9.59239 % | The Vanguard Group, Inc. | 28,450,070 | 1,360,613 | 31/12/2566 |
9.46001 % | Perceptive Advisors LLC | 28,057,456 | 364,539 | 31/12/2566 |
9.23834 % | Avoro Capital Advisors LLC | 27,400,000 | 0 | 31/12/2566 |
6.96287 % | BlackRock Institutional Trust Company, N.A. | 20,651,163 | 1,971,281 | 31/12/2566 |
5.12156 % | Wellington Management Company, LLP | 15,190,024 | 7,666,335 | 31/12/2566 |
4.99960 % | Redmile Group, LLC | 14,828,321 | -2,116,300 | 31/12/2566 |
4.43814 % | State Street Global Advisors (US) | 13,163,085 | 1,790,649 | 31/12/2566 |
3.93502 % | JP Morgan Asset Management | 11,670,883 | 4,804,623 | 31/12/2566 |
3.92698 % | William Blair Investment Management, LLC | 11,647,026 | 1,270,263 | 31/12/2566 |
3.87981 % | Janus Henderson Investors | 11,507,129 | -3,426,892 | 31/12/2566 |
3.83699 % | Morgan Stanley & Co. LLC | 11,380,117 | 1,254,072 | 31/12/2566 |
3.49766 % | Palo Alto Investors LP | 10,373,715 | -150,307 | 31/12/2566 |
2.43265 % | Macquarie Investment Management | 7,215,010 | 2,358 | 31/12/2566 |
2.35834 % | Pictet Asset Management Ltd. | 6,994,597 | -1,402,914 | 31/12/2566 |
2.00657 % | Geode Capital Management, L.L.C. | 5,951,295 | 345,129 | 31/12/2566 |
1.79493 % | JPMorgan Asset Management U.K. Limited | 5,323,591 | -143,025 | 31/12/2566 |
1.70661 % | Fiera Capital Corporation | 5,061,644 | -24,227 | 31/12/2566 |
1.54492 % | American Century Investment Management, Inc. | 4,582,067 | 238,197 | 31/12/2566 |
1.33247 % | DWS Investments UK Limited | 3,951,977 | 3,818,630 | 31/12/2566 |
0.85337 % | Norges Bank Investment Management (NBIM) | 2,531,000 | -2,869,086 | 31/12/2566 |
0.84291 % | Novo Holdings A/S | 2,500,000 | 404,100 | 31/12/2566 |
0.84044 % | Northern Trust Investments, Inc. | 2,492,674 | 97,960 | 31/12/2566 |
0.81429 % | MFS Investment Management | 2,415,090 | 593,131 | 31/12/2566 |
0.76499 % | Charles Schwab Investment Management, Inc. | 2,268,886 | 90,195 | 31/12/2566 |
0.73990 % | Fidelity Management & Research Company LLC | 2,194,460 | -583,703 | 31/12/2566 |
0.68322 % | Invus Public Equities Advisors, LLC | 2,026,364 | -2,036,203 | 31/12/2566 |
0.61099 % | DWS Investment S.A. | 1,812,149 | 1,812,149 | 31/12/2566 |
0.59095 % | Victory Capital Management Inc. | 1,752,687 | -1,196,519 | 31/12/2566 |
0.58721 % | Goldman Sachs & Company, Inc. | 1,741,597 | -88,568 | 31/12/2566 |
0.57082 % | Pictet Asset Management (Japan) Ltd. | 1,692,993 | 439,503 | 31/10/2566 |
0.52481 % | Balyasny Asset Management LP | 1,556,540 | -1,828,892 | 31/12/2566 |
0.50205 % | Finepoint Capital LP | 1,489,025 | 0 | 31/12/2566 |
0.49739 % | New York State Common Retirement Fund | 1,475,212 | 1,039 | 31/12/2566 |
0.47113 % | PanAgora Asset Management Inc. | 1,397,312 | -33,112 | 31/12/2566 |
0.46958 % | Nuveen LLC | 1,392,742 | 152,535 | 31/12/2566 |
0.43174 % | Great Point Partners, LLC | 1,280,500 | 423,500 | 31/12/2566 |
0.41591 % | Clarus Ventures, LLC | 1,233,552 | 1,233,552 | 31/12/2566 |
0.41591 % | Blackstone Alternative Credit Advisors LP | 1,233,552 | 1,233,552 | 31/12/2566 |
0.41426 % | T. Rowe Price Associates, Inc. | 1,228,659 | -23,851 | 31/12/2566 |
0.38540 % | Managed Account Advisors LLC | 1,143,052 | -472,002 | 31/12/2566 |
0.36893 % | PRIMECAP Management Company | 1,094,200 | 0 | 31/12/2566 |
0.36869 % | BlackRock Financial Management, Inc. | 1,093,483 | 68,591 | 31/12/2566 |
0.35941 % | Rice Hall James & Associates, LLC | 1,065,965 | -12,900 | 31/12/2566 |
0.35868 % | Rock Springs Capital Management LP | 1,063,806 | 0 | 31/12/2566 |
0.35835 % | BofA Global Research (US) | 1,062,845 | 433,266 | 31/12/2566 |
0.35587 % | Morgan Stanley Investment Management Inc. (US) | 1,055,476 | 1,050,060 | 31/12/2566 |
0.32716 % | Voya Investment Management LLC | 970,313 | 239,792 | 31/12/2566 |
0.31944 % | Cutter Capital Management, LP | 947,418 | 947,418 | 31/12/2566 |
0.31122 % | BNP Paribas Securities Corp. North America | 923,045 | 536,480 | 31/12/2566 |
0.29091 % | StemPoint Capital LP | 862,815 | 862,815 | 31/12/2566 |
0.29047 % | abrdn Inc. | 861,508 | 861,508 | 29/2/2567 |
0.27806 % | UBS Financial Services, Inc. | 824,708 | 303,038 | 31/12/2566 |
0.27176 % | OrbiMed Advisors, LLC | 806,000 | 806,000 | 31/12/2566 |
0.26817 % | Rafferty Asset Management LLC | 795,351 | 87,112 | 31/12/2566 |
0.25619 % | Candriam Luxembourg S.A. | 759,823 | 0 | 29/2/2567 |
0.25262 % | BNY Mellon Asset Management | 749,242 | 1,737 | 31/12/2566 |
0.24777 % | Voloridge Investment Management, LLC | 734,867 | 734,867 | 31/12/2566 |
0.24418 % | Barclays Bank PLC | 724,227 | 315,439 | 31/12/2566 |
0.24199 % | Neuberger Berman, LLC | 717,714 | 171,029 | 31/12/2566 |
0.24137 % | BioImpact Capital LLC | 715,883 | -256 | 31/12/2566 |
0.24127 % | BlackRock Investment Management, LLC | 715,574 | 13,306 | 31/12/2566 |
0.23958 % | M&G Investment Management Ltd. | 710,557 | 509,632 | 31/12/2566 |
0.22076 % | Medical Strategy GmbH | 654,742 | 0 | 31/12/2566 |
0.20410 % | Peregrine Capital Management, LLC | 605,348 | -123,337 | 31/12/2566 |
0.18675 % | Candriam Belgium S.A. | 553,879 | -25,000 | 31/12/2566 |
0.17386 % | JPMorgan Private Bank (United States) | 515,649 | 206,395 | 31/12/2566 |
0.17195 % | Schroder Investment Management Ltd. (SIM) | 510,000 | 510,000 | 31/12/2566 |
0.16691 % | Wells Fargo Advisors | 495,047 | -14,688 | 31/12/2566 |
0.16513 % | Columbia Threadneedle Investments (US) | 489,756 | 109,622 | 31/12/2566 |
0.15974 % | Campbell (Bradley Lewis) | 473,777 | 0 | 1/4/2567 |
0.15891 % | Citi Investment Research (US) | 471,318 | 96,651 | 31/12/2566 |
0.15172 % | CM Management, LLC | 450,000 | 0 | 31/12/2566 |
0.14309 % | Schweizerische Nationalbank | 424,400 | -44,800 | 31/12/2566 |
0.14005 % | Envestnet Asset Management, Inc. | 415,382 | 21,654 | 31/12/2566 |
0.13576 % | Rhumbline Advisers Ltd. Partnership | 402,640 | -13,480 | 31/12/2566 |
0.13051 % | Mellon Investments Corporation | 387,065 | 3,294 | 31/12/2566 |
0.12651 % | Conestoga Capital Advisors, LLC | 375,202 | -10,180 | 29/2/2567 |
0.12555 % | ExodusPoint Capital Management, LP | 372,380 | -569,053 | 31/12/2566 |
0.12400 % | Goldman Sachs Asset Management, L.P. | 367,757 | -295,357 | 31/12/2566 |
0.12138 % | Hudson Bay Capital Management LP | 360,000 | 185,000 | 31/12/2566 |
0.12102 % | Silvercrest Asset Management Group LLC | 358,925 | -74 | 31/12/2566 |
0.11475 % | AllianceBernstein L.P. | 340,349 | 3,000 | 31/12/2566 |
0.11463 % | Parametric Portfolio Associates LLC | 339,971 | 14,794 | 31/12/2566 |
0.11358 % | BlackRock Advisors (UK) Limited | 336,870 | 12,488 | 31/3/2567 |
0.10999 % | Credit Suisse Funds AG | 326,217 | 4,816 | 31/12/2566 |
0.10790 % | J.P. Morgan Securities LLC | 320,034 | -20,380 | 31/12/2566 |
0.10739 % | HOOPP Investment Management | 318,500 | 43,000 | 31/12/2566 |
0.10451 % | Transcend Capital Advisors, LLC | 309,978 | 23,474 | 31/12/2566 |
0.10098 % | Caption Management, LLC | 299,500 | 272,500 | 31/12/2566 |
0.09923 % | Hillsdale Investment Management Inc. | 294,300 | 23,640 | 31/12/2566 |
0.09650 % | D. E. Shaw & Co., L.P. | 286,224 | -73,967 | 31/12/2566 |
0.09206 % | Northern Trust Global Investments | 273,054 | -47,039 | 31/12/2566 |
0.09137 % | Ambassador Advisors, LLC | 270,993 | -1,180 | 31/12/2566 |
0.08999 % | BlackRock Asset Management Ireland Limited | 266,911 | 20,636 | 31/12/2566 |
0.08845 % | Jane Street Capital, L.L.C. | 262,333 | 129,730 | 31/12/2566 |
0.08845 % | Allianz Global Investors GmbH | 262,332 | 7,478 | 31/12/2566 |
0.08796 % | FundLogic SAS | 260,870 | 194,317 | 31/12/2566 |
0.08548 % | New Jersey Division of Investment | 253,532 | 46,541 | 31/12/2566 |
0.08496 % | Simplex Trading, LLC | 251,989 | 220,670 | 31/12/2566 |
0.08429 % | Quimi (Daphne) | 249,991 | -14,605 | 12/4/2566 |