| 8,41495 % | The Vanguard Group, Inc. | 15 730 075 | −849 902 | |
| 7,66367 % | Farallon Capital Management, L.L.C. | 14 325 692 | 791 000 | |
| 5,66561 % | Janus Henderson Investors | 10 590 727 | 400 656 | |
| 5,48855 % | Wellington Management Company, LLP | 10 259 738 | −1 528 183 | |
| 5,00988 % | Baker Bros. Advisors LP | 9 364 972 | 1 428 000 | |
| 4,45319 % | Fidelity Management & Research Company LLC | 8 324 353 | 919 012 | |
| 4,19575 % | BlackRock Institutional Trust Company, N.A. | 7 843 111 | −4 942 738 | |
| 4,06627 % | Nextech Invest, Ltd. | 7 601 087 | 0 | |
| 3,25966 % | Paradigm BioCapital Advisors LP | 6 093 291 | −84 820 | |
| 2,66537 % | BVF Partners L.P. | 4 982 384 | 0 | |
| 2,52442 % | State Street Global Advisors (US) | 4 718 906 | −1 086 013 | |
| 2,50859 % | T. Rowe Price Investment Management, Inc. | 4 689 298 | 3 015 869 | |
| 2,44974 % | Bellevue Asset Management AG | 4 579 300 | 205 000 | |
| 2,43235 % | T. Rowe Price Associates, Inc. | 4 546 792 | −888 076 | |
| 2,21114 % | Alphabet, Inc. | 4 133 277 | 0 | |
| 1,94348 % | Holocene Advisors, LP | 3 632 952 | −58 792 | |
| 1,81034 % | Deerfield Management Company, L.P. | 3 384 072 | 66 740 | |
| 1,60160 % | Geode Capital Management, L.L.C. | 2 993 866 | −1 148 548 | |
| 1,55971 % | Woodline Partners LP | 2 915 572 | −971 464 | |
| 1,54493 % | Casdin Capital, LLC | 2 887 933 | −810 000 | |
| 1,47035 % | Andreessen Horowitz | 2 748 523 | 0 | |
| 1,24894 % | Borisy (Alexis) | 2 334 636 | 3 142 | |
| 1,24289 % | JP Morgan Asset Management | 2 323 338 | −522 633 | |
| 1,17488 % | Lunate Capital LLC | 2 196 200 | 0 | |
| 0,91003 % | Norges Bank Investment Management (NBIM) | 1 701 111 | −40 928 | |
| 0,90943 % | Logos Global Management LP | 1 700 000 | 100 000 | |
| 0,88236 % | Westfield Capital Management Company, L.P. | 1 649 404 | 585 358 | |
| 0,85631 % | Charles Schwab Investment Management, Inc. | 1 600 693 | −329 775 | |
| 0,79050 % | Citadel Advisors LLC | 1 477 675 | 1 344 608 | |
| 0,79041 % | Goldman Sachs & Company, Inc. | 1 477 511 | 131 367 | |
| 0,73869 % | Millennium Management LLC | 1 380 841 | 1 224 488 | |
| 0,71201 % | Rock Springs Capital Management LP | 1 330 960 | 49 320 | |
| 0,69014 % | Jane Street Capital, L.L.C. | 1 290 075 | 952 673 | |
| 0,64195 % | Vestal Point Capital, LP | 1 200 000 | 1 200 000 | |
| 0,60238 % | Hood River Capital Management LLC | 1 126 020 | −591 028 | |
| 0,54136 % | Pictet Asset Management Ltd. | 1 011 960 | 264 400 | |
| 0,53360 % | Frazier Life Sciences Management, L.P. | 997 455 | 0 | |
| 0,53289 % | Dimensional Fund Advisors, L.P. | 996 124 | 622 370 | |
| 0,50220 % | Invus Public Equities Advisors, LLC | 938 755 | 375 000 | |
| 0,46995 % | Candriam Luxembourg S.A. | 878 484 | 142 939 | |
| 0,46237 % | Columbia Threadneedle Investments (UK) | 864 301 | −214 363 | |
| 0,42421 % | Boxer Capital Management, LLC | 792 977 | −525 000 | |
| 0,42049 % | Qube Research & Technologies Ltd | 786 017 | 602 877 | |
| 0,40467 % | Northern Trust Investments, Inc. | 756 452 | −660 570 | |
| 0,40211 % | Polar Capital LLP | 751 655 | 990 | |
| 0,38978 % | Goldsmith Mark A | 728 620 | 23 504 | |
| 0,38491 % | Candriam Belgium S.A. | 719 513 | 64 379 | |
| 0,36721 % | HRT Financial LP | 686 426 | 662 719 | |
| 0,36226 % | Dafna Capital Management, LLC | 677 176 | 21 000 | |
| 0,35669 % | Goldman Sachs Asset Management, L.P. | 666 768 | −143 764 | |
| 0,35314 % | D. E. Shaw & Co., L.P. | 660 132 | 660 132 | |
| 0,34068 % | Caligan Partners, LP | 636 835 | 171 835 | |
| 0,27206 % | MIC Capital Management UK LLP | 508 569 | 0 | |
| 0,27168 % | UBS Financial Services, Inc. | 507 853 | 31 246 | |
| 0,27155 % | TD Asset Management Inc. | 507 600 | 181 724 | |
| 0,25857 % | Morgan Stanley & Co. LLC | 483 345 | −489 265 | |
| 0,25743 % | BofA Global Research (US) | 481 221 | 131 990 | |
| 0,24318 % | American Century Investment Management, Inc. | 454 572 | −287 288 | |
| 0,24245 % | JPMorgan Asset Management U.K. Limited | 453 214 | −65 978 | |
| 0,22232 % | First Turn Management, LLC | 415 591 | 75 482 | |
| 0,21259 % | Adage Capital Management, L.P. | 397 400 | 3 400 | |
| 0,19913 % | Eventide Asset Management, LLC | 372 229 | 0 | |
| 0,19893 % | Ensign Peak Advisors, Inc. | 371 857 | −55 609 | |
| 0,19651 % | BNP Paribas Securities Corp. North America | 367 345 | −157 083 | |
| 0,19638 % | Victory Capital Management Inc. | 367 093 | 29 212 | |
| 0,18324 % | JPMorgan Asset Management (Europe) S.à.r.l. | 342 524 | −2 481 | |
| 0,18122 % | Squarepoint Capital LLP | 338 753 | 245 934 | |
| 0,18092 % | Partners HealthCare System, Inc | 338 191 | 0 | |
| 0,17386 % | Integral Health Asset Management, LLC | 325 000 | 75 000 | |
| 0,16890 % | MPM BioImpact LLC | 315 722 | −1 361 | |
| 0,16887 % | Citi Investment Research (US) | 315 662 | −293 726 | |
| 0,16762 % | Morgan Stanley Investment Management Inc. (US) | 313 339 | 308 858 | |
| 0,16251 % | Weiss Asset Management | 303 772 | 303 772 | |
| 0,15244 % | Comerica, Inc. | 284 959 | 91 240 | |
| 0,14986 % | Mellon Investments Corporation | 280 130 | 30 119 | |
| 0,14979 % | Checkpoint Capital L.P. | 280 000 | −112 011 | |
| 0,14667 % | Columbia Threadneedle Investments (US) | 274 177 | 67 783 | |
| 0,14409 % | BlackRock Financial Management, Inc. | 269 355 | −470 219 | |
| 0,14253 % | Schweizerische Nationalbank | 266 431 | −10 100 | |
| 0,13792 % | WCM Investment Management | 257 814 | 11 817 | |
| 0,13664 % | UBS Asset Management (Switzerland) | 255 423 | 133 339 | |
| 0,13639 % | Pzena Investment Management, LLC | 254 957 | −135 176 | |
| 0,13552 % | Trexquant Investment LP | 253 335 | 194 121 | |
| 0,13420 % | Franklin Advisers, Inc. | 250 858 | 250 858 | |
| 0,13030 % | Bessemer Trust Company, N.A. (US) | 243 571 | 0 | |
| 0,13026 % | Renaissance Technologies LLC | 243 504 | 100 700 | |
| 0,12980 % | Barclays Bank PLC | 242 631 | −29 155 | |
| 0,12776 % | Nuveen LLC | 238 822 | −220 605 | |
| 0,12229 % | Avidity Partners Management LP | 228 600 | 15 600 | |
| 0,12090 % | Decheng Capital LLC | 226 000 | 0 | |
| 0,11471 % | California Public Employees' Retirement System | 214 430 | 1 515 | |
| 0,11419 % | HSBC Global Asset Management (France) S.A. | 213 454 | 0 | |
| 0,11419 % | HSBC Private Bank (Suisse) S.A. | 213 454 | 0 | |
| 0,11165 % | BlackRock Asset Management Ireland Limited | 208 699 | −257 232 | |
| 0,10930 % | Edgestream Partners, L.P. | 204 313 | −11 404 | |
| 0,10920 % | Brevan Howard Capital Management LP | 204 120 | 204 120 | |
| 0,10175 % | Russell Investments Trust Company | 190 196 | −86 034 | |
| 0,10119 % | Columbia Wanger Asset Management, LLC | 189 147 | 0 | |
| 0,09942 % | Boothbay Fund Management, LLC | 185 842 | 9 981 | |
| 0,09933 % | Susquehanna International Group, LLP | 185 669 | −58 384 | |