| 16,41143 % | BlackRock Institutional Trust Company, N.A. | 10 674 208 | -68 432 | |
| 16,18560 % | PRIMECAP Management Company | 10 527 322 | 766 310 | |
| 10,92192 % | The Vanguard Group, Inc. | 7 103 758 | -1 505 751 | |
| 9,44748 % | EcoR1 Capital, LLC | 6 144 767 | 0 | |
| 7,10217 % | BVF Partners L.P. | 4 619 341 | 1 879 200 | |
| 5,86952 % | State Street Investment Management (US) | 3 817 610 | 133 895 | |
| 5,61736 % | T. Rowe Price Associates, Inc. | 3 653 607 | -176 241 | |
| 3,77012 % | TCG Crossover Management, LLC | 2 452 138 | 0 | |
| 3,69440 % | RTW Investments L.P. | 2 402 883 | 0 | |
| 2,73760 % | Dimensional Fund Advisors, L.P. | 1 780 570 | 43 182 | |
| 2,61936 % | Geode Capital Management, L.L.C. | 1 703 664 | 29 316 | |
| 2,54560 % | Braidwell LP | 1 655 690 | 0 | |
| 1,92186 % | Logos Global Management LP | 1 250 000 | 1 250 000 | |
| 1,56692 % | Two Sigma Investments, LP | 1 019 143 | 315 712 | |
| 1,44369 % | BofA Global Research (US) | 938 993 | 456 302 | |
| 1,29655 % | Woodline Partners LP | 843 296 | 0 | |
| 1,26090 % | Nantahala Capital Management, LLC | 820 103 | 363 362 | |
| 1,19339 % | UBS Financial Services, Inc. | 776 196 | -165 646 | |
| 1,15013 % | Johnson & Johnson Innovation-JJDC, Inc. | 748 062 | 0 | |
| 1,03078 % | Baker Bros. Advisors LP | 670 431 | 0 | |
| 1,00606 % | Barclays Bank PLC | 654 353 | 478 251 | |
| 0,98696 % | Goldman Sachs & Company, Inc. | 641 930 | -45 039 | |
| 0,93365 % | Northern Trust Investments, Inc. | 607 258 | 334 | |
| 0,92568 % | BlackRock Financial Management, Inc. | 602 072 | 38 399 | |
| 0,92227 % | Morgan Stanley & Co. LLC | 599 859 | -38 042 | |
| 0,92101 % | Charles Schwab Investment Management, Inc. | 599 039 | -37 617 | |
| 0,85916 % | abrdn Inc. | 558 810 | 181 698 | |
| 0,84475 % | Deep Track Capital LP | 549 439 | 0 | |
| 0,80206 % | Jacobs Levy Equity Management, Inc. | 521 667 | -382 818 | |
| 0,75166 % | PanAgora Asset Management Inc. | 488 892 | 198 564 | |
| 0,74568 % | Hudson Bay Capital Management LP | 485 000 | 24 110 | |
| 0,64643 % | Parametric Portfolio Associates LLC | 420 449 | 206 056 | |
| 0,61857 % | Dahiyat (Bassil Ishmael) | 402 326 | 90 029 | |
| 0,58455 % | Erste Asset Management GmbH | 380 200 | 0 | |
| 0,55834 % | Squarepoint Capital LLP | 363 153 | 351 979 | |
| 0,54248 % | Principal Global Investors (Equity) | 352 839 | 4 113 | |
| 0,53341 % | Millennium Management LLC | 346 934 | 287 551 | |
| 0,51582 % | Cubist Systematic Strategies, LLC | 335 493 | 179 913 | |
| 0,48408 % | Columbia Threadneedle Investments (US) | 314 853 | 5 895 | |
| 0,45325 % | ExodusPoint Capital Management, LP | 294 798 | 128 109 | |
| 0,41575 % | Mellon Investments Corporation | 270 412 | 10 343 | |
| 0,41151 % | J.P. Morgan Securities LLC | 267 653 | 265 161 | |
| 0,39983 % | BlackRock Investment Management, LLC | 260 055 | 54 123 | |
| 0,38238 % | Walleye Capital LLC | 248 706 | 248 706 | |
| 0,37307 % | PSP Investments | 242 652 | 20 681 | |
| 0,33866 % | Citadel Advisors LLC | 220 268 | 161 784 | |
| 0,32743 % | Desjarlais (John R) | 212 963 | 20 154 | |
| 0,31982 % | BlackRock Advisors (UK) Limited | 208 016 | -1 564 | |
| 0,30750 % | Macquarie Investment Management | 200 000 | 0 | |
| 0,29374 % | BlackRock Asset Management Ireland Limited | 191 055 | -124 676 | |
| 0,27814 % | Legal & General Investment Management Ltd. | 180 905 | -2 722 | |
| 0,27122 % | Rhumbline Advisers Ltd. Partnership | 176 404 | 12 547 | |
| 0,26502 % | Invesco Capital Management LLC | 172 371 | -439 144 | |
| 0,26356 % | Trexquant Investment LP | 171 420 | 38 060 | |
| 0,25484 % | Rhenman & Partners Asset Management AB | 165 750 | -30 000 | |
| 0,23981 % | American Century Investment Management, Inc. | 155 973 | 16 731 | |
| 0,21525 % | DCF Advisers, LLC | 140 000 | -62 167 | |
| 0,20759 % | BNY Mellon Asset Management | 135 020 | 5 755 | |
| 0,20390 % | Nuveen LLC | 132 618 | -27 098 | |
| 0,20302 % | Algert Global LLC | 132 045 | 132 045 | |
| 0,19854 % | Kuch John J | 129 136 | 36 542 | |
| 0,19826 % | Verition Fund Management LLC | 128 949 | 100 917 | |
| 0,19522 % | Jump Financial, LLC | 126 972 | 76 499 | |
| 0,19461 % | UBS Asset Management (Switzerland) | 126 575 | 43 552 | |
| 0,18932 % | Y-Intercept (Hong Kong) Ltd | 123 138 | 27 393 | |
| 0,18625 % | Thrivent Asset Management, LLC | 121 137 | 930 | |
| 0,18291 % | BNP Paribas Securities Corp. North America | 118 970 | 81 640 | |
| 0,17727 % | Schweizerische Nationalbank | 115 300 | 0 | |
| 0,16386 % | T. Rowe Price International Ltd | 106 577 | 5 778 | |
| 0,16090 % | Manulife Investment Management (North America) Limited | 104 650 | 3 243 | |
| 0,15640 % | TD Asset Management Inc. | 101 722 | 0 | |
| 0,15353 % | Essex LLC | 99 861 | -6 100 | |
| 0,15249 % | Citi Investment Research (US) | 99 184 | -65 995 | |
| 0,15181 % | Los Angeles Capital Management LLC | 98 738 | 2 891 | |
| 0,14806 % | AQR Capital Management, LLC | 96 301 | 55 174 | |
| 0,14319 % | Susquehanna International Group, LLP | 93 130 | -6 448 | |
| 0,14239 % | Acadian Asset Management LLC | 92 614 | 92 614 | |
| 0,14028 % | Winton Capital Management Ltd. | 91 241 | 5 271 | |
| 0,13929 % | Rafferty Asset Management LLC | 90 599 | 3 858 | |
| 0,13914 % | SG Americas Securities, L.L.C. | 90 501 | 90 501 | |
| 0,13196 % | Adar1 Capital Management LLC | 85 826 | -312 326 | |
| 0,11448 % | Goldman Sachs Asset Management, L.P. | 74 462 | 34 697 | |
| 0,11084 % | AllianceBernstein L.P. | 72 090 | 0 | |
| 0,11068 % | PGIM Quantitative Solutions LLC | 71 990 | 3 715 | |
| 0,10864 % | Aperio Group, LLC | 70 660 | 21 280 | |
| 0,10765 % | Canada Life Asset Management Limited | 70 015 | 2 256 | |
| 0,10762 % | Birchview Capital, LP | 70 000 | 44 000 | |
| 0,10580 % | Fubon Asset Management Company Ltd. | 68 816 | 2 329 | |
| 0,10554 % | Polen Capital Management, LLC | 68 646 | -48 291 | |
| 0,10505 % | Fidelity Management & Research Company LLC | 68 327 | -8 325 | |
| 0,10475 % | Dimensional Fund Advisors, Ltd. | 68 134 | -21 513 | |
| 0,10081 % | State of Wisconsin Investment Board | 65 566 | 28 537 | |
| 0,09868 % | Susquehanna Fundamental Investments, LLC | 64 184 | -37 208 | |
| 0,09494 % | Numeric Investors LLC | 61 752 | 61 752 | |
| 0,09436 % | INTECH Investment Management LLC | 61 376 | -3 305 | |
| 0,09167 % | New York State Teachers' Retirement System | 59 626 | 200 | |
| 0,09134 % | UBS Fund Management (Switzerland) AG | 59 408 | -12 954 | |
| 0,08548 % | Renaissance Technologies LLC | 55 600 | -96 800 | |
| 0,08332 % | California State Teachers Retirement System | 54 193 | -4 937 | |
| 0,08312 % | Northern Trust Global Investments Limited | 54 061 | 138 | |