8,18 % | Merck Serono SA | 20 647 152 | 0 | |
6,33 % | Patient Capital Management, LLC | 15 983 700 | 2 230 524 | |
38,21 % | Third Security, LLC | 96 445 913 | 85 470 | |
3,95 % | BlackRock Institutional Trust Company, N.A. | 9 959 256 | 860 980 | |
2,67 % | The Vanguard Group, Inc. | 6 748 359 | −202 515 | |
1,20 % | Geode Capital Management, L.L.C. | 3 021 297 | 110 042 | |
1,13 % | Millennium Management LLC | 2 845 911 | 1 423 117 | |
1,06 % | State Street Global Advisors (US) | 2 684 533 | −81 934 | |
0,88 % | Sabzevari (Helen) | 2 221 076 | 661 072 | |
0,79 % | Iridian Asset Management LLC | 2 004 934 | −73 286 | |
0,48 % | JPMorgan Asset Management U.K. Limited | 1 202 663 | 0 | |
0,41 % | Hassan (Fred) | 1 029 834 | 150 892 | |
0,41 % | Frank (Steven R) | 1 024 160 | 141 802 | |
0,40 % | Opaleye Management Inc. | 1 012 500 | 84 000 | |
0,40 % | D. E. Shaw & Co., L.P. | 1 009 447 | 355 755 | |
0,40 % | Charles Schwab Investment Management, Inc. | 1 009 418 | −51 102 | |
0,40 % | Northern Trust Investments, Inc. | 999 017 | −9 760 | |
0,35 % | Renaissance Technologies LLC | 874 303 | −442 987 | |
0,29 % | Morgan Stanley Smith Barney LLC | 726 877 | 2 202 | |
0,28 % | Sanders Morris LLC | 705 000 | 705 000 | |
0,23 % | GSA Capital Partners LLP | 571 463 | 236 674 | |
0,23 % | Alvarez (Cesar Licinio) | 569 933 | 150 543 | |
0,22 % | Perez Jeffrey Thomas | 557 561 | 98 658 | |
0,21 % | Lehr Donald P | 538 126 | 109 210 | |
0,21 % | Morgan Stanley & Co. LLC | 531 966 | 297 065 | |
0,21 % | Citadel Advisors LLC | 531 520 | 234 718 | |
0,21 % | Nuveen LLC | 525 028 | 0 | |
0,21 % | EMFO, LLC | 519 475 | 94 475 | |
0,20 % | Mitchell (Dean J) | 503 183 | 146 347 | |
0,19 % | ClariVest Asset Management LLC | 477 505 | 11 361 | |
0,19 % | BlackRock Financial Management, Inc. | 476 430 | −138 789 | |
0,19 % | Turley (James S) | 472 441 | 150 543 | |
0,18 % | Gupta (Vinita D) | 452 622 | 150 892 | |
0,16 % | Kindler (Jeffrey B) | 393 363 | 155 088 | |
0,15 % | BlackRock Investment Management, LLC | 382 745 | −10 142 | |
0,15 % | Jacobs Levy Equity Management, Inc. | 373 013 | −314 781 | |
0,14 % | BofA Global Research (US) | 359 210 | 138 143 | |
0,14 % | Fore Capital, LLC | 356 791 | −70 000 | |
0,14 % | MSD Partners, L.P. | 355 000 | −605 000 | |
0,13 % | BNY Mellon Asset Management | 332 110 | −5 886 | |
0,13 % | Shapiro (Robert B) | 329 656 | −56 043 | |
0,12 % | Osaic Holdings, Inc. | 312 078 | −1 575 | |
0,12 % | PanAgora Asset Management Inc. | 303 385 | 303 385 | |
0,10 % | Fidelity Management & Research Company LLC | 255 916 | −57 449 | |
0,10 % | Cetera Investment Advisers LLC | 251 575 | 10 750 | |
0,10 % | Two Sigma Investments, LP | 240 859 | 18 015 | |
0,09 % | Thomasian (Harry Jr.) | 229 376 | 68 325 | |
0,08 % | UBS Financial Services, Inc. | 214 555 | 174 835 | |
0,08 % | Shah (Rutul R.) | 209 746 | 76 272 | |
0,08 % | Rhumbline Advisers Ltd. Partnership | 208 000 | −1 054 | |
0,08 % | Barclays Bank PLC | 206 540 | 161 448 | |
0,08 % | Jane Street Capital, L.L.C. | 206 197 | 173 228 | |
0,08 % | Exchange Traded Concepts, LLC | 199 255 | 105 164 | |
0,07 % | AllianceBernstein L.P. | 184 770 | −11 980 | |
0,07 % | Goldman Sachs Asset Management, L.P. | 178 864 | −11 191 | |
0,07 % | Assenagon Asset Management S.A. | 168 856 | 12 291 | |
0,07 % | CIBC Private Wealth Management | 166 171 | 0 | |
0,06 % | T. Rowe Price International Ltd | 159 848 | 0 | |
0,06 % | Aperio Group, LLC | 150 224 | −80 263 | |
0,06 % | BlackRock Asset Management Ireland Limited | 141 155 | 32 076 | |
0,05 % | BlackRock Advisors (UK) Limited | 132 083 | 6 370 | |
0,05 % | Mellon Investments Corporation | 114 169 | −2 951 | |
0,04 % | Vident Investment Advisory, LLC | 107 685 | 107 685 | |
0,04 % | Goldman Sachs & Company, Inc. | 106 206 | −88 593 | |
0,04 % | Summit Trail Advisors, LLC | 104 529 | 0 | |
0,04 % | JPMorgan Private Bank (United States) | 91 696 | 91 696 | |
0,04 % | Susquehanna International Group, LLP | 90 561 | −61 452 | |
0,04 % | Lexaurum Advisors, LLC | 89 166 | −8 600 | |
0,03 % | Cary Street Partners Investment Advisory LLC | 85 873 | 0 | |
0,03 % | Hightower Advisors, LLC | 85 853 | 12 348 | |
0,03 % | Acuitas Investments LLC | 84 640 | 11 361 | |
0,03 % | Northern Trust Global Investments | 83 435 | −2 242 | |
0,03 % | T. Rowe Price Associates, Inc. | 77 440 | 0 | |
0,03 % | SG Americas Securities, L.L.C. | 76 352 | 8 478 | |
0,03 % | Virtus Etf Advisers LLC | 73 477 | −6 277 | |
0,03 % | Tudor Investment Corporation | 71 464 | 0 | |
0,03 % | Cambridge Investment Research Advisors, Inc. | 69 384 | −12 150 | |
0,03 % | Principal Global Investors (Equity) | 67 271 | −6 818 | |
0,03 % | SunAmerica Asset Management, LLC | 67 160 | −272 | |
0,03 % | MetLife Investment Management, LLC | 66 164 | 0 | |
0,03 % | XTX Markets LLC | 66 162 | −61 413 | |
0,03 % | American Financial Group, Inc. | 66 114 | 0 | |
0,03 % | Virtu Americas LLC | 65 526 | 65 526 | |
0,03 % | New York State Common Retirement Fund | 64 042 | −168 | |
0,02 % | Dimensional Fund Advisors, L.P. | 58 755 | 0 | |
0,02 % | Commonwealth Financial Network | 57 340 | −3 359 | |
0,02 % | DWS Investments UK Limited | 57 248 | 0 | |
0,02 % | Wells Fargo Advisors | 57 003 | −164 | |
0,02 % | Vaughan Nelson Investment Management, L.P. | 56 210 | 0 | |
0,02 % | Voya Investment Management LLC | 53 961 | −5 106 | |
0,02 % | LMR Partners LLP | 53 230 | 3 108 | |
0,02 % | Cerity Partners LLC | 50 585 | 1 000 | |
0,02 % | State Teachers Retirement System of Ohio | 50 200 | 0 | |
0,02 % | Greenwich Wealth Management LLC | 50 000 | 0 | |
0,02 % | Synovus Securities, Inc. | 49 065 | 0 | |
0,02 % | J.P. Morgan Securities plc | 48 917 | −596 | |
0,02 % | Diametric Capital | 48 518 | 48 518 | |
0,02 % | Aptus Capital Advisors, LLC | 44 399 | 0 | |
0,02 % | Guardian Wealth Advisors, LLC (North Carolina) | 44 399 | 0 | |
0,02 % | Carson Wealth Management Group | 42 912 | 0 | |