13,50521 % | Wellington Management Company, LLP | 16 445 290 | 1 278 246 | |
10,51683 % | Morningside Venture Investments, Ltd. | 12 806 342 | 0 | |
9,17555 % | EcoR1 Capital, LLC | 11 173 068 | 273 209 | |
9,12467 % | Avoro Capital Advisors LLC | 11 111 111 | 0 | |
7,83257 % | The Vanguard Group, Inc. | 9 537 719 | 85 701 | |
5,17663 % | T. Rowe Price Investment Management, Inc. | 6 303 584 | −215 887 | |
3,96886 % | BlackRock Institutional Trust Company, N.A. | 4 832 877 | 92 717 | |
2,69025 % | Jennison Associates LLC | 3 275 922 | −266 287 | |
2,39420 % | State Street Global Advisors (US) | 2 915 422 | −322 692 | |
2,30515 % | Octagon Capital Advisors LP | 2 806 980 | −323 020 | |
2,29551 % | Morgan Stanley & Co. LLC | 2 795 240 | 1 601 542 | |
1,96998 % | T. Rowe Price Associates, Inc. | 2 398 842 | 669 759 | |
1,76152 % | Assenagon Asset Management S.A. | 2 145 004 | 1 121 497 | |
1,71837 % | Fidelity Management & Research Company LLC | 2 092 464 | −167 086 | |
1,41743 % | Boxer Capital, L.L.C. | 1 726 000 | 0 | |
1,40927 % | JP Morgan Asset Management | 1 716 070 | 70 134 | |
1,33912 % | Geode Capital Management, L.L.C. | 1 630 642 | 75 816 | |
1,16724 % | Invus Public Equities Advisors, LLC | 1 421 346 | −243 226 | |
1,10418 % | Pictet Asset Management Ltd. | 1 344 563 | 610 413 | |
0,87320 % | Deschatelets (Pascal) | 1 063 301 | 0 | |
0,86511 % | Polar Capital LLP | 1 053 440 | −435 | |
0,78016 % | Logos Global Management LLC | 950 000 | 200 000 | |
0,77705 % | Norges Bank Investment Management (NBIM) | 946 213 | −101 241 | |
0,75733 % | OrbiMed Advisors, LLC | 922 200 | −338 300 | |
0,75478 % | Fiera Capital Corporation | 919 090 | −600 | |
0,74272 % | Charles Schwab Investment Management, Inc. | 904 409 | 25 052 | |
0,72692 % | Frazier Healthcare Partners | 885 165 | 271 122 | |
0,67488 % | Bellevue Asset Management AG | 821 800 | 27 959 | |
0,63960 % | Machiels (Alec) | 778 844 | 3 341 | |
0,53660 % | Francois (Cedric G) | 653 418 | 0 | |
0,51326 % | Cormorant Asset Management, LP | 625 000 | −1 375 000 | |
0,50610 % | Victory Capital Management Inc. | 616 272 | −122 239 | |
0,50246 % | JPMorgan Asset Management U.K. Limited | 611 840 | 137 145 | |
0,47912 % | Macquarie Investment Management | 583 429 | −493 119 | |
0,40627 % | Invesco Advisers, Inc. | 494 709 | 2 597 | |
0,40201 % | Columbia Threadneedle Investments (US) | 489 522 | 213 188 | |
0,39691 % | TD Asset Management Inc. | 483 322 | 112 465 | |
0,39542 % | Driehaus Capital Management, LLC | 481 501 | 300 177 | |
0,38146 % | Candriam Luxembourg S.A. | 464 507 | 95 000 | |
0,36626 % | Eagle Asset Management, Inc. | 446 000 | −3 970 | |
0,35699 % | Jane Street Capital, L.L.C. | 434 701 | 161 475 | |
0,33028 % | Dunlop (Sinclair Andrew) | 402 185 | 1 500 | |
0,32277 % | Caption Management, LLC | 393 031 | 119 781 | |
0,31834 % | Northern Trust Investments, Inc. | 387 643 | 18 292 | |
0,31439 % | Susquehanna International Group, LLP | 382 832 | 10 047 | |
0,30263 % | BMO Capital Markets (US) | 368 510 | −62 000 | |
0,29558 % | DWS Investments UK Limited | 359 928 | 356 000 | |
0,27963 % | New York State Common Retirement Fund | 340 507 | −62 437 | |
0,27717 % | Candriam Belgium S.A. | 337 507 | 11 000 | |
0,26608 % | PGIM Securities Investment Trust Enterprise | 324 000 | 23 000 | |
0,23414 % | Citadel Advisors LLC | 285 117 | 270 370 | |
0,23188 % | Medical Strategy GmbH | 282 365 | −6 200 | |
0,21905 % | Nuveen LLC | 266 739 | −6 439 | |
0,21067 % | Voya Investment Management LLC | 256 533 | 174 366 | |
0,20851 % | Group One Trading, L.P. | 253 905 | 27 221 | |
0,20166 % | Ensign Peak Advisors, Inc. | 245 566 | 60 000 | |
0,19923 % | Fiduciary Trust Company | 242 607 | −22 600 | |
0,19822 % | Amundi Asset Management US, Inc. | 241 371 | 135 315 | |
0,18960 % | Marshall Wace LLP | 230 876 | 61 582 | |
0,18857 % | Franklin Advisers, Inc. | 229 622 | 229 622 | |
0,17229 % | Eventide Asset Management, LLC | 209 794 | 209 794 | |
0,17095 % | Great Lakes Advisors, LLC | 208 163 | 208 163 | |
0,16569 % | Managed Account Advisors LLC | 201 764 | −138 260 | |
0,15998 % | Barclays Bank PLC | 194 813 | −133 008 | |
0,15722 % | Goldman Sachs Asset Management, L.P. | 191 449 | −31 387 | |
0,15676 % | DWS Investment S.A. | 190 889 | 190 889 | |
0,15479 % | DWS Investment GmbH | 188 493 | −15 577 | |
0,15374 % | BNY Mellon Asset Management | 187 210 | 3 829 | |
0,15293 % | Woodline Partners LP | 186 224 | 186 224 | |
0,15160 % | BlackRock Financial Management, Inc. | 184 605 | −347 | |
0,14227 % | Tekla Capital Management LLC_NLE | 173 248 | 38 124 | |
0,13883 % | abrdn Inc. | 169 051 | 169 051 | |
0,13754 % | BNP Paribas Securities Corp. North America | 167 488 | −68 867 | |
0,13443 % | Mellon Investments Corporation | 163 694 | −2 386 | |
0,13337 % | Schweizerische Nationalbank | 162 400 | −16 800 | |
0,12499 % | Altitude Crest Partners Inc | 152 200 | 152 200 | |
0,12440 % | Morgan Stanley Smith Barney LLC | 151 483 | −120 351 | |
0,12343 % | BlackRock Asset Management Ireland Limited | 150 301 | 4 920 | |
0,12318 % | Ally Bridge Group NY LLC | 150 000 | −31 805 | |
0,12127 % | Walleye Capital LLC | 147 674 | 13 691 | |
0,11976 % | California Public Employees' Retirement System | 145 833 | −38 011 | |
0,11936 % | J.P. Morgan Securities plc | 145 342 | 145 342 | |
0,11753 % | Rafferty Asset Management LLC | 143 118 | −71 043 | |
0,11737 % | Saturn V Capital Management LLC | 142 927 | 142 927 | |
0,10970 % | Rhumbline Advisers Ltd. Partnership | 133 586 | 1 292 | |
0,10791 % | Pictet Asset Management (Japan) Ltd. | 131 404 | 131 404 | |
0,10766 % | Lombard Odier Asset Management (Europe) Ltd | 131 098 | −38 956 | |
0,10676 % | 683 Capital Management LLC | 130 000 | −110 000 | |
0,10282 % | Wells Fargo Advisors | 125 206 | 15 309 | |
0,09826 % | PNC Investments LLC | 119 653 | 57 | |
0,09774 % | BofA Global Research (US) | 119 017 | −245 914 | |
0,09481 % | Allspring Global Investments, LLC | 115 453 | 56 178 | |
0,09428 % | Goldman Sachs & Company, Inc. | 114 810 | 5 853 | |
0,09368 % | LMR Partners LLP | 114 069 | 56 940 | |
0,08869 % | Cutter Capital Management, LP | 108 000 | 108 000 | |
0,08705 % | Manulife Investment Management (North America) Limited | 106 002 | 51 737 | |
0,08274 % | Parametric Portfolio Associates LLC | 100 752 | 14 566 | |
0,08245 % | Rhenman & Partners Asset Management AB | 100 400 | −114 600 | |
0,08196 % | BMO Nesbitt Burns Inc. | 99 800 | 99 800 | |
0,08025 % | Thrivent Asset Management, LLC | 97 716 | 18 255 | |