٩٫٧٩٨٢٤ % | EcoR1 Capital, LLC | ٦٬٧٢٦٬٤٩١ | ١٬٢٥٩٬٤٢٨ | ٣١/١٢/٢٠٢٣ |
٧٫٠٥٣٤٢ % | The Vanguard Group, Inc. | ٤٬٨٤٢٬١٧٤ | ٢٤٣٬١٦٧ | ٣١/١٢/٢٠٢٣ |
٦٫١٣٧٦٣ % | RTW Investments L.P. | ٤٬٢١٣٬٤٨٣ | ٤٬٢١٣٬٤٨٣ | ٣١/١٢/٢٠٢٣ |
٦٫٠٧١٥٠ % | BlackRock Institutional Trust Company, N.A. | ٤٬١٦٨٬٠٨٥ | ٣٥٧٬٢٤٤ | ٣١/١٢/٢٠٢٣ |
٥٫٤٣١٧٢ % | T. Rowe Price Associates, Inc. | ٣٬٧٢٨٬٨٧٣ | ١٬١٣٢٬٨٩٨ | ٣١/١٢/٢٠٢٣ |
٤٫٣٤٨٣١ % | Avidity Partners Management LP | ٢٬٩٨٥٬١١٧ | ٣٧٠٬١٥٧ | ٣١/١٢/٢٠٢٣ |
٣٫٦٥٢٩٢ % | Bellevue Asset Management AG | ٢٬٥٠٧٬٧٣١ | ٣٨٢٬٥٣١ | ٣١/١٢/٢٠٢٣ |
٣٫٥٥٤٢٣ % | Citadel Advisors LLC | ٢٬٤٣٩٬٩٨١ | ١٬٨١٥٬٤٠٣ | ٣١/١٢/٢٠٢٣ |
٢٫٤٦٩٩٩ % | Nextech Invest, Ltd. | ١٬٦٩٥٬٦٤٥ | ١٬٤٠٨٬٣٩٤ | ٣١/١٢/٢٠٢٣ |
٢٫٢٨٦٨١ % | ArrowMark Colorado Holdings, LLC | ١٬٥٦٩٬٨٩٥ | -٥١٧٬٣٩٧ | ٣١/١٢/٢٠٢٣ |
١٫٨٧٨٤٠ % | New Leaf Venture Partners LLC | ١٬٢٨٩٬٥٢١ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٧٣١٩٩ % | Fidelity Institutional Asset Management | ١٬١٨٩٬٠١١ | -٣٧٤٬١٦٤ | ٣١/١٢/٢٠٢٣ |
١٫٧٢٨٢٩ % | State Street Global Advisors (US) | ١٬١٨٦٬٤٧٤ | ٢٧٬٠٢٢ | ٣١/١٢/٢٠٢٣ |
١٫٦٣٥٢٩ % | Geode Capital Management, L.L.C. | ١٬١٢٢٬٦٢٧ | ٦٥٬٢٣٧ | ٣١/١٢/٢٠٢٣ |
١٫٥٦٤٢٤ % | JP Morgan Asset Management | ١٬٠٧٣٬٨٥٤ | -١٣٨٬٠٧٧ | ٣١/١٢/٢٠٢٣ |
١٫٥٣٦٧٩ % | Fidelity Management & Research Company LLC | ١٬٠٥٥٬٠٠٨ | -٢٬٢٥٠٬١١٢ | ٣١/١٢/٢٠٢٣ |
١٫٥٣٥٦٠ % | Houston (John G) | ١٬٠٥٤٬١٩١ | ١١٩٬٢٥٤ | ٢٣/٢/٢٠٢٤ |
١٫٤٨٢١٠ % | JPMorgan Asset Management U.K. Limited | ١٬٠١٧٬٤٦٣ | ٣٠٧٬١٩٢ | ٣١/١٢/٢٠٢٣ |
١٫٤٥٦٦٦ % | Commodore Capital LP | ١٬٠٠٠٬٠٠٠ | ١٬٠٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٣٥٦٦٠ % | Paradigm BioCapital Advisors LP | ٩٣١٬٣٠٣ | ٩٣١٬٣٠٣ | ٣١/١٢/٢٠٢٣ |
١٫٢٧٨٥٣ % | Norges Bank Investment Management (NBIM) | ٨٧٧٬٧٠٨ | ١٧٥٬٩٥٣ | ٣١/١٢/٢٠٢٣ |
١٫١٥٠٠١ % | Adage Capital Management, L.P. | ٧٨٩٬٤٨٥ | ٧٨٩٬٤٨٥ | ٣١/١٢/٢٠٢٣ |
١٫٠٨٤٤٤ % | Holocene Advisors, LP | ٧٤٤٬٤٦٥ | ٧٤٤٬٤٦٥ | ٣١/١٢/٢٠٢٣ |
١٫٠٨٣٣٦ % | BlackRock Financial Management, Inc. | ٧٤٣٬٧٢٨ | -٦٬٦٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫٩١٤٤٨ % | VR Adviser, LLC | ٦٢٧٬٧٨٨ | ٦٢٧٬٧٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫٨٨٦٥٥ % | Boxer Capital, L.L.C. | ٦٠٨٬٦١٤ | ٦٠٨٬٦١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٨٢٤٤٨ % | Morgan Stanley & Co. LLC | ٥٦٦٬٠٠٣ | ٢٤٥٬٤٦٠ | ٣١/١٢/٢٠٢٣ |
٠٫٧٣٥١٨ % | Finepoint Capital LP | ٥٠٤٬٧٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٧١٦٥٠ % | Dimensional Fund Advisors, L.P. | ٤٩١٬٨٧٧ | ٢٢٬٤٧٩ | ٣١/١٢/٢٠٢٣ |
٠٫٧١٢٥٣ % | Aquilo Capital Management, LLC | ٤٨٩٬١٥٣ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٧١٠٢٠ % | Candriam Belgium S.A. | ٤٨٧٬٥٥٥ | ٤٠٬٠٠٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٨٣٨٧ % | Charles Schwab Investment Management, Inc. | ٤٦٩٬٤٧٤ | ٣٩٬٤٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٧٣٧٦ % | Candriam Luxembourg S.A. | ٤٦٢٬٥٣٦ | -٢٥٬٠٠٠ | ٢٩/٢/٢٠٢٤ |
٠٫٦٤٤٥٩ % | Northern Trust Investments, Inc. | ٤٤٢٬٥١٢ | ٢٤٬٧٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦١٣٧٦ % | RA Capital Management, LP | ٤٢١٬٣٤٨ | ٤٢١٬٣٤٨ | ٣١/١٢/٢٠٢٣ |
٠٫٥٧٥٩٢ % | American Century Investment Management, Inc. | ٣٩٥٬٣٦٧ | -٤١٨٬١٠٢ | ٣١/١٢/٢٠٢٣ |
٠٫٥٦٤٦٥ % | Woodline Partners LP | ٣٨٧٬٦٣٠ | ٢١٥٬٠٣٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٢٢٦٧ % | Millennium Management LLC | ٣٥٨٬٨١٣ | -٤٦٩٬٣١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٥١٦٩٧ % | Nuveen LLC | ٣٥٤٬٨٩٨ | ١٧٬٧٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٥١٥٧٨ % | Perceptive Advisors LLC | ٣٥٤٬٠٨٢ | ٣٥٤٬٠٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٤٨٥٨٣ % | Gilder Gagnon Howe & Co. LLC | ٣٣٣٬٥٢٤ | ١٦٢٬٦٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٤٥١٠٨ % | Voloridge Investment Management, LLC | ٣٠٩٬٦٦٣ | ٣٠٩٬٦٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫٤١٥٦٣ % | Frazier Healthcare Partners | ٢٨٥٬٣٣١ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٤٠٦٠٣ % | Nordea Funds Oy | ٢٧٨٬٧٣٧ | -٦٬٣١٧ | ٣١/١٢/٢٠٢٣ |
٠٫٣٨٦٦٤ % | Brown Advisory | ٢٦٥٬٤٣١ | -١٧٠٬١٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫٣٨٤١٢ % | Opaleye Management Inc. | ٢٦٣٬٧٠٠ | ٢٦٣٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧٤٣٤ % | UBS Financial Services, Inc. | ٢٥٦٬٩٨٦ | -٦٢٬٧٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥٨١٥ % | Schonfeld Strategic Advisors LLC | ٢٤٥٬٨٦٨ | ١٨١٬٨٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٤٦٠٦ % | Renaissance Technologies LLC | ٢٣٧٬٥٧٣ | ١٢٣٬٨٧٣ | ٣١/١٢/٢٠٢٣ |
٠٫٣٤٠٩٨ % | Great Point Partners, LLC | ٢٣٤٬٠٨٢ | ٢٣٤٬٠٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٣١٤٢٤ % | Goldman Sachs & Company, Inc. | ٢١٥٬٧٢٨ | ١١٥٬٢١٩ | ٣١/١٢/٢٠٢٣ |
٠٫٣٠٤٣٢ % | BlackRock Advisors (UK) Limited | ٢٠٨٬٩١٩ | ١٠٬٢٤٢ | ٣١/٣/٢٠٢٤ |
٠٫٣٠٢١٥ % | Wasatch Global Investors Inc | ٢٠٧٬٤٢٦ | -١٥٬٥١٦ | ٣١/٣/٢٠٢٤ |
٠٫٢٨٧٠٤ % | BNP Paribas Securities Corp. North America | ١٩٧٬٠٥٢ | ٩٧٬٦٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٨٥١٠ % | Amundi Asset Management US, Inc. | ١٩٥٬٧٢٠ | ٤٬٤٢٣ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧١٩٧ % | Cassidy (Sean A) | ١٨٦٬٧٠٧ | -١٬٧٠٢ | ٢٣/٢/٢٠٢٤ |
٠٫٢٥٤٩٢ % | Integral Health Asset Management, LLC | ١٧٥٬٠٠٠ | ١٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٥٤٥٢ % | BlackRock Asset Management Ireland Limited | ١٧٤٬٧٢٨ | ٩٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٤٣٢٦ % | Parkman Healthcare Partners LLC | ١٦٧٬٠٠١ | ٦٢٬٨٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢٥٩٧ % | UBS Asset Management (Americas), Inc. | ١٥٥٬١٢٩ | ٤٥٬٩٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢٥٨٤ % | BofA Global Research (US) | ١٥٥٬٠٣٦ | ٤٧٬٤٩٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٩٢٥ % | Invesco Capital Management LLC | ١٥٠٬٥١٦ | ١٢٩٬٣١٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٨٨٠ % | Taylor (Ian) | ١٥٠٬٢٠٧ | ٣٧٬٥٤٩ | ٢٣/٢/٢٠٢٤ |
٠٫٢١٨٥٠ % | Wanjia Asset Management Co., Ltd. | ١٥٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٢١٧٢١ % | BlackRock Investment Management, LLC | ١٤٩٬١١٦ | ٢٦٬٦٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٤٠٥ % | TD Asset Management Inc. | ١٤٦٬٩٤٨ | ٥٢٬٠٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٩٠٦ % | Yale University | ١٤٣٬٥٢٢ | ١٤٣٬٥٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٧٠٠ % | Credit Suisse Funds AG | ١٤٢٬١٠٨ | ٨٦٬٨٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠١٩٨ % | Citi Investment Research (US) | ١٣٨٬٦٥٦ | ١٣٣٬٩٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠١٠٦ % | Federated MDTA LLC | ١٣٨٬٠٢٨ | ٣٣٬٧٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٨٢٣ % | BNY Mellon Asset Management | ١٣٦٬٠٨٥ | -٢٬٥٥٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٥٥٩ % | Rhenman & Partners Asset Management AB | ١٣٤٬٢٧٠ | ٤٩٬٢٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٩١٥٤ % | Nordea Investment Management AB (Denmark) | ١٣١٬٤٩٤ | ٥٥ | ٢٩/٢/٢٠٢٤ |
٠٫١٦٦٢١ % | First Trust Advisors L.P. | ١١٤٬١٠٥ | ١٬٥٦٩ | ٢٩/٢/٢٠٢٤ |
٠٫١٦٥٦٧ % | Goldman Sachs Asset Management, L.P. | ١١٣٬٧٣١ | ١٩٬٥٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٠٤٠ % | T. Rowe Price International Ltd | ١٠٣٬٢٥٠ | ١٠٬٥٥٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٠٢١ % | Putnam Investment Management, L.L.C. | ١٠٣٬١١٨ | ٨٧٬٦٧١ | ٣١/١٢/٢٠٢٣ |
٠٫١٤٨٣٣ % | Parametric Portfolio Associates LLC | ١٠١٬٨٢٦ | ٣٦٬١٨٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٤١٦١ % | Jane Street Capital, L.L.C. | ٩٧٬٢١٧ | ٤٦٬٨٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٥٣٧ % | Banque Pictet & Cie S.A. | ٩٢٬٩٣٣ | ٩٢٬٩٣٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٢٧٥ % | UBS O'Connor LLC | ٩١٬١٣٢ | -١٩٬٠٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٠٣٧ % | Schweizerische Nationalbank | ٨٩٬٥٠٠ | -١٠٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٩٩٨ % | Manulife Investment Management (North America) Limited | ٨٩٬٢٢٨ | ٢١٬٩١١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٣٧٢ % | D. E. Shaw & Co., L.P. | ٨٤٬٩٣١ | ٦٤٬١٣١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢١٨١ % | Barclays Bank PLC | ٨٣٬٦٢١ | ٤٩٬٨٢٤ | ٣١/١٢/٢٠٢٣ |
٠٫١١٧٤٧ % | Shannon (Timothy M) | ٨٠٬٦٤٣ | 0 | ٣١/٣/٢٠٢٣ |
٠٫١١٦٥٣ % | Tang Capital Management, LLC | ٨٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٠٨٦٢ % | Algert Global LLC | ٧٤٬٥٧١ | -٩٨٬٨٤٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٧٧٩ % | HOOPP Investment Management | ٧٤٬٠٠٠ | ٧٤٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٧٧٦ % | Columbia Threadneedle Investments (US) | ٧٣٬٩٧٥ | ١٥٬١٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٤٤٤ % | Zacks Investment Management, Inc. | ٧١٬٦٩٥ | ٦٤٬٣٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٤٢٥ % | CastleArk Management, LLC | ٧١٬٥٧٠ | ٧١٬٥٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٢٨٦ % | JPMorgan Private Bank (United States) | ٧٠٬٦١٢ | ٢٢٬٢٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٠٣٥ % | Rhumbline Advisers Ltd. Partnership | ٦٨٬٨٩٠ | -١١٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٨٥٣ % | Conestoga Capital Advisors, LLC | ٦٧٬٦٤٠ | -١٬٨٣٧ | ٢٩/٢/٢٠٢٤ |
٠٫٠٩٦١٤ % | Bank Vontobel AG | ٦٦٬٠٠٠ | ٦٦٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٦١٤ % | Sectoral Asset Management Inc. | ٦٦٬٠٠٠ | ٥٨٬٩٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٢٤٣ % | Berkowitz (Noah) | ٦٣٬٤٥٢ | ٦٣٬٤٥٢ | ١٨/٣/٢٠٢٤ |
٠٫٠٩٠١١ % | Hennion & Walsh Asset Management, Inc. | ٦١٬٨٦٢ | ٢٥٬٧٧٨ | ٣١/٣/٢٠٢٤ |
٠٫٠٨٩٢١ % | Trexquant Investment LP | ٦١٬٢٤٣ | ٦١٬٢٤٣ | ٣١/١٢/٢٠٢٣ |