11,39730 % | Janus Henderson Investors | 2 485 751 | −115 531 | |
9,42483 % | Avoro Capital Advisors LLC | 2 055 555 | 111 111 | |
9,05360 % | Baker Bros. Advisors LP | 1 974 590 | 4 792 | |
8,78433 % | RTW Investments L.P. | 1 915 862 | 1 518 815 | |
8,48235 % | Paulson & Co. Inc. | 1 850 000 | 75 000 | |
8,27190 % | The Vanguard Group, Inc. | 1 804 102 | 137 898 | |
5,80662 % | BlackRock Institutional Trust Company, N.A. | 1 266 424 | 183 195 | |
4,99680 % | Taub (Rebecca A) | 1 089 802 | 650 804 | |
4,20389 % | Friedman (Paul A) | 916 868 | 714 | |
3,85727 % | T. Rowe Price Associates, Inc. | 841 271 | 53 080 | |
3,41455 % | State Street Global Advisors (US) | 744 714 | 119 776 | |
3,09025 % | Fidelity Management & Research Company LLC | 673 983 | 68 468 | |
3,00569 % | SQN, L.L.C. | 655 540 | 0 | |
1,99513 % | Craves (Frederick B) | 435 138 | −15 000 | |
1,83335 % | Geode Capital Management, L.L.C. | 399 854 | 52 997 | |
1,58223 % | Artisan Partners Limited Partnership | 345 085 | −56 624 | |
1,21320 % | Perceptive Advisors LLC | 264 600 | −165 353 | |
1,12563 % | Rock Springs Capital Management LP | 245 499 | −40 432 | |
0,85921 % | ArrowMark Colorado Holdings, LLC | 187 393 | 153 174 | |
0,68776 % | Armistice Capital LLC | 150 000 | −18 000 | |
0,68447 % | TCG Crossover Management, LLC | 149 283 | 0 | |
0,63588 % | BofA Global Research (US) | 138 686 | 105 463 | |
0,63418 % | Charles Schwab Investment Management, Inc. | 138 314 | 15 622 | |
0,63415 % | Woodline Partners LP | 138 309 | 118 609 | |
0,62941 % | Pictet Asset Management Ltd. | 137 275 | −46 888 | |
0,62467 % | UBS Financial Services, Inc. | 136 240 | 10 825 | |
0,62001 % | Morgan Stanley & Co. LLC | 135 224 | −72 014 | |
0,59848 % | Tao Capital Management LP | 130 529 | 0 | |
0,57451 % | Polar Capital LLP | 125 300 | 95 | |
0,55347 % | Northern Trust Investments, Inc. | 120 712 | −145 | |
0,55012 % | Invesco Advisers, Inc. | 119 982 | 54 331 | |
0,53199 % | Norges Bank Investment Management (NBIM) | 116 027 | −29 562 | |
0,52737 % | Fidelity Institutional Asset Management | 115 020 | 6 621 | |
0,52136 % | Fiera Capital Inc. | 113 709 | 113 709 | |
0,50946 % | American Century Investment Management, Inc. | 111 113 | 13 361 | |
0,50436 % | Affinity Asset Advisors LLC | 110 000 | −5 000 | |
0,49445 % | Goldman Sachs & Company, Inc. | 107 839 | 38 878 | |
0,46976 % | Fred Alger Management, LLC | 102 455 | 37 879 | |
0,45491 % | Rheos Capital Works Inc. | 99 215 | −11 000 | |
0,42496 % | Managed Account Advisors LLC | 92 683 | 14 387 | |
0,42041 % | Mirae Asset Global Investments (USA) LLC | 91 691 | −562 | |
0,41371 % | Pictet Asset Management (Japan) Ltd. | 90 230 | 34 875 | |
0,38787 % | AlpInvest Partners B.V. | 84 595 | −21 149 | |
0,38227 % | Ensign Peak Advisors, Inc. | 83 373 | −8 845 | |
0,38084 % | Connor, Clark & Lunn Investment Management Ltd. | 83 062 | −10 535 | |
0,35029 % | Group One Trading, L.P. | 76 399 | 33 228 | |
0,34388 % | EcoR1 Capital, LLC | 75 000 | 0 | |
0,32639 % | MPM BioImpact LLC | 71 185 | 9 786 | |
0,32119 % | BlackRock Financial Management, Inc. | 70 051 | 19 642 | |
0,31977 % | Nuveen LLC | 69 741 | 9 288 | |
0,29964 % | Tri Locum Partners LP | 65 352 | 11 997 | |
0,29166 % | Goldman Sachs Asset Management, L.P. | 63 612 | 40 784 | |
0,27210 % | Morgan Stanley Smith Barney LLC | 59 345 | −1 560 | |
0,25624 % | Sibold (William John) | 55 887 | −6 363 | |
0,25552 % | TD Asset Management Inc. | 55 730 | 5 400 | |
0,22445 % | Emerald Advisers LLC | 48 952 | −123 571 | |
0,21295 % | New York State Common Retirement Fund | 46 445 | −4 728 | |
0,20967 % | University of Wisconsin Foundation | 45 730 | −10 646 | |
0,20706 % | BlackRock Investment Management, LLC | 45 159 | 9 730 | |
0,20436 % | AllianceBernstein L.P. | 44 570 | 16 670 | |
0,20365 % | Sofinnova Investments, Inc | 44 417 | 25 388 | |
0,20224 % | Bessemer Trust Company, N.A. (US) | 44 109 | −10 360 | |
0,19730 % | Propel Bio Management, LLC | 43 032 | 0 | |
0,19725 % | Voya Investment Management LLC | 43 020 | 25 493 | |
0,19695 % | BNY Mellon Asset Management | 42 954 | 8 609 | |
0,18779 % | Point72 Asset Management, L.P. | 40 958 | −52 613 | |
0,17716 % | DWS Investment GmbH | 38 638 | 0 | |
0,17596 % | Gilder Gagnon Howe & Co. LLC | 38 377 | −706 | |
0,17326 % | JP Morgan Asset Management | 37 787 | −351 | |
0,16965 % | UBS Switzerland AG | 37 000 | 37 000 | |
0,16698 % | Rafferty Asset Management LLC | 36 418 | 501 | |
0,16600 % | Jane Street Capital, L.L.C. | 36 204 | 11 053 | |
0,16359 % | Manulife Investment Management (North America) Limited | 35 678 | 4 937 | |
0,16099 % | SEB Investment Management AB | 35 112 | 0 | |
0,14901 % | Handelsbanken Kapitalf¿rvaltning AB | 32 500 | 900 | |
0,13779 % | CIBC Private Wealth Management | 30 051 | 1 | |
0,13743 % | PFM Health Sciences, LP | 29 973 | 0 | |
0,13067 % | Macquarie Investment Management | 28 500 | −30 457 | |
0,12918 % | Mellon Investments Corporation | 28 174 | 7 313 | |
0,12150 % | Rhenman & Partners Asset Management AB | 26 500 | −10 000 | |
0,11758 % | T. Rowe Price Investment Management, Inc. | 25 644 | −17 342 | |
0,11624 % | Rhumbline Advisers Ltd. Partnership | 25 351 | 4 209 | |
0,11371 % | Schweizerische Nationalbank | 24 800 | 1 400 | |
0,11215 % | Schonfeld Strategic Advisors LLC | 24 460 | 24 460 | |
0,11188 % | Erste Asset Management GmbH | 24 400 | 0 | |
0,11010 % | Wells Fargo Advisors | 24 012 | 11 742 | |
0,10843 % | Rokos Capital Management LLP | 23 649 | −14 113 | |
0,10689 % | Simplify Asset Management Inc | 23 313 | 19 | |
0,10671 % | BlackRock Advisors (UK) Limited | 23 274 | 585 | |
0,10207 % | California Public Employees' Retirement System | 22 262 | 2 072 | |
0,09798 % | Wintrust Investments, LLC | 21 370 | 2 100 | |
0,09275 % | BlackRock Asset Management Ireland Limited | 20 229 | 1 340 | |
0,09037 % | Parametric Portfolio Associates LLC | 19 710 | 4 141 | |
0,08910 % | Raymond James & Associates, Inc. | 19 433 | −888 | |
0,08752 % | Rockefeller Capital Management | 19 088 | −16 073 | |
0,08674 % | Hennion & Walsh Asset Management, Inc. | 18 917 | −1 420 | |
0,08391 % | International Biotechnology Trust PLC | 18 300 | 0 | |
0,08021 % | T. Rowe Price International Ltd | 17 494 | 2 472 | |
0,07365 % | Citi Investment Research (US) | 16 062 | −16 728 | |
0,07244 % | Cutler Group, LP | 15 800 | 2 300 | |