١١٫٥٤٧٠٠ % | Fidelity Management & Research Company LLC | ١٤٬٣٩٢٬١٧٥ | -٢٣٨٬٤٦٦ | ٣٠/٦/٢٠٢٤ |
٧٫٨٤٤٢٢ % | The Vanguard Group, Inc. | ٩٬٧٧٧٬٠٤٠ | ٥٨٬٦٣٠ | ٣٠/٦/٢٠٢٤ |
٧٫١١٥٦٢ % | Janus Henderson Investors | ٨٬٨٦٨٬٩٠٧ | ١٬١٩٥٬٠٣٩ | ٣٠/٦/٢٠٢٤ |
٦٫٥٨١٩٦ % | RA Capital Management, LP | ٨٬٢٠٣٬٧٥٤ | 0 | ٣٠/٦/٢٠٢٤ |
٦٫٣٢٦٥١ % | BlackRock Institutional Trust Company, N.A. | ٧٬٨٨٥٬٣٦١ | ٣١٤٬٣٨٥ | ٣٠/٦/٢٠٢٤ |
٣٫٦٨٥٠٧ % | Wellington Management Company, LLP | ٤٬٥٩٣٬٠٦٦ | -٣٢٦٬٣٠٤ | ٣٠/٦/٢٠٢٤ |
٣٫٣١٦٣٩ % | Capital Research Global Investors | ٤٬١٣٣٬٥٤٤ | -٦٬٩٧٧ | ٣٠/٦/٢٠٢٤ |
٣٫٢٢٧٣٧ % | T. Rowe Price Investment Management, Inc. | ٤٬٠٢٢٬٥٨٩ | ٤٦٩٬٦٢٢ | ٣٠/٦/٢٠٢٤ |
٢٫٧٠١٥٠ % | State Street Global Advisors (US) | ٣٬٣٦٧٬١٤٧ | ٣٠٬٠٥٥ | ٣٠/٦/٢٠٢٤ |
٢٫٤٧٠٠١ % | T. Rowe Price Associates, Inc. | ٣٬٠٧٨٬٦١٥ | -٨٬٢١٢ | ٣٠/٦/٢٠٢٤ |
١٫٩٥٩٠٦ % | Geode Capital Management, L.L.C. | ٢٬٤٤١٬٧٧٢ | ١٥٤٬٣٩٧ | ٣٠/٦/٢٠٢٤ |
١٫٧٤٥١٩ % | Franklin Advisers, Inc. | ٢٬١٧٥٬٢٠٥ | ٢٧٨٬١٢٤ | ٣٠/٦/٢٠٢٤ |
١٫٦٦٩٥٧ % | Darwin Global Management Ltd | ٢٬٠٨٠٬٩٤٦ | -٦٦٩٬٨٥٨ | ٣٠/٦/٢٠٢٤ |
١٫٥٥٢٢٧ % | Driehaus Capital Management, LLC | ١٬٩٣٤٬٧٤٧ | ٦٦٬٩٤٠ | ٣٠/٦/٢٠٢٤ |
١٫٥٤٧٩٤ % | Westfield Capital Management Company, L.P. | ١٬٩٢٩٬٣٤٨ | ٣٤٣٬٢٥٣ | ٣٠/٦/٢٠٢٤ |
١٫٤٩٤٣٩ % | Perceptive Advisors LLC | ١٬٨٦٢٬٦٠٨ | -٧٠٬١٥١ | ٣٠/٦/٢٠٢٤ |
١٫٤٢٤٢٣ % | Fidelity Institutional Asset Management | ١٬٧٧٥٬١٦٥ | ١٤٤٬٦٤٧ | ٣٠/٦/٢٠٢٤ |
١٫٣٩١٨٧ % | AllianceBernstein L.P. | ١٬٧٣٤٬٨٢١ | -٤٥٬٨٨٢ | ٣٠/٦/٢٠٢٤ |
١٫١٠٩٧٠ % | Jennison Associates LLC | ١٬٣٨٣٬١٣١ | ١٢٦٬٢٤٨ | ٣٠/٦/٢٠٢٤ |
١٫٠٥١٣٨ % | Fred Alger Management, LLC | ١٬٣١٠٬٤٣٦ | -٨٦٬٢٧٥ | ٣٠/٦/٢٠٢٤ |
١٫٠٤٧٠٢ % | Commodore Capital LP | ١٬٣٠٥٬٠٠٠ | ٤٤٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٩٨٢٥٣ % | BlackRock Financial Management, Inc. | ١٬٢٢٤٬٦٢١ | ٤٥٬٠٦٩ | ٣٠/٦/٢٠٢٤ |
٠٫٨٨٢٥٤ % | Cormorant Asset Management, LP | ١٬١٠٠٬٠٠٠ | ٤١٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٨٣٣٩٣ % | Frazier Life Sciences Management, L.P. | ١٬٠٣٩٬٤٠٥ | -١٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٨١٧٥٨ % | Invesco Advisers, Inc. | ١٬٠١٩٬٠٣٥ | -١٬٨٥٨ | ٣٠/٦/٢٠٢٤ |
٠٫٨٠٤٩٩ % | JP Morgan Asset Management | ١٬٠٠٣٬٣٣٦ | ٣٧٬٨٣٦ | ٣٠/٦/٢٠٢٤ |
٠٫٧٨٩٨٥ % | Norges Bank Investment Management (NBIM) | ٩٨٤٬٤٦٤ | ٦٨٬٩٥٢ | ٣٠/٦/٢٠٢٤ |
٠٫٧٢٣٨٤ % | Fidelity Investments Canada ULC | ٩٠٢٬١٩٧ | ٧٬٢٦٧ | ٣٠/٦/٢٠٢٤ |
٠٫٧٠٣٠١ % | Charles Schwab Investment Management, Inc. | ٨٧٦٬٢٣٧ | ٤٢٬٦١٩ | ٣٠/٦/٢٠٢٤ |
٠٫٦٧٢٤٥ % | Northern Trust Investments, Inc. | ٨٣٨٬١٤٢ | -٢٨٬٩٢٦ | ٣٠/٦/٢٠٢٤ |
٠٫٦٤٨٥١ % | Braidwell LP | ٨٠٨٬٣٠٣ | -٤٠٤٬٤٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٦٣٨٥٦ % | OrbiMed Advisors, LLC | ٧٩٥٬٩٠٠ | -٢٧٠٬٢٣١ | ٣٠/٦/٢٠٢٤ |
٠٫٦٣٦٢٦ % | Pivotal Bioventure Partners Investment Advisor LLC | ٧٩٣٬٠٣٦ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٦٠٤٣٣ % | Kynam Capital Management LP | ٧٥٣٬٢٤٠ | ٨٬٢٤٠ | ٣٠/٦/٢٠٢٤ |
٠٫٦٠١٧٣ % | Novo Holdings A/S | ٧٥٠٬٠٠٠ | -٢٠٠٬٠٠٠ | ٣٠/٩/٢٠٢٤ |
٠٫٥٩٣٠٣ % | Eventide Asset Management, LLC | ٧٣٩٬١٥٣ | ٨١٬٩٤٧ | ٣٠/٦/٢٠٢٤ |
٠٫٥٦٧١٦ % | Woodline Partners LP | ٧٠٦٬٩٠٣ | ٣١٣٬١٩٩ | ٣٠/٦/٢٠٢٤ |
٠٫٥٥١٩٢ % | Maverick Capital, Ltd. | ٦٨٧٬٩٠٨ | ٣٣٢٬٧٧٧ | ٣٠/٦/٢٠٢٤ |
٠٫٥٠٣٢١ % | Paradigm BioCapital Advisors LP | ٦٢٧٬٢٠٢ | -٦١٢٬٧٩٣ | ٣٠/٦/٢٠٢٤ |
٠٫٤٦١٣٣ % | Avoro Capital Advisors LLC | ٥٧٥٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٤٢٧٥٥ % | Pictet Asset Management Ltd. | ٥٣٢٬٩٠٤ | -٣٢٨٬٦٦٥ | ٣٠/٦/٢٠٢٤ |
٠٫٤٢٣٢٩ % | American Century Investment Management, Inc. | ٥٢٧٬٥٩٤ | ٦٥٬٨٧٠ | ٣٠/٦/٢٠٢٤ |
٠٫٣٧١٢١ % | Ensign Peak Advisors, Inc. | ٤٦٢٬٦٨٢ | -١٣٬٠١٨ | ٣٠/٦/٢٠٢٤ |
٠٫٣٥٤٨٧ % | Amundi Asset Management US, Inc. | ٤٤٢٬٣٠٨ | ١٣٩٬٩٥١ | ٣٠/٦/٢٠٢٤ |
٠٫٣٤٣٢١ % | Pickering (Grant E) | ٤٢٧٬٧٧٩ | -١٥٬٠٠٠ | ٨/١٠/٢٠٢٤ |
٠٫٣٤١٥٠ % | Federated Hermes Global Investment Management Corp. | ٤٢٥٬٦٤٠ | -١١٠ | ٣٠/٦/٢٠٢٤ |
٠٫٣٣٥٩٤ % | Balyasny Asset Management LP | ٤١٨٬٧١٥ | ٤١٨٬٧١٥ | ٣٠/٦/٢٠٢٤ |
٠٫٣٠٩٢٩ % | BofA Global Research (US) | ٣٨٥٬٤٩٤ | ١٧٥٬٤٢٠ | ٣٠/٦/٢٠٢٤ |
٠٫٣٠٥٣٨ % | Goldman Sachs & Company, Inc. | ٣٨٠٬٦٢٩ | -٣١٬١٧٥ | ٣٠/٦/٢٠٢٤ |
٠٫٢٩٤٦٢ % | Brown Advisory | ٣٦٧٬٢١٧ | ٣١٦٬٧٣٤ | ٣٠/٦/٢٠٢٤ |
٠٫٢٧٩٠٠ % | Goldman Sachs Asset Management, L.P. | ٣٤٧٬٧٤٧ | ٦١٬٠٥٩ | ٣٠/٦/٢٠٢٤ |
٠٫٢٧٨٧٨ % | Allspring Global Investments, LLC | ٣٤٧٬٤٧٤ | ٣٬٩٢٢ | ٣٠/٩/٢٠٢٤ |
٠٫٢٥٤٥٩ % | Nuveen LLC | ٣١٧٬٣٢٣ | ١٠٬٠٥٢ | ٣٠/٦/٢٠٢٤ |
٠٫٢٥٠٦٦ % | TD Asset Management Inc. | ٣١٢٬٤٢٦ | ٣١٬١٣٨ | ٣٠/٦/٢٠٢٤ |
٠٫٢٤٦٧٢ % | Victory Capital Management Inc. | ٣٠٧٬٥١٦ | ٢٦٬٦٤١ | ٣٠/٦/٢٠٢٤ |
٠٫٢٤٢٥٦ % | BlackRock Investment Management, LLC | ٣٠٢٬٣٢٧ | ٢٣٬٤٤٦ | ٣٠/٦/٢٠٢٤ |
٠٫٢٤٠٦٩ % | EcoR1 Capital, LLC | ٣٠٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٢٤٠٦٩ % | Tang Capital Management, LLC | ٣٠٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٢٣٢٦٧ % | Farallon Capital Management, L.L.C. | ٢٩٠٬٠٠٠ | -٨٧٬٤٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٩١٧ % | Putnam Investment Management, L.L.C. | ٢٨٥٬٦٤٠ | ٤١٬١٧١ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٧٨٦ % | Avidity Partners Management LP | ٢٨٤٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٧٢٢ % | BlackRock Investment Management (UK) Ltd. | ٢٨٣٬٢٠٤ | ٢٦٬٤٦٤ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٦٥٣ % | Eagle Asset Management, Inc. | ٢٨٢٬٣٥١ | -٥٦٬٤٤٩ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٤١٦ % | Voya Investment Management LLC | ٢٧٩٬٣٩٨ | ٩٦٬٢٦٧ | ٣٠/٦/٢٠٢٤ |
٠٫٢١٩٥٢ % | Cercano Management LLC | ٢٧٣٬٦٠٨ | ١٬٤٥٧ | ٣٠/٦/٢٠٢٤ |
٠٫٢١٩٠٥ % | Comerica, Inc. | ٢٧٣٬٠٢٥ | ٨٤٬٩٤١ | ٣٠/٦/٢٠٢٤ |
٠٫٢١٤٩٥ % | BNY Mellon Asset Management | ٢٦٧٬٩١٥ | ٢٠٬٨٥٥ | ٣٠/٦/٢٠٢٤ |
٠٫٢٠٨٩٥ % | Columbia Threadneedle Investments (US) | ٢٦٠٬٤٣١ | ١٦٢٬٠١٢ | ٣٠/٦/٢٠٢٤ |
٠٫٢٠٨٨٣ % | First Turn Management, LLC | ٢٦٠٬٢٨١ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫١٩٧٥٦ % | Lord, Abbett & Co. LLC | ٢٤٦٬٢٤٢ | -١٣٨٬١٢١ | ٣٠/٦/٢٠٢٤ |
٠٫١٨٤٧٠ % | D. E. Shaw & Co., L.P. | ٢٣٠٬٢٠٧ | -١٣٧٬٠٤٢ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٧٥٥ % | Morgan Stanley & Co. LLC | ٢٢١٬٢٩٦ | -٧٢٬٤١٥ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٣٠٤ % | Saturn V Capital Management LP | ٢١٥٬٦٨٠ | ٣٠٬٥٠٥ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٣٤٦ % | Millennium Management LLC | ٢٠٣٬٧٣١ | -٣٬٢٥١ | ٣٠/٦/٢٠٢٤ |
٠٫١٤٩٣٤ % | ClearBridge Investments, LLC | ١٨٦٬١٤١ | ١٨٦٬١٤١ | ٣٠/٦/٢٠٢٤ |
٠٫١٤٨٦٣ % | Soleus Capital Management, L.P. | ١٨٥٬٢٥٠ | -٢٢٬٥٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٤٧٦٢ % | BlackRock Advisors (UK) Limited | ١٨٣٬٩٨٨ | ٣٬٢٩٣ | ٣٠/٩/٢٠٢٤ |
٠٫١٤٥٦٧ % | Parametric Portfolio Associates LLC | ١٨١٬٥٦٣ | -٧٬٦١٤ | ٣٠/٦/٢٠٢٤ |
٠٫١٤٥٤٦ % | Schweizerische Nationalbank | ١٨١٬٣٠٠ | ٣٬٣٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٤١٣٥ % | Mellon Investments Corporation | ١٧٦٬١٨٢ | ٣٠٬٠٠٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٣٣٠٢ % | Citi Investment Research (US) | ١٦٥٬٧٩٥ | ٢٠٬٩٢٨ | ٣٠/٦/٢٠٢٤ |
٠٫١٣٢٢٦ % | SEI Investments Management Corporation | ١٦٤٬٨٤٣ | ٦٧٬٩٣٩ | ٣٠/٦/٢٠٢٤ |
٠٫١٣٠٣٢ % | Segall Bryant & Hamill, LLC | ١٦٢٬٤٣٢ | ٤٬٤١١ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٧٨٠ % | Rhumbline Advisers Ltd. Partnership | ١٥٩٬٢٩٥ | ١١٬٠٠١ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٧٥٨ % | Macquarie Investment Management | ١٥٩٬٠١٢ | ٣٩٬٠٣٩ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٦٩٥ % | BlackRock Asset Management Ireland Limited | ١٥٨٬٢٣٥ | ١٬٢٣٦ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٢٥٨ % | California Public Employees' Retirement System | ١٥٢٬٧٧٨ | -٤٬٢٠٨ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٠٥٠ % | Parkman Healthcare Partners LLC | ١٥٠٬١٩١ | ٢٣٥ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٠٣٥ % | Ghost Tree Capital, LLC | ١٥٠٬٠٠٠ | ٥٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١١٢١١ % | First Light Asset Management, LLC | ١٣٩٬٧٢٩ | ٧٩٬٤٤٥ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٥٧٠ % | Manulife Investment Management (North America) Limited | ١٣١٬٧٤٩ | ١٢٬٦٦٧ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٢٦٦ % | Barclays Bank PLC | ١٢٧٬٩٥٢ | -١٬٣٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩٢٢٤ % | Pier Capital, LLC | ١١٤٬٩٦٩ | -١٢٬٤١٥ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩٠٩٤ % | Tri Locum Partners LP | ١١٣٬٣٤٤ | ١١٣٬٣٤٤ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٨٥٨ % | Acuta Capital Partners, LLC | ١١٠٬٤٠٠ | ٥٬٥٧٠ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٦٧٢ % | Neuberger Berman, LLC | ١٠٨٬٠٩٢ | ٥٬٧٨١ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٥٥٤ % | Jane Street Capital, L.L.C. | ١٠٦٬٦١١ | ٩٠٬٩٢٩ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٥٠٢ % | JPMorgan Asset Management U.K. Limited | ١٠٥٬٩٧٤ | ١٬٠٥٢ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٤٢٣ % | Legal & General Investment Management Ltd. | ١٠٤٬٩٨٤ | ١٠٬٢٠١ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٣٣٦ % | MFS Investment Management | ١٠٣٬٩٠٦ | ٢٬٩٦٧ | ٣١/٨/٢٠٢٤ |