20,47890 % | RP Management, LLC | 34 471 927 | 2 638 593 | 2022-06-27 |
9,22169 % | PRIMECAP Management Company | 15 522 777 | 175 000 | 2022-03-31 |
5,51374 % | BlackRock Institutional Trust Company, N.A. | 9 281 231 | 3 008 931 | 2022-03-31 |
4,42595 % | The Vanguard Group, Inc. | 7 450 156 | 1 465 248 | 2022-03-31 |
4,31755 % | Rock Springs Capital Management LP | 7 267 696 | 3 460 034 | 2022-03-31 |
4,02458 % | Palo Alto Investors LP | 6 774 541 | 1 289 328 | 2022-03-31 |
3,92319 % | Platinum Asset Management | 6 603 870 | 3 780 934 | 2022-03-31 |
3,69504 % | Millennium Management LLC | 6 219 821 | 4 265 693 | 2022-03-31 |
3,35535 % | Goldman Sachs & Company, Inc. | 5 648 034 | 2 551 775 | 2022-03-31 |
2,72489 % | BofA Global Research (US) | 4 586 777 | 1 630 807 | 2022-03-31 |
2,49753 % | Citadel Advisors LLC | 4 204 066 | 3 427 731 | 2022-03-31 |
2,28016 % | Kleiner, Perkins, Caufield & Byers | 3 838 166 | 0 | 2021-09-30 |
2,03483 % | BioImpact Capital LLC | 3 425 202 | 0 | 2022-03-31 |
2,00854 % | Bay City Capital L.L.C. | 3 380 951 | 0 | 2022-03-01 |
1,91598 % | Assenagon Asset Management S.A. | 3 225 145 | 2 648 661 | 2022-03-31 |
1,73258 % | State Street Global Advisors (US) | 2 916 434 | 1 075 905 | 2022-03-31 |
1,55863 % | Fidelity Management & Research Company LLC | 2 623 632 | 1 758 259 | 2022-03-31 |
1,48519 % | Point72 Asset Management, L.P. | 2 500 000 | 2 500 000 | 2022-03-31 |
1,41625 % | Geode Capital Management, L.L.C. | 2 383 960 | 725 024 | 2022-03-31 |
1,37867 % | D. E. Shaw & Co., L.P. | 2 320 698 | 2 061 176 | 2022-03-31 |
0,89111 % | Woodline Partners LP | 1 500 000 | 1 500 000 | 2022-03-31 |
0,88803 % | Two Sigma Investments, LP | 1 494 816 | 156 789 | 2022-03-31 |
0,72170 % | Northern Trust Investments, Inc. | 1 214 833 | 378 581 | 2022-03-31 |
0,60662 % | Charles Schwab Investment Management, Inc. | 1 021 113 | 383 632 | 2022-03-31 |
0,59407 % | Baker Bros. Advisors LP | 1 000 000 | 1 000 000 | 2022-03-31 |
0,52019 % | BlackRock Asset Management Ireland Limited | 875 630 | 174 062 | 2022-03-31 |
0,48646 % | Norges Bank Investment Management (NBIM) | 818 853 | −86 712 | 2021-12-31 |
0,47348 % | CIBC Private Wealth Management | 797 000 | −85 000 | 2022-03-31 |
0,46115 % | Morgan Stanley & Co. LLC | 776 255 | 31 671 | 2022-03-31 |
0,43924 % | Frazier Healthcare Partners | 739 369 | 0 | 2022-03-31 |
0,39909 % | Renaissance Technologies LLC | 671 788 | 162 600 | 2022-03-31 |
0,27793 % | GSA Capital Partners LLP | 467 836 | 343 336 | 2022-03-31 |
0,27189 % | AQR Capital Management, LLC | 457 670 | 439 427 | 2022-03-31 |
0,27059 % | BNP Paribas Securities Corp. North America | 455 486 | −27 308 | 2022-03-31 |
0,26999 % | Redmile Group, LLC | 454 475 | 0 | 2022-03-31 |
0,19724 % | Hennion & Walsh Asset Management, Inc. | 332 004 | −10 823 | 2022-06-30 |
0,19432 % | Schweizerische Nationalbank | 327 100 | 170 100 | 2022-03-31 |
0,19212 % | Mott (David M) | 323 387 | 16 156 | 2022-06-30 |
0,18798 % | BlackRock Investment Management, LLC | 316 432 | 45 493 | 2022-03-31 |
0,17506 % | Acadian Asset Management LLC | 294 671 | 294 671 | 2022-03-31 |
0,17353 % | Nuveen LLC | 292 102 | 7 244 | 2022-03-31 |
0,17086 % | BNY Mellon Asset Management | 287 611 | 62 230 | 2022-03-31 |
0,15992 % | Bridgeway Capital Management, LLC | 269 200 | 269 200 | 2022-03-31 |
0,14852 % | NewGen Asset Management Limited | 250 000 | 250 000 | 2022-03-31 |
0,13093 % | BlackRock Financial Management, Inc. | 220 401 | 27 207 | 2022-03-31 |
0,12974 % | Tudor Investment Corporation | 218 384 | 75 737 | 2022-03-31 |
0,12072 % | Macquarie Investment Management | 203 200 | 0 | 2022-03-31 |
0,10779 % | California State Teachers Retirement System | 181 440 | 72 569 | 2022-03-31 |
0,10465 % | DWS Investments UK Limited | 176 158 | 121 662 | 2022-03-31 |
0,09686 % | NISA Investment Advisors, L.L.C. | 163 050 | 162 000 | 2022-03-31 |
0,09319 % | Susquehanna International Group, LLP | 156 867 | −158 595 | 2022-03-31 |
0,09227 % | Bazemore (Robert B) | 155 322 | 82 298 | 2022-03-01 |
0,08643 % | JP Morgan Asset Management | 145 484 | −3 308 | 2022-03-31 |
0,08540 % | Foresite Capital Management, LLC | 143 759 | −690 002 | 2022-03-31 |
0,08382 % | T. Rowe Price Associates, Inc. | 141 097 | 83 839 | 2022-03-31 |
0,08149 % | Mellon Investments Corporation | 137 165 | 51 224 | 2022-03-31 |
0,07727 % | Rhumbline Advisers Ltd. Partnership | 130 067 | 17 351 | 2022-03-31 |
0,07394 % | Northern Trust Global Investments | 124 455 | 47 395 | 2022-03-31 |
0,07362 % | Jane Street Capital, L.L.C. | 123 930 | −68 350 | 2022-03-31 |
0,07129 % | State of Wisconsin Investment Board | 120 000 | 0 | 2022-03-31 |
0,07022 % | Jennison Associates LLC | 118 200 | 97 200 | 2022-03-31 |
0,06847 % | Numeric Investors LLC | 115 254 | 115 254 | 2022-03-31 |
0,06719 % | UBS Asset Management (UK) Ltd. | 113 096 | 81 004 | 2022-03-31 |
0,06689 % | PGIM Quantitative Solutions LLC | 112 590 | 10 550 | 2022-03-31 |
0,06429 % | Credit Suisse Asset Management | 108 218 | 18 125 | 2022-03-31 |
0,06061 % | Mercer Global Investments Management Ltd | 102 029 | 0 | 2022-04-30 |
0,05906 % | Caxton Associates LP | 99 409 | 69 109 | 2022-03-31 |
0,05828 % | ExodusPoint Capital Management, LP | 98 107 | −261 365 | 2022-03-31 |
0,05727 % | AllianceBernstein L.P. | 96 400 | 297 | 2022-03-31 |
0,05644 % | LUNIS Vermögensmanagement AG | 95 000 | 0 | 2021-09-30 |
0,05591 % | Goldman Sachs Asset Management, L.P. | 94 106 | −52 966 | 2022-03-31 |
0,05416 % | Los Angeles Capital Management And Equity Research, Inc. | 91 173 | 88 793 | 2022-03-31 |
0,05186 % | Voya Investment Management LLC | 87 293 | 51 891 | 2022-03-31 |
0,05003 % | JPMorgan Private Bank (United States) | 84 209 | 33 332 | 2022-03-31 |
0,04767 % | BlackRock Advisors (UK) Limited | 80 246 | −779 015 | 2022-06-30 |
0,04456 % | Alpine Global Management, LLC | 75 000 | 25 608 | 2022-03-31 |
0,04283 % | Mirabella Financial Services LLP | 72 100 | 72 100 | 2022-03-31 |
0,04227 % | SunAmerica Asset Management, LLC | 71 149 | 22 537 | 2022-03-31 |
0,04202 % | BlackRock Investment Management (UK) Ltd. | 70 724 | 0 | 2022-03-31 |
0,04159 % | Virtu Americas LLC | 70 012 | 27 262 | 2022-03-31 |
0,04111 % | UBS Asset Management (Switzerland) | 69 197 | 0 | 2022-03-31 |
0,04105 % | XTX Markets LLC | 69 097 | 58 341 | 2022-03-31 |
0,03223 % | Conroy (Kevin T) | 54 258 | 10 204 | 2022-06-30 |
0,03203 % | Legal & General Investment Management Ltd. | 53 909 | −8 858 | 2022-03-31 |
0,03084 % | Manulife Investment Management (North America) Limited | 51 916 | 1 010 | 2021-12-31 |
0,03029 % | New York State Common Retirement Fund | 50 980 | −8 | 2022-03-31 |
0,02974 % | Agarwal (Shefali) | 50 060 | −35 753 | 2022-03-01 |
0,02970 % | FNY Investment Advisers LLC | 50 000 | 50 000 | 2022-06-30 |
0,02963 % | Lazard Asset Management, L.L.C. | 49 878 | 49 878 | 2022-03-31 |
0,02864 % | Invesco Advisers, Inc. | 48 217 | 11 068 | 2022-03-31 |
0,02806 % | Ros (Matthew) | 47 229 | −10 747 | 2022-03-01 |
0,02735 % | Beveridge (Roy A M.D.) | 46 037 | 8 928 | 2022-06-30 |
0,02710 % | Graham Capital Management, L.P. | 45 622 | −28 597 | 2022-03-31 |
0,02583 % | ProShare Advisors LLC | 43 486 | 8 868 | 2022-03-31 |
0,02562 % | Wedbush Securities, Inc. | 43 133 | 0 | 2022-06-30 |
0,02378 % | Morgan Stanley Smith Barney LLC | 40 030 | −1 597 | 2022-03-31 |
0,02234 % | Principal Global Investors (Equity) | 37 606 | 9 809 | 2022-03-31 |
0,02222 % | Arizona State Retirement System | 37 398 | 18 134 | 2022-03-31 |
0,02213 % | Florida State Board of Administration | 37 251 | −25 876 | 2022-03-31 |
0,02093 % | Northern Trust Global Investments Limited | 35 234 | 0 | 2022-03-31 |