10.79290 % | Baker Bros. Advisors LP | 4,257,735 | 1,579,182 | 31/3/2568 |
8.78594 % | BVF Partners L.P. | 3,466,000 | 0 | 31/3/2568 |
7.66754 % | Sullivan (Brian F) | 3,024,798 | 8,155 | 14/4/2568 |
6.52512 % | Soleus Capital Management, L.P. | 2,574,122 | 9,035 | 31/3/2568 |
5.98812 % | Perceptive Advisors LLC | 2,362,279 | 0 | 31/3/2568 |
5.13730 % | BlackRock Institutional Trust Company, N.A. | 2,026,633 | 10,036 | 31/3/2568 |
4.23895 % | The Vanguard Group, Inc. | 1,672,242 | 20,261 | 31/3/2568 |
3.20829 % | Eventide Asset Management, LLC | 1,265,653 | 0 | 31/3/2568 |
3.16862 % | New Enterprise Associates (NEA) | 1,250,001 | 0 | 31/3/2568 |
3.16862 % | Laing (Lance G Ph.D.) | 1,250,000 | 0 | 17/3/2568 |
2.77235 % | Saturn V Capital Management LP | 1,093,677 | 29,894 | 31/3/2568 |
2.40417 % | Citadel Advisors LLC | 948,429 | 112,406 | 31/3/2568 |
2.24162 % | Braidwell LP | 884,306 | 0 | 31/3/2568 |
2.02026 % | Janus Henderson Investors | 796,981 | 148,863 | 31/3/2568 |
1.82492 % | Geode Capital Management, L.L.C. | 719,920 | 27,548 | 31/3/2568 |
1.76340 % | Commodore Capital LP | 695,650 | 295,650 | 31/3/2568 |
1.54755 % | Vivo Capital, LLC | 610,500 | 0 | 31/3/2568 |
1.52720 % | Columbia Threadneedle Investments (US) | 602,472 | 155,301 | 31/3/2568 |
1.48337 % | State Street Global Advisors (US) | 585,180 | -294,612 | 31/3/2568 |
1.41346 % | CAPTRUST Financial Advisors | 557,603 | 95,809 | 31/3/2568 |
1.15248 % | Artisan Partners Limited Partnership | 454,646 | -36,861 | 31/3/2568 |
1.00331 % | Morgan Stanley Investment Management Inc. (US) | 395,800 | -55,830 | 31/3/2568 |
0.95143 % | Morgan Stanley & Co. LLC | 375,332 | 42,123 | 31/3/2568 |
0.93732 % | Candriam Luxembourg S.A. | 369,767 | 660 | 30/4/2568 |
0.88571 % | Pfizer Inc | 349,406 | 0 | 31/3/2568 |
0.72734 % | Northern Trust Investments, Inc. | 286,932 | -13,017 | 31/3/2568 |
0.66817 % | Candriam Belgium S.A. | 263,590 | 0 | 31/3/2568 |
0.63811 % | BofA Global Research (US) | 251,729 | -36,530 | 31/3/2568 |
0.59399 % | Dalvey David F | 234,325 | 0 | 17/3/2568 |
0.58819 % | Charles Schwab Investment Management, Inc. | 232,036 | -5,670 | 31/3/2568 |
0.51024 % | Quantinno Capital Management LP | 201,286 | 201,286 | 31/3/2568 |
0.42774 % | Hennion & Walsh Asset Management, Inc. | 168,740 | 24,708 | 31/3/2568 |
0.25626 % | Nigon (Richard J) | 101,093 | 0 | 17/3/2568 |
0.21502 % | Wellington Management Company, LLP | 84,825 | 22,049 | 31/3/2568 |
0.20751 % | BlackRock Investment Management, LLC | 81,863 | 1,299 | 31/3/2568 |
0.19582 % | Goldman Sachs & Company, Inc. | 77,248 | -30,418 | 31/3/2568 |
0.18632 % | BlackRock Financial Management, Inc. | 73,503 | 1,607 | 31/3/2568 |
0.17640 % | Nuveen LLC | 69,587 | 0 | 31/3/2568 |
0.17298 % | UBS Financial Services, Inc. | 68,239 | -15,675 | 31/3/2568 |
0.16023 % | Jacob Asset Management of New York, LLC | 63,209 | -3,000 | 30/9/2566 |
0.14781 % | Morgan Stanley Smith Barney LLC | 58,311 | -25,502 | 31/3/2568 |
0.13767 % | Gagnon Securities LLC | 54,310 | 1,831 | 31/3/2568 |
0.13523 % | PFM Health Sciences, LP | 53,349 | -105,397 | 31/3/2568 |
0.13162 % | BNY Mellon Asset Management | 51,924 | 3,394 | 31/3/2568 |
0.10696 % | Rhumbline Advisers Ltd. Partnership | 42,194 | 3,439 | 31/3/2568 |
0.10147 % | Susquehanna International Group, LLP | 40,031 | 18,715 | 31/3/2568 |
0.09656 % | JNBA Financial Advisors LLC | 38,091 | 0 | 31/3/2568 |
0.09344 % | Bessemer Trust Company, N.A. (US) | 36,861 | -14,230 | 31/1/2568 |
0.08967 % | Barclays Bank PLC | 35,376 | -21,823 | 31/3/2568 |
0.08943 % | Two Sigma Investments, LP | 35,278 | -67,760 | 31/3/2568 |
0.07380 % | Accredited Investors Wealth Management | 29,115 | 0 | 31/3/2568 |
0.07302 % | Aperio Group, LLC | 28,806 | 20,592 | 31/3/2568 |
0.07300 % | Alps Advisors, Inc. | 28,798 | -1,230 | 31/3/2568 |
0.07197 % | New York State Common Retirement Fund | 28,391 | 0 | 31/3/2568 |
0.06824 % | Trexquant Investment LP | 26,920 | 15,280 | 31/3/2568 |
0.06727 % | Wealth Enhancement Advisory Services, LLC | 26,539 | 162 | 31/3/2568 |
0.06258 % | Entrypoint Capital LLC | 24,687 | 3,840 | 31/3/2568 |
0.06003 % | AllianceBernstein L.P. | 23,680 | 0 | 31/3/2568 |
0.05893 % | Citi Investment Research (US) | 23,247 | -15,561 | 31/3/2568 |
0.05472 % | Fubon Asset Management Company Ltd. | 21,588 | -155 | 28/2/2568 |
0.05396 % | Paloma Partners Management Company | 21,288 | 21,288 | 31/3/2568 |
0.05329 % | Commonwealth Financial Network | 21,024 | 21,024 | 31/3/2568 |
0.05159 % | Millennium Management LLC | 20,351 | -19,309 | 31/3/2568 |
0.05037 % | MetLife Investment Management, LLC | 19,872 | -512 | 31/3/2568 |
0.04908 % | Mirae Asset Global Investments (USA) LLC | 19,361 | -364 | 31/3/2568 |
0.04781 % | Hahne (Vicky) | 18,860 | 303 | 17/3/2568 |
0.04692 % | Cresset Asset Management, LLC | 18,510 | 0 | 31/3/2568 |
0.04634 % | DWS Investments UK Limited | 18,282 | -4,028 | 31/3/2568 |
0.04472 % | Pale Fire Capital SE | 17,640 | 182 | 31/3/2568 |
0.04372 % | Trust Point Inc. | 17,247 | -600 | 31/3/2568 |
0.04269 % | Mellon Investments Corporation | 16,842 | 1,247 | 31/3/2568 |
0.04061 % | Corebridge Financial Inc. | 16,019 | -237 | 31/3/2568 |
0.04021 % | Wells Fargo Bank, N.A. | 15,863 | 349 | 31/3/2568 |
0.03959 % | NEOS Investment Management, LLC | 15,619 | 116 | 31/3/2568 |
0.03920 % | JPMorgan Private Bank (United States) | 15,463 | 1,084 | 31/3/2568 |
0.03625 % | Shay Capital LLC | 14,300 | 0 | 31/3/2568 |
0.03585 % | Numeric Investors LLC | 14,144 | 14,144 | 31/3/2568 |
0.03582 % | T. Rowe Price International Ltd | 14,132 | 1,411 | 31/3/2568 |
0.03580 % | INTECH Investment Management LLC | 14,121 | -2,528 | 31/3/2568 |
0.03300 % | Virtus Investment Advisers, Inc. | 13,020 | 13,020 | 31/3/2568 |
0.03061 % | Metropolitan Life Insurance Co. (US) | 12,075 | 12,075 | 31/3/2568 |
0.02998 % | Goldman Sachs Asset Management, L.P. | 11,825 | 1,732 | 31/3/2568 |
0.02973 % | Manulife Investment Management (North America) Limited | 11,728 | 902 | 31/3/2568 |
0.02877 % | Perkins Capital Management, Inc. | 11,350 | 11,350 | 31/3/2568 |
0.02849 % | SG Americas Securities, L.L.C. | 11,240 | -3,406 | 31/3/2568 |
0.02725 % | Furcht (Leo M.D.) | 10,750 | 0 | 17/3/2568 |
0.02710 % | Focus Financial Network, Inc. | 10,691 | 10,691 | 31/3/2568 |
0.02061 % | Harvest Fund Management Co., Ltd. | 8,129 | 8,129 | 31/12/2567 |
0.02020 % | RBC Capital Markets Wealth Management | 7,969 | -372 | 31/3/2568 |
0.01954 % | Buller (Richard E) | 7,710 | -50 | 27/5/2568 |
0.01820 % | Parametric Portfolio Associates LLC | 7,179 | -943 | 31/3/2568 |
0.01662 % | Voya Investment Management LLC | 6,558 | 0 | 30/4/2568 |
0.01635 % | Police and Firemen's Retirement System of New Jersey | 6,451 | 0 | 31/3/2568 |
0.01444 % | ProShare Advisors LLC | 5,698 | 183 | 31/5/2568 |
0.01364 % | Northern Trust Global Investments | 5,380 | 172 | 31/3/2568 |
0.01267 % | Murphy (Polly A) | 5,000 | 0 | 17/3/2568 |
0.01262 % | Florida State Board of Administration | 4,980 | 0 | 31/3/2568 |
0.01068 % | Principal Global Investors (Equity) | 4,213 | 621 | 30/4/2568 |
0.01015 % | Allspring Global Investments, LLC | 4,006 | 0 | 30/4/2568 |
0.00952 % | BlackRock Advisors, LLC | 3,756 | 833 | 31/12/2567 |