12,13451 % | State Street Global Advisors (US) | 16 002 989 | 2 260 435 | |
6,68261 % | BVF Partners L.P. | 8 813 021 | 0 | |
4,87271 % | BlackRock Institutional Trust Company, N.A. | 6 426 136 | 405 152 | |
4,20730 % | The Vanguard Group, Inc. | 5 548 591 | 762 568 | |
3,74136 % | Stonepine Capital Management, LLC | 4 934 100 | −735 288 | |
3,61144 % | Millennium Management LLC | 4 762 769 | 8 641 | |
3,49297 % | Sofinnova Investments, Inc | 4 606 527 | 994 151 | |
2,95248 % | Bleichroeder LP | 3 893 730 | −50 000 | |
2,86420 % | Bain Capital Life Sciences Investors, LLC | 3 777 308 | 3 777 308 | |
2,80759 % | Lion Point Capital, L.P. | 3 702 651 | −686 895 | |
2,79472 % | New Enterprise Associates (NEA) | 3 685 683 | 0 | |
2,09198 % | Wellington Management Company, LLP | 2 758 903 | −60 760 | |
1,94735 % | Medical Strategy GmbH | 2 568 167 | 0 | |
1,45113 % | Geode Capital Management, L.L.C. | 1 913 754 | 134 785 | |
1,40279 % | Ghost Tree Capital, LLC | 1 850 000 | −150 000 | |
1,33288 % | Point72 Asset Management, L.P. | 1 757 800 | 1 649 890 | |
1,32514 % | Schonfeld Strategic Advisors LLC | 1 747 600 | 418 124 | |
1,11568 % | Rafferty Asset Management LLC | 1 471 357 | 378 314 | |
1,10372 % | Verition Fund Management LLC | 1 455 589 | 214 278 | |
1,06812 % | Parkman Healthcare Partners LLC | 1 408 642 | 198 497 | |
1,00551 % | Ensign Peak Advisors, Inc. | 1 326 062 | 619 785 | |
0,98844 % | Nuveen LLC | 1 303 552 | −49 957 | |
0,94143 % | Two Sigma Investments, LP | 1 241 564 | 101 702 | |
0,86019 % | Goldman Sachs & Company, Inc. | 1 134 419 | −213 286 | |
0,80378 % | AIGH Capital Management, LLC. | 1 060 023 | 1 060 023 | |
0,74333 % | Sectoral Asset Management Inc. | 980 300 | 12 000 | |
0,73476 % | JP Morgan Asset Management | 969 004 | −33 191 | |
0,70243 % | BofA Global Research (US) | 926 363 | 211 300 | |
0,70239 % | UBS Financial Services, Inc. | 926 309 | 782 053 | |
0,66076 % | Balyasny Asset Management LP | 871 409 | 871 409 | |
0,59477 % | Northern Trust Investments, Inc. | 784 389 | 57 217 | |
0,57504 % | Barclays Bank PLC | 758 361 | 79 748 | |
0,48690 % | Citi Investment Research (US) | 642 121 | −347 325 | |
0,48295 % | J. Goldman & Co., L.P. | 636 920 | 372 507 | |
0,42970 % | Knott Partners Management, LLC | 566 687 | 0 | |
0,37011 % | Norges Bank Investment Management (NBIM) | 488 100 | 488 100 | |
0,34122 % | Altium Capital Management LP | 450 000 | 23 000 | |
0,32306 % | Morgan Stanley & Co. LLC | 426 046 | 134 548 | |
0,32082 % | Susquehanna International Group, LLP | 423 104 | −220 888 | |
0,27676 % | Worth Venture Partners, LLC | 364 995 | 364 995 | |
0,25023 % | Sio Capital Management, LLC | 330 000 | 330 000 | |
0,23416 % | ExodusPoint Capital Management, LP | 308 813 | 308 813 | |
0,22748 % | Tang Capital Management, LLC | 300 000 | 0 | |
0,22430 % | BlackRock Investment Management, LLC | 295 807 | −6 506 | |
0,20986 % | BlackRock Financial Management, Inc. | 276 767 | 28 717 | |
0,20758 % | BNP Paribas Securities Corp. North America | 273 763 | −56 043 | |
0,20481 % | Charles Schwab Investment Management, Inc. | 270 101 | 12 405 | |
0,19801 % | BNY Mellon Asset Management | 261 142 | 15 190 | |
0,19287 % | SilverArc Capital Management, LLC | 254 361 | −729 155 | |
0,16758 % | Schweizerische Nationalbank | 221 000 | 221 000 | |
0,15713 % | BG Fund Management Luxembourg S.A. | 207 226 | 47 847 | |
0,14647 % | Walleye Capital LLC | 193 170 | −203 802 | |
0,14622 % | Gyon Technologies Capital Management, LP | 192 831 | 111 891 | |
0,13785 % | Allspring Global Investments, LLC | 181 791 | −921 | |
0,13567 % | Parametric Portfolio Associates LLC | 178 919 | −202 220 | |
0,13389 % | Kennedy Capital Management, Inc. | 176 571 | −135 | |
0,12634 % | Nomura Securities Co., Ltd. | 166 622 | 165 612 | |
0,11374 % | Islet Management, LP | 150 000 | −475 000 | |
0,10949 % | Rhumbline Advisers Ltd. Partnership | 144 396 | 2 481 | |
0,10741 % | Capital Fund Management S.A. | 141 656 | 141 656 | |
0,10448 % | Cubist Systematic Strategies, LLC | 137 794 | −126 162 | |
0,10410 % | JPMorgan Private Bank (United States) | 137 292 | 377 | |
0,10040 % | William Blair & Company, L.L.C. (Research) | 132 413 | −43 785 | |
0,09058 % | California State Teachers Retirement System | 119 460 | 79 936 | |
0,08356 % | AllianceBernstein L.P. | 110 200 | 0 | |
0,08110 % | Boothbay Fund Management, LLC | 106 949 | 106 949 | |
0,07225 % | Lakeside Advisors, Inc. | 95 280 | 0 | |
0,07120 % | SEB Investment Management AB | 93 903 | −5 442 | |
0,06954 % | State of Wisconsin Investment Board | 91 714 | 91 714 | |
0,06954 % | Mackenzie Financial Corporation | 91 714 | 80 801 | |
0,06953 % | Jump Financial, LLC | 91 693 | 58 204 | |
0,06824 % | Candriam Belgium S.A. | 90 000 | 90 000 | |
0,06824 % | Candriam Luxembourg S.A. | 90 000 | 0 | |
0,06061 % | Jane Street Capital, L.L.C. | 79 936 | −302 750 | |
0,06035 % | J.P. Morgan Securities LLC | 79 595 | 79 595 | |
0,05970 % | GSA Capital Partners LLP | 78 729 | −55 625 | |
0,05846 % | E Fund Management Co. Ltd. | 77 101 | 1 968 | |
0,05705 % | Northern Trust Global Investments | 75 232 | −2 115 | |
0,05621 % | Credit Suisse Asset Management | 74 129 | 74 129 | |
0,05458 % | Hightower Advisors, LLC | 71 982 | 1 500 | |
0,05436 % | Mellon Investments Corporation | 71 692 | 581 | |
0,04978 % | Goldman Sachs Asset Management, L.P. | 65 654 | −122 185 | |
0,04910 % | New York State Common Retirement Fund | 64 753 | 53 | |
0,04724 % | Bayesian Capital Management, LP | 62 300 | 62 300 | |
0,04108 % | State Street Global Advisors Ireland Limited | 54 175 | 3 400 | |
0,03991 % | Apo Asset Management GmbH | 52 627 | 0 | |
0,03920 % | UBS Asset Management (Switzerland) | 51 700 | 51 700 | |
0,03908 % | Virtus Etf Advisers LLC | 51 542 | 8 172 | |
0,03908 % | LifeSci Index Partners, LLC | 51 542 | 0 | |
0,03891 % | Citadel Advisors LLC | 51 311 | −439 486 | |
0,03816 % | HRT Financial LP | 50 326 | 50 326 | |
0,03791 % | Caption Management, LLC | 50 000 | 50 000 | |
0,03727 % | SG Americas Securities, L.L.C. | 49 149 | −2 555 | |
0,03692 % | MetLife Investment Management, LLC | 48 688 | 0 | |
0,03688 % | Tuckson (Reed Vaughn M.D.) | 48 639 | −43 785 | |
0,03592 % | SunAmerica Asset Management, LLC | 47 365 | −172 | |
0,03329 % | Seeley (Bruce J) | 43 905 | 0 | |
0,03271 % | Perry Matthew D | 43 139 | 0 | |
0,03231 % | DWS Investments UK Limited | 42 610 | 668 | |
0,02986 % | Manulife Investment Management (North America) Limited | 39 378 | 1 652 | |