16.36437 % | Sofinnova Investments, Inc | 3,606,707 | 0 | 31/12/2564 |
13.59283 % | VenBio Partners LLC | 2,995,859 | -677,515 | 26/4/2565 |
9.80939 % | Novo Holdings A/S | 2,161,990 | -8,110 | 25/2/2565 |
8.14279 % | Longitude Capital Management Co., LLC | 1,794,671 | 1,794,671 | 11/8/2563 |
6.81359 % | Medicxi Ventures (UK) LLP | 1,501,716 | 0 | 31/12/2564 |
6.05740 % | Omega Fund Management, LLC | 1,335,050 | 0 | 31/12/2564 |
6.04925 % | Decheng Capital China Life Sciences USD Fund I, L.P. | 1,333,254 | -100 | 31/12/2564 |
5.92843 % | Clough Capital Partners, LP | 1,306,626 | -260,700 | 31/12/2564 |
4.63296 % | Krieg (Arthur M) | 1,021,105 | 10,802 | 18/6/2564 |
4.38850 % | Fidelity Management & Research Company LLC | 967,226 | 1,000 | 31/12/2564 |
2.63095 % | The Vanguard Group, Inc. | 579,861 | 243,274 | 31/12/2564 |
2.45810 % | Sectoral Asset Management Inc. | 541,766 | 0 | 31/12/2564 |
0.48321 % | Bridgeway Capital Management, LLC | 106,500 | 0 | 31/12/2564 |
0.42348 % | Ensign Peak Advisors, Inc. | 93,334 | -26,581 | 31/12/2564 |
0.30868 % | RBF Capital, LLC | 68,034 | -800 | 31/12/2564 |
0.18267 % | Geode Capital Management, L.L.C. | 40,260 | 0 | 31/12/2564 |
0.13862 % | BlackRock Institutional Trust Company, N.A. | 30,551 | 575 | 31/12/2564 |
0.13612 % | Federated Hermes Equity Management Company of Pennsylvania | 30,000 | 10,000 | 31/12/2564 |
0.11166 % | Cambridge Trust Company | 24,609 | 0 | 31/12/2564 |
0.08819 % | BlackRock Financial Management, Inc. | 19,437 | 0 | 31/12/2564 |
0.05030 % | State Street Global Advisors (US) | 11,087 | 0 | 31/12/2564 |
0.04824 % | Millennium Management LLC | 10,633 | 10,633 | 31/12/2564 |
0.03630 % | Chaudhary (Kleem) | 8,000 | 0 | 23/4/2564 |
0.01849 % | Morgan Stanley & Co. LLC | 4,075 | 1 | 31/12/2564 |
0.00907 % | U.S. Bancorp Asset Management, Inc. | 2,000 | 0 | 31/12/2564 |
0.00819 % | BlackRock Investment Management, LLC | 1,806 | 0 | 31/12/2564 |
0.00819 % | Lord, Abbett & Co. LLC | 1,806 | 0 | 28/2/2565 |
0.00538 % | Manulife Investment Management (North America) Limited | 1,186 | 0 | 28/2/2565 |
0.00505 % | BofA Global Research (US) | 1,112 | -2,258 | 31/12/2564 |
0.00501 % | UBS Financial Services, Inc. | 1,105 | 922 | 31/12/2564 |
0.00261 % | BlackRock Japan Co., Ltd. | 575 | 0 | 31/12/2564 |
0.00091 % | Midwest Financial | 200 | 0 | 31/3/2565 |
0.00076 % | RBC Capital Partners | 168 | 0 | 31/12/2564 |
0.00042 % | Federated Hermes MDTA LLC | 92 | 92 | 31/12/2564 |
0.00015 % | Wells Fargo Bank, N.A. | 33 | 0 | 31/12/2564 |
0 % | Ergoteles Capital | 0 | -25,870 | 31/12/2564 |
0 % | HRT Financial LP | 0 | -18,298 | 31/12/2564 |
0 % | Advisory Services Network, LLC | 0 | -7,800 | 30/9/2564 |
0 % | Zimmer Partners, LP | 0 | -25,000 | 31/12/2563 |
0 % | BMO Nesbitt Burns Inc. | 0 | -280 | 30/6/2564 |
0 % | Principal Funds, Inc. | 0 | -1,478 | 30/6/2564 |
0 % | DWS Investments UK Limited | 0 | -5,639 | 30/6/2564 |
0 % | Assenagon Asset Management S.A. | 0 | -199 | 30/6/2564 |
0 % | Pacific Asset Management | 0 | -1,100 | 30/6/2564 |
0 % | ProShare Advisors LLC | 0 | -2,494 | 30/6/2564 |
0 % | Laurie J. Hall Trustee | 0 | -100,530 | 31/3/2564 |
0 % | Tower Research Capital LLC | 0 | -1,426 | 31/12/2564 |
0 % | Northern Trust Global Investments | 0 | -8,015 | 30/6/2564 |
0 % | DNCA Investments | 0 | -71,261 | 31/12/2564 |
0 % | CPP Investment Board | 0 | -10,000 | 30/6/2564 |
0 % | Morgan Stanley & Co. International Plc | 0 | -46 | 31/12/2564 |
0 % | ProFund Advisors LLC | 0 | -194 | 31/7/2564 |
0 % | Renaissance Technologies LLC | 0 | -10,667 | 31/12/2564 |
0 % | Moore Capital Management, LP | 0 | -10,000 | 31/12/2563 |
0 % | PGIM Quantitative Solutions LLC | 0 | -1,554 | 30/4/2564 |
0 % | Charles Schwab Investment Management, Inc. | 0 | -19,146 | 30/6/2564 |
0 % | Legal & General Investment Management Ltd. | 0 | -876 | 30/6/2564 |
0 % | DWS Investment GmbH | 0 | -134,760 | 30/9/2564 |
0 % | Vaughan Nelson Investment Management, L.P. | 0 | -290 | 30/6/2564 |
0 % | Citi Investment Research (US) | 0 | -1 | 30/9/2564 |
0 % | AXA Rosenberg Investment Management LLC | 0 | -2,371 | 30/6/2564 |
0 % | PNC Wealth Management | 0 | -5,000 | 31/12/2564 |
0 % | T. Rowe Price Associates, Inc. | 0 | -145 | 30/6/2564 |
0 % | State Teachers Retirement System of Ohio | 0 | -19,300 | 30/6/2564 |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -77 | 30/9/2564 |
0 % | SunAmerica Asset Management, LLC | 0 | -5,217 | 30/6/2564 |
0 % | Goldman Sachs & Company, Inc. | 0 | -12,600 | 31/12/2563 |
0 % | Nuveen LLC | 0 | -16,328 | 30/6/2564 |
0 % | JPMorgan Private Bank (United States) | 0 | -3,531 | 30/6/2564 |
0 % | Ameritas Investment Partners, Inc. | 0 | -430 | 30/6/2564 |
0 % | BNY Mellon Asset Management | 0 | -15,196 | 30/6/2564 |
0 % | Northern Trust Investments, Inc. | 0 | -73,344 | 30/6/2564 |
0 % | Jacobs Levy Equity Management, Inc. | 0 | -36,511 | 31/12/2564 |
0 % | Federated Hermes Global Investment Management Corp. | 0 | -10,781 | 30/6/2564 |
0 % | BMO Capital Markets (US) | 0 | -328 | 30/6/2564 |
0 % | Westfield Capital Management Company, L.P. | 0 | -77 | 30/6/2564 |
0 % | J.P. Morgan Securities LLC | 0 | -185 | 31/12/2564 |
0 % | Alberta Investment Management Corporation | 0 | -25,000 | 30/9/2564 |
0 % | New York State Common Retirement Fund | 0 | -77 | 30/9/2564 |
0 % | California State Teachers Retirement System | 0 | -13,503 | 30/6/2564 |
0 % | Mellon Investments Corporation | 0 | -1,992 | 30/6/2564 |
0 % | Franklin Mutual Advisers, LLC | 0 | -398 | 30/6/2564 |
0 % | Voya Investment Management LLC | 0 | -4,304 | 30/6/2564 |
0 % | CaaS Capital Management LP | 0 | -44,966 | 31/12/2563 |