18,87544 % | Fidelity Management & Research Company LLC | 5 449 340 | 176 940 | 30. 9. 2021 |
16,00206 % | MDV Management Company, L.L.C. | 4 619 796 | 0 | 16. 2. 2021 |
13,85521 % | Armistice Capital LLC | 4 000 000 | 144 000 | 30. 9. 2021 |
13,56057 % | Stonepine Capital Management, LLC | 3 914 938 | 1 220 643 | 30. 9. 2021 |
10,84841 % | Magnetar Capital Partners LP | 3 131 937 | 3 131 937 | 18. 10. 2021 |
6,11372 % | The Vanguard Group, Inc. | 1 765 031 | 13 211 | 30. 9. 2021 |
5,14375 % | Swedbank Robur Fonder AB | 1 485 000 | 0 | 30. 9. 2021 |
5,05715 % | Opaleye Management Inc. | 1 460 000 | -210 600 | 30. 9. 2021 |
3,98337 % | Point72 Asset Management, L.P. | 1 150 000 | -1 101 255 | 30. 9. 2021 |
3,63389 % | Medical Strategy GmbH | 1 049 103 | 0 | 30. 6. 2021 |
2,77139 % | Cooper Creek Partners Management LLC | 800 100 | 0 | 30. 9. 2021 |
2,64362 % | Renaissance Technologies LLC | 763 212 | -19 600 | 30. 9. 2021 |
2,43595 % | Two Sigma Investments, LP | 703 258 | -413 601 | 30. 9. 2021 |
2,31225 % | MAI Capital Management, LLC | 667 546 | 123 730 | 30. 9. 2021 |
2,16650 % | Altium Capital Management LP | 625 469 | 154 520 | 30. 9. 2021 |
2,16515 % | Worth Venture Partners, LLC | 625 080 | 34 350 | 30. 9. 2021 |
2,02017 % | BlackRock Institutional Trust Company, N.A. | 583 223 | -13 551 | 30. 9. 2021 |
1,82067 % | Acadian Asset Management LLC | 525 628 | -67 637 | 30. 9. 2021 |
1,24953 % | Geode Capital Management, L.L.C. | 360 738 | 25 632 | 30. 9. 2021 |
1,23398 % | McFarlane (Neil F) | 356 250 | 300 000 | 2. 3. 2021 |
1,01638 % | D. E. Shaw & Co., L.P. | 293 428 | -175 432 | 30. 9. 2021 |
0,99772 % | SilverArc Capital Management, LLC | 288 042 | -250 702 | 30. 9. 2021 |
0,81795 % | BMO Capital Markets (US) | 236 142 | 236 142 | 30. 9. 2021 |
0,79559 % | BMO Asset Management U.S. | 229 688 | -12 702 | 30. 9. 2021 |
0,68237 % | MacPhee (John A) | 197 000 | 5 000 | 2. 6. 2021 |
0,48493 % | DCF Advisers, LLC | 140 000 | 0 | 30. 9. 2021 |
0,39799 % | Bridgeway Capital Management, LLC | 114 900 | -150 000 | 30. 9. 2021 |
0,39092 % | State Street Global Advisors (US) | 112 859 | 9 700 | 30. 9. 2021 |
0,39065 % | Mahoney (David L) | 112 781 | 5 000 | 2. 6. 2021 |
0,37485 % | Prentiss (Christopher B.) | 108 219 | 72 578 | 22. 3. 2021 |
0,34638 % | Healthcare Value Capital, LLC | 100 000 | 0 | 30. 9. 2021 |
0,34568 % | Shreedhar (Vishvanath) | 99 797 | -6 200 | 21. 6. 2021 |
0,33907 % | Newton Investment Management North America, LLC | 97 890 | 97 890 | 30. 9. 2021 |
0,33061 % | Northern Trust Investments, Inc. | 95 446 | 14 876 | 30. 9. 2021 |
0,31629 % | Mosaic Family Wealth, LLC | 91 314 | 0 | 30. 9. 2021 |
0,25277 % | BlackRock Financial Management, Inc. | 72 975 | 10 338 | 30. 9. 2021 |
0,23900 % | Lieberburg (Ivan M) | 69 000 | 5 000 | 3. 6. 2020 |
0,23119 % | BofA Global Research (US) | 66 745 | 6 406 | 30. 9. 2021 |
0,21880 % | Principal Global Investors (Equity) | 63 167 | -474 | 30. 9. 2021 |
0,20824 % | Morgan Stanley & Co. LLC | 60 118 | -6 115 | 30. 9. 2021 |
0,15006 % | Apo Asset Management GmbH | 43 322 | 0 | 31. 8. 2021 |
0,13351 % | Susquehanna International Group, LLP | 38 545 | 38 545 | 30. 9. 2021 |
0,11802 % | SG Americas Securities, L.L.C. | 34 073 | -42 | 30. 9. 2021 |
0,11614 % | Jacobs Levy Equity Management, Inc. | 33 530 | -17 173 | 30. 9. 2021 |
0,10523 % | BNY Mellon Asset Management | 30 381 | 0 | 30. 9. 2021 |
0,10218 % | Campbell & Company, Inc. | 29 500 | 29 500 | 30. 9. 2021 |
0,09621 % | Citadel Advisors LLC | 27 776 | 12 649 | 30. 9. 2021 |
0,09468 % | Asset Management One Co., Ltd. | 27 333 | 33 | 31. 8. 2020 |
0,09006 % | T. Rowe Price Associates, Inc. | 26 000 | -7 700 | 30. 9. 2021 |
0,08105 % | Zebra Capital Management, LLC | 23 400 | 0 | 30. 9. 2021 |
0,07341 % | HighVista Strategies LLC | 21 193 | 6 437 | 30. 9. 2021 |
0,07265 % | Papapetropoulos (Spyridon) | 20 975 | 5 000 | 2. 6. 2021 |
0,06923 % | Goldman Sachs Asset Management, L.P. | 19 986 | -3 765 | 30. 9. 2021 |
0,06543 % | Clear Harbor Asset Management, LLC | 18 889 | -1 500 | 30. 9. 2021 |
0,06517 % | Goldman Sachs & Company, Inc. | 18 816 | -21 489 | 30. 9. 2021 |
0,06191 % | Charles Schwab Investment Management, Inc. | 17 873 | 0 | 30. 9. 2021 |
0,05709 % | Group One Trading, L.P. | 16 483 | 16 483 | 30. 9. 2021 |
0,05542 % | Dowling & Yahnke, LLC | 16 000 | 0 | 30. 9. 2021 |
0,05542 % | Demski (Martha J) | 16 000 | 3 000 | 7. 6. 2021 |
0,05520 % | Algert Global LLC | 15 936 | 15 936 | 30. 9. 2021 |
0,05196 % | Richo (Anna S.) | 15 000 | 5 000 | 2. 6. 2021 |
0,04662 % | Cubist Systematic Strategies, LLC | 13 460 | -900 | 30. 9. 2021 |
0,04503 % | PNC Wealth Management | 13 000 | 3 000 | 30. 9. 2021 |
0,04337 % | Hightower Advisors, LLC | 12 521 | 0 | 30. 9. 2021 |
0,03907 % | Barclays Bank PLC | 11 279 | 5 553 | 30. 9. 2021 |
0,03879 % | United Bank, Inc. | 11 200 | 11 200 | 30. 9. 2021 |
0,03817 % | Nuveen Asset Management, LLC | 11 020 | 0 | 30. 4. 2020 |
0,03506 % | Capstone Investment Advisors, LLC | 10 123 | 10 123 | 30. 9. 2021 |
0,03182 % | BlackRock Japan Co., Ltd. | 9 185 | 0 | 30. 9. 2021 |
0,02840 % | Blackstone Alternative Investment Advisors LLC | 8 200 | 0 | 30. 6. 2021 |
0,02613 % | Northern Trust Global Investments | 7 545 | 0 | 30. 9. 2021 |
0,02600 % | BlackRock Investment Management, LLC | 7 507 | -803 | 30. 9. 2021 |
0,02425 % | Morgan Stanley Smith Barney LLC | 7 000 | 0 | 30. 9. 2021 |
0,02212 % | BlackRock Investment Management (UK) Ltd. | 6 386 | 0 | 30. 9. 2021 |
0,02032 % | Mackenzie Financial Corporation | 5 865 | 5 865 | 30. 6. 2021 |
0,01732 % | Bigham (Michael F) | 5 000 | 5 000 | 2. 6. 2021 |
0,01732 % | Dier (Mardi C) | 5 000 | 5 000 | 2. 6. 2021 |
0,01732 % | Ericson (William) | 5 000 | 5 000 | 2. 6. 2021 |
0,01705 % | BlackRock Fund Advisors | 4 923 | 4 923 | 30. 6. 2021 |
0,01455 % | Advisor Group, Inc | 4 200 | -2 000 | 30. 9. 2021 |
0,01239 % | Rockefeller Capital Management | 3 576 | 0 | 30. 9. 2021 |
0,00786 % | UBS Financial Services, Inc. | 2 270 | 685 | 30. 9. 2021 |
0,00381 % | Cutler Group, LP | 1 100 | 0 | 30. 9. 2021 |
0,00221 % | Truvestments Capital LLC | 637 | 0 | 30. 9. 2021 |
0,00104 % | Clearview Wealth Advisors LLC | 300 | 0 | 30. 9. 2021 |
0,00104 % | Wells Fargo Advisors | 300 | 0 | 30. 9. 2021 |
0,00077 % | Wells Fargo Bank, N.A. | 221 | -36 | 30. 9. 2021 |
0,00069 % | RBC Capital Markets Wealth Management | 200 | 0 | 30. 9. 2021 |
0,00026 % | BNY Mellon Wealth Management | 76 | 0 | 30. 9. 2021 |
0,00016 % | Aperio Group, LLC | 47 | 0 | 30. 9. 2021 |
0,00010 % | J.P. Morgan Securities plc | 28 | 0 | 30. 9. 2021 |
0,00000 % | BNP Paribas Securities Corp. North America | 1 | 0 | 30. 9. 2021 |
0 % | Walleye Capital LLC | 0 | -16 700 | 30. 6. 2021 |
0 % | AIGH Capital Management, LLC. | 0 | -2 585 743 | 11. 10. 2021 |
0 % | Avidity Partners Management LP | 0 | -2 200 200 | 30. 6. 2021 |
0 % | Maven Investment Partners US Ltd. | 0 | -250 000 | 30. 6. 2021 |
0 % | XTX Markets LLC | 0 | -16 357 | 30. 9. 2021 |
0 % | Jump Financial, LLC | 0 | -23 191 | 30. 9. 2021 |
0 % | Voya Investment Management LLC | 0 | -40 980 | 30. 6. 2020 |
0 % | Franklin Mutual Advisers, LLC | 0 | -1 243 | 30. 6. 2020 |