31,54640 % | Artal International S.C.A. | 114 037 070 | 0 | |
6,75970 % | BVF Partners L.P. | 24 435 632 | 4 440 300 | |
3,84355 % | Fidelity Management & Research Company LLC | 13 894 062 | 11 617 594 | |
1,75252 % | BlackRock Institutional Trust Company, N.A. | 6 335 170 | 357 950 | |
1,65437 % | The Vanguard Group, Inc. | 5 980 371 | −397 939 | |
1,50798 % | Ulys, L.L.C. | 5 451 204 | 0 | |
0,97270 % | Invus Public Equities Advisors, LLC | 3 516 214 | 0 | |
0,75322 % | JP Morgan Asset Management | 2 722 804 | 174 669 | |
0,65902 % | New Enterprise Associates (NEA) | 2 382 286 | 0 | |
0,64979 % | Geode Capital Management, L.L.C. | 2 348 916 | 222 779 | |
0,52348 % | State Street Global Advisors (US) | 1 892 319 | 16 180 | |
0,52289 % | Columbia Threadneedle Investments (US) | 1 890 200 | 675 522 | |
0,47880 % | Pinnacle Associates Ltd. | 1 730 821 | −182 048 | |
0,47262 % | Medical Strategy GmbH | 1 708 481 | −322 382 | |
0,45179 % | Millennium Management LLC | 1 633 176 | −2 252 577 | |
0,37092 % | Debbane (Raymond) | 1 340 847 | 0 | |
0,30376 % | Coats (Lonnel) | 1 098 068 | 0 | |
0,23906 % | Charles Schwab Investment Management, Inc. | 864 175 | 12 254 | |
0,23865 % | Morgan Stanley & Co. LLC | 862 680 | 705 664 | |
0,21748 % | Citadel Advisors LLC | 786 160 | 784 249 | |
0,21579 % | GSA Capital Partners LLP | 780 077 | 780 077 | |
0,21574 % | Northern Trust Investments, Inc. | 779 869 | −87 003 | |
0,11558 % | Susquehanna International Group, LLP | 417 813 | 89 307 | |
0,11402 % | Renaissance Technologies LLC | 412 175 | 139 920 | |
0,11319 % | Nuveen LLC | 409 179 | 0 | |
0,09937 % | D. E. Shaw & Co., L.P. | 359 210 | −424 912 | |
0,08969 % | Wade (Jeffrey L) | 324 214 | 0 | |
0,08962 % | Entrypoint Capital LLC | 323 968 | 323 968 | |
0,07814 % | Connor, Clark & Lunn Investment Management Ltd. | 282 467 | −54 597 | |
0,07695 % | BNY Mellon Asset Management | 278 154 | 9 754 | |
0,07555 % | JPMorgan Private Bank (United States) | 273 102 | 52 943 | |
0,07535 % | Jane Street Capital, L.L.C. | 272 367 | 190 437 | |
0,07074 % | Main (Alan J) | 255 724 | 0 | |
0,06941 % | Virtus Etf Advisers LLC | 250 923 | 129 212 | |
0,06941 % | LifeSci Index Partners, LLC | 250 923 | 125 063 | |
0,06941 % | BlackRock Investment Management, LLC | 250 893 | 0 | |
0,06786 % | AllianceBernstein L.P. | 245 301 | 0 | |
0,06671 % | Two Sigma Investments, LP | 241 155 | −439 057 | |
0,06648 % | Amouyal (Philippe J) | 240 332 | 0 | |
0,06236 % | BlackRock Financial Management, Inc. | 225 432 | −43 034 | |
0,06224 % | Citi Investment Research (US) | 224 998 | 188 983 | |
0,05829 % | BofA Global Research (US) | 210 725 | 46 249 | |
0,04910 % | Crum (Brian T) | 177 497 | 0 | |
0,04692 % | UBS Financial Services, Inc. | 169 616 | 44 254 | |
0,04568 % | Assenagon Asset Management S.A. | 165 143 | 12 053 | |
0,04528 % | Goldman Sachs & Company, Inc. | 163 672 | −98 443 | |
0,04500 % | Kassler-Taub (Kenneth B) | 162 672 | 43 047 | |
0,04399 % | Sobecki (Christopher J) | 159 023 | 0 | |
0,04152 % | CIBC Private Wealth Management | 150 100 | 150 100 | |
0,03685 % | BlackRock Advisors (UK) Limited | 133 200 | −1 524 | |
0,03662 % | BlackRock Asset Management Ireland Limited | 132 371 | 30 535 | |
0,03604 % | Rhumbline Advisers Ltd. Partnership | 130 291 | 0 | |
0,03514 % | Barclays Bank PLC | 127 016 | 87 827 | |
0,02853 % | Deerfield Management Company, L.P. | 103 144 | 103 144 | |
0,02785 % | T. Rowe Price International Ltd | 100 691 | 0 | |
0,02600 % | Compagnie Lombard Odier SCmA | 94 000 | 0 | |
0,02205 % | Northern Trust Global Investments | 79 719 | −143 846 | |
0,02202 % | Barker (Samuel L) | 79 617 | 0 | |
0,01983 % | Goldman Sachs Asset Management, L.P. | 71 667 | 137 | |
0,01671 % | Aperio Group, LLC | 60 389 | 32 077 | |
0,01601 % | Mellon Investments Corporation | 57 863 | 0 | |
0,01509 % | Amundi Asset Management, SAS | 54 532 | 0 | |
0,01501 % | Simplex Trading, LLC | 54 248 | 54 248 | |
0,01470 % | Seth (Kiernan) | 53 136 | 31 269 | |
0,01458 % | McDermott (Wendy) | 52 694 | 24 216 | |
0,01358 % | Russell Investments Trust Company | 49 100 | 0 | |
0,01322 % | Alexander (Kristen) | 47 800 | 17 450 | |
0,01317 % | Granowitz (Craig B. M.D., Ph.D.) | 47 626 | 0 | |
0,01311 % | J.P. Morgan Securities plc | 47 385 | 645 | |
0,01303 % | Tudor Investment Corporation | 47 101 | 0 | |
0,01274 % | SunAmerica Asset Management, LLC | 46 049 | −186 | |
0,01251 % | T. Rowe Price Associates, Inc. | 45 209 | 0 | |
0,01235 % | CAPTRUST Financial Advisors | 44 636 | 18 | |
0,01217 % | LPL Financial LLC | 43 994 | 17 000 | |
0,01211 % | SG Americas Securities, L.L.C. | 43 793 | −14 914 | |
0,01191 % | Morgan Stanley Smith Barney LLC | 43 047 | 115 | |
0,01162 % | LUNIS Vermögensmanagement AG | 42 000 | 0 | |
0,01135 % | Nies (Alan S) | 41 046 | 9 302 | |
0,01124 % | KWB Wealth | 40 640 | 0 | |
0,01116 % | Swain (Judith L) | 40 332 | 0 | |
0,01116 % | Lefkowitz (Robert J) | 40 332 | 0 | |
0,01116 % | Palantoni (Frank P) | 40 332 | 9 302 | |
0,01097 % | Stifel, Nicolaus & Company, Incorporated | 39 652 | −42 315 | |
0,01081 % | DWS Investments UK Limited | 39 082 | 0 | |
0,01033 % | Voya Investment Management LLC | 37 359 | 0 | |
0,00988 % | University of Texas Investment Management Company | 35 714 | 0 | |
0,00961 % | Invesco Capital Management LLC | 34 724 | 10 766 | |
0,00953 % | Pathstone | 34 445 | 34 445 | |
0,00946 % | Commonwealth Financial Network | 34 184 | −5 385 | |
0,00931 % | New York State Common Retirement Fund | 33 670 | −206 | |
0,00900 % | BNP Paribas Securities Corp. North America | 32 519 | −88 053 | |
0,00890 % | Victory Capital Management Inc. | 32 187 | 5 813 | |
0,00889 % | Bayesian Capital Management, LP | 32 119 | 32 119 | |
0,00885 % | RPO LLC | 32 000 | 32 000 | |
0,00871 % | Prosperity Financial Group, Inc. | 31 500 | 0 | |
0,00857 % | ProShare Advisors LLC | 30 982 | 2 933 | |
0,00784 % | China Universal Asset Management Co., Ltd. | 28 329 | 22 043 | |
0,00747 % | TIAA Trust, National Association | 27 000 | 0 | |
0,00740 % | Wells Fargo Bank, N.A. | 26 734 | 5 571 | |
0,00732 % | Invesco Advisers, Inc. | 26 458 | −1 521 | |