12,07725 % | Manning (Paul B.) | 24 751 111 | 1 333 333 | 2024-06-27 |
10,34968 % | Fidelity Management & Research Company LLC | 21 210 636 | 1 099 919 | 2024-06-30 |
9,17356 % | RTW Investments L.P. | 18 800 299 | 207 114 | 2024-06-30 |
9,10022 % | Avoro Capital Advisors LLC | 18 650 000 | 0 | 2024-06-30 |
5,30521 % | RA Capital Management, LP | 10 872 503 | 0 | 2024-06-30 |
5,26234 % | BlackRock Institutional Trust Company, N.A. | 10 784 648 | 8 291 921 | 2024-06-30 |
4,39153 % | VR Adviser, LLC | 9 000 000 | 0 | 2024-06-30 |
3,54559 % | Audentes Therapeutics Inc | 7 266 342 | 0 | 2023-08-16 |
3,49729 % | The Vanguard Group, Inc. | 7 167 337 | 1 249 923 | 2024-06-30 |
3,09922 % | Morgan Stanley & Co. LLC | 6 351 537 | 3 181 251 | 2024-06-30 |
2,23101 % | Octagon Capital Advisors LP | 4 572 222 | 1 542 222 | 2024-06-30 |
2,12463 % | Invus Public Equities Advisors, LLC | 4 354 214 | 666 666 | 2024-06-30 |
1,95411 % | Baker Bros. Advisors LP | 4 004 756 | 0 | 2024-06-30 |
1,80541 % | Tybourne Capital Management (HK) Limited | 3 700 000 | 0 | 2024-06-30 |
1,61922 % | State Street Global Advisors (US) | 3 318 421 | 2 978 901 | 2024-06-30 |
1,47604 % | Polar Capital LLP | 3 025 000 | 506 091 | 2024-06-30 |
1,40553 % | Geode Capital Management, L.L.C. | 2 880 485 | 1 860 694 | 2024-06-30 |
1,30100 % | JP Morgan Asset Management | 2 666 262 | 1 715 808 | 2024-06-30 |
1,23622 % | DWS Investments UK Limited | 2 533 502 | 2 533 502 | 2024-06-30 |
1,13738 % | Acuta Capital Partners, LLC | 2 330 937 | −1 002 396 | 2024-06-30 |
0,96755 % | Stalfort (John A III) | 1 982 891 | 49 220 | 2024-05-29 |
0,84053 % | Eagle Asset Management, Inc. | 1 722 586 | −66 808 | 2024-06-30 |
0,74927 % | Nolan Capital LLC | 1 535 545 | 0 | 2024-03-31 |
0,60993 % | Ghost Tree Capital, LLC | 1 250 000 | 300 000 | 2024-06-30 |
0,59797 % | T. Rowe Price Associates, Inc. | 1 225 474 | 126 145 | 2024-06-30 |
0,57954 % | Medical Strategy GmbH | 1 187 719 | 0 | 2024-06-30 |
0,50742 % | Nuveen LLC | 1 039 911 | 1 039 911 | 2024-06-30 |
0,50077 % | Woodline Partners LP | 1 026 269 | 1 026 269 | 2024-06-30 |
0,47111 % | Morgan Stanley Investment Management Inc. (US) | 965 500 | −878 300 | 2024-06-30 |
0,39586 % | Palo Alto Investors LP | 811 268 | 0 | 2024-06-30 |
0,39509 % | Granahan Investment Management, LLC | 809 691 | 809 691 | 2024-06-30 |
0,38357 % | Marshall Wace LLP | 786 094 | −244 563 | 2024-06-30 |
0,37533 % | Schonfeld Strategic Advisors LLC | 769 200 | 216 605 | 2024-06-30 |
0,35646 % | Quantum Private Wealth, LLC | 730 520 | 32 000 | 2024-06-30 |
0,35370 % | Sands Capital Ventures LLC | 724 873 | 0 | 2024-06-30 |
0,34686 % | Goldman Sachs & Company, Inc. | 710 853 | −348 109 | 2024-06-30 |
0,31272 % | Alphabet, Inc. | 640 882 | 0 | 2024-06-30 |
0,30863 % | Qube Research & Technologies Ltd | 632 500 | −439 570 | 2024-06-30 |
0,25001 % | Diametric Capital | 512 361 | 358 883 | 2024-06-30 |
0,20969 % | Charles Schwab Investment Management, Inc. | 429 744 | 378 282 | 2024-06-30 |
0,20901 % | BlackRock Investment Management, LLC | 428 343 | 428 343 | 2024-06-30 |
0,20031 % | BlackRock Financial Management, Inc. | 410 508 | 410 508 | 2024-06-30 |
0,16943 % | BNY Mellon Asset Management | 347 227 | 347 227 | 2024-06-30 |
0,16626 % | Millennium Management LLC | 340 724 | −2 794 593 | 2024-06-30 |
0,15786 % | Invesco Capital Management LLC | 323 520 | 317 289 | 2024-06-30 |
0,15427 % | Goldman Sachs Asset Management, L.P. | 316 165 | 316 165 | 2024-06-30 |
0,14286 % | Kovitz Investment Group Partners, LLC | 292 778 | 15 000 | 2024-06-30 |
0,13480 % | JPMorgan Private Bank (United States) | 276 262 | 276 262 | 2024-06-30 |
0,12574 % | Jefferies LLC | 257 694 | 209 594 | 2024-06-30 |
0,12436 % | Northern Trust Investments, Inc. | 254 862 | 60 375 | 2024-06-30 |
0,12238 % | Adar1 Capital Management LLC | 250 800 | 207 300 | 2024-06-30 |
0,09437 % | Bellecapital AG | 193 394 | 0 | 2024-03-31 |
0,09105 % | Prelude Capital Management, LLC | 186 591 | 130 698 | 2024-06-30 |
0,08992 % | Rhumbline Advisers Ltd. Partnership | 184 284 | 184 284 | 2024-06-30 |
0,08568 % | TD Asset Management Inc. | 175 600 | 0 | 2024-06-30 |
0,07970 % | Donenberg (Phillip Brian) | 163 331 | 49 220 | 2024-05-29 |
0,07807 % | Abaris Investment Management AG | 160 000 | 160 000 | 2023-12-31 |
0,07724 % | Alam (Kamran CPA) | 158 297 | −587 398 | 2024-03-31 |
0,07392 % | Alpine Global Management, LLC | 151 483 | 151 483 | 2024-06-30 |
0,07074 % | Morgan Stanley Smith Barney LLC | 144 977 | −2 515 | 2024-06-30 |
0,06919 % | GSA Capital Partners LLP | 141 805 | 141 805 | 2024-06-30 |
0,06500 % | Manulife Investment Management (North America) Limited | 133 213 | 69 487 | 2024-06-30 |
0,06304 % | Susquehanna International Group, LLP | 129 200 | −1 180 427 | 2024-06-30 |
0,06252 % | Jane Street Capital, L.L.C. | 128 124 | 69 238 | 2024-06-30 |
0,06049 % | BofA Global Research (US) | 123 974 | −1 739 | 2024-06-30 |
0,05766 % | Chicago Partners Wealth Advisors | 118 175 | 1 270 | 2024-09-30 |
0,05370 % | BlackRock Asset Management Ireland Limited | 110 047 | 10 851 | 2024-06-30 |
0,05233 % | Mellon Investments Corporation | 107 237 | 107 237 | 2024-06-30 |
0,04806 % | Privium Fund Management BV | 98 500 | 98 500 | 2024-06-30 |
0,04665 % | AllianceBernstein L.P. | 95 600 | 95 600 | 2024-06-30 |
0,04199 % | SunAmerica Asset Management, LLC | 86 058 | 0 | 2024-07-31 |
0,04199 % | Corebridge Financial Inc | 86 058 | 86 058 | 2024-06-30 |
0,03952 % | Assenagon Asset Management S.A. | 80 994 | 5 723 | 2024-09-30 |
0,03916 % | Squarepoint Capital LLP | 80 255 | −133 691 | 2024-06-30 |
0,03622 % | Invesco Advisers, Inc. | 74 230 | 74 230 | 2024-06-30 |
0,03122 % | SG Americas Securities, L.L.C. | 63 984 | 63 984 | 2024-09-30 |
0,02791 % | Virtu Americas LLC | 57 191 | 57 191 | 2024-06-30 |
0,02736 % | UBS Financial Services, Inc. | 56 079 | −133 205 | 2024-06-30 |
0,02646 % | Barclays Bank PLC | 54 234 | 54 234 | 2024-06-30 |
0,02632 % | Metropolitan Life Insurance Co. (US) | 53 946 | 53 946 | 2024-06-30 |
0,02632 % | Voya Investment Management LLC | 53 934 | 53 934 | 2024-06-30 |
0,02499 % | Wells Fargo Bank, N.A. | 51 213 | 50 497 | 2024-06-30 |
0,02494 % | T. Rowe Price International Ltd | 51 104 | 34 504 | 2024-06-30 |
0,02402 % | Long (Alison S) | 49 220 | 49 220 | 2024-05-29 |
0,02402 % | Sepp-Lorenzino (Laura) | 49 220 | 49 220 | 2024-05-29 |
0,02396 % | Los Angeles Capital Management LLC | 49 102 | 9 836 | 2024-08-31 |
0,02345 % | LPL Financial LLC | 48 060 | 5 998 | 2024-06-30 |
0,02286 % | Citadel Advisors LLC | 46 854 | 46 657 | 2024-06-30 |
0,02264 % | Redwood Wealth Management Group, LLC | 46 400 | 46 400 | 2024-06-30 |
0,02212 % | Marathon Trading Investment Management LLC | 45 340 | −178 560 | 2024-06-30 |
0,02196 % | Williams & Novak Wealth Management, LLC | 45 000 | 0 | 2024-09-30 |
0,02144 % | Citi Investment Research (US) | 43 935 | −211 268 | 2024-06-30 |
0,02115 % | Scientech Research LLC | 43 350 | 43 350 | 2024-06-30 |
0,02039 % | MetLife Investment Management, LLC | 41 794 | 41 794 | 2024-06-30 |
0,02005 % | Renaissance Technologies LLC | 41 100 | −287 400 | 2024-06-30 |
0,01923 % | China Universal Asset Management Co., Ltd. | 39 417 | 17 446 | 2024-09-30 |
0,01912 % | Nuveen Asset Management, LLC | 39 188 | 39 188 | 2024-06-30 |
0,01894 % | Goldman Sachs Asset Management International | 38 825 | 13 656 | 2024-07-31 |
0,01670 % | Nagendran (Sukumar) | 34 226 | −863 617 | 2024-03-31 |
0,01424 % | LSV Asset Management | 29 186 | 0 | 2024-09-30 |