٧٫٦٠٠٢٢ % | Fidelity Management & Research Company LLC | ٥٬٢٠٣٬١١٠ | ٣٬٥٤٠٬٥٦٥ | ٣٠/٦/٢٠٢٤ |
٦٫٠٩٠٢٦ % | RTW Investments L.P. | ٤٬١٦٩٬٣٩٣ | ٦٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٤٫٦٧٤٢٦ % | Commodore Capital LP | ٣٬٢٠٠٬٠٠٠ | -١٬١٦٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٤٫٠١٦٠٧ % | Deerfield Management Company, L.P. | ٢٬٧٤٩٬٤٠١ | ١٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٣٫٥٠٣٩٤ % | Federated Hermes Global Investment Management Corp. | ٢٬٣٩٨٬٨٠٠ | ١٥٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٣٫٣٩٤٩٧ % | Samlyn Capital, LLC | ٢٬٣٢٤٬١٩٥ | ٢٤٧٬٦٠٥ | ٣٠/٦/٢٠٢٤ |
٣٫٠٧٦٤٩ % | Franklin Advisers, Inc. | ٢٬١٠٦٬١٦٣ | ٢٤١٬٩١٥ | ٣٠/٦/٢٠٢٤ |
٢٫٩٥٠٣٦ % | Paradigm BioCapital Advisors LP | ٢٬٠١٩٬٨١٤ | ٢٬٠١٩٬٨١٤ | ٣٠/٦/٢٠٢٤ |
٢٫٧٧٥٣٤ % | Boxer Capital, L.L.C. | ١٬٩٠٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٢٫٤٢٩٠٧ % | Wellington Management Company, LLP | ١٬٦٦٢٬٩٤١ | ٤١٤٬٣٠١ | ٣٠/٦/٢٠٢٤ |
٢٫٢٩٨٩٦ % | Holocene Advisors, LP | ١٬٥٧٣٬٨٦٦ | ٦٣٤٬٢٩٠ | ٣٠/٦/٢٠٢٤ |
٢٫٢٦٤١١ % | Driehaus Capital Management, LLC | ١٬٥٥٠٬٠٠٩ | ٣٢٣٬٥١٨ | ٣٠/٦/٢٠٢٤ |
٢٫١٦٩٢٨ % | Morgan Stanley & Co. LLC | ١٬٤٨٥٬٠٩٢ | ٥٥٦٬٢٨١ | ٣٠/٦/٢٠٢٤ |
٢٫١١٩٥٣ % | Two Sigma Investments, LP | ١٬٤٥١٬٠٢٧ | ٢٠٬٤١٨ | ٣٠/٦/٢٠٢٤ |
٢٫٠٢٣٣٩ % | T. Rowe Price Associates, Inc. | ١٬٣٨٥٬٢١٦ | ١٩٩٬٨٦٢ | ٣٠/٦/٢٠٢٤ |
١٫٩٧٩٢٦ % | Avoro Capital Advisors LLC | ١٬٣٥٥٬٠٠٠ | ٤٦٦٬١١٢ | ٣٠/٦/٢٠٢٤ |
١٫٨٦٨٣٢ % | BVF Partners L.P. | ١٬٢٧٩٬٠٤٩ | ١٠٦٬٨٠٠ | ٣٠/٦/٢٠٢٤ |
١٫٨٥٠٧٩ % | Polar Capital LLP | ١٬٢٦٧٬٠٥٢ | ١٬٢٦٧٬٠٥٢ | ٣٠/٦/٢٠٢٤ |
١٫٨٤٥١٩ % | VR Adviser, LLC | ١٬٢٦٣٬٢١٤ | -٥٢٧٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
١٫٧٦٢٦٥ % | Lynx1 Capital Advisors LLC | ١٬٢٠٦٬٧٠٧ | -٣٠٢٬٣٠٠ | ٣٠/٦/٢٠٢٤ |
١٫٤٩٢٥٨ % | Fidelity Institutional Asset Management | ١٬٠٢١٬٨٢٢ | ١٬٠٢١٬٨٢٢ | ٣٠/٦/٢٠٢٤ |
١٫٤٨٥٥٥ % | Janus Henderson Investors | ١٬٠١٧٬٠٠٧ | ٤٧٤٬٤٢٧ | ٣٠/٦/٢٠٢٤ |
١٫٤٧٢٥٠ % | Incyte Corp | ١٬٠٠٨٬٠٧٦ | -٢٬٩٩٦٬٤٦٨ | ٣٠/٦/٢٠٢٤ |
١٫٤٦٢٢٧ % | Rock Springs Capital Management LP | ١٬٠٠١٬٠٧٣ | -١٤٥٬٤٨٧ | ٣٠/٦/٢٠٢٤ |
١٫٤٠٠٤٨ % | Woodline Partners LP | ٩٥٨٬٧٦٩ | ٢٨٧٬٩٧٠ | ٣٠/٦/٢٠٢٤ |
١٫٣٩٩٢٩ % | Marshall Wace LLP | ٩٥٧٬٩٥٢ | ٨٥٣٬٠٦٠ | ٣٠/٦/٢٠٢٤ |
١٫٢٤١٦٠ % | Logos Global Management LLC | ٨٥٠٬٠٠٠ | ٨٥٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
١٫٢٣٣٥٣ % | Pictet Asset Management Ltd. | ٨٤٤٬٤٧٤ | ٢١٤٬٧٩٩ | ٣٠/٦/٢٠٢٤ |
١٫٢٢٦٩٩ % | Cormorant Asset Management, LP | ٨٤٠٬٠٠٠ | ١٢٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
١٫١٢٤٧٤ % | Adage Capital Management, L.P. | ٧٧٠٬٠٠٠ | ٤٤٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
١٫١١٠٦٦ % | Invus Public Equities Advisors, LLC | ٧٦٠٬٣٥٥ | ٣٠٥٬٢٧٤ | ٣٠/٦/٢٠٢٤ |
١٫٠٨٤١٧ % | BlackRock Financial Management, Inc. | ٧٤٢٬٢٢٥ | ٣٬٠٣٣ | ٣٠/٦/٢٠٢٤ |
١٫٠٥٢٧٠ % | T. Rowe Price Investment Management, Inc. | ٧٢٠٬٦٧٦ | -٨٬٣٣٩ | ٣٠/٦/٢٠٢٤ |
١٫٠٢٢٤٩ % | Novo Holdings A/S | ٧٠٠٬٠٠٠ | ٢٥٬٠٠٠ | ٣٠/٩/٢٠٢٤ |
١٫٠١٩٥٧ % | Candriam Luxembourg S.A. | ٦٩٧٬٩٩٧ | 0 | ٣٠/٩/٢٠٢٤ |
٠٫٩٩٠٣٩ % | AllianceBernstein L.P. | ٦٧٨٬٠٢١ | ٥٩٤٬٧٦١ | ٣٠/٦/٢٠٢٤ |
٠٫٩١٠٩٤ % | SilverArc Capital Management, LLC | ٦٢٣٬٦٢٨ | ٥٧٬٣٤١ | ٣٠/٦/٢٠٢٤ |
٠٫٨٥٤٥٥ % | Balyasny Asset Management LP | ٥٨٥٬٠٢٤ | ٥٨٥٬٠٢٤ | ٣٠/٦/٢٠٢٤ |
٠٫٨٤٧١٦ % | Invesco Advisers, Inc. | ٥٧٩٬٩٦٧ | ٥٧٨٬٨١١ | ٣٠/٦/٢٠٢٤ |
٠٫٧٦٤٣٧ % | Great Point Partners, LLC | ٥٢٣٬٢٨٨ | ٣٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٧٦١٥٢ % | D. E. Shaw & Co., L.P. | ٥٢١٬٣٣٩ | ٢٤٧٬٨١٣ | ٣٠/٦/٢٠٢٤ |
٠٫٦٢٥٨٣ % | BlackRock Institutional Trust Company, N.A. | ٤٢٨٬٤٤٣ | ٢٦٬١٠٣ | ٣٠/٦/٢٠٢٤ |
٠٫٥٩٨٠٨ % | Dafna Capital Management, LLC | ٤٠٩٬٤٤٥ | ٣٠٬٤٥٠ | ٣٠/٦/٢٠٢٤ |
٠٫٥٧٧٩٦ % | Lord, Abbett & Co. LLC | ٣٩٥٬٦٧٢ | ٧١٬٠٤٢ | ٣٠/٦/٢٠٢٤ |
٠٫٥٤٩٦٩ % | Soleus Capital Management, L.P. | ٣٧٦٬٣٢١ | ١٨٠٬٧٤٤ | ٣٠/٦/٢٠٢٤ |
٠٫٥٤٤٩٩ % | Frazier Life Sciences Management, L.P. | ٣٧٣٬١٠٠ | -٣٧٣٬٣٧٩ | ٣٠/٦/٢٠٢٤ |
٠٫٤٩٠٠٩ % | Tri Locum Partners LP | ٣٣٥٬٥١٤ | ٤٩٬١٩٢ | ٣٠/٦/٢٠٢٤ |
٠٫٤٨١٣٤ % | Medical Strategy GmbH | ٣٢٩٬٥٢٢ | ١٨٬٣٢١ | ٣٠/٦/٢٠٢٤ |
٠٫٤٧٠٢١ % | First Turn Management, LLC | ٣٢١٬٩٠٦ | ٣٢١٬٩٠٦ | ٣٠/٦/٢٠٢٤ |
٠٫٤٣٨٢١ % | Perceptive Advisors LLC | ٣٠٠٬٠٠٠ | ٣٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٤٣٨٢١ % | Baker Bros. Advisors LP | ٣٠٠٬٠٠٠ | ٣٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٤٢١٦٦ % | StemPoint Capital LP | ٢٨٨٬٦٦٨ | ٥٤٬٧٩٧ | ٣٠/٦/٢٠٢٤ |
٠٫٣٨٦٩٠ % | State Street Global Advisors (US) | ٢٦٤٬٨٧٣ | ٢٠٬١٩٧ | ٣٠/٦/٢٠٢٤ |
٠٫٣٥٥٣٣ % | Millennium Management LLC | ٢٤٣٬٢٥٧ | ٩٢٬٩٨٧ | ٣٠/٦/٢٠٢٤ |
٠٫٣١٣٨٢ % | Voloridge Investment Management, LLC | ٢١٤٬٨٣٨ | ١٤٩٬١٣٧ | ٣٠/٦/٢٠٢٤ |
٠٫٣٠٥١٤ % | Handelsbanken Kapitalf¿rvaltning AB | ٢٠٨٬٩٠٠ | ٣٤٬٢٠٠ | ٣٠/٩/٢٠٢٤ |
٠٫٣٠٢٦٧ % | Goldman Sachs & Company, Inc. | ٢٠٧٬٢٠٩ | ١٠٢٬٤٩٥ | ٣٠/٦/٢٠٢٤ |
٠٫٢٩٦٦٦ % | BlackRock Advisors (UK) Limited | ٢٠٣٬٠٩٢ | ٦٧٥ | ٣٠/٩/٢٠٢٤ |
٠٫٢٨١٠٤ % | BlackRock Asset Management Ireland Limited | ١٩٢٬٣٩٧ | -٧٬٧٢١ | ٣٠/٦/٢٠٢٤ |
٠٫٢٦٦١٧ % | TimesSquare Capital Management, LLC | ١٨٢٬٢٢٠ | ١٧٤٬٢١٦ | ٣٠/٦/٢٠٢٤ |
٠٫٢٦٥٦٣ % | Citadel Advisors LLC | ١٨١٬٨٥٣ | -١٧٠٬٣٥٥ | ٣٠/٦/٢٠٢٤ |
٠٫٢٦١٦١ % | Decheng Capital LLC | ١٧٩٬٠٩٨ | ٧٧٬٣٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٥٥٤٠ % | Ally Bridge Group NY LLC | ١٧٤٬٨٤٤ | -٨١٬٠٨٤ | ٣٠/٦/٢٠٢٤ |
٠٫٢٤٩٥٥ % | BNP Paribas Securities Corp. North America | ١٧٠٬٨٤٤ | ٦٧٬٩٥٩ | ٣٠/٦/٢٠٢٤ |
٠٫٢٤٠٦٩ % | Saturn V Capital Management LP | ١٦٤٬٧٧٣ | -٢١١٬٨٥٦ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٨٠٢ % | OrbiMed Advisors, LLC | ١٥٦٬١٠٠ | ١٥٦٬١٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٧٨٩ % | Liu (Hui) | ١٥٦٬٠١٦ | ٩٨٬٠٨٥ | ١٥/٣/٢٠٢٤ |
٠٫٢٢٦٧٨ % | The Vanguard Group, Inc. | ١٥٥٬٢٥٧ | ٨٬٢٣٢ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٣٥٤ % | State of Wisconsin Investment Board | ١٥٣٬٠٣٨ | ١٣٠٬٣٠٧ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٢١٣ % | Lundberg (Sven Ante) | ١٥٢٬٠٧١ | 0 | ١٥/٣/٢٠٢٤ |
٠٫٢١٦٣٤ % | Aquilo Capital Management, LLC | ١٤٨٬١٠٩ | -١٠٧٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢١٥٦٥ % | Sphera Funds Management Ltd. | ١٤٧٬٦٣٣ | -١٬٧٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٩٤٧٥ % | Algert Global LLC | ١٣٣٬٣٢٣ | ٣٥٬٥٤٩ | ٣٠/٦/٢٠٢٤ |
٠٫١٨٦٣٢ % | TD Asset Management Inc. | ١٢٧٬٥٥٤ | -٢٣٬٦٢٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٨٤٦٩ % | BlackRock Investment Management (UK) Ltd. | ١٢٦٬٤٤٢ | ٤٠٬٥٣٧ | ٣٠/٦/٢٠٢٤ |
٠٫١٨٢٥٩ % | Affinity Asset Advisors LLC | ١٢٥٬٠٠٠ | ١٢٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٧٥٢ % | Invesco Capital Management LLC | ١٢١٬٥٢٩ | -٥٬٥٦٤ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٥٣٤ % | Nan Fung Life Sciences | ١٢٠٬٠٣٨ | ٣٠٬٥٢٢ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٠٤٩ % | HighVista Strategies LLC | ١١٦٬٧١٨ | -٤٬٩٦٢ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٦٥٢ % | Ensign Peak Advisors, Inc. | ١١٤٬٠٠٠ | ١١٤٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٠٦٨ % | DWS Investment GmbH | ١١٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫١٤٦٠٧ % | Integral Health Asset Management, LLC | ١٠٠٬٠٠٠ | -٦٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٤٦٠٧ % | Tang Capital Management, LLC | ١٠٠٬٠٠٠ | ١٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٣٢١٩ % | Rhenman & Partners Asset Management AB | ٩٠٬٥٠٠ | ٩٠٬٥٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٣٠٤٣ % | Wellington Management Singapore Pte. Ltd. | ٨٩٬٢٩٥ | ٨٩٬٢٩٥ | ٣١/٣/٢٠٢٤ |
٠٫١٣٠٤٣ % | Wellington Management Japan Pte Ltd | ٨٩٬٢٩٥ | -٦١٬٨١٨ | ٣٠/٦/٢٠٢٣ |
٠٫١٢٧٤٠ % | abrdn Inc. | ٨٧٬٢١٥ | ٨٧٬٢١٥ | ٣٠/٩/٢٠٢٤ |
٠٫١٢٧٠٨ % | Nomura Asset Management Co., Ltd. | ٨٧٬٠٠٠ | ٨٧٬٠٠٠ | ٣٠/١١/٢٠٢٣ |
٠٫١٢٢٧٨ % | Voya Investment Management LLC | ٨٤٬٠٥٥ | ٥٤٬٢٠٥ | ٣٠/٦/٢٠٢٤ |
٠٫١١٨١٣ % | BofA Global Research (US) | ٨٠٬٨٧٣ | ٢٥٬٦٩٠ | ٣٠/٦/٢٠٢٤ |
٠٫١١٧٥٩ % | Nicholas Investment Partners, L.P. | ٨٠٬٥٠٣ | ٦٢٬٨١٨ | ٣٠/٦/٢٠٢٤ |
٠٫١١٤٣١ % | Schweizerische Nationalbank | ٧٨٬٢٥٤ | ٤٬٢٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١١٢٩١ % | First Trust Advisors L.P. | ٧٧٬٢٩٦ | ٢٦٬٢٣٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٨٨٨ % | Jane Street Capital, L.L.C. | ٧٤٬٥٤٢ | ٦١٬٧٦٤ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٧٦٩ % | Platinum Asset Management | ٧٣٬٧٢٢ | -٢٥٬٧٦٨ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٧٤٧ % | Iwicki (Mark T.) | ٧٣٬٥٧٦ | ٧٣٬٥٧٦ | ١٥/٣/٢٠٢٤ |
٠٫١٠٥٩٤ % | Principal Global Investors (Equity) | ٧٢٬٥٢٦ | ٣٬٧٤٠ | ٣١/٨/٢٠٢٤ |
٠٫١٠٣٢٠ % | J.P. Morgan Securities LLC | ٧٠٬٦٥٢ | -٢٦٬٠٢٤ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩٧١٠ % | Eversept Partners, LP | ٦٦٬٤٧٤ | -٥٣٬٠٠٨ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩١٧٦ % | Fred Alger Management, LLC | ٦٢٬٨١٦ | ٤٢٬٢١٩ | ٣٠/٦/٢٠٢٤ |