12,84798 % | Kynam Capital Management LP | 4 420 349 | 2 747 308 | 31.12.2022 |
10,54789 % | BVF Partners L.P. | 3 629 000 | 0 | 31.12.2022 |
5,55438 % | The Vanguard Group, Inc. | 1 910 984 | 69 214 | 31.12.2022 |
5,03528 % | Nantahala Capital Management, LLC | 1 732 388 | −54 771 | 31.12.2022 |
4,19048 % | Millennium Management LLC | 1 441 735 | 122 227 | 31.12.2022 |
4,04389 % | Citadel Advisors LLC | 1 391 302 | 269 873 | 31.12.2022 |
3,89565 % | Point72 Asset Management, L.P. | 1 340 300 | 1 069 700 | 31.12.2022 |
3,80289 % | BofA Global Research (US) | 1 308 386 | 4391 | 31.12.2022 |
3,76641 % | Ingalls & Snyder LLC (Asset Management) | 1 295 833 | −34 600 | 31.12.2022 |
3,49799 % | Parkman Healthcare Partners LLC | 1 203 484 | 65 897 | 31.12.2022 |
3,43564 % | BlackRock Institutional Trust Company, N.A. | 1 182 032 | 380 848 | 31.12.2022 |
3,34254 % | Tang Capital Management, LLC | 1 150 000 | 146 983 | 31.12.2022 |
3,16319 % | RA Capital Management, LP | 1 088 296 | 0 | 31.12.2022 |
2,91464 % | Sphera Funds Management Ltd. | 1 002 783 | 50 000 | 31.12.2022 |
2,84641 % | Medical Strategy GmbH | 979 309 | 0 | 30.9.2022 |
2,25235 % | Dimensional Fund Advisors, L.P. | 774 922 | 112 822 | 31.12.2022 |
2,23612 % | Assenagon Asset Management S.A. | 769 336 | −140 554 | 31.12.2022 |
2,18904 % | Acadian Asset Management LLC | 753 140 | 123 841 | 31.12.2022 |
1,93769 % | AWM Investment Company, Inc. | 666 661 | 0 | 31.12.2022 |
1,59324 % | Barclays Bank PLC | 548 155 | 97 922 | 31.12.2022 |
1,59134 % | NewEdge Wealth, LLC | 547 501 | 0 | 31.12.2022 |
1,57884 % | BMO Capital Markets (US) | 543 200 | 543 200 | 31.12.2022 |
1,56541 % | Alyeska Investment Group, L.P. | 538 579 | 38 579 | 31.12.2022 |
1,52196 % | Goldman Sachs & Company, Inc. | 523 630 | 189 551 | 31.12.2022 |
1,51077 % | Morgan Stanley & Co. LLC | 519 782 | −32 140 | 31.12.2022 |
1,46396 % | Schonfeld Strategic Advisors LLC | 503 674 | 244 574 | 31.12.2022 |
1,45504 % | Renaissance Technologies LLC | 500 605 | −142 000 | 31.12.2022 |
1,42742 % | Two Sigma Investments, LP | 491 105 | −365 147 | 31.12.2022 |
1,33749 % | IndexIQ Advisors LLC | 460 165 | 460 165 | 28.2.2023 |
1,21453 % | Geode Capital Management, L.L.C. | 417 858 | 9369 | 31.12.2022 |
0,84463 % | Connor, Clark & Lunn Investment Management Ltd. | 290 595 | −9763 | 31.12.2022 |
0,79709 % | J.P. Morgan Securities LLC | 274 240 | 186 915 | 31.12.2022 |
0,69813 % | Susquehanna International Group, LLP | 240 190 | 202 781 | 31.12.2022 |
0,61228 % | Stuart Nancy | 210 654 | −6048 | 15.2.2023 |
0,60028 % | Pura Vida Investments, LLC | 206 525 | 206 525 | 31.12.2022 |
0,58364 % | International Biotechnology Trust PLC | 200 800 | 0 | 31.12.2022 |
0,56413 % | Citi Investment Research (US) | 194 090 | 73 373 | 31.12.2022 |
0,44455 % | Manulife Investment Management (North America) Limited | 152 947 | 151 883 | 31.1.2023 |
0,43075 % | Bridgeway Capital Management, LLC | 148 200 | 0 | 31.12.2022 |
0,40953 % | State Street Global Advisors (US) | 140 898 | 20 300 | 31.12.2022 |
0,33091 % | D. E. Shaw & Co., L.P. | 113 848 | 113 848 | 31.12.2022 |
0,33018 % | Aberdeen Asset Managers Ltd. | 113 600 | −105 700 | 28.2.2023 |
0,31414 % | Northern Trust Investments, Inc. | 108 079 | −437 | 31.12.2022 |
0,30025 % | ClariVest Asset Management LLC | 103 300 | −1500 | 31.12.2022 |
0,29066 % | BZ Bank AG (Asset Management) | 100 000 | 0 | 30.11.2022 |
0,25694 % | Florida State Board of Administration | 88 400 | 88 400 | 30.9.2022 |
0,25677 % | Ensign Peak Advisors, Inc. | 88 341 | 0 | 31.12.2022 |
0,25345 % | City National Rochdale, LLC | 87 200 | 87 200 | 31.12.2022 |
0,24413 % | Caxton Associates LP | 83 993 | −40 122 | 31.12.2022 |
0,21668 % | Walleye Capital LLC | 74 548 | 74 548 | 31.12.2022 |
0,20637 % | Black Diamond Financial, LLC | 71 000 | 0 | 31.12.2022 |
0,20410 % | Morgan Stanley Smith Barney LLC | 70 221 | 0 | 31.12.2022 |
0,17466 % | BG Fund Management Luxembourg S.A. | 60 092 | 0 | 31.12.2022 |
0,17032 % | Kensington Investment Counsel, LLC | 58 599 | −18 202 | 31.12.2022 |
0,14278 % | RBF Capital, LLC | 49 122 | −15 781 | 31.12.2022 |
0,13701 % | Qube Research & Technologies Ltd | 47 137 | 13 399 | 31.12.2022 |
0,13419 % | Cubist Systematic Strategies, LLC | 46 167 | −26 901 | 31.12.2022 |
0,11401 % | Aldrich (Richard H) | 39 226 | −358 500 | 6.3.2023 |
0,11245 % | Cassella (James V) | 38 690 | −3762 | 15.2.2023 |
0,11062 % | 683 Capital Management LLC | 38 058 | 38 058 | 31.12.2022 |
0,10733 % | van Heek (Christine) | 36 926 | 26 926 | 9.6.2022 |
0,10289 % | Lake Street Advisors | 35 398 | 0 | 31.12.2022 |
0,09451 % | Alps Advisors, Inc. | 32 516 | 6319 | 31.12.2022 |
0,08926 % | BlackRock Advisors (UK) Limited | 30 710 | 8243 | 28.2.2023 |
0,08720 % | ACCI Capital Investments SGIIC, SA | 30 000 | −10 000 | 31.12.2022 |
0,08546 % | Jane Street Capital, L.L.C. | 29 404 | 18 992 | 31.12.2022 |
0,08491 % | Dimensional Fund Advisors, Ltd. | 29 215 | 4867 | 31.1.2023 |
0,08438 % | Marshall Wace LLP | 29 030 | 29 030 | 31.12.2022 |
0,08400 % | Auchincloss (Thomas G Jr) | 28 900 | 22 400 | 9.6.2022 |
0,08201 % | Apo Asset Management GmbH | 28 215 | 0 | 31.1.2023 |
0,07553 % | AHL Partners LLP | 25 987 | 25 987 | 31.12.2022 |
0,07097 % | Occudo Quantitative Strategies LP | 24 418 | −38 386 | 31.12.2022 |
0,07081 % | Hutt (Peter Barton) | 24 363 | 0 | 14.10.2022 |
0,07051 % | BlackRock Financial Management, Inc. | 24 259 | 8692 | 31.12.2022 |
0,06928 % | Barclays Capital Inc. | 23 835 | 21 314 | 31.12.2022 |
0,06589 % | BlackRock Asset Management Ireland Limited | 22 668 | 22 668 | 31.12.2022 |
0,06049 % | Northern Trust Global Investments | 20 813 | −5 | 31.12.2022 |
0,06030 % | Lighthouse Partners | 20 746 | 20 746 | 31.12.2022 |
0,05918 % | SG Americas Securities, L.L.C. | 20 361 | 3352 | 31.12.2022 |
0,05813 % | Birchview Capital, LP | 20 000 | 0 | 31.12.2022 |
0,05352 % | Boothbay Fund Management, LLC | 18 414 | 18 414 | 31.12.2022 |
0,05346 % | Becker (Marc A) | 18 392 | −3762 | 15.2.2023 |
0,05022 % | BNY Mellon Asset Management | 17 278 | 0 | 31.12.2022 |
0,04941 % | Alpine Associates Management Inc. | 17 000 | −17 700 | 28.2.2023 |
0,04767 % | Hoeiland (Jesper) | 16 400 | 16 400 | 9.6.2022 |
0,04767 % | Jaeger (Wilfred E) | 16 400 | 16 400 | 9.6.2022 |
0,04592 % | Acuitas Investments LLC | 15 800 | −600 | 31.12.2022 |
0,04559 % | Charles Schwab Investment Management, Inc. | 15 686 | 0 | 31.12.2022 |
0,04526 % | HSBC Global Asset Management (UK) Limited | 15 571 | 0 | 31.12.2022 |
0,04479 % | Tung (Roger D) | 15 411 | −814 343 | 6.3.2023 |
0,04479 % | Mirabella Financial Services LLP | 15 410 | 15 410 | 31.12.2022 |
0,04191 % | Jump Financial, LLC | 14 418 | −21 782 | 31.12.2022 |
0,03488 % | Cantor Fitzgerald, L.P | 12 000 | −30 100 | 31.12.2022 |
0,03008 % | Flagship Harbor Advisors LLC | 10 350 | 0 | 31.12.2022 |
0,02907 % | Roanoke Asset Management Corp. | 10 000 | 0 | 31.12.2022 |
0,02848 % | Blackstone Alternative Investment Advisors LLC | 9800 | 8000 | 30.9.2022 |
0,02323 % | Lord, Abbett & Co. LLC | 7992 | 0 | 31.1.2023 |
0,02323 % | BlackRock Investment Management, LLC | 7992 | 242 | 31.12.2022 |
0,02150 % | Tower Research Capital LLC | 7398 | 5351 | 31.12.2022 |
0,02122 % | UBS Financial Services, Inc. | 7301 | −6560 | 31.12.2022 |