٩٫٨٨٤٤٧ % | The Vanguard Group, Inc. | ١٦٬٥٧٩٬٩٧٧ | -٤٨٩٬٥٢٣ | ٣١/٣/٢٠٢٥ |
٨٫٠٦٨٩٦ % | Farallon Capital Management, L.L.C. | ١٣٬٥٣٤٬٦٩٢ | ٢٨٦٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٧٫٦٢٢٥٣ % | BlackRock Institutional Trust Company, N.A. | ١٢٬٧٨٥٬٨٤٩ | ١٥١٬١٤٢ | ٣١/٣/٢٠٢٥ |
٧٫٠٢٧٥٩ % | Wellington Management Company, LLP | ١١٬٧٨٧٬٩٢١ | ٩٦٦٬٢٣٠ | ٣١/٣/٢٠٢٥ |
٦٫٠٧٥٠٠ % | Janus Henderson Investors | ١٠٬١٩٠٬٠٧١ | ٧٠٦٬٠٧٢ | ٣١/٣/٢٠٢٥ |
٤٫٧٣١٧٨ % | Baker Bros. Advisors LP | ٧٬٩٣٦٬٩٧٢ | 0 | ٣١/٣/٢٠٢٥ |
٤٫٥٣١٥٣ % | Nextech Invest, Ltd. | ٧٬٦٠١٬٠٨٧ | 0 | ٣١/٣/٢٠٢٥ |
٤٫٤١٤٨٣ % | Fidelity Management & Research Company LLC | ٧٬٤٠٥٬٣٤١ | ٨٧٦٬٧٥٦ | ٣١/٣/٢٠٢٥ |
٣٫٦٨٣٢٠ % | Paradigm BioCapital Advisors LP | ٦٬١٧٨٬١١١ | -٣٧٥٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٣٫٤٦٠٧١ % | State Street Global Advisors (US) | ٥٬٨٠٤٬٩١٩ | ١٣٬١٦٧ | ٣١/٣/٢٠٢٥ |
٣٫٢٤٠١٠ % | T. Rowe Price Associates, Inc. | ٥٬٤٣٤٬٨٦٨ | -٢٨٣٬٠٣٢ | ٣١/٣/٢٠٢٥ |
٢٫٩٧٠٣٤ % | BVF Partners L.P. | ٤٬٩٨٢٬٣٨٤ | ٨٠١٬٢٠٥ | ٣١/٣/٢٠٢٥ |
٢٫٦٠٧٨٢ % | Bellevue Asset Management AG | ٤٬٣٧٤٬٣٠٠ | -١٢٬٦٠٠ | ٣١/٣/٢٠٢٥ |
٢٫٤٦٩٥٨ % | Geode Capital Management, L.L.C. | ٤٬١٤٢٬٤١٤ | ٥٦٬٢١٥ | ٣١/٣/٢٠٢٥ |
٢٫٤٦٤١٣ % | Alphabet, Inc. | ٤٬١٣٣٬٢٧٧ | 0 | ٣١/٣/٢٠٢٥ |
٢٫٣١٧٣٣ % | Woodline Partners LP | ٣٬٨٨٧٬٠٣٦ | ١٬٣٢٣ | ٣١/٣/٢٠٢٥ |
٢٫٢٠٤٥٩ % | Casdin Capital, LLC | ٣٬٦٩٧٬٩٣٣ | -١٬٣٥٠ | ٣١/٣/٢٠٢٥ |
٢٫٢٠٠٩٠ % | Holocene Advisors, LP | ٣٬٦٩١٬٧٤٤ | ٦٩٥٬٠٣٤ | ٣١/٣/٢٠٢٥ |
١٫٩٧٧٦٩ % | Deerfield Management Company, L.P. | ٣٬٣١٧٬٣٣٢ | ٥٩٬٠٠٠ | ٣١/٣/٢٠٢٥ |
١٫٦٩٦٦٨ % | JP Morgan Asset Management | ٢٬٨٤٥٬٩٧١ | ٣٬٥٤٧ | ٣١/٣/٢٠٢٥ |
١٫٦٣٨٥٨ % | Andreessen Horowitz | ٢٬٧٤٨٬٥٢٣ | 0 | ٣١/٣/٢٠٢٥ |
١٫٣٨٩٩٦ % | Borisy (Alexis) | ٢٬٣٣١٬٤٩٤ | ٩٥٢ | ٣١/٣/٢٠٢٥ |
١٫٣٠٩٣١ % | Lunate Capital LLC | ٢٬١٩٦٬٢٠٠ | 0 | ٣١/٣/٢٠٢٥ |
١٫١٥٠٨٨ % | Charles Schwab Investment Management, Inc. | ١٬٩٣٠٬٤٦٨ | -٦٤٦ | ٣١/٣/٢٠٢٥ |
١٫٠٣٨٥٥ % | Norges Bank Investment Management (NBIM) | ١٬٧٤٢٬٠٣٩ | -١٠٦٬٦٠٨ | ٣١/١٢/٢٠٢٤ |
١٫٠٢٣٦٥ % | Hood River Capital Management LLC | ١٬٧١٧٬٠٤٨ | ٣٨٬٦١٤ | ٣١/٣/٢٠٢٥ |
٠٫٩٩٧٦٥ % | T. Rowe Price Investment Management, Inc. | ١٬٦٧٣٬٤٢٩ | ١٬٦٧٣٬٤٢٩ | ٣١/٣/٢٠٢٥ |
٠٫٩٥٣٨٧ % | Logos Global Management LP | ١٬٦٠٠٬٠٠٠ | ١٥٠٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٠٫٨٤٤٧٨ % | Northern Trust Investments, Inc. | ١٬٤١٧٬٠٢٢ | -٤٧٬٩٥٦ | ٣١/٣/٢٠٢٥ |
٠٫٨٠٢٥٣ % | Goldman Sachs & Company, Inc. | ١٬٣٤٦٬١٤٤ | -٤٩٦٬٠٩٢ | ٣١/٣/٢٠٢٥ |
٠٫٧٨٥٧٤ % | Boxer Capital Management, LLC | ١٬٣١٧٬٩٧٧ | -٢٬٩٦١٬٤٨٧ | ٣١/٣/٢٠٢٥ |
٠٫٧٦٤٠٧ % | Rock Springs Capital Management LP | ١٬٢٨١٬٦٤٠ | ٦٨٬٣٨٣ | ٣١/٣/٢٠٢٥ |
٠٫٦٤٣٠٧ % | Columbia Threadneedle Investments (UK) | ١٬٠٧٨٬٦٦٤ | ٧١٬٨٩١ | ٣١/٣/٢٠٢٥ |
٠٫٦٣٤٣٥ % | Westfield Capital Management Company, L.P. | ١٬٠٦٤٬٠٤٦ | ١٬٠٥٨٬٢٤٧ | ٣١/٣/٢٠٢٥ |
٠٫٥٩٤٦٥ % | Frazier Life Sciences Management, L.P. | ٩٩٧٬٤٥٥ | 0 | ٣١/٣/٢٠٢٥ |
٠٫٥٧٩٨٤ % | Morgan Stanley & Co. LLC | ٩٧٢٬٦١٠ | ٤٠٩٬٥٤٩ | ٣١/٣/٢٠٢٥ |
٠٫٤٨٣٢١ % | Goldman Sachs Asset Management, L.P. | ٨١٠٬٥٣٢ | ٣٦٬٤٥٠ | ٣١/٣/٢٠٢٥ |
٠٫٤٤٧٥٢ % | Polar Capital LLP | ٧٥٠٬٦٦٥ | 0 | ٣١/٣/٢٠٢٥ |
٠٫٤٤٥٦٧ % | Pictet Asset Management Ltd. | ٧٤٧٬٥٦٠ | ٣٤٬٩٦٤ | ٣١/٣/٢٠٢٥ |
٠٫٤٤٢٢٧ % | American Century Investment Management, Inc. | ٧٤١٬٨٦٠ | ١٠٠٬٢١٤ | ٣١/٣/٢٠٢٥ |
٠٫٤٤٠٩١ % | BlackRock Financial Management, Inc. | ٧٣٩٬٥٧٤ | -١٨٤٬٦١٢ | ٣١/٣/٢٠٢٥ |
٠٫٤٤٠٢٦ % | Candriam Luxembourg S.A. | ٧٣٨٬٤٨٧ | -٧٧٬٥٣٠ | ٣٠/٤/٢٠٢٥ |
٠٫٤٢٠٣٧ % | Goldsmith Mark A | ٧٠٥٬١١٦ | ٥٣٬٧٧٥ | ٣١/٣/٢٠٢٥ |
٠٫٤١٢١١ % | Finepoint Capital LP | ٦٩١٬٢٦٠ | -١٩٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٠٫٣٩١١٩ % | Dafna Capital Management, LLC | ٦٥٦٬١٧٦ | ٢٥٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٠٫٣٩٠٥٧ % | Candriam Belgium S.A. | ٦٥٥٬١٣٤ | -١٬٦٠٦ | ٣١/٣/٢٠٢٥ |
٠٫٣٦٣٣٠ % | Citi Investment Research (US) | ٦٠٩٬٣٨٨ | ٣٤٠٬٩٣٤ | ٣١/٣/٢٠٢٥ |
٠٫٣٣٦٠٩ % | Invus Public Equities Advisors, LLC | ٥٦٣٬٧٥٥ | -٧٬٧٩٣ | ٣١/٣/٢٠٢٥ |
٠٫٣١٢٦٥ % | BNP Paribas Securities Corp. North America | ٥٢٤٬٤٢٨ | ٢٧٦٬١٠٢ | ٣١/٣/٢٠٢٥ |
٠٫٣٠٩٥٣ % | JPMorgan Asset Management U.K. Limited | ٥١٩٬١٩٢ | ٤٧٬١٩١ | ٣١/٣/٢٠٢٥ |
٠٫٣٠٣١٩ % | MIC Capital Management UK LLP | ٥٠٨٬٥٦٩ | 0 | ٣١/٣/٢٠٢٥ |
٠٫٢٨٧٣٥ % | BlackRock Advisors (UK) Limited | ٤٨١٬٩٨٩ | -٥٬١٠٦ | ٣١/٥/٢٠٢٥ |
٠٫٢٨٤١٤ % | UBS Financial Services, Inc. | ٤٧٦٬٦٠٧ | ١٨١٬٨٧٩ | ٣١/٣/٢٠٢٥ |
٠٫٢٧٧٧٧ % | BlackRock Asset Management Ireland Limited | ٤٦٥٬٩٣١ | ١٤٬٩٢٨ | ٣١/٣/٢٠٢٥ |
٠٫٢٧٧٢٢ % | Caligan Partners, LP | ٤٦٥٬٠٠٠ | ٤٦٥٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٠٫٢٧٣٩٠ % | Nuveen LLC | ٤٥٩٬٤٢٧ | ٣٧٬٣٨٦ | ٣١/٣/٢٠٢٥ |
٠٫٢٦٥٣٠ % | BlackRock Investment Management, LLC | ٤٤٥٬٠٠٧ | -٣٬٨٩٥ | ٣١/٣/٢٠٢٥ |
٠٫٢٥٤٨٤ % | Ensign Peak Advisors, Inc. | ٤٢٧٬٤٦٦ | ١٢٢٬٢٩٤ | ٣١/٣/٢٠٢٥ |
٠٫٢٣٤٨٩ % | Adage Capital Management, L.P. | ٣٩٤٬٠٠٠ | -٢٥٦٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٠٫٢٣٣٧٠ % | Checkpoint Capital L.P. | ٣٩٢٬٠١١ | ١٨٢٬٠١١ | ٣١/٣/٢٠٢٥ |
٠٫٢٣٢٥٩ % | Pzena Investment Management, LLC | ٣٩٠٬١٣٣ | -٦٨٬٣٢١ | ٣١/٣/٢٠٢٥ |
٠٫٢٢٢٨٢ % | Dimensional Fund Advisors, L.P. | ٣٧٣٬٧٥٤ | -١٤٬٠٢١ | ٣١/٣/٢٠٢٥ |
٠٫٢٢١٩١ % | Eventide Asset Management, LLC | ٣٧٢٬٢٢٩ | 0 | ٣١/٣/٢٠٢٥ |
٠٫٢١٩١٧ % | Lord, Abbett & Co. LLC | ٣٦٧٬٦٣٠ | -١٬٦١١٬٠٩٠ | ٣١/٣/٢٠٢٥ |
٠٫٢١٤٨٦ % | JPMorgan Asset Management (Europe) S.à.r.l. | ٣٦٠٬٤٠٥ | ٤٩٬٨٩٩ | ٣١/٣/٢٠٢٥ |
٠٫٢٠٨٢٠ % | BofA Global Research (US) | ٣٤٩٬٢٣١ | ٣٨٬٤١٨ | ٣١/٣/٢٠٢٥ |
٠٫٢٠٢٧٦ % | First Turn Management, LLC | ٣٤٠٬١٠٩ | -٦٣٬٨٠٦ | ٣١/٣/٢٠٢٥ |
٠٫٢٠١٦٢ % | Partners HealthCare System, Inc | ٣٣٨٬١٩١ | 0 | ٣٠/٩/٢٠٢٤ |
٠٫٢٠١٤٣ % | Victory Capital Management Inc. | ٣٣٧٬٨٨١ | -٩٢٬٥٨١ | ٣١/٣/٢٠٢٥ |
٠٫٢٠١١٥ % | Jane Street Capital, L.L.C. | ٣٣٧٬٤٠٢ | ٢٧٣٬٤٧١ | ٣١/٣/٢٠٢٥ |
٠٫١٩٤٢٨ % | TD Asset Management Inc. | ٣٢٥٬٨٧٦ | ٤٤٬٤٩٠ | ٣١/٣/٢٠٢٥ |
٠٫١٩٠٤٧ % | Voya Investment Management LLC | ٣١٩٬٤٩١ | ٣٬٤٦٣ | ٣١/٣/٢٠٢٥ |
٠٫١٩٠٠٥ % | StemPoint Capital LP | ٣١٨٬٧٨٢ | ١٢٥٬٢٤٧ | ٣١/٣/٢٠٢٥ |
٠٫١٨٩٠٤ % | MPM BioImpact LLC | ٣١٧٬٠٨٣ | ٣٬٢٦٦ | ٣١/٣/٢٠٢٥ |
٠٫١٨١٤٣ % | BNY Mellon Asset Management | ٣٠٤٬٣٣٠ | ٩٬٧٣٢ | ٣١/٣/٢٠٢٥ |
٠٫١٦٤٨٦ % | Schweizerische Nationalbank | ٢٧٦٬٥٣١ | ٤٦٬٦٠٠ | ٣١/٣/٢٠٢٥ |
٠٫١٦٤٦٨ % | Russell Investments Trust Company | ٢٧٦٬٢٣٠ | ٢٧١٬٩٨٧ | ٣١/٣/٢٠٢٥ |
٠٫١٦٢٠٣ % | Barclays Bank PLC | ٢٧١٬٧٨٦ | -١٣٤٬٧٨٩ | ٣١/٣/٢٠٢٥ |
٠٫١٥٣٣٠ % | Rhumbline Advisers Ltd. Partnership | ٢٥٧٬١٥٠ | ٥٬٦٨٥ | ٣١/٣/٢٠٢٥ |
٠٫١٤٩٠٥ % | Mellon Investments Corporation | ٢٥٠٬٠١١ | ٣٠٣ | ٣١/٣/٢٠٢٥ |
٠٫١٤٩٠٤ % | Integral Health Asset Management, LLC | ٢٥٠٬٠٠٠ | -٣٠٠٬٠٠٠ | ٣١/٣/٢٠٢٥ |
٠٫١٤٦٦٦ % | WCM Investment Management | ٢٤٥٬٩٩٧ | ٨٨٬٥٢٠ | ٣١/٣/٢٠٢٥ |
٠٫١٤٥٥٠ % | Susquehanna International Group, LLP | ٢٤٤٬٠٥٣ | ٩٧٬٨٦٥ | ٣١/٣/٢٠٢٥ |
٠٫١٤٥٢١ % | Bessemer Trust Company, N.A. (US) | ٢٤٣٬٥٧١ | ١٣ | ٣١/٣/٢٠٢٥ |
٠٫١٤٣١٤ % | Manulife Investment Management (North America) Limited | ٢٤٠٬٠٩٥ | ٢٬٥٥٦ | ٣١/٣/٢٠٢٥ |
٠٫١٣٤٧٣ % | Decheng Capital LLC | ٢٢٦٬٠٠٠ | 0 | ٣١/٣/٢٠٢٥ |
٠٫١٢٨٦٠ % | Edgestream Partners, L.P. | ٢١٥٬٧١٧ | ٢٠٧٬٩٣٨ | ٣١/٣/٢٠٢٥ |
٠٫١٢٧٢٥ % | HSBC Private Bank (Suisse) S.A. | ٢١٣٬٤٥٤ | -٣٦٬٣٧٤ | ٣١/٣/٢٠٢٥ |
٠٫١٢٧٢٥ % | HSBC Global Asset Management (France) S.A. | ٢١٣٬٤٥٤ | -٣٦٬٣٧٤ | ٣١/٣/٢٠٢٥ |
٠٫١٢٦٩٨ % | Avidity Partners Management LP | ٢١٣٬٠٠٠ | -٢٣٣٬٢٠٠ | ٣١/٣/٢٠٢٥ |
٠٫١٢٦٩٣ % | California Public Employees' Retirement System | ٢١٢٬٩١٥ | -٥٥٬٣٧٤ | ٣١/٣/٢٠٢٥ |
٠٫١٢٣٠٥ % | Columbia Threadneedle Investments (US) | ٢٠٦٬٣٩٤ | ٢٣٬٣٢٦ | ٣١/٣/٢٠٢٥ |
٠٫١١٥٧٠ % | AllianceBernstein L.P. | ١٩٤٬٠٧٨ | -٤٠٬٨٥١ | ٣١/٣/٢٠٢٥ |
٠٫١١٥٤٩ % | Comerica, Inc. | ١٩٣٬٧١٩ | ١٩٣٬٢٦٧ | ٣١/٣/٢٠٢٥ |
٠٫١١٢٧٦ % | Columbia Wanger Asset Management, LLC | ١٨٩٬١٤٧ | -٢٣١٬٢٦٧ | ٣١/٣/٢٠٢٥ |
٠٫١١٢٢٠ % | Kelsey (Stephen Michael) | ١٨٨٬٢٠١ | ٣٤٬٥١٩ | ٣١/٣/٢٠٢٥ |
٠٫١١١٦٠ % | Marshall Wace LLP | ١٨٧٬١٨٨ | -١٬٣١٧٬٦١٣ | ٣١/٣/٢٠٢٥ |
٠٫١١١٠٣ % | J.P. Morgan Securities LLC | ١٨٦٬٢٤٢ | -١٩٣٬٢٩١ | ٣١/٣/٢٠٢٥ |
٠٫١٠٩٦٠ % | Parametric Portfolio Associates LLC | ١٨٣٬٨٣٩ | -٣٨٬٧٩١ | ٣١/٣/٢٠٢٥ |
٠٫١٠٩١٨ % | Qube Research & Technologies Ltd | ١٨٣٬١٤٠ | -٤٧٬٧٠٥ | ٣١/٣/٢٠٢٥ |