7,47976 % | Avoro Capital Advisors LLC | 5 666 666 | 766 666 | 31.12.2023 |
6,40800 % | Fidelity Management & Research Company LLC | 4 854 702 | 602 161 | 31.12.2023 |
5,73545 % | Driehaus Capital Management, LLC | 4 345 180 | -167 825 | 31.12.2023 |
5,49453 % | Wellington Management Company, LLP | 4 162 654 | 2 434 546 | 31.12.2023 |
4,04782 % | Polar Capital LLP | 3 066 628 | 62 881 | 31.12.2023 |
3,53952 % | Capital World Investors | 2 681 537 | 406 563 | 31.12.2023 |
3,24140 % | Capital International Investors | 2 455 683 | 8863 | 31.12.2023 |
2,86140 % | Commodore Capital LP | 2 167 793 | 322 793 | 31.12.2023 |
2,80808 % | Paradigm BioCapital Advisors LP | 2 127 400 | 635 565 | 31.12.2023 |
2,69324 % | Pictet Asset Management Ltd. | 2 040 400 | 101 621 | 31.12.2023 |
2,17438 % | Braidwell LP | 1 647 311 | -456 085 | 31.12.2023 |
2,17198 % | First Light Asset Management, LLC | 1 645 490 | 1 043 420 | 31.12.2023 |
2,07836 % | AllianceBernstein L.P. | 1 574 568 | 490 231 | 31.12.2023 |
2,01775 % | Marshall Wace LLP | 1 528 648 | -625 746 | 31.12.2023 |
1,67218 % | Citadel Advisors LLC | 1 266 844 | 543 320 | 31.12.2023 |
1,65731 % | Rock Springs Capital Management LP | 1 255 577 | 77 575 | 31.12.2023 |
1,45294 % | Perceptive Advisors LLC | 1 100 748 | 483 248 | 31.12.2023 |
1,38427 % | Adage Capital Management, L.P. | 1 048 725 | 498 725 | 31.12.2023 |
1,31161 % | Baker Bros. Advisors LP | 993 679 | 242 040 | 31.12.2023 |
1,27516 % | Janus Henderson Investors | 966 065 | 583 760 | 31.12.2023 |
1,21857 % | BlackRock Financial Management, Inc. | 923 185 | 904 476 | 31.12.2023 |
1,17628 % | T. Rowe Price Investment Management, Inc. | 891 149 | 891 149 | 31.12.2023 |
1,17486 % | BVF Partners L.P. | 890 072 | -937 886 | 31.12.2023 |
1,15505 % | Point72 Asset Management, L.P. | 875 065 | -250 643 | 31.12.2023 |
1,07708 % | Avidity Partners Management LP | 815 993 | 494 593 | 31.12.2023 |
1,05758 % | Fidelity Institutional Asset Management | 801 220 | 800 895 | 31.12.2023 |
1,04799 % | TimesSquare Capital Management, LLC | 793 954 | 203 379 | 31.12.2023 |
0,97135 % | BlackRock Institutional Trust Company, N.A. | 735 897 | 118 486 | 31.12.2023 |
0,94769 % | Lord, Abbett & Co. LLC | 717 972 | -431 196 | 31.12.2023 |
0,93492 % | Loomis, Sayles & Company, L.P. | 708 295 | -22 421 | 31.12.2023 |
0,93024 % | Invesco Advisers, Inc. | 704 751 | 2872 | 31.12.2023 |
0,89808 % | First Turn Management, LLC | 680 389 | 680 389 | 31.12.2023 |
0,79910 % | Norges Bank Investment Management (NBIM) | 605 398 | 470 940 | 31.12.2023 |
0,79197 % | Boxer Capital, L.L.C. | 600 000 | 0 | 31.12.2023 |
0,79197 % | Great Point Partners, LLC | 600 000 | 99 999 | 31.12.2023 |
0,78236 % | Two Sigma Investments, LP | 592 715 | 447 182 | 31.12.2023 |
0,74762 % | Jennison Associates LLC | 566 396 | 352 573 | 31.12.2023 |
0,72998 % | Fiera Capital Corporation | 553 030 | -7516 | 31.12.2023 |
0,72598 % | OrbiMed Advisors, LLC | 550 000 | -408 793 | 31.12.2023 |
0,70074 % | Candriam Belgium S.A. | 530 884 | -39 000 | 31.12.2023 |
0,70074 % | Candriam Luxembourg S.A. | 530 884 | 0 | 29.02.2024 |
0,60718 % | Affinity Asset Advisors LLC | 460 000 | 159 562 | 31.12.2023 |
0,55591 % | Samlyn Capital, LLC | 421 155 | -530 600 | 31.12.2023 |
0,53150 % | Dimensional Fund Advisors, L.P. | 402 668 | -24 457 | 31.12.2023 |
0,50871 % | Medical Strategy GmbH | 385 399 | -6400 | 31.12.2023 |
0,50350 % | BNP Paribas Asset Management USA, Inc. | 381 453 | 2380 | 31.03.2024 |
0,46180 % | Goldman Sachs & Company, Inc. | 349 858 | 94 490 | 31.12.2023 |
0,45749 % | Federated Hermes Global Investment Management Corp. | 346 596 | 346 596 | 31.12.2023 |
0,40983 % | The Vanguard Group, Inc. | 310 486 | 52 594 | 31.12.2023 |
0,40220 % | BlackRock Advisors (UK) Limited | 304 703 | -1012 | 31.03.2024 |
0,39939 % | Granahan Investment Management, LLC | 302 581 | 66 291 | 31.12.2023 |
0,38911 % | Parkman Healthcare Partners LLC | 294 788 | 78 144 | 31.12.2023 |
0,38784 % | Franklin Advisers, Inc. | 293 825 | 121 213 | 31.12.2023 |
0,38349 % | Altium Capital Management LP | 290 535 | 62 535 | 31.12.2023 |
0,37078 % | BlackRock Asset Management Ireland Limited | 280 900 | 1875 | 31.12.2023 |
0,36528 % | Dafna Capital Management, LLC | 276 739 | -3799 | 31.12.2023 |
0,33716 % | Boone Capital Management LLC | 255 432 | 255 432 | 31.12.2023 |
0,31938 % | Ally Bridge Group NY LLC | 241 961 | -25 000 | 31.12.2023 |
0,31348 % | Westfield Capital Management Company, L.P. | 237 495 | 237 495 | 31.12.2023 |
0,29968 % | State Street Global Advisors (US) | 227 040 | 14 670 | 31.12.2023 |
0,29773 % | Tri Locum Partners LP | 225 564 | 53 809 | 31.12.2023 |
0,28685 % | Algert Global LLC | 217 320 | 88 833 | 31.12.2023 |
0,28451 % | Putnam Investment Management, L.L.C. | 215 545 | 43 609 | 31.12.2023 |
0,26649 % | Morgan Stanley & Co. LLC | 201 895 | -16 922 | 31.12.2023 |
0,25931 % | Woodline Partners LP | 196 453 | 53 002 | 31.12.2023 |
0,25456 % | PFM Health Sciences, LP | 192 856 | 114 269 | 31.12.2023 |
0,25120 % | New York State Common Retirement Fund | 190 312 | 5680 | 31.12.2023 |
0,24792 % | AXA Investment Managers UK Ltd. | 187 821 | -4542 | 31.12.2023 |
0,23099 % | Vestal Point Capital, LP | 175 000 | 175 000 | 31.12.2023 |
0,22230 % | Russell Investments Trust Company | 168 418 | 2930 | 31.12.2023 |
0,21815 % | ExodusPoint Capital Management, LP | 165 267 | -194 571 | 31.12.2023 |
0,21697 % | Ensign Peak Advisors, Inc. | 164 380 | 0 | 31.12.2023 |
0,21537 % | SilverArc Capital Management, LLC | 163 168 | 109 172 | 31.12.2023 |
0,19931 % | Nomura Asset Management Co., Ltd. | 151 000 | -34 400 | 30.11.2023 |
0,19799 % | Logos Global Management LLC | 150 000 | -300 000 | 31.12.2023 |
0,19377 % | Bridger Management, LLC | 146 800 | 146 800 | 31.12.2023 |
0,16664 % | DNB Asset Management AS | 126 250 | -125 | 31.03.2024 |
0,16341 % | Schweizerische Nationalbank | 123 800 | 12 100 | 31.12.2023 |
0,14526 % | Tenax Capital Ltd. | 110 047 | 0 | 31.05.2023 |
0,14500 % | Principal Global Investors (Equity) | 109 852 | -4600 | 29.02.2024 |
0,14125 % | New Jersey Division of Investment | 107 013 | 6559 | 31.12.2023 |
0,14081 % | Nan Fung Life Sciences | 106 680 | 0 | 31.12.2023 |
0,13638 % | UBS Switzerland AG | 103 325 | 0 | 31.12.2023 |
0,13213 % | Baron Capital Management, Inc. | 100 100 | 0 | 31.12.2023 |
0,13164 % | Assenagon Asset Management S.A. | 99 731 | -47 962 | 31.12.2023 |
0,13134 % | Barclays Capital Inc. | 99 500 | 99 300 | 31.12.2023 |
0,12647 % | MFS Investment Management | 95 813 | -2894 | 29.02.2024 |
0,12584 % | State of Wisconsin Investment Board | 95 336 | -738 | 31.12.2023 |
0,12306 % | Atika Capital Management LLC | 93 234 | 93 234 | 31.12.2023 |
0,12078 % | Schroder Investment Management Ltd. (SIM) | 91 500 | 91 500 | 31.12.2023 |
0,12078 % | International Biotechnology Trust PLC | 91 500 | 66 000 | 30.09.2023 |
0,11583 % | Nicholas Investment Partners, L.P. | 87 752 | -766 695 | 31.12.2023 |
0,11550 % | Schonfeld Strategic Advisors LLC | 87 500 | -111 484 | 31.12.2023 |
0,11108 % | D. E. Shaw & Co., L.P. | 84 153 | 43 606 | 31.12.2023 |
0,10965 % | HRT Financial LP | 83 069 | 47 859 | 31.12.2023 |
0,10797 % | Credit Suisse Funds AG | 81 795 | 16 209 | 31.12.2023 |
0,10159 % | Millennium Management LLC | 76 965 | -18 528 | 31.12.2023 |
0,09900 % | Laurion Capital Management LP | 75 000 | 75 000 | 31.12.2023 |
0,09797 % | Azab (Mohammad) | 74 225 | 4320 | 19.12.2023 |
0,08911 % | Tekla Capital Management LLC_NLE | 67 506 | -16 208 | 30.06.2023 |