١٣٫٩٥٢٧٧ % | State Street Global Advisors (US) | ١٦٬٠٠٢٬٩٨٩ | ٢٬٢٦٠٬٤٣٥ | ٣١/١٢/٢٠٢٢ |
٧٫٦٨٣٩٤ % | BVF Partners L.P. | ٨٬٨١٣٬٠٢١ | 0 | ٣١/١٢/٢٠٢٢ |
٥٫٦٠٢٨٥ % | BlackRock Institutional Trust Company, N.A. | ٦٬٤٢٦٬١٣٦ | ٤٠٥٬١٥٢ | ٣١/١٢/٢٠٢٢ |
٤٫٨٣٧٧٣ % | The Vanguard Group, Inc. | ٥٬٥٤٨٬٥٩١ | ٧٦٢٬٥٦٨ | ٣١/١٢/٢٠٢٢ |
٤٫٣٠١٩٧ % | Stonepine Capital Management, LLC | ٤٬٩٣٤٬١٠٠ | -٧٣٥٬٢٨٨ | ٣١/١٢/٢٠٢٢ |
٤٫١٥٢٥٩ % | Millennium Management LLC | ٤٬٧٦٢٬٧٦٩ | ٨٬٦٤١ | ٣١/١٢/٢٠٢٢ |
٤٫٠١٦٣٦ % | Sofinnova Investments, Inc | ٤٬٦٠٦٬٥٢٧ | ٩٩٤٬١٥١ | ٣١/١٢/٢٠٢٢ |
٣٫٣٩٤٨٩ % | Bleichroeder LP | ٣٬٨٩٣٬٧٣٠ | -٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٣٫٢٩٣٣٨ % | Bain Capital Life Sciences Investors, LLC | ٣٬٧٧٧٬٣٠٨ | ٣٬٧٧٧٬٣٠٨ | ٣١/١٢/٢٠٢٢ |
٣٫٢٢٨٢٩ % | Lion Point Capital, L.P. | ٣٬٧٠٢٬٦٥١ | -٦٨٦٬٨٩٥ | ٣١/١٢/٢٠٢٢ |
٣٫٢١٣٤٩ % | New Enterprise Associates (NEA) | ٣٬٦٨٥٬٦٨٣ | 0 | ٣١/١٢/٢٠٢٢ |
٢٫٤٠٥٤٥ % | Wellington Management Company, LLP | ٢٬٧٥٨٬٩٠٣ | -٦٠٬٧٦٠ | ٣١/١٢/٢٠٢٢ |
٢٫٢٣٩١٥ % | Medical Strategy GmbH | ٢٬٥٦٨٬١٦٧ | 0 | ٣٠/٩/٢٠٢٢ |
١٫٦٦٨٥٧ % | Geode Capital Management, L.L.C. | ١٬٩١٣٬٧٥٤ | ١٣٤٬٧٨٥ | ٣١/١٢/٢٠٢٢ |
١٫٦١٢٩٩ % | Ghost Tree Capital, LLC | ١٬٨٥٠٬٠٠٠ | -١٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
١٫٥٣٢٦٠ % | Point72 Asset Management, L.P. | ١٬٧٥٧٬٨٠٠ | ١٬٦٤٩٬٨٩٠ | ٣١/١٢/٢٠٢٢ |
١٫٥٢٣٧١ % | Schonfeld Strategic Advisors LLC | ١٬٧٤٧٬٦٠٠ | ٤١٨٬١٢٤ | ٣١/١٢/٢٠٢٢ |
١٫٢٨٢٨٥ % | Rafferty Asset Management LLC | ١٬٤٧١٬٣٥٧ | ٣٧٨٬٣١٤ | ٣١/١٢/٢٠٢٢ |
١٫٢٦٩١١ % | Verition Fund Management LLC | ١٬٤٥٥٬٥٨٩ | ٢١٤٬٢٧٨ | ٣١/١٢/٢٠٢٢ |
١٫٢٢٨١٧ % | Parkman Healthcare Partners LLC | ١٬٤٠٨٬٦٤٢ | ١٩٨٬٤٩٧ | ٣١/١٢/٢٠٢٢ |
١٫١٥٦١٧ % | Ensign Peak Advisors, Inc. | ١٬٣٢٦٬٠٦٢ | ٦١٩٬٧٨٥ | ٣١/١٢/٢٠٢٢ |
١٫١٣٦٥٥ % | Nuveen LLC | ١٬٣٠٣٬٥٥٢ | -٤٩٬٩٥٧ | ٣١/١٢/٢٠٢٢ |
١٫٠٨٢٥٠ % | Two Sigma Investments, LP | ١٬٢٤١٬٥٦٤ | ١٠١٬٧٠٢ | ٣١/١٢/٢٠٢٢ |
٠٫٩٨٩٠٨ % | Goldman Sachs & Company, Inc. | ١٬١٣٤٬٤١٩ | -٢١٣٬٢٨٦ | ٣١/١٢/٢٠٢٢ |
٠٫٩٢٤٢٢ % | AIGH Capital Management, LLC. | ١٬٠٦٠٬٠٢٣ | ١٬٠٦٠٬٠٢٣ | ٣١/١٢/٢٠٢٢ |
٠٫٨٥٤٧١ % | Sectoral Asset Management Inc. | ٩٨٠٬٣٠٠ | ١٢٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٨٤٤٨٦ % | JP Morgan Asset Management | ٩٦٩٬٠٠٤ | -٣٣٬١٩١ | ٣١/١٢/٢٠٢٢ |
٠٫٨٠٧٦٨ % | BofA Global Research (US) | ٩٢٦٬٣٦٣ | ٢١١٬٣٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٨٠٧٦٤ % | UBS Financial Services, Inc. | ٩٢٦٬٣٠٩ | ٧٨٢٬٠٥٣ | ٣١/١٢/٢٠٢٢ |
٠٫٧٥٩٧٧ % | Balyasny Asset Management LP | ٨٧١٬٤٠٩ | ٨٧١٬٤٠٩ | ٣١/١٢/٢٠٢٢ |
٠٫٦٨٣٩٠ % | Northern Trust Investments, Inc. | ٧٨٤٬٣٨٩ | ٥٧٬٢١٧ | ٣١/١٢/٢٠٢٢ |
٠٫٦٦١٢٠ % | Barclays Bank PLC | ٧٥٨٬٣٦١ | ٧٩٬٧٤٨ | ٣١/١٢/٢٠٢٢ |
٠٫٥٥٩٨٦ % | Citi Investment Research (US) | ٦٤٢٬١٢١ | -٣٤٧٬٣٢٥ | ٣١/١٢/٢٠٢٢ |
٠٫٥٥٥٣٢ % | J. Goldman & Co., L.P. | ٦٣٦٬٩٢٠ | ٣٧٢٬٥٠٧ | ٣١/١٢/٢٠٢٢ |
٠٫٤٩٤٠٩ % | Knott Partners Management, LLC | ٥٦٦٬٦٨٧ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٤٢٥٥٧ % | Norges Bank Investment Management (NBIM) | ٤٨٨٬١٠٠ | ٤٨٨٬١٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٣٩٢٣٥ % | Altium Capital Management LP | ٤٥٠٬٠٠٠ | ٢٣٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٣٧١٤٦ % | Morgan Stanley & Co. LLC | ٤٢٦٬٠٤٦ | ١٣٤٬٥٤٨ | ٣١/١٢/٢٠٢٢ |
٠٫٣٦٨٩٠ % | Susquehanna International Group, LLP | ٤٢٣٬١٠٤ | -٢٢٠٬٨٨٨ | ٣١/١٢/٢٠٢٢ |
٠٫٣١٨٢٣ % | Worth Venture Partners, LLC | ٣٦٤٬٩٩٥ | ٣٦٤٬٩٩٥ | ٣١/١٢/٢٠٢٢ |
٠٫٢٨٧٧٢ % | Sio Capital Management, LLC | ٣٣٠٬٠٠٠ | ٣٣٠٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٢٦٩٢٥ % | ExodusPoint Capital Management, LP | ٣٠٨٬٨١٣ | ٣٠٨٬٨١٣ | ٣١/١٢/٢٠٢٢ |
٠٫٢٦١٥٧ % | Tang Capital Management, LLC | ٣٠٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٢٥٧٩١ % | BlackRock Investment Management, LLC | ٢٩٥٬٨٠٧ | -٦٬٥٠٦ | ٣١/١٢/٢٠٢٢ |
٠٫٢٤١٣١ % | BlackRock Financial Management, Inc. | ٢٧٦٬٧٦٧ | ٢٨٬٧١٧ | ٣١/١٢/٢٠٢٢ |
٠٫٢٣٨٦٩ % | BNP Paribas Securities Corp. North America | ٢٧٣٬٧٦٣ | -٥٦٬٠٤٣ | ٣١/١٢/٢٠٢٢ |
٠٫٢٣٥٥٠ % | Charles Schwab Investment Management, Inc. | ٢٧٠٬١٠١ | ١٢٬٤٠٥ | ٣١/١٢/٢٠٢٢ |
٠٫٢٢٧٦٩ % | BNY Mellon Asset Management | ٢٦١٬١٤٢ | ١٥٬١٩٠ | ٣١/١٢/٢٠٢٢ |
٠٫٢٢١٧٧ % | SilverArc Capital Management, LLC | ٢٥٤٬٣٦١ | -٧٢٩٬١٥٥ | ٣١/١٢/٢٠٢٢ |
٠٫١٩٢٦٩ % | Schweizerische Nationalbank | ٢٢١٬٠٠٠ | ٢٢١٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٨٠٦٨ % | BG Fund Management Luxembourg S.A. | ٢٠٧٬٢٢٦ | ٤٧٬٨٤٧ | ٣١/١٢/٢٠٢٢ |
٠٫١٦٨٤٢ % | Walleye Capital LLC | ١٩٣٬١٧٠ | -٢٠٣٬٨٠٢ | ٣١/١٢/٢٠٢٢ |
٠٫١٦٨١٣ % | Gyon Technologies Capital Management, LP | ١٩٢٬٨٣١ | ١١١٬٨٩١ | ٣١/١٢/٢٠٢٢ |
٠٫١٥٨٥٠ % | Allspring Global Investments, LLC | ١٨١٬٧٩١ | -٩٢١ | ٣١/١٢/٢٠٢٢ |
٠٫١٥٦٠٠ % | Parametric Portfolio Associates LLC | ١٧٨٬٩١٩ | -٢٠٢٬٢٢٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٥٣٩٥ % | Kennedy Capital Management, Inc. | ١٧٦٬٥٧١ | -١٣٥ | ٣١/١٢/٢٠٢٢ |
٠٫١٤٥٢٨ % | Nomura Securities Co., Ltd. | ١٦٦٬٦٢٢ | ١٦٥٬٦١٢ | ٣١/١٢/٢٠٢٢ |
٠٫١٣٠٧٨ % | Islet Management, LP | ١٥٠٬٠٠٠ | -٤٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٢٥٩٠ % | Rhumbline Advisers Ltd. Partnership | ١٤٤٬٣٩٦ | ٢٬٤٨١ | ٣١/١٢/٢٠٢٢ |
٠٫١٢٣٥١ % | Capital Fund Management S.A. | ١٤١٬٦٥٦ | ١٤١٬٦٥٦ | ٣١/١٢/٢٠٢٢ |
٠٫١٢٠١٤ % | Cubist Systematic Strategies, LLC | ١٣٧٬٧٩٤ | -١٢٦٬١٦٢ | ٣١/١٢/٢٠٢٢ |
٠٫١١٩٧٠ % | JPMorgan Private Bank (United States) | ١٣٧٬٢٩٢ | ٣٧٧ | ٣١/١٢/٢٠٢٢ |
٠٫١١٥٤٥ % | William Blair & Company, L.L.C. (Research) | ١٣٢٬٤١٣ | -٤٣٬٧٨٥ | ٣١/١٢/٢٠٢٢ |
٠٫١٠٤١٦ % | California State Teachers Retirement System | ١١٩٬٤٦٠ | ٧٩٬٩٣٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٩٦٠٨ % | AllianceBernstein L.P. | ١١٠٬٢٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٩٣٢٥ % | Boothbay Fund Management, LLC | ١٠٦٬٩٤٩ | ١٠٦٬٩٤٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٨٣٠٧ % | Lakeside Advisors, Inc. | ٩٥٬٢٨٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٨١٨٧ % | SEB Investment Management AB | ٩٣٬٩٠٣ | -٥٬٤٤٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٩٩٦ % | State of Wisconsin Investment Board | ٩١٬٧١٤ | ٩١٬٧١٤ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٩٩٦ % | Mackenzie Financial Corporation | ٩١٬٧١٤ | ٨٠٬٨٠١ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٩٩٥ % | Jump Financial, LLC | ٩١٬٦٩٣ | ٥٨٬٢٠٤ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٨٤٧ % | Candriam Belgium S.A. | ٩٠٬٠٠٠ | ٩٠٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٨٤٧ % | Candriam Luxembourg S.A. | ٩٠٬٠٠٠ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٦٩٧٠ % | Jane Street Capital, L.L.C. | ٧٩٬٩٣٦ | -٣٠٢٬٧٥٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٩٤٠ % | J.P. Morgan Securities LLC | ٧٩٬٥٩٥ | ٧٩٬٥٩٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٨٦٤ % | GSA Capital Partners LLP | ٧٨٬٧٢٩ | -٥٥٬٦٢٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٧٢٢ % | E Fund Management Co. Ltd. | ٧٧٬١٠١ | ١٬٩٦٨ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٥٥٩ % | Northern Trust Global Investments | ٧٥٬٢٣٢ | -٢٬١١٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٤٦٣ % | Credit Suisse Asset Management | ٧٤٬١٢٩ | ٧٤٬١٢٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٢٧٦ % | Hightower Advisors, LLC | ٧١٬٩٨٢ | ١٬٥٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٢٥١ % | Mellon Investments Corporation | ٧١٬٦٩٢ | ٥٨١ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٧٢٤ % | Goldman Sachs Asset Management, L.P. | ٦٥٬٦٥٤ | -١٢٢٬١٨٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٦٤٦ % | New York State Common Retirement Fund | ٦٤٬٧٥٣ | ٥٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥٤٣٢ % | Bayesian Capital Management, LP | ٦٢٬٣٠٠ | ٦٢٬٣٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٧٢٣ % | State Street Global Advisors Ireland Limited | ٥٤٬١٧٥ | ٣٬٤٠٠ | ٣٠/١١/٢٠٢٢ |
٠٫٠٤٥٨٨ % | Apo Asset Management GmbH | ٥٢٬٦٢٧ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٤٥٠٨ % | UBS Asset Management (Switzerland) | ٥١٬٧٠٠ | ٥١٬٧٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٤٩٤ % | Virtus Etf Advisers LLC | ٥١٬٥٤٢ | ٨٬١٧٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٤٩٤ % | LifeSci Index Partners, LLC | ٥١٬٥٤٢ | 0 | ٢٨/٢/٢٠٢٣ |
٠٫٠٤٤٧٤ % | Citadel Advisors LLC | ٥١٬٣١١ | -٤٣٩٬٤٨٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٣٨٨ % | HRT Financial LP | ٥٠٬٣٢٦ | ٥٠٬٣٢٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٣٥٩ % | Caption Management, LLC | ٥٠٬٠٠٠ | ٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٢٨٥ % | SG Americas Securities, L.L.C. | ٤٩٬١٤٩ | -٢٬٥٥٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٢٤٥ % | MetLife Investment Management, LLC | ٤٨٬٦٨٨ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٤٢٤١ % | Tuckson (Reed Vaughn M.D.) | ٤٨٬٦٣٩ | -٤٣٬٧٨٥ | ١٦/١٢/٢٠٢٢ |
٠٫٠٤١٣٠ % | SunAmerica Asset Management, LLC | ٤٧٬٣٦٥ | -١٧٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٨٢٨ % | Seeley (Bruce J) | ٤٣٬٩٠٥ | 0 | ٢١/٣/٢٠٢٢ |
٠٫٠٣٧٦١ % | Perry Matthew D | ٤٣٬١٣٩ | 0 | ٩/٨/٢٠٢٢ |
٠٫٠٣٧١٥ % | DWS Investments UK Limited | ٤٢٬٦١٠ | ٦٦٨ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣٤٣٣ % | Manulife Investment Management (North America) Limited | ٣٩٬٣٧٨ | ١٬٦٥٢ | ٣١/١٢/٢٠٢٢ |