١١٫٣٩٧٣٠ % | Janus Henderson Investors | ٢٬٤٨٥٬٧٥١ | -١١٥٬٥٣١ | ٣٠/٦/٢٠٢٤ |
٩٫٤٢٤٨٣ % | Avoro Capital Advisors LLC | ٢٬٠٥٥٬٥٥٥ | ١١١٬١١١ | ٣٠/٦/٢٠٢٤ |
٩٫٠٥٣٦٠ % | Baker Bros. Advisors LP | ١٬٩٧٤٬٥٩٠ | ٤٬٧٩٢ | ٣٠/٦/٢٠٢٤ |
٨٫٧٨٤٣٣ % | RTW Investments L.P. | ١٬٩١٥٬٨٦٢ | ١٬٥١٨٬٨١٥ | ٣٠/٦/٢٠٢٤ |
٨٫٤٨٢٣٥ % | Paulson & Co. Inc. | ١٬٨٥٠٬٠٠٠ | ٧٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٨٫٢٧١٩٠ % | The Vanguard Group, Inc. | ١٬٨٠٤٬١٠٢ | ١٣٧٬٨٩٨ | ٣٠/٦/٢٠٢٤ |
٥٫٨٠٦٦٢ % | BlackRock Institutional Trust Company, N.A. | ١٬٢٦٦٬٤٢٤ | ١٨٣٬١٩٥ | ٣٠/٦/٢٠٢٤ |
٤٫٩٩٦٨٠ % | Taub (Rebecca A) | ١٬٠٨٩٬٨٠٢ | ٦٥٠٬٨٠٤ | ٢٢/٤/٢٠٢٤ |
٤٫٢٠٣٨٩ % | Friedman (Paul A) | ٩١٦٬٨٦٨ | ٧١٤ | ٢٥/٦/٢٠٢٤ |
٣٫٨٥٧٢٧ % | T. Rowe Price Associates, Inc. | ٨٤١٬٢٧١ | ٥٣٬٠٨٠ | ٣٠/٦/٢٠٢٤ |
٣٫٤١٤٥٥ % | State Street Global Advisors (US) | ٧٤٤٬٧١٤ | ١١٩٬٧٧٦ | ٣٠/٦/٢٠٢٤ |
٣٫٠٩٠٢٥ % | Fidelity Management & Research Company LLC | ٦٧٣٬٩٨٣ | ٦٨٬٤٦٨ | ٣٠/٦/٢٠٢٤ |
٣٫٠٠٥٦٩ % | SQN, L.L.C. | ٦٥٥٬٥٤٠ | 0 | ٢٢/٤/٢٠٢٤ |
١٫٩٩٥١٣ % | Craves (Frederick B) | ٤٣٥٬١٣٨ | -١٥٬٠٠٠ | ١٣/٩/٢٠٢٤ |
١٫٨٣٣٣٥ % | Geode Capital Management, L.L.C. | ٣٩٩٬٨٥٤ | ٥٢٬٩٩٧ | ٣٠/٦/٢٠٢٤ |
١٫٥٨٢٢٣ % | Artisan Partners Limited Partnership | ٣٤٥٬٠٨٥ | -٥٦٬٦٢٤ | ٣٠/٦/٢٠٢٤ |
١٫٢١٣٢٠ % | Perceptive Advisors LLC | ٢٦٤٬٦٠٠ | -١٦٥٬٣٥٣ | ٣٠/٦/٢٠٢٤ |
١٫١٢٥٦٣ % | Rock Springs Capital Management LP | ٢٤٥٬٤٩٩ | -٤٠٬٤٣٢ | ٣٠/٦/٢٠٢٤ |
٠٫٨٥٩٢١ % | ArrowMark Colorado Holdings, LLC | ١٨٧٬٣٩٣ | ١٥٣٬١٧٤ | ٣٠/٦/٢٠٢٤ |
٠٫٦٨٧٧٦ % | Armistice Capital LLC | ١٥٠٬٠٠٠ | -١٨٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٦٨٤٤٧ % | TCG Crossover Management, LLC | ١٤٩٬٢٨٣ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٦٣٥٨٨ % | BofA Global Research (US) | ١٣٨٬٦٨٦ | ١٠٥٬٤٦٣ | ٣٠/٦/٢٠٢٤ |
٠٫٦٣٤١٨ % | Charles Schwab Investment Management, Inc. | ١٣٨٬٣١٤ | ١٥٬٦٢٢ | ٣٠/٦/٢٠٢٤ |
٠٫٦٣٤١٥ % | Woodline Partners LP | ١٣٨٬٣٠٩ | ١١٨٬٦٠٩ | ٣٠/٦/٢٠٢٤ |
٠٫٦٢٩٤١ % | Pictet Asset Management Ltd. | ١٣٧٬٢٧٥ | -٤٦٬٨٨٨ | ٣٠/٦/٢٠٢٤ |
٠٫٦٢٤٦٧ % | UBS Financial Services, Inc. | ١٣٦٬٢٤٠ | ١٠٬٨٢٥ | ٣٠/٦/٢٠٢٤ |
٠٫٦٢٠٠١ % | Morgan Stanley & Co. LLC | ١٣٥٬٢٢٤ | -٧٢٬٠١٤ | ٣٠/٦/٢٠٢٤ |
٠٫٥٩٨٤٨ % | Tao Capital Management LP | ١٣٠٬٥٢٩ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٥٧٤٥١ % | Polar Capital LLP | ١٢٥٬٣٠٠ | ٩٥ | ٣٠/٦/٢٠٢٤ |
٠٫٥٥٣٤٧ % | Northern Trust Investments, Inc. | ١٢٠٬٧١٢ | -١٤٥ | ٣٠/٦/٢٠٢٤ |
٠٫٥٥٠١٢ % | Invesco Advisers, Inc. | ١١٩٬٩٨٢ | ٥٤٬٣٣١ | ٣٠/٦/٢٠٢٤ |
٠٫٥٣١٩٩ % | Norges Bank Investment Management (NBIM) | ١١٦٬٠٢٧ | -٢٩٬٥٦٢ | ٣٠/٦/٢٠٢٤ |
٠٫٥٢٧٣٧ % | Fidelity Institutional Asset Management | ١١٥٬٠٢٠ | ٦٬٦٢١ | ٣٠/٦/٢٠٢٤ |
٠٫٥٢١٣٦ % | Fiera Capital Inc. | ١١٣٬٧٠٩ | ١١٣٬٧٠٩ | ٣٠/٦/٢٠٢٤ |
٠٫٥٠٩٤٦ % | American Century Investment Management, Inc. | ١١١٬١١٣ | ١٣٬٣٦١ | ٣٠/٦/٢٠٢٤ |
٠٫٥٠٤٣٦ % | Affinity Asset Advisors LLC | ١١٠٬٠٠٠ | -٥٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٤٩٤٤٥ % | Goldman Sachs & Company, Inc. | ١٠٧٬٨٣٩ | ٣٨٬٨٧٨ | ٣٠/٦/٢٠٢٤ |
٠٫٤٦٩٧٦ % | Fred Alger Management, LLC | ١٠٢٬٤٥٥ | ٣٧٬٨٧٩ | ٣٠/٦/٢٠٢٤ |
٠٫٤٥٤٩١ % | Rheos Capital Works Inc. | ٩٩٬٢١٥ | -١١٬٠٠٠ | ٣٠/٩/٢٠٢٤ |
٠٫٤٢٤٩٦ % | Managed Account Advisors LLC | ٩٢٬٦٨٣ | ١٤٬٣٨٧ | ٣٠/٦/٢٠٢٤ |
٠٫٤٢٠٤١ % | Mirae Asset Global Investments (USA) LLC | ٩١٬٦٩١ | -٥٦٢ | ٣٠/٦/٢٠٢٤ |
٠٫٤١٣٧١ % | Pictet Asset Management (Japan) Ltd. | ٩٠٬٢٣٠ | ٣٤٬٨٧٥ | ٣٠/٤/٢٠٢٤ |
٠٫٣٨٧٨٧ % | AlpInvest Partners B.V. | ٨٤٬٥٩٥ | -٢١٬١٤٩ | ٣٠/٦/٢٠٢٤ |
٠٫٣٨٢٢٧ % | Ensign Peak Advisors, Inc. | ٨٣٬٣٧٣ | -٨٬٨٤٥ | ٣٠/٦/٢٠٢٤ |
٠٫٣٨٠٨٤ % | Connor, Clark & Lunn Investment Management Ltd. | ٨٣٬٠٦٢ | -١٠٬٥٣٥ | ٣٠/٦/٢٠٢٤ |
٠٫٣٥٠٢٩ % | Group One Trading, L.P. | ٧٦٬٣٩٩ | ٣٣٬٢٢٨ | ٣٠/٦/٢٠٢٤ |
٠٫٣٤٣٨٨ % | EcoR1 Capital, LLC | ٧٥٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫٣٢٦٣٩ % | MPM BioImpact LLC | ٧١٬١٨٥ | ٩٬٧٨٦ | ٣٠/٦/٢٠٢٤ |
٠٫٣٢١١٩ % | BlackRock Financial Management, Inc. | ٧٠٬٠٥١ | ١٩٬٦٤٢ | ٣٠/٦/٢٠٢٤ |
٠٫٣١٩٧٧ % | Nuveen LLC | ٦٩٬٧٤١ | ٩٬٢٨٨ | ٣٠/٦/٢٠٢٤ |
٠٫٢٩٩٦٤ % | Tri Locum Partners LP | ٦٥٬٣٥٢ | ١١٬٩٩٧ | ٣٠/٦/٢٠٢٤ |
٠٫٢٩١٦٦ % | Goldman Sachs Asset Management, L.P. | ٦٣٬٦١٢ | ٤٠٬٧٨٤ | ٣٠/٦/٢٠٢٤ |
٠٫٢٧٢١٠ % | Morgan Stanley Smith Barney LLC | ٥٩٬٣٤٥ | -١٬٥٦٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٥٦٢٤ % | Sibold (William John) | ٥٥٬٨٨٧ | -٦٬٣٦٣ | ٩/٩/٢٠٢٤ |
٠٫٢٥٥٥٢ % | TD Asset Management Inc. | ٥٥٬٧٣٠ | ٥٬٤٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٢٤٤٥ % | Emerald Advisers LLC | ٤٨٬٩٥٢ | -١٢٣٬٥٧١ | ٣٠/٩/٢٠٢٤ |
٠٫٢١٢٩٥ % | New York State Common Retirement Fund | ٤٦٬٤٤٥ | -٤٬٧٢٨ | ٣٠/٩/٢٠٢٤ |
٠٫٢٠٩٦٧ % | University of Wisconsin Foundation | ٤٥٬٧٣٠ | -١٠٬٦٤٦ | ٣٠/٦/٢٠٢٤ |
٠٫٢٠٧٠٦ % | BlackRock Investment Management, LLC | ٤٥٬١٥٩ | ٩٬٧٣٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٠٤٣٦ % | AllianceBernstein L.P. | ٤٤٬٥٧٠ | ١٦٬٦٧٠ | ٣٠/٦/٢٠٢٤ |
٠٫٢٠٣٦٥ % | Sofinnova Investments, Inc | ٤٤٬٤١٧ | ٢٥٬٣٨٨ | ٣٠/٦/٢٠٢٤ |
٠٫٢٠٢٢٤ % | Bessemer Trust Company, N.A. (US) | ٤٤٬١٠٩ | -١٠٬٣٦٠ | ٣١/٧/٢٠٢٤ |
٠٫١٩٧٣٠ % | Propel Bio Management, LLC | ٤٣٬٠٣٢ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫١٩٧٢٥ % | Voya Investment Management LLC | ٤٣٬٠٢٠ | ٢٥٬٤٩٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٩٦٩٥ % | BNY Mellon Asset Management | ٤٢٬٩٥٤ | ٨٬٦٠٩ | ٣٠/٦/٢٠٢٤ |
٠٫١٨٧٧٩ % | Point72 Asset Management, L.P. | ٤٠٬٩٥٨ | -٥٢٬٦١٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٧١٦ % | DWS Investment GmbH | ٣٨٬٦٣٨ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫١٧٥٩٦ % | Gilder Gagnon Howe & Co. LLC | ٣٨٬٣٧٧ | -٧٠٦ | ٣٠/٦/٢٠٢٤ |
٠٫١٧٣٢٦ % | JP Morgan Asset Management | ٣٧٬٧٨٧ | -٣٥١ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٩٦٥ % | UBS Switzerland AG | ٣٧٬٠٠٠ | ٣٧٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٦٩٨ % | Rafferty Asset Management LLC | ٣٦٬٤١٨ | ٥٠١ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٦٠٠ % | Jane Street Capital, L.L.C. | ٣٦٬٢٠٤ | ١١٬٠٥٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٣٥٩ % | Manulife Investment Management (North America) Limited | ٣٥٬٦٧٨ | ٤٬٩٣٧ | ٣٠/٦/٢٠٢٤ |
٠٫١٦٠٩٩ % | SEB Investment Management AB | ٣٥٬١١٢ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫١٤٩٠١ % | Handelsbanken Kapitalf¿rvaltning AB | ٣٢٬٥٠٠ | ٩٠٠ | ٣٠/٩/٢٠٢٤ |
٠٫١٣٧٧٩ % | CIBC Private Wealth Management | ٣٠٬٠٥١ | ١ | ٣٠/٦/٢٠٢٤ |
٠٫١٣٧٤٣ % | PFM Health Sciences, LP | ٢٩٬٩٧٣ | 0 | ٣٠/٦/٢٠٢٤ |
٠٫١٣٠٦٧ % | Macquarie Investment Management | ٢٨٬٥٠٠ | -٣٠٬٤٥٧ | ٣٠/٦/٢٠٢٤ |
٠٫١٢٩١٨ % | Mellon Investments Corporation | ٢٨٬١٧٤ | ٧٬٣١٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٢١٥٠ % | Rhenman & Partners Asset Management AB | ٢٦٬٥٠٠ | -١٠٬٠٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١١٧٥٨ % | T. Rowe Price Investment Management, Inc. | ٢٥٬٦٤٤ | -١٧٬٣٤٢ | ٣٠/٦/٢٠٢٤ |
٠٫١١٦٢٤ % | Rhumbline Advisers Ltd. Partnership | ٢٥٬٣٥١ | ٤٬٢٠٩ | ٣٠/٦/٢٠٢٤ |
٠٫١١٣٧١ % | Schweizerische Nationalbank | ٢٤٬٨٠٠ | ١٬٤٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫١١٢١٥ % | Schonfeld Strategic Advisors LLC | ٢٤٬٤٦٠ | ٢٤٬٤٦٠ | ٣٠/٦/٢٠٢٤ |
٠٫١١١٨٨ % | Erste Asset Management GmbH | ٢٤٬٤٠٠ | 0 | ٣١/٨/٢٠٢٤ |
٠٫١١٠١٠ % | Wells Fargo Advisors | ٢٤٬٠١٢ | ١١٬٧٤٢ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٨٤٣ % | Rokos Capital Management LLP | ٢٣٬٦٤٩ | -١٤٬١١٣ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٦٨٩ % | Simplify Asset Management Inc | ٢٣٬٣١٣ | ١٩ | ٣٠/٦/٢٠٢٤ |
٠٫١٠٦٧١ % | BlackRock Advisors (UK) Limited | ٢٣٬٢٧٤ | ٥٨٥ | ٣٠/٩/٢٠٢٤ |
٠٫١٠٢٠٧ % | California Public Employees' Retirement System | ٢٢٬٢٦٢ | ٢٬٠٧٢ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩٧٩٨ % | Wintrust Investments, LLC | ٢١٬٣٧٠ | ٢٬١٠٠ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩٢٧٥ % | BlackRock Asset Management Ireland Limited | ٢٠٬٢٢٩ | ١٬٣٤٠ | ٣٠/٦/٢٠٢٤ |
٠٫٠٩٠٣٧ % | Parametric Portfolio Associates LLC | ١٩٬٧١٠ | ٤٬١٤١ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٩١٠ % | Raymond James & Associates, Inc. | ١٩٬٤٣٣ | -٨٨٨ | ٣٠/٩/٢٠٢٤ |
٠٫٠٨٧٥٢ % | Rockefeller Capital Management | ١٩٬٠٨٨ | -١٦٬٠٧٣ | ٣٠/٦/٢٠٢٤ |
٠٫٠٨٦٧٤ % | Hennion & Walsh Asset Management, Inc. | ١٨٬٩١٧ | -١٬٤٢٠ | ٣٠/٩/٢٠٢٤ |
٠٫٠٨٣٩١ % | International Biotechnology Trust PLC | ١٨٬٣٠٠ | 0 | ٣٠/٩/٢٠٢٣ |
٠٫٠٨٠٢١ % | T. Rowe Price International Ltd | ١٧٬٤٩٤ | ٢٬٤٧٢ | ٣٠/٦/٢٠٢٤ |
٠٫٠٧٣٦٥ % | Citi Investment Research (US) | ١٦٬٠٦٢ | -١٦٬٧٢٨ | ٣٠/٦/٢٠٢٤ |
٠٫٠٧٢٤٤ % | Cutler Group, LP | ١٥٬٨٠٠ | ٢٬٣٠٠ | ٣١/٣/٢٠٢٤ |