٦٫٩٥٩٩٤ % | Commodore Capital LP | ٤٬٧٤٧٬٣٧٣ | ٣١٩٬٣٠١ | ٣١/١٢/٢٠٢٣ |
٥٫٨٧٠٩٠ % | Incyte Corp | ٤٬٠٠٤٬٥٤٤ | 0 | ٢٥/٣/٢٠٢٤ |
٥٫٠٠٢٨٠ % | Samlyn Capital, LLC | ٣٬٤١٢٬٤١٠ | ١٥٥٬٨٩٢ | ٣١/١٢/٢٠٢٣ |
٤٫٤٢٧٣٦ % | Deerfield Management Company, L.P. | ٣٬٠١٩٬٩٠١ | -٨٥٧٬٠٣٧ | ٣١/١٢/٢٠٢٣ |
٤٫٠٣٥٢١ % | BVF Partners L.P. | ٢٬٧٥٢٬٤٢٠ | 0 | ٣١/١٢/٢٠٢٣ |
٣٫٤٧٩٨٨ % | RTW Investments L.P. | ٢٬٣٧٣٬٦٢٥ | ٣٧٦٬٨٦١ | ٣١/١٢/٢٠٢٣ |
٣٫٣٦٨٥٧ % | Federated Hermes Global Investment Management Corp. | ٢٬٢٩٧٬٧٠٠ | -١٬٣٣٩٬٦٠٩ | ٢٩/٢/٢٠٢٤ |
٣٫١٤٩٤١ % | VR Adviser, LLC | ٢٬١٤٨٬٢١٤ | ٤٢٢٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٢٫٩٤٥٩١ % | Wellington Management Company, LLP | ٢٬٠٠٩٬٤٠٣ | -٧٢٥٬٨٤٤ | ٣١/١٢/٢٠٢٣ |
٢٫٧٨٥٥٢ % | Boxer Capital, L.L.C. | ١٬٩٠٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٢٫٧٤٩٤٤ % | Franklin Advisers, Inc. | ١٬٨٧٥٬٣٩١ | -٩٬١٣٥ | ٣١/١٢/٢٠٢٣ |
١٫٩٢٢٠٢ % | Driehaus Capital Management, LLC | ١٬٣١١٬٠١٣ | ١٧٥٬٨١٨ | ٣١/١٢/٢٠٢٣ |
١٫٨٠٨٠٠ % | Balyasny Asset Management LP | ١٬٢٣٣٬٢٣٨ | ٣٧٢٬٨٧٩ | ٣١/١٢/٢٠٢٣ |
١٫٨٠٧٣٧ % | Pictet Asset Management Ltd. | ١٬٢٣٢٬٨٠٨ | ٢٦٨٬٩٦١ | ٣١/١٢/٢٠٢٣ |
١٫٧١٣٨٧ % | Medicxi Ventures (UK) LLP | ١٬١٦٩٬٠٢٨ | -٤٣٠٬٩٧٢ | ٣١/٣/٢٠٢٤ |
١٫٦٦٤٣١ % | Lynx1 Capital Advisors LLC | ١٬١٣٥٬٢٢٥ | -١٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٣٠٣١٦ % | Avoro Capital Advisors LLC | ٨٨٨٬٨٨٨ | ٤٤٤٬٤٤٤ | ٣١/١٢/٢٠٢٣ |
١٫٢٧٨٥١ % | Rock Springs Capital Management LP | ٨٧٢٬٠٦٩ | ٣٣٬٦٤١ | ٣١/١٢/٢٠٢٣ |
١٫١٥٨١٧ % | BlackRock Financial Management, Inc. | ٧٨٩٬٩٨٦ | ٢٤٢ | ٣١/١٢/٢٠٢٣ |
١٫٠٩٤٤٩ % | Two Sigma Investments, LP | ٧٤٦٬٥٥٣ | ٤٦٩٬٢٦٣ | ٣١/١٢/٢٠٢٣ |
١٫٠٩٤٣٨ % | Frazier Healthcare Partners | ٧٤٦٬٤٧٩ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٠٧٠٨٩ % | Fidelity Management & Research Company LLC | ٧٣٠٬٤٥٣ | -٤٤٬٥٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٠٥١٥٤ % | Fairmount Funds Management LLC | ٧١٧٬٢٥٤ | -١٬١٦٤٬٠٩١ | ٣١/١٢/٢٠٢٣ |
١٫٠١٦٤٦ % | Millennium Management LLC | ٦٩٣٬٣٢٧ | ٦٤٬١٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫٩٤٦٤٦ % | SilverArc Capital Management, LLC | ٦٤٥٬٥٨١ | ١٤٥٬٥٨١ | ٣١/١٢/٢٠٢٣ |
٠٫٧٧٨٥٤ % | Janus Henderson Investors | ٥٣١٬٠٤٤ | ٣٣٢٬٧٥٦ | ٣١/١٢/٢٠٢٣ |
٠٫٧٦٤٦٠ % | 5AM Ventures | ٥٢١٬٥٣١ | ٥٢١٬٥٣١ | ٣١/١٢/٢٠٢٣ |
٠٫٧٣٥٦٨ % | StemPoint Capital LP | ٥٠١٬٨٠٦ | ٥٠١٬٨٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫٧٠٤٠٤ % | Candriam Luxembourg S.A. | ٤٨٠٬٢٢٧ | 0 | ٢٩/٢/٢٠٢٤ |
٠٫٦٦٦٨٧ % | Dafna Capital Management, LLC | ٤٥٤٬٨٧٠ | -٣٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٩٢٠٨ % | Carmignac Gestion | ٤٠٣٬٨٦١ | -٥٠٬٤٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٧٠٧٩ % | Saturn V Capital Management LLC | ٣٨٩٬٣٣٣ | ٣٤٩٬٢٦٧ | ٣١/١٢/٢٠٢٣ |
٠٫٥٦٩٨٧ % | BlackRock Institutional Trust Company, N.A. | ٣٨٨٬٧٠٨ | -٣٣٬٤٤٨ | ٣١/١٢/٢٠٢٣ |
٠٫٥٥٤٨٧ % | Goldman Sachs & Company, Inc. | ٣٧٨٬٤٧٧ | ١٧٢٬٥٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٤٣٤٤ % | Braidwell LP | ٣٧٠٬٦٧٩ | -١٬٥٣٠٬٦٥٨ | ٣١/١٢/٢٠٢٣ |
٠٫٥٢٠٦١ % | Aquilo Capital Management, LLC | ٣٥٥٬١٠٩ | -٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٨٥٩٨ % | Medical Strategy GmbH | ٣٣١٬٤٨٧ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٤٨٣٨٠ % | Adage Capital Management, L.P. | ٣٣٠٬٠٠٠ | ٢٣٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٤٣٦٠ % | Soleus Capital Management, L.P. | ٣٠٢٬٥٧٧ | -٨١٬٩١٣ | ٣١/١٢/٢٠٢٣ |
٠٫٤٤٣٥٣ % | Morgan Stanley & Co. LLC | ٣٠٢٬٥٣١ | ١١٣٬٣٨٦ | ٣١/١٢/٢٠٢٣ |
٠٫٤١٠٨٦ % | Citadel Advisors LLC | ٢٨٠٬٢٥١ | ٢٧٧٬٠٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫٤٠٣٠٥ % | Ally Bridge Group NY LLC | ٢٧٤٬٩٢٣ | ٥٣٬٥٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧٧٣٩ % | Candriam Belgium S.A. | ٢٥٧٬٤١٩ | -٦٠٥٬٦٥٧ | ٣٠/١١/٢٠٢٣ |
٠٫٣٥٦٥٩ % | Woodline Partners LP | ٢٤٣٬٢٢٩ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٣٤٥٥٣ % | State Street Global Advisors (US) | ٢٣٥٬٦٨٨ | ١٥٬٩١٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٣٧٦٨ % | Sphera Funds Management Ltd. | ٢٣٠٬٣٣٣ | -٢٣٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٠٤٥٢ % | BlackRock Advisors (UK) Limited | ٢٠٧٬٧١٥ | -١٢٩ | ٣١/٣/٢٠٢٤ |
٠٫٢٧٤٤١ % | BlackRock Asset Management Ireland Limited | ١٨٧٬١٧٢ | ٢٬٠٣١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧٣١٣ % | T. Rowe Price Investment Management, Inc. | ١٨٦٬٣٠٠ | ١٨٦٬٣٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٢٤٧٩١ % | AllianceBernstein L.P. | ١٦٩٬٠٩٨ | -٢٣٬١٨٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣١٣٧ % | Parkman Healthcare Partners LLC | ١٥٧٬٨١٧ | ٢٧٬٠٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢٨٧٣ % | Liu (Hui) | ١٥٦٬٠١٦ | ٩٨٬٠٨٥ | ١٥/٣/٢٠٢٤ |
٠٫٢٢٢٩٥ % | Lundberg (Sven Ante) | ١٥٢٬٠٧١ | 0 | ١٥/٣/٢٠٢٤ |
٠٫٢٠٩٤٠ % | The Vanguard Group, Inc. | ١٤٢٬٨٣٣ | -٢٧٬٠٩٣ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٨٢٢ % | Platinum Asset Management | ١٤٢٬٠٢٩ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٠٩١ % | Nan Fung Life Sciences | ١٣٧٬٠٣٨ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٩٥٨٢ % | HighVista Strategies LLC | ١٣٣٬٥٧٢ | ١٠٬٩٤١ | ٣١/١٢/٢٠٢٣ |
٠٫١٨٥٤٦ % | Cubist Systematic Strategies, LLC | ١٢٦٬٥٠٥ | ١٢٦٬٥٠٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٧٧٨٣ % | UBS O'Connor LLC | ١٢١٬٣٠٠ | -٣٠٬٨٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٩٦٦ % | Eversept Partners, LP | ١١٥٬٧٢٦ | -١٨٬٢٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٦١٢٧ % | DWS Investment GmbH | ١١٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٤٦٥١ % | Morgan Stanley Investment Management Inc. (US) | ٩٩٬٩٣٤ | -٥١٬٣٢٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٧٧٧ % | Allianz Global Investors U.S. LLC_NLE | ٩٣٬٩٧٥ | 0 | ٣٠/٩/٢٠٢٣ |
٠٫١٣٧٧٧ % | Voya Investment Management LLC | ٩٣٬٩٧٥ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٣٠٩١ % | Wellington Management Japan Pte Ltd | ٨٩٬٢٩٥ | -٦١٬٨١٨ | ٣٠/٦/٢٠٢٣ |
٠٫١٢٧٨٤ % | Hudson Bay Capital Management LP | ٨٧٬٢٠٠ | -٨٠٬٦١٨ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٧٥٥ % | Nomura Asset Management Co., Ltd. | ٨٧٬٠٠٠ | ٨٧٬٠٠٠ | ٣٠/١١/٢٠٢٣ |
٠٫١٠٧٨٧ % | Iwicki (Mark T.) | ٧٣٬٥٧٦ | ٧٣٬٥٧٦ | ١٥/٣/٢٠٢٤ |
٠٫١٠٦٥٢ % | Schweizerische Nationalbank | ٧٢٬٦٥٤ | -٢٠٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠١٠٦ % | Algert Global LLC | ٦٨٬٩٣٣ | -١٬٥٤٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٢١١ % | BNP Paribas Securities Corp. North America | ٦٢٬٨٢٥ | ٣٦٬١٦٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٨٤٠ % | Norges Bank Investment Management (NBIM) | ٦٠٬٣٠٠ | -١٤٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٦٥٥ % | D. E. Shaw & Co., L.P. | ٥٩٬٠٣٣ | ٥٩٬٠٣٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٢١٠ % | Deka Vermögensmanagement GmbH | ٥٦٬٠٠٠ | ٣١٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٢١٠ % | HBM Partners AG | ٥٦٬٠٠٠ | ٥٬٠٠٠ | ٣٠/٩/٢٠٢٣ |
٠٫٠٧٨٥٩ % | Geode Capital Management, L.L.C. | ٥٣٬٦٠٨ | ١٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٠٣٨ % | Campbell & Company, Inc. | ٤٨٬٠٠٧ | ٤٨٬٠٠٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٠٢٦ % | MFS Investment Management | ٤٧٬٩٢٦ | -١٬٤٤٧ | ٢٩/٢/٢٠٢٤ |
٠٫٠٦٧٧٤ % | Invesco Capital Management LLC | ٤٦٬٢٠٨ | ٤٦٬٢٠٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٧٦١ % | Jump Financial, LLC | ٤٦٬١٢٠ | ٤٦٬١٢٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٥٩٦ % | Credit Suisse Funds AG | ٤٤٬٩٩٠ | -٣٬٦٧٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٤٠٣ % | Nuveen LLC | ٤٣٬٦٧٧ | -١٤٬٢١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٩٣٦ % | Trexquant Investment LP | ٤٠٬٤٨٩ | ٢٣٬٥٠٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٨٨٣ % | Alps Advisors, Inc. | ٤٠٬١٢٨ | ٤٠٬١٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٧٣٠ % | ExodusPoint Capital Management, LP | ٣٩٬٠٨٧ | ٣٩٬٠٨٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٧٢٧ % | T. Rowe Price Associates, Inc. | ٣٩٬٠٦٤ | ٩٬٥٦٩ | ٢٩/٢/٢٠٢٤ |
٠٫٠٥٦٢٧ % | Assenagon Asset Management S.A. | ٣٨٬٣٨٣ | ٢٬٨٢٠ | ٢٩/٢/٢٠٢٤ |
٠٫٠٥٥٧٤ % | Northern Trust Investments, Inc. | ٣٨٬٠٢٢ | ٩٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٥٣٨ % | HRT Financial LP | ٣٧٬٧٧٣ | ١١٬٢٦٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٥١٢ % | Schonfeld Strategic Advisors LLC | ٣٧٬٦٠٠ | -٢٠١٬٧٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٤٨٧ % | UBS Asset Management (Americas), Inc. | ٣٧٬٤٢٦ | -١٬٠٩٣ | ٣١/٣/٢٠٢٣ |
٠٫٠٥٢١١ % | Atom Investors LP | ٣٥٬٥٤٤ | ٢١٬٩٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥١٥٨ % | First Trust Advisors L.P. | ٣٥٬١٨٥ | ١٬٢٤٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٠٧٦ % | Legal & General Investment Management Ltd. | ٣٤٬٦٢١ | -١٬٨٤٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤٨١٠ % | California State Teachers Retirement System | ٣٢٬٨٠٩ | -٤٬٧٥٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٧٥٦ % | State of Wisconsin Investment Board | ٢٥٬٦١٨ | -١٬٧٣٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٦٦٥ % | Deka Investment GmbH | ٢٥٬٠٠٠ | ٢٠٬٦٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٦٤٦ % | Sanders Morris LLC | ٢٤٬٨٧٠ | 0 | ٣١/٣/٢٠٢٤ |
٠٫٠٣٦١١ % | Susquehanna Portfolio Strategies, LLC | ٢٤٬٦٢٨ | ٢٤٬٦٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٥٨٣ % | Tudor Investment Corporation | ٢٤٬٤٤٣ | ٨٠٥ | ٣١/١٢/٢٠٢٣ |