١٩٫٥٠٥٩٧ % | BVF Partners L.P. | ٨٬٢٩١٬٩٨٨ | 0 | ٣١/١٢/٢٠٢٢ |
٧٫٨١٥٧٨ % | OrbiMed Advisors, LLC | ٣٬٣٢٢٬٤٨٨ | 0 | ٣١/١٢/٢٠٢٢ |
٦٫٩٨١٠٧ % | Versant Ventures | ٢٬٩٦٧٬٦٥٢ | -٥٧٧٬٢١٠ | ٢٩/١٢/٢٠٢٢ |
٦٫٥٨٦٩٨ % | Cowen Investment Management LLC | ٢٬٨٠٠٬١٢٦ | -٢٦٩٬٧٢١ | ٣١/١٢/٢٠٢٢ |
٦٫٤١٦٣٩ % | Deep Track Capital LP | ٢٬٧٢٧٬٦٠٦ | -٤٠٠٬٠٦١ | ٣١/١٢/٢٠٢٢ |
٦٫٣١٤٧٤ % | Redmile Group, LLC | ٢٬٦٨٤٬٣٩٦ | 0 | ٣١/١٢/٢٠٢٢ |
٥٫٧١١٧٣ % | ARK Investment Management LLC | ٢٬٤٢٨٬٠٥٥ | -٢٠٣٬٩٧٣ | ٣١/١٢/٢٠٢٢ |
٥٫٢٧٥٥٥ % | MPM Capital Inc. | ٢٬٢٤٢٬٦٣٦ | 0 | ٣١/١٢/٢٠٢٢ |
٤٫٥١١٩٤ % | T. Rowe Price Investment Management, Inc. | ١٬٩١٨٬٠٢٦ | ١٥٥٬٢٨٣ | ٣١/١٢/٢٠٢٢ |
٣٫٨٥٧٥٦ % | BioImpact Capital LLC | ١٬٦٣٩٬٨٤٩ | 0 | ٣١/١٢/٢٠٢٢ |
١٫٦٤٨٢٦ % | Fidelity Institutional Asset Management | ٧٠٠٬٦٧٦ | ٦٩٨٬٤٠٦ | ٣١/١٢/٢٠٢٢ |
١٫٦٤٦٦٧ % | Invus Public Equities Advisors, LLC | ٧٠٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
١٫٥٠٩١١ % | Medical Strategy GmbH | ٦٤١٬٥٢٤ | 0 | ٣٠/٩/٢٠٢٢ |
١٫٤٢٣٨٧ % | Millennium Management LLC | ٦٠٥٬٢٨٧ | ٣٥٧٬٩٦٦ | ٣١/١٢/٢٠٢٢ |
٠٫٦٦٦٠٣ % | BlackRock Institutional Trust Company, N.A. | ٢٨٣٬١٣١ | ٣٠٬٠٦٤ | ٣١/١٢/٢٠٢٢ |
٠٫٦١٣٧١ % | BofA Global Research (US) | ٢٦٠٬٨٨٦ | ٢٤٧٬٩٢٦ | ٣١/١٢/٢٠٢٢ |
٠٫٤٥٢٧٨ % | Citadel Advisors LLC | ١٩٢٬٤٧٨ | -١٢٠٬٧٩٨ | ٣١/١٢/٢٠٢٢ |
٠٫٤٢١٤١ % | Segal (Lloyd Mitchell) | ١٧٩٬١٤٣ | ٧٨٬٥٥٠ | ٣٠/١/٢٠٢٣ |
٠٫٤١٣٩٣ % | Koehler (Maria) | ١٧٥٬٩٦٣ | ٢٦٬٤٥٠ | ٣٠/١/٢٠٢٣ |
٠٫٤١٢٨٥ % | Fidelity Management & Research Company LLC | ١٧٥٬٥٠٢ | ٥٤٢ | ٣١/١٢/٢٠٢٢ |
٠٫٤٠٩٣٩ % | Nikko Asset Management Co., Ltd. | ١٧٤٬٠٣٣ | -١٣٬٠٠٤ | ٣١/١٢/٢٠٢٢ |
٠٫٣٨٧٨٩ % | HighVista Strategies LLC | ١٦٤٬٨٩٠ | -١٣٩٬٢٩١ | ٣١/١٢/٢٠٢٢ |
٠٫٣٨٤٣٨ % | Renaissance Technologies LLC | ١٦٣٬٤٠٠ | ٢٨٬٢٧٩ | ٣١/١٢/٢٠٢٢ |
٠٫٣٧٥٧٩ % | BlackRock Advisors (UK) Limited | ١٥٩٬٧٤٩ | -١٤ | ٢٨/٢/٢٠٢٣ |
٠٫٣٦٧٩٢ % | BlackRock Asset Management Ireland Limited | ١٥٦٬٤٠٢ | ١٠٬١٦٠ | ٣١/١٢/٢٠٢٢ |
٠٫٣١٣١٩ % | UBS Asset Management (Americas), Inc. | ١٣٣٬١٣٨ | ٢٢٬٩٨٦ | ٣١/١٢/٢٠٢٢ |
٠٫٣٠٢٣٣ % | BMO Private Investment Counsel Inc. | ١٢٨٬٥١٩ | -٥٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٢٥٢٣٥ % | D. E. Shaw & Co., L.P. | ١٠٧٬٢٧٤ | ٤١٬٨٩٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٩٩٠٢ % | Ensign Peak Advisors, Inc. | ٨٤٬٦٠٣ | -٦٬٢٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٧٢٩٤ % | The Vanguard Group, Inc. | ٧٣٬٥١٥ | ١٬٢٦٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٧٠٨٣ % | Trexquant Investment LP | ٧٢٬٦١٨ | -٧٬٠٥٦ | ٣١/١٢/٢٠٢٢ |
٠٫١٦٦٠٦ % | Zinda (Michael) | ٧٠٬٥٩١ | ٢٤٬٥٥٠ | ٣٠/١/٢٠٢٣ |
٠٫١٥٢٢٧ % | Versant Venture Capital V (Canada), LP. | ٦٤٬٧٣١ | -٨٠٬١٤٨ | ٦/٦/٢٠٢٢ |
٠٫١٢٥٤٥ % | State Street Global Advisors (US) | ٥٣٬٣٣٠ | -١٤٥ | ٣١/١٢/٢٠٢٢ |
٠٫١٢٥١١ % | Dimensional Fund Advisors, L.P. | ٥٣٬١٨٥ | ٤٠٬٢٠٦ | ٣١/١٢/٢٠٢٢ |
٠٫١٠٨٨٣ % | Parametric Portfolio Associates LLC | ٤٦٬٢٦٢ | -٢٥٬٣١٥ | ٣١/١٢/٢٠٢٢ |
٠٫١٠٧٠٣ % | Schweizerische Nationalbank | ٤٥٬٥٠٠ | ١٬٢٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٩٢٨٩ % | Marshall Wace LLP | ٣٩٬٤٨٩ | ٣٩٬٤٨٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٩١٤٣ % | Goldman Sachs & Company, Inc. | ٣٨٬٨٦٧ | ١٠٬٧٦٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٨١٣٣ % | Harbor Capital Advisors, Inc. | ٣٤٬٥٧٢ | ٣٢٬٢٥٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٢١٩ % | Forte (Steve) | ٣٠٬٦٨٧ | ٢٤٬٥٣٠ | ٣٠/١/٢٠٢٣ |
٠٫٠٧١٠٢ % | Susquehanna International Group, LLP | ٣٠٬١٨٩ | ٣٠٬١٨٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٨٥٧ % | Tekla Capital Management LLC | ٢٩٬١٥٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٦٧٠ % | Algert Global LLC | ٢٨٬٣٥٥ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٦٦٢ % | Versant Ophthalmic Affiliates Fund I, L.P. | ٢٨٬٣٢٢ | -٣٥٬٠٦٥ | ٦/٦/٢٠٢٢ |
٠٫٠٦٦٣٣ % | Jane Street Capital, L.L.C. | ٢٨٬١٩٧ | ٢٨٬١٩٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٥٨٧ % | Jump Financial, LLC | ٢٨٬٠٠٠ | ٩٬٨٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٣٢٧ % | T. Rowe Price Associates, Inc. | ٢٦٬٨٩٤ | ٨٬٥٦٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٢٤٤ % | Geode Capital Management, L.L.C. | ٢٦٬٥٤٤ | ٥٬١٤٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦١٥٥ % | Acadian Asset Management LLC | ٢٦٬١٦٥ | ٢٦٬١٦٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٠١٩ % | Versant Affiliates Fund V, L.P. | ٢٥٬٥٨٧ | -٣١٬٦٧٧ | ٦/٦/٢٠٢٢ |
٠٫٠٦٠١٧ % | Goldman Sachs Asset Management, L.P. | ٢٥٬٥٧٧ | ٤٬٣٧٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٩١٢ % | Davis (Jerel C) | ٢٥٬١٣١ | ٤٬٢٥٤ | ٢٩/١٢/٢٠٢٢ |
٠٫٠٥٨٧٤ % | XTX Markets LLC | ٢٤٬٩٦٩ | ٢٤٬٩٦٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٧٦٢ % | Assenagon Asset Management S.A. | ٢٤٬٤٩٥ | -١٬٠١٠ | ٢٨/٢/٢٠٢٣ |
٠٫٠٥٣٥٤ % | TD Asset Management Inc. | ٢٢٬٧٥٨ | -٦٬٥٠٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٣١٥ % | The Blackstone Group | ٢٢٬٥٩٥ | ٣٬٤٢٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٣٠٠ % | HRT Financial LP | ٢٢٬٥٢٩ | ٢٢٬٥٢٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٠٨٨ % | Nuveen LLC | ٢١٬٦٣٠ | -١٨٨ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٠٠٩ % | Credit Suisse Asset Management | ٢١٬٢٩٣ | ٧٬٠٤٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٧١٨ % | Fred Alger Management, LLC | ٢٠٬٠٥٥ | -٤٬٢٥٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٦٥٩ % | Black (Cameron) | ١٩٬٨٠٤ | ٧٢٩ | ١٥/٢/٢٠٢٢ |
٠٫٠٤٦٠٨ % | Cubist Systematic Strategies, LLC | ١٩٬٥٩٠ | ١٩٬٥٩٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٣٦٣ % | Apo Asset Management GmbH | ١٨٬٥٤٥ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٤٢٦٨ % | Morgan Stanley & Co. LLC | ١٨٬١٤٣ | -١٠٬٧٦٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤١٨٩ % | AQR Capital Management, LLC | ١٧٬٨٠٧ | ١٧٬٨٠٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٠٠٧ % | Tudor Investment Corporation | ١٧٬٠٣٤ | ١٧٬٠٣٤ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٨٥٥ % | California State Teachers Retirement System | ١٦٬٣٨٦ | ١٦٤ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٨٢٤ % | State of Wisconsin Investment Board | ١٦٬٢٥٦ | -١٬١٤١ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٦٨٢ % | Two Sigma Investments, LP | ١٥٬٦٥٣ | ١٥٬٦٥٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٦٢٦ % | Difesa Capital Management, LP | ١٥٬٤١٦ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٦٢١ % | Northern Trust Investments, Inc. | ١٥٬٣٩٢ | ١٬٠٤٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٤٣٤ % | Deka Investment GmbH | ١٤٬٦٠٠ | ١٬٣٠٠ | ٣٠/٦/٢٠٢٢ |
٠٫٠٣٤٣٤ % | Deka Vermögensmanagement GmbH | ١٤٬٦٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٣٩٩ % | BlackRock Financial Management, Inc. | ١٤٬٤٥٠ | ٧٬٢٣٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٢٨٩٦ % | SETH KIM | ١٢٬٣١٢ | ١١٬٦٢٥ | ٢/١٢/٢٠٢١ |
٠٫٠٢٨٨٨ % | HarbourVest Partners, L.L.C. | ١٢٬٢٧٦ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٢٨٨٧ % | DuPont Capital Management Corporation | ١٢٬٢٧١ | ١٢٬٢٧١ | ٣١/١٢/٢٠٢٢ |
٠٫٠٢٧٨٠ % | Emerge Canada Inc | ١١٬٨١٦ | -١٬٢٠٤ | ٣١/١/٢٠٢٣ |
٠٫٠٢٦٥٥ % | UBS Asset Management (Switzerland) | ١١٬٢٨٦ | -٩٠٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٢٦٥٢ % | Morgan Stanley Smith Barney LLC | ١١٬٢٧٣ | -٣٥٬٢٠٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٢٥٨٨ % | Abaris Investment Management AG | ١١٬٠٠٠ | 0 | ٣١/١٢/٢٠٢١ |
٠٫٠٢٥٠٩ % | Qube Research & Technologies Ltd | ١٠٬٦٦٤ | -١٬٥٦٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٢٢١٧ % | Virtus Etf Advisers LLC | ٩٬٤٢٦ | ١٬٧٨٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠١٨٨٢ % | Schafer (Carol Anne) | ٨٬٠٠٠ | 0 | ١٥/٣/٢٠٢٢ |
٠٫٠١٨٣٢ % | Lazard Asset Management, L.L.C. | ٧٬٧٨٨ | ٧٬٧٨٨ | ٣١/١٢/٢٠٢٢ |
٠٫٠١٧٦٤ % | Civik (Thomas) | ٧٬٥٠٠ | 0 | ١٥/٣/٢٠٢٢ |
٠٫٠١٥٩٩ % | Simplex Trading, LLC | ٦٬٧٩٧ | ٦٬٧٧٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠١٢٩٤ % | Handelsbanken Kapitalförvaltning AB | ٥٬٥٠٠ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠١١٨٦ % | UBS Financial Services, Inc. | ٥٬٠٤٢ | ١٬٤٩١ | ٣١/١٢/٢٠٢٢ |
٠٫٠١١٢٩ % | Morrison Briggs W | ٤٬٨٠٠ | 0 | ١٥/٣/٢٠٢٢ |
٠٫٠١٠٩٠ % | Legal & General Investment Management Ltd. | ٤٬٦٣٣ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠١٠٢٧ % | American Century Investment Management, Inc. | ٤٬٣٦٧ | ٢٬٨٤٨ | ٣١/١٢/٢٠٢٢ |
٠٫٠٠٩٧٢ % | BlackRock Investment Management (UK) Ltd. | ٤٬١٣٣ | ١٧٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٠٩٧٠ % | Dimensional Fund Advisors, Ltd. | ٤٬١٢٤ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٠٩٤١ % | KLP Fondsforvaltning AS | ٤٬٠٠٠ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٠٩٤١ % | Rhoads (Ann D) | ٤٬٠٠٠ | 0 | ١٥/٣/٢٠٢٢ |
٠٫٠٠٩٣٦ % | Northern Trust Global Investments | ٣٬٩٧٧ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٠٨٤٢ % | Northern Trust Global Investments Limited | ٣٬٥٧٨ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٠٧٦٢ % | ProShare Advisors LLC | ٣٬٢٣٩ | -٣٤٥ | ٢٨/٢/٢٠٢٣ |