 000 | |
0,65773 % | National Bank of Canada | 404 242 | 36 725 | |
0,64331 % | Candriam Luxembourg S.A. | 395 377 | 0 | |
0,45434 % | Loomis, Sayles & Company, L.P. | 279 237 | 0 | |
0,44158 % | Candriam Belgium S.A. | 271 398 | 271 398 | |
0,44137 % | Artisan Partners Limited Partnership | 271 267 | −154 | |
0,34947 % | Putnam Investment Management, L.L.C. | 214 785 | 10 143 | |
0,32920 % | Wellington Management Company, LLP | 202 326 | 8 803 | |
0,31141 % | Invesco Advisers, Inc. | 191 391 | 105 913 | |
0,30046 % | SilverArc Capital Management, LLC | 184 662 | 886 | |
0,28886 % | BlackRock Investment Management, LLC | 177 532 | 3 820 | |
0,28410 % | Meeker (David P) | 174 605 | −986 | |
0,28091 % | Samsara BioCapital, LLC | 172 647 | 0 | |
0,27544 % | Oppenheimer Asset Management Inc. | 169 288 | 169 288 | |
0,25430 % | BlackRock Advisors (UK) Limited | 156 292 | 332 | |
0,23837 % | Jane Street Capital, L.L.C. | 146 500 | 120 182 | |
0,23799 % | Nuveen LLC | 146 270 | 6 384 | |
0,23499 % | BlackRock Asset Management Ireland Limited | 144 426 | 79 800 | |
0,22208 % | UBS Asset Management (Americas), Inc. | 136 493 | −89 | |
0,21805 % | BNY Mellon Asset Management | 134 012 | 9 007 | |
0,19100 % | Ghost Tree Capital, LLC | 117 388 | −7 612 | |
0,18354 % | abrdn Inc. | 112 804 | 0 | |
0,17379 % | Marshall Wace LLP | 106 809 | 87 059 | |
0,17217 % | JGP Gest¿o de Recursos Ltda. | 105 814 | 100 126 | |
0,16943 % | Algert Global LLC | 104 132 | 35 084 | |
0,16894 % | AQR Capital Management, LLC | 103 830 | 32 831 | |
0,16692 % | Lord, Abbett & Co. LLC | 102 591 | −178 566 | |
0,16510 % | Samsung Asset Management Co., Ltd. | 101 469 | −4 859 | |
0,16427 % | Hennion & Walsh Asset Management, Inc. | 100 961 | 4 583 | |
0,15935 % | Smith (Hunter C) | 97 939 | 0 | |
0,15923 % | J.P. Morgan Securities plc | 97 865 | 82 413 | |
0,14808 % | First Trust Advisors L.P. | 91 010 | 91 010 | |
0,14432 % | Schweizerische Nationalbank | 88 700 | −4 600 | |
0,14336 % | ClearBridge Investments, LLC | 88 108 | −1 896 | |
0,14019 % | BofA Global Research (US) | 86 161 | −19 012 | |
0,13880 % | Invesco Capital Management LLC | 85 309 | 82 582 | |
0,13515 % | Rhumbline Advisers Ltd. Partnership | 83 063 | 6 339 | |
0,11806 % | Rafferty Asset Management LLC | 72 562 | −146 095 | |
0,10778 % | NISA Investment Advisors, L.L.C. | 66 240 | −308 107 | |
0,10729 % | UBS Financial Services, Inc. | 65 942 | −105 623 | |
0,10113 % | Northern Trust Global Investments | 62 156 | 11 335 | |
0,09937 % | AllianceBernstein L.P. | 61 070 | 7 640 | |
0,09854 % | Goldman Sachs Asset Management, L.P. | 60 561 | −46 218 | |
0,09338 % | UBS Asset Management (Switzerland) | 57 391 | 9 896 | |
0,08851 % | Mellon Investments Corporation | 54 397 | 15 068 | |
0,08726 % | Barclays Bank PLC | 53 631 | −73 905 | |
0,08709 % | Legal & General Investment Management Ltd. | 53 526 | 6 110 | |
0,08020 % | Manulife Investment Management (North America) Limited | 49 291 | 1 667 | |
0,07992 % | Nan Fung Life Sciences | 49 120 | 0 | |
0,07947 % | WEDGE Capital Management, L.L.P. | 48 844 | −14 353 | |
0,07319 % | Caption Management, LLC | 44 984 | 44 984 | |
0,07282 % | California State Teachers Retirement System | 44 757 | −3 137 | |
0,07199 % | Woodline Partners LP | 44 247 | −127 960 | |
0,07151 % | Ostrum Asset Management | 43 951 | 37 901 | |
0,07035 % | Norges Bank Investment Management (NBIM) | 43 238 | 43 238 | |
0,06731 % | Harbor Capital Advisors, Inc. | 41 368 | 6 741 | |
0,06576 % | Columbia Threadneedle Investments (US) | 40 415 | 19 435 | |
0,06540 % | MFS Investment Management | 40 192 | −115 | |
0,06415 % | State of Wisconsin Investment Board | 39 427 | 6 123 | |
0,06152 % | Voya Investment Management LLC | 37 811 | −131 900 | |
0,05939 % | Nomura Asset Management Co., Ltd. | 36 500 | 36 500 | |
0,05674 % | Mazabraud (Yann) | 34 870 | 10 375 | |
0,05412 % | T. Rowe Price International Ltd | 33 260 | 2 197 | |
0,05361 % | UBS Fund Management (Switzerland) AG | 32 946 | −10 218 | |
0,05241 % | Mirae Asset Global Investments (USA) LLC | 32 211 | 32 211 | |
0,05150 % | MetLife Investment Management, LLC | 31 652 | 4 529 | |
0,05044 % | TD Asset Management Inc. | 31 000 | 3 400 | |
0,04792 % | Corebridge Financial Inc | 29 454 | 29 454 | |
0,04741 % | Fulcrum Asset Management LLP | 29 140 | −279 | |