| 10,65346 % | The Vanguard Group, Inc. | 41 620 949 | 1 367 173 | |
| 5,59196 % | Baillie Gifford & Co. | 21 846 666 | −247 458 | |
| 5,02650 % | BlackRock Institutional Trust Company, N.A. | 19 637 528 | 1 762 948 | |
| 4,98112 % | Fidelity Management & Research Company LLC | 19 460 247 | −1 366 827 | |
| 4,42066 % | State Street Investment Management (US) | 17 270 631 | −507 927 | |
| 3,78184 % | Two Sigma Investments, LP | 14 774 908 | 6 512 305 | |
| 2,35760 % | Boston Biotech Ventures, L.L.C. | 9 210 686 | 0 | |
| 2,27226 % | Geode Capital Management, L.L.C. | 8 877 280 | 1 420 690 | |
| 2,01413 % | Theleme Partners LLP | 7 868 810 | 626 420 | |
| 1,91040 % | D. E. Shaw & Co., L.P. | 7 463 555 | 1 827 404 | |
| 1,68037 % | OCHA, L.L.C. | 6 564 880 | 0 | |
| 1,60424 % | Invesco Capital Management LLC | 6 267 436 | 1 091 957 | |
| 1,40624 % | Bancel (Stephane J) | 5 493 897 | 0 | |
| 1,18566 % | Flagship Ventures | 4 632 149 | 0 | |
| 1,16838 % | Morgan Stanley & Co. LLC | 4 564 637 | 167 910 | |
| 0,96799 % | Jane Street Capital, L.L.C. | 3 781 759 | 193 722 | |
| 0,88052 % | Norges Bank Investment Management (NBIM) | 3 439 999 | −500 195 | |
| 0,87116 % | Voloridge Investment Management, LLC | 3 403 434 | 142 888 | |
| 0,80135 % | Banque Pictet & Cie S.A. | 3 130 724 | −2 250 | |
| 0,77816 % | Charles Schwab Investment Management, Inc. | 3 040 117 | 410 252 | |
| 0,72927 % | Susquehanna International Group, LLP | 2 849 112 | 1 620 401 | |
| 0,72923 % | Federated MDTA LLC | 2 848 944 | 2 232 933 | |
| 0,65883 % | BlackRock Asset Management Ireland Limited | 2 573 907 | −469 874 | |
| 0,64735 % | Parametric Portfolio Associates LLC | 2 529 068 | 593 944 | |
| 0,63664 % | Northern Trust Investments, Inc. | 2 487 243 | 42 631 | |
| 0,63176 % | BlackRock Financial Management, Inc. | 2 468 165 | 769 574 | |
| 0,62548 % | Citi Investment Research (US) | 2 443 644 | −65 288 | |
| 0,59081 % | Merck & Co Inc | 2 308 190 | 0 | |
| 0,56927 % | Afeyan (Noubar Boghos) | 2 224 015 | 0 | |
| 0,55539 % | BlackRock Investment Management (UK) Ltd. | 2 169 800 | 303 152 | |
| 0,52924 % | UBS Switzerland AG | 2 067 624 | −1 796 860 | |
| 0,47879 % | UBS Financial Services, Inc. | 1 870 555 | −626 091 | |
| 0,46962 % | Citadel Advisors LLC | 1 834 708 | 74 423 | |
| 0,45566 % | Barclays Bank PLC | 1 780 158 | 763 594 | |
| 0,41199 % | Hoge (Stephen) | 1 609 561 | 0 | |
| 0,40571 % | Goldman Sachs Asset Management, L.P. | 1 585 017 | 187 150 | |
| 0,38022 % | BofA Global Research (US) | 1 485 457 | 520 123 | |
| 0,36505 % | Legal & General Investment Management Ltd. | 1 426 164 | −845 459 | |
| 0,35770 % | Capital Fund Management S.A. | 1 397 477 | 895 400 | |
| 0,34451 % | Jacobs Levy Equity Management, Inc. | 1 345 950 | 347 447 | |
| 0,33668 % | Goldman Sachs Bank AG | 1 315 332 | 320 | |
| 0,31705 % | Bellevue Asset Management AG | 1 238 668 | −279 454 | |
| 0,31559 % | First Trust Advisors L.P. | 1 232 952 | 318 183 | |
| 0,31359 % | BNP Paribas Securities Corp. North America | 1 225 135 | −222 939 | |
| 0,28884 % | Douglas C. Lane & Associates | 1 128 434 | 198 269 | |
| 0,28837 % | UBS Asset Management (Switzerland) | 1 126 610 | −238 912 | |
| 0,28545 % | DWS Investments UK Limited | 1 115 187 | −290 089 | |
| 0,28398 % | Dimensional Fund Advisors, L.P. | 1 109 467 | −421 563 | |
| 0,25696 % | Renaissance Technologies LLC | 1 003 900 | −356 200 | |
| 0,25596 % | Deerfield Management Company, L.P. | 1 000 000 | 1 000 000 | |
| 0,24003 % | UBS Asset Management (UK) Ltd. | 937 765 | −173 884 | |
| 0,23502 % | Letko, Brosseau & Associates Inc. | 918 190 | 21 765 | |
| 0,23278 % | Amundi Asset Management, SAS | 909 429 | −424 445 | |
| 0,23247 % | Nuveen LLC | 908 207 | 245 010 | |
| 0,22256 % | Millennium Management LLC | 869 492 | 720 698 | |
| 0,21516 % | WorldQuant Millennium Advisors LLC | 840 595 | 840 595 | |
| 0,21397 % | J.P. Morgan Securities LLC | 835 925 | 827 279 | |
| 0,21226 % | Invesco Advisers, Inc. | 829 248 | 139 078 | |
| 0,20451 % | J.P. Morgan Securities plc | 798 972 | 627 866 | |
| 0,19020 % | Sessa Capital | 743 081 | 0 | |
| 0,18800 % | RBC Capital Markets Wealth Management | 734 464 | 130 568 | |
| 0,18401 % | Mellon Investments Corporation | 718 884 | −295 094 | |
| 0,17989 % | BNY Mellon Asset Management | 702 792 | −75 837 | |
| 0,17470 % | Pictet Asset Management Ltd. | 682 499 | 2 751 | |
| 0,16988 % | Schweizerische Nationalbank | 663 700 | −258 800 | |
| 0,16865 % | TB Alternative Assets Ltd. | 658 881 | −602 072 | |
| 0,16499 % | Acadian Asset Management LLC | 644 571 | 477 072 | |
| 0,15943 % | Rhumbline Advisers Ltd. Partnership | 622 857 | 25 390 | |
| 0,15436 % | BlackRock Investment Management, LLC | 603 071 | 153 143 | |
| 0,15387 % | CPP Investment Board | 601 146 | 232 874 | |
| 0,15170 % | UBS Asset Management (Americas) LLC | 592 651 | −288 930 | |
| 0,15158 % | National Bank of Canada | 592 194 | −432 917 | |
| 0,13711 % | Tudor Investment Corporation | 535 665 | 219 273 | |
| 0,13535 % | Pictet Asset Management (Japan) Ltd. | 528 773 | 23 668 | |
| 0,13238 % | Suvretta Capital Management, LLC | 517 163 | 0 | |
| 0,12852 % | HSBC Global Asset Management (UK) Limited | 502 083 | −49 626 | |
| 0,12682 % | Goldman Sachs & Company, Inc. | 495 463 | 7 747 | |
| 0,12648 % | Sagan (Paul L) | 494 133 | 0 | |
| 0,12136 % | T. Rowe Price International Ltd | 474 138 | −18 773 | |
| 0,11395 % | California Public Employees' Retirement System | 445 190 | 73 654 | |
| 0,11366 % | Aperio Group, LLC | 444 034 | 57 031 | |
| 0,11229 % | IMC Chicago, LLC | 438 683 | −53 574 | |
| 0,11193 % | Morgan Stanley Smith Barney LLC | 437 290 | −167 420 | |
| 0,10947 % | AllianceBernstein L.P. | 427 664 | 73 896 | |
| 0,10649 % | Mitsubishi UFJ Asset Management Co., Ltd. | 416 020 | −243 230 | |
| 0,10332 % | BlackRock (Netherlands) B.V. | 403 644 | −511 969 | |
| 0,10100 % | Rafferty Asset Management LLC | 394 599 | 45 740 | |
| 0,10007 % | Manulife Investment Management (North America) Limited | 390 954 | 688 | |
| 0,09991 % | Carson Wealth Management Group | 390 333 | 130 200 | |
| 0,09772 % | Simplex Trading, LLC | 381 787 | 190 557 | |
| 0,09565 % | Group One Trading, L.P. | 373 688 | −70 750 | |
| 0,09550 % | Lingotto Investment Management LLP | 373 095 | 0 | |
| 0,09512 % | Principal Global Investors (Equity) | 371 612 | −9 | |
| 0,09294 % | JPMorgan Private Bank (United States) | 363 106 | 6 010 | |
| 0,09108 % | UBS Fund Management (Switzerland) AG | 355 821 | 124 767 | |
| 0,08822 % | Boston Management and Research | 344 651 | 0 | |
| 0,08381 % | California State Teachers Retirement System | 327 429 | −168 739 | |
| 0,08310 % | Pictet & Cie (Europe) S.A. | 324 665 | −409 021 | |
| 0,08143 % | Florida State Board of Administration | 318 137 | −12 749 | |
| 0,08041 % | Peak6 Capital Management LLC | 314 138 | 48 888 | |