7,34185 % | The Vanguard Group, Inc. | 10 130 061 | 4 027 497 | 31. 12. 2022 |
6,34731 % | BlackRock Institutional Trust Company, N.A. | 8 757 830 | 1 460 583 | 31. 12. 2022 |
5,70973 % | Deep Track Capital LP | 7 878 119 | 878 119 | 31. 12. 2022 |
4,89212 % | Avoro Capital Advisors LLC | 6 750 000 | 850 000 | 31. 12. 2022 |
4,59268 % | State Street Global Advisors (US) | 6 336 836 | 92 480 | 31. 12. 2022 |
3,72607 % | TCG Crossover Management, LLC | 5 141 118 | 1 263 215 | 31. 12. 2022 |
3,47054 % | T. Rowe Price Associates, Inc. | 4 788 545 | 1 392 712 | 31. 12. 2022 |
3,30048 % | Janus Henderson Investors | 4 553 904 | -559 587 | 31. 12. 2022 |
3,26294 % | Redmile Group, LLC | 4 502 111 | 1 102 211 | 31. 12. 2022 |
3,06712 % | AllianceBernstein L.P. | 4 231 917 | 1 870 847 | 31. 12. 2022 |
2,61874 % | Yiheng Capital Management, L.P. | 3 613 254 | 0 | 31. 12. 2022 |
2,48219 % | Deerfield Management Company, L.P. | 3 424 852 | -2 176 148 | 31. 12. 2022 |
2,42164 % | Braidwell LP | 3 341 300 | 3 341 300 | 31. 12. 2022 |
2,15089 % | Point72 Asset Management, L.P. | 2 967 729 | 2 360 829 | 31. 12. 2022 |
1,75089 % | Geode Capital Management, L.L.C. | 2 415 829 | 355 148 | 31. 12. 2022 |
1,72727 % | DWS Investments UK Limited | 2 383 230 | 13 555 | 31. 12. 2022 |
1,57384 % | Millennium Management LLC | 2 171 533 | 846 603 | 31. 12. 2022 |
1,56845 % | Capital International Investors | 2 164 099 | 0 | 31. 12. 2022 |
1,53267 % | Soleus Capital Management, L.P. | 2 114 728 | -387 873 | 31. 12. 2022 |
1,35430 % | Polar Capital LLP | 1 868 628 | 0 | 31. 12. 2022 |
1,29877 % | Armistice Capital LLC | 1 792 000 | 428 000 | 31. 12. 2022 |
1,23686 % | Franklin Advisers, Inc. | 1 706 581 | -714 | 31. 12. 2022 |
1,09345 % | Nuveen LLC | 1 508 711 | 134 188 | 31. 12. 2022 |
1,08850 % | Samlyn Capital, LLC | 1 501 875 | 301 389 | 31. 12. 2022 |
1,08714 % | Logos Global Management LLC | 1 500 000 | 0 | 31. 12. 2022 |
1,05960 % | Farallon Capital Management, L.L.C. | 1 462 000 | 145 000 | 31. 12. 2022 |
1,03950 % | Dimensional Fund Advisors, L.P. | 1 434 275 | -124 938 | 31. 12. 2022 |
0,98511 % | Emerald Advisers LLC | 1 359 225 | -335 773 | 31. 12. 2022 |
0,96492 % | American Century Investment Management, Inc. | 1 331 374 | 1 331 374 | 31. 12. 2022 |
0,92624 % | Octagon Capital Advisors LP | 1 278 000 | 1 278 000 | 31. 12. 2022 |
0,85737 % | Pura Vida Investments, LLC | 1 182 975 | 207 545 | 31. 12. 2022 |
0,84132 % | Candriam Luxembourg S.A. | 1 160 832 | 25 000 | 31. 1. 2023 |
0,82734 % | Goldman Sachs & Company, Inc. | 1 141 541 | 347 009 | 31. 12. 2022 |
0,82320 % | Candriam Belgium S.A. | 1 135 832 | 533 000 | 31. 12. 2022 |
0,78568 % | Northern Trust Investments, Inc. | 1 084 058 | 135 848 | 31. 12. 2022 |
0,78389 % | Invesco Advisers, Inc. | 1 081 592 | 1 031 076 | 31. 12. 2022 |
0,76802 % | BioImpact Capital LLC | 1 059 688 | 9 688 | 31. 12. 2022 |
0,76561 % | Columbia Threadneedle Investments (US) | 1 056 364 | 813 701 | 31. 12. 2022 |
0,73319 % | TimesSquare Capital Management, LLC | 1 011 640 | 953 640 | 31. 12. 2022 |
0,72476 % | Invus Public Equities Advisors, LLC | 1 000 000 | 250 000 | 31. 12. 2022 |
0,69893 % | Charles Schwab Investment Management, Inc. | 964 361 | 140 208 | 31. 12. 2022 |
0,66501 % | PFM Health Sciences, LP | 917 557 | 661 273 | 31. 12. 2022 |
0,61822 % | Kingdon Capital Management, L.L.C. | 853 000 | 853 000 | 31. 12. 2022 |
0,61120 % | Balyasny Asset Management LP | 843 311 | -839 924 | 31. 12. 2022 |
0,60764 % | Avidity Partners Management LP | 838 407 | 838 407 | 31. 12. 2022 |
0,59793 % | Boxer Capital, L.L.C. | 825 000 | 825 000 | 31. 12. 2022 |
0,59793 % | Great Point Partners, LLC | 825 000 | 825 000 | 31. 12. 2022 |
0,59524 % | RTW Investments L.P. | 821 288 | -2 803 712 | 31. 12. 2022 |
0,58920 % | D. E. Shaw & Co., L.P. | 812 967 | 726 378 | 31. 12. 2022 |
0,58563 % | Samsara BioCapital, LLC | 808 041 | 0 | 31. 12. 2022 |
0,57314 % | SEB Investment Management AB | 790 802 | -6 584 | 31. 12. 2022 |
0,56728 % | Driehaus Capital Management, LLC | 782 722 | 31 232 | 31. 12. 2022 |
0,55279 % | APG Asset Management N.V. | 762 721 | 696 975 | 30. 6. 2022 |
0,51284 % | Finepoint Capital LP | 707 600 | -280 000 | 31. 12. 2022 |
0,46268 % | Sofinnova Investments, Inc | 638 398 | -182 267 | 31. 12. 2022 |
0,43919 % | Dafna Capital Management, LLC | 605 975 | 204 499 | 31. 12. 2022 |
0,43095 % | Polar Asset Management Partners Inc. | 594 615 | -13 485 | 31. 12. 2022 |
0,42572 % | Perceptive Advisors LLC | 587 400 | -446 769 | 31. 12. 2022 |
0,36685 % | Ensign Peak Advisors, Inc. | 506 165 | -120 459 | 31. 12. 2022 |
0,36572 % | Artia Global Partners LP | 504 615 | 504 615 | 31. 12. 2022 |
0,36460 % | BofA Global Research (US) | 503 070 | 138 260 | 31. 12. 2022 |
0,34035 % | Fidelity Management & Research Company LLC | 469 602 | -103 890 | 31. 12. 2022 |
0,32963 % | Walleye Capital LLC | 454 815 | -187 136 | 31. 12. 2022 |
0,32614 % | Ghost Tree Capital, LLC | 450 000 | -13 700 | 31. 12. 2022 |
0,32238 % | JP Morgan Asset Management | 444 816 | 15 224 | 31. 12. 2022 |
0,31165 % | Rhenman & Partners Asset Management AB | 430 000 | 65 000 | 31. 12. 2022 |
0,28871 % | Rafferty Asset Management LLC | 398 356 | 25 594 | 31. 12. 2022 |
0,27876 % | 5AM Ventures | 384 626 | -124 221 | 31. 12. 2022 |
0,27325 % | Ikarian Capital LLC | 377 021 | -601 762 | 31. 12. 2022 |
0,27317 % | Putnam Investment Management, L.L.C. | 376 909 | 232 209 | 31. 12. 2022 |
0,27250 % | Asymmetry Capital Management, L.P | 375 989 | 20 593 | 31. 12. 2021 |
0,27072 % | Voya Investment Management LLC | 373 531 | 171 434 | 31. 12. 2022 |
0,26128 % | Acuta Capital Partners, LLC | 360 500 | -203 107 | 31. 12. 2022 |
0,25787 % | BNY Mellon Asset Management | 355 796 | 39 027 | 31. 12. 2022 |
0,25421 % | Eversept Partners, LP | 350 747 | 350 747 | 31. 12. 2022 |
0,25399 % | BlackRock Investment Management, LLC | 350 441 | 45 191 | 31. 12. 2022 |
0,25367 % | BlackRock Financial Management, Inc. | 350 009 | 55 348 | 31. 12. 2022 |
0,23971 % | Invesco Capital Management LLC | 330 744 | -22 693 | 31. 12. 2022 |
0,22133 % | J. Goldman & Co., L.P. | 305 378 | 270 971 | 31. 12. 2022 |
0,21369 % | Thornburg Investment Management, Inc. | 294 841 | -14 427 | 31. 12. 2022 |
0,19945 % | Schweizerische Nationalbank | 275 200 | 82 000 | 31. 12. 2022 |
0,19589 % | UBS Financial Services, Inc. | 270 277 | 186 872 | 31. 12. 2022 |
0,19245 % | Schonfeld Strategic Advisors LLC | 265 534 | 35 965 | 31. 12. 2022 |
0,17617 % | Tri Locum Partners LP | 243 079 | 52 482 | 31. 12. 2022 |
0,17378 % | SG Americas Securities, L.L.C. | 239 776 | 220 173 | 31. 12. 2022 |
0,17072 % | Banque Lombard Odier & Cie SA | 235 559 | 173 942 | 31. 12. 2022 |
0,17067 % | Lombard Odier Asset Management (Europe) Ltd | 235 484 | 69 199 | 31. 12. 2022 |
0,16970 % | Barclays Bank PLC | 234 152 | -28 221 | 31. 12. 2022 |
0,16827 % | Citadel Advisors LLC | 232 169 | -2 326 202 | 31. 12. 2022 |
0,16618 % | Schroder Investment Management Ltd. (SIM) | 229 285 | 229 285 | 31. 12. 2022 |
0,16579 % | Pier Capital, LLC | 228 752 | -3 230 | 31. 12. 2022 |
0,16458 % | Sblendorio (Glenn P) | 227 087 | 14 053 | 3. 1. 2023 |
0,15318 % | Mellon Investments Corporation | 211 360 | 125 254 | 31. 12. 2022 |
0,15220 % | Moore Capital Management, LP | 210 000 | -29 944 | 31. 12. 2022 |
0,15218 % | Nicholas Investment Partners, L.P. | 209 976 | 0 | 31. 12. 2022 |
0,15073 % | Boothbay Fund Management, LLC | 207 977 | 27 908 | 31. 12. 2022 |
0,14623 % | Lisanti Capital Growth, LLC | 201 760 | 201 760 | 31. 12. 2022 |
0,14495 % | Alyeska Investment Group, L.P. | 200 000 | 200 000 | 31. 12. 2022 |
0,14176 % | Sphera Funds Management Ltd. | 195 591 | -386 238 | 31. 12. 2022 |
0,13770 % | Altium Capital Management LP | 190 000 | 65 000 | 31. 12. 2022 |