8,43569 % | The Vanguard Group, Inc. | 3 218 215 | 21 201 | 2023-12-31 |
7,51056 % | Fidelity Management & Research Company LLC | 2 865 278 | −2 691 695 | 2023-12-31 |
7,10257 % | T. Rowe Price Investment Management, Inc. | 2 709 629 | −32 828 | 2023-12-31 |
5,03766 % | T. Rowe Price Associates, Inc. | 1 921 869 | −777 197 | 2023-12-31 |
4,44435 % | BlackRock Institutional Trust Company, N.A. | 1 695 518 | 50 701 | 2023-12-31 |
4,01458 % | PureTech Health, L.L.C. | 1 531 564 | −125 000 | 2022-08-12 |
3,62031 % | Sofinnova Investments, Inc | 1 381 149 | 0 | 2024-01-17 |
2,97260 % | Wellington Management Company, LLP | 1 134 046 | −151 462 | 2023-12-31 |
2,79476 % | Pentwater Capital Management LP | 1 066 200 | 1 037 700 | 2023-12-31 |
2,58640 % | General Atlantic LLC | 986 710 | 0 | 2023-12-31 |
2,55477 % | State Street Global Advisors (US) | 974 643 | 45 673 | 2023-12-31 |
2,08914 % | Pivotal Bioventure Partners Investment Advisor LLC | 797 008 | 0 | 2023-12-31 |
1,49337 % | Geode Capital Management, L.L.C. | 569 722 | 24 649 | 2023-12-31 |
1,35000 % | Rock Springs Capital Management LP | 515 024 | 9 591 | 2023-12-31 |
1,17658 % | Capital International Investors | 448 866 | −3 778 236 | 2024-01-31 |
1,10663 % | UBS Financial Services, Inc. | 422 178 | 419 217 | 2023-12-31 |
0,98861 % | AllianceBernstein L.P. | 377 155 | 13 787 | 2023-12-31 |
0,93702 % | Woodline Partners LP | 357 473 | 334 751 | 2023-12-31 |
0,87325 % | Brown Advisory | 333 144 | 11 059 | 2023-12-31 |
0,85994 % | Norges Bank Investment Management (NBIM) | 328 067 | 16 582 | 2023-12-31 |
0,82803 % | Balyasny Asset Management LP | 315 892 | 208 093 | 2023-12-31 |
0,77939 % | Invesco Advisers, Inc. | 297 336 | −15 709 | 2023-12-31 |
0,75239 % | First Light Asset Management, LLC | 287 037 | −16 100 | 2023-12-31 |
0,65531 % | Boxer Capital, L.L.C. | 250 000 | 0 | 2023-12-31 |
0,62295 % | Fiera Capital Corporation | 237 656 | 199 | 2023-12-31 |
0,59158 % | Nan Fung Life Sciences | 225 688 | 0 | 2023-12-31 |
0,58993 % | Charles Schwab Investment Management, Inc. | 225 060 | 6 721 | 2023-12-31 |
0,58453 % | Alpine Associates Management Inc. | 223 000 | 223 000 | 2023-12-31 |
0,53997 % | Avidity Partners Management LP | 206 000 | −80 700 | 2023-12-31 |
0,52992 % | Magnetar Capital Partners LP | 202 165 | 198 264 | 2023-12-31 |
0,52701 % | Kryger Capital Limited | 201 053 | 201 053 | 2023-12-31 |
0,49901 % | Goldman Sachs Asset Management, L.P. | 190 371 | 169 488 | 2023-12-31 |
0,49803 % | Eventide Asset Management, LLC | 190 000 | −149 840 | 2023-12-31 |
0,49630 % | TD Asset Management Inc. | 189 340 | −38 378 | 2023-12-31 |
0,46880 % | Eagle Asset Management, Inc. | 178 849 | −26 930 | 2023-12-31 |
0,45660 % | SG Americas Securities, L.L.C. | 174 193 | 167 448 | 2023-12-31 |
0,42724 % | Millennium Management LLC | 162 991 | 64 988 | 2023-12-31 |
0,41419 % | Citadel Advisors LLC | 158 012 | −31 585 | 2023-12-31 |
0,38599 % | AQR Capital Management, LLC | 147 256 | 143 172 | 2023-12-31 |
0,38392 % | Ensign Peak Advisors, Inc. | 146 467 | 5 129 | 2023-12-31 |
0,37153 % | Citi Investment Research (US) | 141 738 | 104 913 | 2023-12-31 |
0,35946 % | Northern Trust Investments, Inc. | 137 134 | 6 670 | 2023-12-31 |
0,34153 % | PFM Health Sciences, LP | 130 293 | −7 916 | 2023-12-31 |
0,33451 % | Nuveen LLC | 127 614 | −22 405 | 2023-12-31 |
0,33082 % | Twin Capital Management, LLC | 126 206 | 126 206 | 2023-12-31 |
0,33029 % | BlackRock Financial Management, Inc. | 126 004 | −168 | 2023-12-31 |
0,32765 % | Avoro Capital Advisors LLC | 125 000 | 125 000 | 2023-12-31 |
0,32146 % | Franklin Advisers, Inc. | 122 636 | −77 897 | 2023-12-31 |
0,31679 % | BlackRock Asset Management Ireland Limited | 120 857 | −2 911 | 2023-12-31 |
0,31405 % | Bank of Nova Scotia | 119 810 | 119 810 | 2023-12-31 |
0,31164 % | Morgan Stanley & Co. LLC | 118 890 | 93 499 | 2023-12-31 |
0,29106 % | Mellon Investments Corporation | 111 039 | −8 865 | 2023-12-31 |
0,29068 % | Paul (Steven M) | 110 895 | −804 | 2024-02-09 |
0,27727 % | ClearBridge Investments, LLC | 105 780 | 11 390 | 2023-12-31 |
0,27374 % | UBS Asset Management (Switzerland) | 104 432 | −18 731 | 2023-12-31 |
0,26759 % | Allspring Global Investments, LLC | 102 086 | 1 057 | 2023-12-31 |
0,26518 % | Westchester Capital Management, LLC | 101 166 | 101 166 | 2023-12-31 |
0,25275 % | Driehaus Capital Management, LLC | 96 424 | 5 745 | 2023-12-31 |
0,24401 % | New York State Common Retirement Fund | 93 089 | −4 694 | 2023-12-31 |
0,23591 % | Logos Global Management LLC | 90 000 | −25 000 | 2023-12-31 |
0,23591 % | Carlson Capital, L.P. | 90 000 | 90 000 | 2023-12-31 |
0,22901 % | First Turn Management, LLC | 87 369 | 87 369 | 2023-12-31 |
0,22890 % | Water Island Capital, LLC | 87 325 | 87 325 | 2023-12-31 |
0,22068 % | Gabelli Funds, LLC | 84 190 | 84 190 | 2023-12-31 |
0,20408 % | Ignelzi (Troy A) | 77 855 | 56 018 | 2024-01-17 |
0,20408 % | Catalyst Private Wealth, L.L.C. | 77 855 | 56 018 | 2023-12-31 |
0,19558 % | Segantii Capital Management Limited | 74 613 | 74 613 | 2023-12-31 |
0,18194 % | Glazer Capital, LLC | 69 410 | 69 410 | 2023-12-31 |
0,18181 % | BNY Mellon Asset Management | 69 359 | −161 | 2023-12-31 |
0,18152 % | The Clarius Group, LLC | 69 248 | −29 973 | 2023-12-31 |
0,17956 % | Corient Private Wealth LLC | 68 504 | 19 912 | 2023-12-31 |
0,16941 % | Point72 Asset Management, L.P. | 64 630 | −283 170 | 2023-12-31 |
0,16847 % | SEB Investment Management AB | 64 273 | 55 374 | 2023-12-31 |
0,16540 % | Schweizerische Nationalbank | 63 100 | −6 900 | 2023-12-31 |
0,16514 % | P. Schoenfeld Asset Management LP | 63 000 | 63 000 | 2023-12-31 |
0,16182 % | Barclays Bank PLC | 61 734 | 33 152 | 2023-12-31 |
0,15697 % | Fidelity International | 59 885 | 0 | 2023-12-31 |
0,15625 % | AQR Arbitrage, LLC | 59 608 | 59 608 | 2023-12-31 |
0,15354 % | Tekla Capital Management LLC | 58 577 | 5 125 | 2023-06-30 |
0,15335 % | Neuberger Berman, LLC | 58 503 | 57 215 | 2023-12-31 |
0,14994 % | Candriam Belgium S.A. | 57 201 | −4 000 | 2023-12-31 |
0,14994 % | Candriam Luxembourg S.A. | 57 201 | 0 | 2023-12-31 |
0,14417 % | Picton Mahoney Asset Management | 55 000 | 55 000 | 2023-12-31 |
0,13966 % | BioImpact Capital LLC | 53 279 | 69 | 2023-12-31 |
0,13602 % | Dimensional Fund Advisors, L.P. | 51 891 | 10 334 | 2023-12-31 |
0,13289 % | California Public Employees' Retirement System | 50 696 | 0 | 2023-12-31 |
0,13179 % | HSBC Global Asset Management (UK) Limited | 50 277 | 50 277 | 2023-12-31 |
0,13157 % | Melqart Asset Management (UK) Limited | 50 194 | 50 194 | 2023-12-31 |
0,13151 % | Rice Hall James & Associates, LLC | 50 171 | 10 790 | 2023-12-31 |
0,13028 % | DWS Investment GmbH | 49 700 | 0 | 2023-12-31 |
0,12620 % | Dafna Capital Management, LLC | 48 145 | −4 728 | 2023-12-31 |
0,12558 % | Summit Partners Public Asset Management, LLC | 47 910 | −49 467 | 2023-12-31 |
0,12366 % | Rhumbline Advisers Ltd. Partnership | 47 175 | −312 | 2023-12-31 |
0,12320 % | Decheng Capital LLC | 47 000 | 47 000 | 2023-12-31 |
0,11812 % | American Century Investment Management, Inc. | 45 064 | 823 | 2023-12-31 |
0,11453 % | Rafferty Asset Management LLC | 43 693 | −4 667 | 2023-12-31 |
0,11194 % | BofA Global Research (US) | 42 705 | 22 | 2023-12-31 |
0,11153 % | Florida State Board of Administration | 42 548 | 1 485 | 2023-12-31 |
0,11085 % | Connor, Clark & Lunn Investment Management Ltd. | 42 289 | −10 401 | 2023-12-31 |
0,10940 % | Ostrum Asset Management | 41 737 | 41 737 | 2023-12-31 |