47,36823 % | Artal International S.C.A. | 171 231 426 | −351 744 | 2024-07-25 |
10,70213 % | Fidelity Management & Research Company LLC | 38 687 123 | 24 793 061 | 2024-06-30 |
2,48210 % | BlackRock Institutional Trust Company, N.A. | 8 972 550 | 1 982 903 | 2024-06-30 |
2,29466 % | Braidwell LP | 8 294 950 | 8 294 950 | 2024-06-30 |
2,12319 % | The Vanguard Group, Inc. | 7 675 125 | 1 273 900 | 2024-06-30 |
1,61722 % | OrbiMed Advisors, LLC | 5 846 100 | 2 304 100 | 2024-06-30 |
1,50798 % | Ulys, L.L.C. | 5 451 204 | 0 | 2024-07-25 |
1,14006 % | Point72 Asset Management, L.P. | 4 121 191 | 3 536 805 | 2024-06-30 |
0,97270 % | Invus Public Equities Advisors, LLC | 3 516 214 | 0 | 2024-07-25 |
0,89920 % | Geode Capital Management, L.L.C. | 3 250 535 | 861 398 | 2024-06-30 |
0,66653 % | Citadel Advisors LLC | 2 409 456 | 2 274 979 | 2024-06-30 |
0,65902 % | New Enterprise Associates (NEA) | 2 382 286 | 0 | 2024-06-30 |
0,63998 % | State Street Global Advisors (US) | 2 313 477 | 325 967 | 2024-06-30 |
0,63740 % | Nantahala Capital Management, LLC | 2 304 150 | 2 304 150 | 2024-06-30 |
0,57891 % | Columbia Threadneedle Investments (US) | 2 092 710 | 674 760 | 2024-06-30 |
0,51869 % | Opaleye Management Inc. | 1 875 000 | 1 875 000 | 2024-06-30 |
0,47466 % | Pinnacle Associates Ltd. | 1 715 831 | −31 999 | 2024-06-30 |
0,37598 % | Charles Schwab Investment Management, Inc. | 1 359 148 | 478 025 | 2024-06-30 |
0,37314 % | Debbane (Raymond) | 1 348 879 | 0 | 2024-07-25 |
0,34930 % | Medical Strategy GmbH | 1 262 672 | −2 030 863 | 2023-12-31 |
0,32932 % | Marshall Wace LLP | 1 190 448 | 691 276 | 2024-06-30 |
0,30376 % | Coats (Lonnel) | 1 098 068 | 0 | 2024-03-18 |
0,25407 % | Northern Trust Investments, Inc. | 918 455 | 127 543 | 2024-06-30 |
0,20433 % | Wellington Management Company, LLP | 738 628 | 52 210 | 2024-06-30 |
0,20226 % | Hennion & Walsh Asset Management, Inc. | 731 138 | 188 239 | 2024-09-30 |
0,16524 % | Millennium Management LLC | 597 321 | 63 137 | 2024-06-30 |
0,15809 % | Schonfeld Strategic Advisors LLC | 571 492 | −388 658 | 2024-06-30 |
0,09356 % | BlackRock Investment Management, LLC | 338 198 | 89 151 | 2024-06-30 |
0,08969 % | Wade (Jeffrey L) | 324 214 | 0 | 2024-03-18 |
0,08536 % | BlackRock Financial Management, Inc. | 308 581 | 55 948 | 2024-06-30 |
0,07795 % | Goldman Sachs & Company, Inc. | 281 772 | 200 893 | 2024-06-30 |
0,07553 % | AllianceBernstein L.P. | 273 041 | 53 100 | 2024-06-30 |
0,07469 % | BBR Partners LLC | 270 000 | 240 000 | 2024-06-30 |
0,07433 % | BNY Mellon Asset Management | 268 692 | 53 050 | 2024-06-30 |
0,07074 % | Main (Alan J) | 255 724 | 0 | 2024-03-18 |
0,06941 % | LifeSci Index Partners, LLC | 250 923 | 125 063 | 2023-12-31 |
0,06871 % | Amouyal (Philippe J) | 248 364 | 0 | 2024-07-25 |
0,05931 % | Nuveen LLC | 214 399 | −307 911 | 2024-06-30 |
0,05690 % | BlackRock Asset Management Ireland Limited | 205 696 | 72 496 | 2024-06-30 |
0,05690 % | BlackRock Advisors (UK) Limited | 205 688 | 4 547 | 2024-09-30 |
0,05533 % | ACCI Capital Investments SGIIC, SA | 200 000 | 20 000 | 2024-07-31 |
0,04979 % | Virtus Etf Advisers LLC | 179 972 | −113 120 | 2024-06-30 |
0,04910 % | Crum (Brian T) | 177 497 | 0 | 2024-03-18 |
0,04796 % | Morgan Stanley & Co. LLC | 173 383 | −12 196 | 2024-06-30 |
0,04621 % | Sobecki (Christopher J) | 167 055 | 0 | 2024-07-25 |
0,04500 % | Kassler-Taub (Kenneth B) | 162 672 | 43 047 | 2024-02-28 |
0,04227 % | Rhumbline Advisers Ltd. Partnership | 152 785 | 17 940 | 2024-06-30 |
0,04070 % | UBS Financial Services, Inc. | 147 111 | −19 850 | 2024-06-30 |
0,03625 % | Assenagon Asset Management S.A. | 131 042 | −720 | 2024-09-30 |
0,03592 % | Jane Street Capital, L.L.C. | 129 856 | −151 732 | 2024-06-30 |
0,03545 % | Mellon Investments Corporation | 128 156 | 56 852 | 2024-06-30 |
0,03375 % | Caspar Asset Management S.A. | 122 000 | 122 000 | 2023-12-31 |
0,03375 % | Altium Capital Management LP | 121 986 | 121 986 | 2024-06-30 |
0,03242 % | T. Rowe Price International Ltd | 117 179 | 11 864 | 2024-06-30 |
0,03157 % | Susquehanna International Group, LLP | 114 126 | 103 283 | 2024-06-30 |
0,03008 % | Commonwealth Financial Network | 108 734 | 7 600 | 2024-09-30 |
0,02766 % | Compagnie Lombard Odier SCmA | 100 000 | 6 000 | 2024-09-30 |
0,02536 % | Goldman Sachs Asset Management, L.P. | 91 659 | 16 324 | 2024-06-30 |
0,02527 % | Parametric Portfolio Associates LLC | 91 351 | 77 491 | 2024-06-30 |
0,02442 % | Morgan Stanley Smith Barney LLC | 88 290 | 44 572 | 2024-06-30 |
0,02425 % | Barker (Samuel L) | 87 649 | 8 032 | 2024-04-28 |
0,02412 % | BofA Global Research (US) | 87 185 | 1 313 | 2024-06-30 |
0,02341 % | Simplex Trading, LLC | 84 637 | 84 637 | 2024-06-30 |
0,02187 % | Northern Trust Global Investments | 79 073 | 3 429 | 2024-06-30 |
0,02143 % | UBS Fund Management (Switzerland) AG | 77 466 | 0 | 2024-09-30 |
0,02105 % | Dimensional Fund Advisors, L.P. | 76 086 | 26 143 | 2024-06-30 |
0,01936 % | BMO Private Investment Counsel Inc. | 70 000 | 30 000 | 2024-06-30 |
0,01923 % | China Universal Asset Management Co., Ltd. | 69 527 | 27 058 | 2024-09-30 |
0,01777 % | Aperio Group, LLC | 64 230 | −3 622 | 2024-06-30 |
0,01709 % | Corebridge Financial Inc | 61 770 | 61 770 | 2024-06-30 |
0,01690 % | LPL Financial LLC | 61 085 | −28 878 | 2024-06-30 |
0,01661 % | Pathstone | 60 038 | −2 687 | 2024-06-30 |
0,01604 % | Mirae Asset Global Investments (USA) LLC | 57 975 | 57 974 | 2024-06-30 |
0,01527 % | MetLife Investment Management, LLC | 55 182 | 22 320 | 2024-06-30 |
0,01470 % | Seth (Kiernan) | 53 136 | 31 269 | 2023-02-28 |
0,01468 % | Russell Investments Trust Company | 53 080 | 3 980 | 2024-06-30 |
0,01458 % | McDermott (Wendy) | 52 694 | 24 216 | 2024-02-28 |
0,01423 % | Stifel, Nicolaus & Company, Incorporated | 51 451 | −723 | 2024-06-30 |
0,01382 % | Manulife Investment Management (North America) Limited | 49 957 | 14 411 | 2024-06-30 |
0,01354 % | JPMorgan Private Bank (United States) | 48 931 | 12 608 | 2024-06-30 |
0,01338 % | Swain (Judith L) | 48 364 | 8 032 | 2024-04-28 |
0,01338 % | Lefkowitz (Robert J) | 48 364 | 8 032 | 2024-04-28 |
0,01328 % | Vanguard Investments Australia Ltd. | 47 993 | 47 993 | 2024-08-31 |
0,01322 % | Alexander (Kristen) | 47 800 | 17 450 | 2024-02-28 |
0,01317 % | Granowitz (Craig B. M.D., Ph.D.) | 47 626 | 0 | 2024-03-18 |
0,01281 % | T. Rowe Price Associates, Inc. | 46 297 | 0 | 2024-06-30 |
0,01275 % | SG Americas Securities, L.L.C. | 46 090 | 23 893 | 2024-09-30 |
0,01263 % | SunAmerica Asset Management, LLC | 45 658 | −391 | 2024-03-31 |
0,01254 % | Victory Capital Management Inc. | 45 341 | 13 972 | 2024-06-30 |
0,01253 % | Wells Fargo Bank, N.A. | 45 301 | 14 587 | 2024-06-30 |
0,01162 % | LUNIS Verm¿gensmanagement AG | 42 000 | 0 | 2024-03-31 |
0,01148 % | J.P. Morgan Securities plc | 41 487 | −12 326 | 2024-06-30 |
0,01135 % | Nies (Alan S) | 41 046 | 9 302 | 2023-05-21 |
0,01130 % | Wedbush Securities, Inc. | 40 850 | −800 | 2024-06-30 |
0,01124 % | KWB Wealth | 40 640 | 0 | 2024-09-30 |
0,01116 % | Palantoni (Frank P) | 40 332 | 9 302 | 2023-05-21 |
0,01097 % | Voya Investment Management LLC | 39 646 | 10 677 | 2024-06-30 |
0,01091 % | Barclays Bank PLC | 39 437 | −25 182 | 2024-06-30 |
0,01022 % | Two Sigma Investments, LP | 36 927 | −152 504 | 2024-06-30 |
0,01004 % | Invesco Capital Management LLC | 36 278 | 11 874 | 2024-06-30 |