14,96185 % | Fidelity Management & Research Company LLC | 7 513 840 | 8 426 | |
9,92223 % | EcoR1 Capital, LLC | 4 982 945 | 1 968 193 | |
6,02575 % | Springer Timothy A | 3 026 133 | −4 608 052 | |
5,86095 % | BlackRock Institutional Trust Company, N.A. | 2 943 371 | 175 446 | |
5,02986 % | Invus Public Equities Advisors, LLC | 2 525 998 | 312 810 | |
4,40149 % | The Vanguard Group, Inc. | 2 210 429 | −45 246 | |
4,28538 % | T. Rowe Price Associates, Inc. | 2 152 117 | −318 042 | |
3,96386 % | Polaris Venture Partners | 1 990 651 | 0 | |
3,55078 % | Woodline Partners LP | 1 783 202 | 1 683 202 | |
3,26186 % | State Street Global Advisors (US) | 1 638 108 | −1 027 402 | |
2,90980 % | Point72 Asset Management, L.P. | 1 461 302 | −3 225 798 | |
2,02691 % | Pictet Asset Management Ltd. | 1 017 912 | −168 996 | |
1,98128 % | Federated Hermes Global Investment Management Corp. | 995 000 | 0 | |
1,93147 % | Geode Capital Management, L.L.C. | 969 986 | 74 786 | |
1,22356 % | Tipirneni (Praveen P) | 614 474 | −42 460 | |
1,21963 % | OrbiMed Advisors, LLC | 612 500 | 54 000 | |
1,15098 % | Two Sigma Investments, LP | 578 020 | −63 831 | |
1,06458 % | Goldman Sachs & Company, Inc. | 534 630 | 103 925 | |
0,96835 % | SilverArc Capital Management, LLC | 486 306 | 2 334 | |
0,73553 % | MPM BioImpact LLC | 369 384 | 44 051 | |
0,65282 % | Charles Schwab Investment Management, Inc. | 327 844 | 1 147 | |
0,64397 % | BlackRock Financial Management, Inc. | 323 403 | 27 905 | |
0,62639 % | Northern Trust Investments, Inc. | 314 575 | −646 | |
0,49895 % | Affinity Asset Advisors LLC | 250 573 | 25 573 | |
0,48772 % | Wellington Management Company, LLP | 244 931 | −5 569 515 | |
0,46147 % | Dafna Capital Management, LLC | 231 748 | 0 | |
0,42685 % | Fiduciary Trust Company | 214 366 | 0 | |
0,42643 % | Candriam Belgium S.A. | 214 154 | −35 779 | |
0,41463 % | Dimensional Fund Advisors, L.P. | 208 225 | −12 937 | |
0,32256 % | Citadel Advisors LLC | 161 988 | −704 910 | |
0,32038 % | Voloridge Investment Management, LLC | 160 896 | 160 896 | |
0,31829 % | Omega Fund Management, LLC | 159 846 | 0 | |
0,30430 % | D. E. Shaw & Co., L.P. | 152 819 | −61 637 | |
0,29980 % | AllianceBernstein L.P. | 150 558 | 38 776 | |
0,29132 % | Nomura Asset Management Co., Ltd. | 146 300 | 146 300 | |
0,26898 % | Morgan Stanley & Co. LLC | 135 082 | −67 468 | |
0,26140 % | Jane Street Capital, L.L.C. | 131 276 | 85 314 | |
0,25826 % | Nuveen LLC | 129 698 | 3 897 | |
0,25679 % | Medical Strategy GmbH | 128 962 | −313 051 | |
0,23456 % | BlackRock Investment Management, LLC | 117 794 | 24 237 | |
0,22677 % | Ensign Peak Advisors, Inc. | 113 883 | −27 340 | |
0,22322 % | TD Asset Management Inc. | 112 100 | −13 800 | |
0,19702 % | Goldman Sachs Asset Management, L.P. | 98 943 | −14 297 | |
0,19167 % | BNY Mellon Asset Management | 96 256 | 5 819 | |
0,17675 % | Barclays Bank PLC | 88 766 | 44 039 | |
0,17118 % | Manulife Investment Management (North America) Limited | 85 966 | 4 021 | |
0,17111 % | Susquehanna International Group, LLP | 85 932 | 16 033 | |
0,16771 % | BofA Global Research (US) | 84 223 | −30 339 | |
0,15940 % | Allianz Global Investors GmbH | 80 049 | −13 621 | |
0,15838 % | Jump Financial, LLC | 79 539 | 67 387 | |
0,15485 % | Capital Fund Management S.A. | 77 767 | 58 100 | |
0,14846 % | Rafferty Asset Management LLC | 74 557 | −146 237 | |
0,14536 % | HOOPP Investment Management | 73 000 | 73 000 | |
0,13267 % | Atom Investors LP | 66 628 | −20 002 | |
0,13019 % | Rhumbline Advisers Ltd. Partnership | 65 379 | 13 677 | |
0,12498 % | BlackRock Asset Management Ireland Limited | 62 765 | 3 150 | |
0,11728 % | Schweizerische Nationalbank | 58 900 | 0 | |
0,11542 % | Connor, Clark & Lunn Investment Management Ltd. | 57 965 | −46 665 | |
0,10966 % | T. Rowe Price International Ltd | 55 070 | 1 643 | |
0,10745 % | Mellon Investments Corporation | 53 963 | 21 651 | |
0,10702 % | PGIM Quantitative Solutions LLC | 53 747 | −26 180 | |
0,09490 % | Saturn V Capital Management LP | 47 660 | −37 972 | |
0,08606 % | BlackRock Investment Management (UK) Ltd. | 43 220 | 9 516 | |
0,08256 % | UBS Financial Services, Inc. | 41 460 | −107 534 | |
0,07777 % | Alps Advisors, Inc. | 39 054 | 3 762 | |
0,06795 % | Millennium Management LLC | 34 125 | 34 125 | |
0,06593 % | Algert Global LLC | 33 108 | 16 531 | |
0,06322 % | Wellington Management Singapore Pte. Ltd. | 31 751 | 31 751 | |
0,06322 % | Wellington Management Japan Pte Ltd | 31 751 | −13 447 | |
0,05983 % | California State Teachers Retirement System | 30 048 | −631 | |
0,05952 % | Carmignac Gestion | 29 892 | 29 892 | |
0,05817 % | Legal & General Investment Management Ltd. | 29 214 | −185 | |
0,05679 % | Victory Capital Management Inc. | 28 520 | −580 | |
0,05645 % | UBS Asset Management (Americas), Inc. | 28 350 | 28 350 | |
0,05350 % | First Trust Advisors L.P. | 26 867 | 26 867 | |
0,05272 % | PDT Partners, LLC | 26 474 | −34 663 | |
0,04978 % | Tudor Investment Corporation | 25 002 | −882 | |
0,04938 % | T. Rowe Price Japan, Inc. | 24 799 | 15 500 | |
0,04864 % | Aperio Group, LLC | 24 427 | 629 | |
0,04860 % | Northern Trust Global Investments | 24 409 | 1 106 | |
0,04842 % | UBS Fund Management (Switzerland) AG | 24 319 | −7 904 | |
0,04776 % | Mirae Asset Global Investments (USA) LLC | 23 986 | 4 698 | |
0,04724 % | Squarepoint Capital LLP | 23 723 | 23 723 | |
0,04607 % | American Century Investment Management, Inc. | 23 134 | 16 606 | |
0,04595 % | MetLife Investment Management, LLC | 23 077 | 3 665 | |
0,04414 % | DeVaul (William David) | 22 167 | 0 | |
0,04273 % | Y-Intercept (Hong Kong) Ltd | 21 459 | 21 459 | |
0,04267 % | Corebridge Financial Inc | 21 431 | 21 431 | |
0,04022 % | Healthinvest Partners AB | 20 199 | 5 247 | |
0,03849 % | ExodusPoint Capital Management, LP | 19 330 | 19 330 | |
0,03804 % | State of Wisconsin Investment Board | 19 105 | −993 | |
0,03743 % | SunAmerica Asset Management, LLC | 18 797 | 533 | |
0,03536 % | Edgestream Partners, L.P. | 17 760 | 17 760 | |
0,03494 % | DWS Investments UK Limited | 17 547 | −1 922 | |
0,03485 % | Wells Fargo Bank, N.A. | 17 504 | 5 837 | |
0,03418 % | Kentucky Teachers' Retirement System | 17 167 | 0 | |
0,03409 % | Citi Investment Research (US) | 17 122 | −173 223 | |
0,03380 % | JPMorgan Private Bank (United States) | 16 976 | 2 137 | |
0,03286 % | Guggenheim Investments | 16 502 | −7 291 | |
0,03256 % | UBS Asset Management (Switzerland) | 16 354 | 4 400 | |