9,65933 % | Fidelity Management & Research Company LLC | 8 160 206 | 7 271 997 | |
5,62893 % | BlackRock Institutional Trust Company, N.A. | 4 755 318 | 752 470 | |
4,59706 % | Federated Hermes Global Investment Management Corp. | 3 883 600 | 500 000 | |
4,20442 % | Janus Henderson Investors | 3 551 891 | 1 828 731 | |
4,16903 % | T. Rowe Price Associates, Inc. | 3 521 999 | 523 472 | |
4,10191 % | The Vanguard Group, Inc. | 3 465 297 | 504 275 | |
3,54155 % | State Street Global Advisors (US) | 2 991 899 | 844 399 | |
3,46247 % | Adage Capital Management, L.P. | 2 925 094 | 638 133 | |
3,11351 % | Deerfield Management Company, L.P. | 2 630 292 | 361 664 | |
2,60750 % | Boxer Capital, L.L.C. | 2 202 812 | 0 | |
2,34004 % | Capital Research Global Investors | 1 976 870 | 600 000 | |
2,13068 % | Logos Global Management LLC | 1 800 000 | −450 000 | |
2,04669 % | BVF Partners L.P. | 1 729 043 | −3 554 446 | |
2,01247 % | Holocene Advisors, LP | 1 700 135 | 667 204 | |
1,94519 % | Citadel Advisors LLC | 1 643 293 | 898 193 | |
1,79924 % | Avidity Partners Management LP | 1 520 000 | −624 971 | |
1,72690 % | Sofinnova Investments, Inc | 1 458 881 | 421 694 | |
1,59959 % | Geode Capital Management, L.L.C. | 1 351 337 | 190 232 | |
1,52261 % | Dimensional Fund Advisors, L.P. | 1 286 300 | 144 058 | |
1,25725 % | Baker Bros. Advisors LP | 1 062 123 | 0 | |
1,16933 % | Morgan Stanley & Co. LLC | 987 851 | 844 492 | |
1,10779 % | Redmile Group, LLC | 935 863 | 935 863 | |
1,08048 % | Driehaus Capital Management, LLC | 912 786 | 215 325 | |
1,03663 % | Pictet Asset Management Ltd. | 875 747 | 211 657 | |
0,80242 % | Hata (Yujiro S.) | 677 887 | 0 | |
0,78402 % | Platinum Asset Management | 662 343 | −104 339 | |
0,66844 % | Soleus Capital Management, L.P. | 564 700 | 564 700 | |
0,63920 % | Candriam Luxembourg S.A. | 540 000 | 145 000 | |
0,63882 % | Fisher Investments | 539 676 | 508 151 | |
0,62970 % | Boone Capital Management LLC | 531 967 | −38 715 | |
0,62678 % | D. E. Shaw & Co., L.P. | 529 506 | 93 148 | |
0,61120 % | Dafna Capital Management, LLC | 516 341 | 16 521 | |
0,60601 % | Northern Trust Investments, Inc. | 511 956 | 61 264 | |
0,58766 % | Charles Schwab Investment Management, Inc. | 496 456 | 59 100 | |
0,58007 % | Ensign Peak Advisors, Inc. | 490 039 | 126 255 | |
0,55193 % | Balyasny Asset Management LP | 466 271 | 466 271 | |
0,53267 % | Cormorant Asset Management, LP | 450 000 | −150 000 | |
0,49013 % | Woodline Partners LP | 414 059 | 173 631 | |
0,46759 % | Candriam Belgium S.A. | 395 019 | −35 000 | |
0,45263 % | First Turn Management, LLC | 382 382 | 382 382 | |
0,44589 % | Nuveen LLC | 376 692 | −169 061 | |
0,41364 % | Medical Strategy GmbH | 349 447 | −3 400 | |
0,41014 % | Victory Capital Management Inc. | 346 490 | 346 490 | |
0,40918 % | First Light Asset Management, LLC | 345 674 | 345 674 | |
0,39654 % | Eventide Asset Management, LLC | 335 000 | 0 | |
0,36873 % | Opaleye Management Inc. | 311 500 | 0 | |
0,36574 % | BlackRock Financial Management, Inc. | 308 979 | 61 814 | |
0,29746 % | Superstring Capital Management LP | 251 295 | 251 295 | |
0,28797 % | AXA Investment Managers UK Ltd. | 243 280 | −100 475 | |
0,26532 % | Columbia Threadneedle Investments (US) | 224 141 | −49 332 | |
0,26037 % | Voya Investment Management LLC | 219 957 | −71 119 | |
0,24671 % | Goldman Sachs & Company, Inc. | 208 417 | −109 529 | |
0,24590 % | BNP Paribas Securities Corp. North America | 207 735 | 155 179 | |
0,23661 % | Walleye Capital LLC | 199 891 | 115 928 | |
0,23240 % | UBS Asset Management (Americas), Inc. | 196 329 | −2 262 | |
0,23069 % | Invesco Capital Management LLC | 194 886 | −72 891 | |
0,22888 % | Rafferty Asset Management LLC | 193 356 | 64 280 | |
0,21626 % | BofA Global Research (US) | 182 695 | 100 942 | |
0,20885 % | Barclays Bank PLC | 176 440 | 90 114 | |
0,19846 % | BlackRock Investment Management, LLC | 167 656 | 22 622 | |
0,18582 % | Morgan Stanley Investment Management Inc. (US) | 156 983 | 155 836 | |
0,18172 % | BNY Mellon Asset Management | 153 513 | 11 507 | |
0,17839 % | UBS Financial Services, Inc. | 150 702 | 94 167 | |
0,16489 % | Nantahala Capital Management, LLC | 139 298 | −6 562 | |
0,16364 % | Jennison Associates LLC | 138 241 | 37 345 | |
0,16299 % | TD Asset Management Inc. | 137 690 | 24 034 | |
0,15856 % | BlackRock Advisors (UK) Limited | 133 952 | 9 014 | |
0,15420 % | Parkman Healthcare Partners LLC | 130 265 | −2 436 | |
0,15015 % | HighVista Strategies LLC | 126 845 | 0 | |
0,14277 % | First Trust Advisors L.P. | 120 614 | 1 076 | |
0,14023 % | Two Sigma Investments, LP | 118 469 | −90 839 | |
0,13062 % | Nicholas Investment Partners, L.P. | 110 351 | 94 094 | |
0,12962 % | Allianz Global Investors GmbH | 109 505 | 0 | |
0,12797 % | EAM Investors, LLC | 108 110 | 20 448 | |
0,12699 % | BlackRock Asset Management Ireland Limited | 107 277 | 7 750 | |
0,11074 % | Northern Trust Global Investments | 93 555 | −2 641 | |
0,10942 % | Manulife Investment Management (North America) Limited | 92 438 | 14 028 | |
0,10618 % | Citi Investment Research (US) | 89 698 | 34 444 | |
0,10176 % | Rhumbline Advisers Ltd. Partnership | 85 966 | 7 172 | |
0,10073 % | Schweizerische Nationalbank | 85 100 | −21 900 | |
0,10002 % | Hudson Bay Capital Management LP | 84 500 | 49 500 | |
0,09941 % | Wellington Management Company, LLP | 83 984 | 83 984 | |
0,09176 % | Qube Research & Technologies Ltd | 77 516 | 42 162 | |
0,09139 % | Parametric Portfolio Associates LLC | 77 204 | −397 | |
0,08828 % | UBS O'Connor LLC | 74 575 | −51 574 | |
0,08404 % | HOOPP Investment Management | 71 000 | 71 000 | |
0,08256 % | Goldman Sachs Asset Management, L.P. | 69 749 | −32 327 | |
0,07694 % | MFS Investment Management | 65 001 | −11 145 | |
0,07411 % | Credit Suisse Funds AG | 62 610 | 1 300 | |
0,07247 % | Campbell & Company, Inc. | 61 226 | 29 536 | |
0,07102 % | DWS Investment GmbH | 60 000 | 57 038 | |
0,06828 % | AllianceBernstein L.P. | 57 680 | 7 140 | |
0,06636 % | UBS Asset Management (Switzerland) | 56 062 | 5 356 | |
0,06539 % | Capstone Investment Advisors, LLC | 55 239 | 55 239 | |
0,06477 % | Mellon Investments Corporation | 54 717 | 7 896 | |
0,06271 % | State of Wisconsin Investment Board | 52 976 | −11 134 | |
0,05919 % | Deka Vermögensmanagement GmbH | 50 000 | 0 | |
0,05854 % | Legal & General Investment Management Ltd. | 49 452 | −1 122 | |
0,05738 % | Dimensional Fund Advisors, Ltd. | 48 478 | 3 106 | |
0,05724 % | California State Teachers Retirement System | 48 359 | −6 659 | |