9,96069 % | Baillie Gifford & Co. | 14 260 724 | -420 303 | 31.12.2023 |
8,90645 % | Biogen Inc | 12 751 365 | -558 878 | 31.12.2023 |
7,55056 % | The Vanguard Group, Inc. | 10 810 137 | 232 597 | 31.12.2023 |
6,61220 % | BlackRock Institutional Trust Company, N.A. | 9 466 684 | 693 719 | 31.12.2023 |
5,08117 % | Wellington Management Company, LLP | 7 274 717 | -14 243 | 31.12.2023 |
4,81665 % | Temasek Holdings Pte. Ltd. | 6 895 992 | 0 | 31.12.2023 |
3,95385 % | Crestline Investors, Inc. | 5 660 732 | -300 000 | 31.12.2023 |
3,83177 % | State Street Global Advisors (US) | 5 485 948 | 1 210 620 | 31.12.2023 |
2,03222 % | Capital Research Global Investors | 2 909 528 | 29 205 | 31.12.2023 |
1,85744 % | Geode Capital Management, L.L.C. | 2 659 296 | 127 461 | 31.12.2023 |
1,82105 % | Baker Bros. Advisors LP | 2 607 196 | 315 193 | 31.12.2023 |
1,73872 % | T. Rowe Price Associates, Inc. | 2 489 326 | -316 720 | 31.12.2023 |
1,62043 % | Flagship Ventures | 2 319 968 | -300 000 | 31.12.2023 |
1,62034 % | Watts (Ryan J) | 2 319 844 | -9589 | 13.02.2024 |
1,47060 % | Tessier-Lavigne (Marc) | 2 105 455 | 4216 | 1.06.2023 |
1,16463 % | Marshall Wace LLP | 1 667 397 | 1 667 397 | 31.12.2023 |
1,09444 % | Credit Suisse Funds AG | 1 566 904 | 7868 | 31.12.2023 |
0,94426 % | Federated Hermes Global Investment Management Corp. | 1 351 900 | 0 | 31.12.2023 |
0,90801 % | Casdin Capital, LLC | 1 300 000 | 0 | 31.12.2023 |
0,85171 % | Gilder Gagnon Howe & Co. LLC | 1 219 392 | -26 807 | 31.12.2023 |
0,84901 % | Mellon Investments Corporation | 1 215 533 | -17 304 | 31.12.2023 |
0,80509 % | Norges Bank Investment Management (NBIM) | 1 152 646 | 128 440 | 31.12.2023 |
0,80372 % | Yiheng Capital Management, L.P. | 1 150 684 | 0 | 31.12.2023 |
0,78203 % | Dimensional Fund Advisors, L.P. | 1 119 628 | 146 394 | 31.12.2023 |
0,74995 % | Principal Global Investors (Equity) | 1 073 704 | 393 626 | 31.12.2023 |
0,72130 % | BlackRock Financial Management, Inc. | 1 032 692 | -17 071 | 31.12.2023 |
0,70336 % | Charles Schwab Investment Management, Inc. | 1 006 997 | 25 938 | 31.12.2023 |
0,69919 % | Northern Trust Investments, Inc. | 1 001 025 | 23 415 | 31.12.2023 |
0,60422 % | Krognes (Steve E) | 865 055 | -92 500 | 1.04.2024 |
0,56080 % | Invus Public Equities Advisors, LLC | 802 899 | 0 | 31.12.2023 |
0,45010 % | Point72 Asset Management, L.P. | 644 406 | 644 406 | 31.12.2023 |
0,44818 % | Fidelity Management & Research Company LLC | 641 653 | -416 844 | 31.12.2023 |
0,44447 % | UBS Asset Management (Switzerland) | 636 345 | 59 807 | 31.12.2023 |
0,43654 % | Cercano Management LLC | 625 000 | 0 | 31.12.2023 |
0,43389 % | Schuth (Alexander O) | 621 203 | 27 156 | 14.02.2024 |
0,40807 % | Morgan Stanley & Co. LLC | 584 237 | -14 389 | 31.12.2023 |
0,36564 % | BlackRock Advisors (UK) Limited | 523 482 | -2250 | 31.03.2024 |
0,34852 % | T. Rowe Price Investment Management, Inc. | 498 969 | -148 044 | 31.12.2023 |
0,34568 % | BlackRock Asset Management Ireland Limited | 494 916 | -18 688 | 31.12.2023 |
0,33072 % | American Century Investment Management, Inc. | 473 494 | -842 | 31.12.2023 |
0,32253 % | Braidwell LP | 461 769 | 461 769 | 31.12.2023 |
0,31618 % | Polar Capital LLP | 452 669 | -554 417 | 31.12.2023 |
0,30678 % | Pictet Asset Management Ltd. | 439 218 | -150 281 | 31.12.2023 |
0,30028 % | BofA Global Research (US) | 429 915 | 172 486 | 31.12.2023 |
0,28391 % | BNY Mellon Asset Management | 406 476 | 6807 | 31.12.2023 |
0,28125 % | Wasatch Global Investors Inc | 402 670 | 90 369 | 31.03.2024 |
0,27395 % | The Clarius Group, LLC | 392 218 | 13 956 | 31.03.2024 |
0,26817 % | Artisan Partners Limited Partnership | 383 942 | -22 680 | 31.12.2023 |
0,26743 % | Candriam Luxembourg S.A. | 382 878 | 25 000 | 29.02.2024 |
0,26629 % | ARCH Venture Partners | 381 249 | -312 500 | 31.12.2023 |
0,24997 % | Candriam Belgium S.A. | 357 878 | 0 | 31.12.2023 |
0,24705 % | AXA Investment Managers UK Ltd. | 353 695 | 866 | 31.12.2023 |
0,24341 % | Ensign Peak Advisors, Inc. | 348 497 | 0 | 31.12.2023 |
0,24321 % | SEB Investment Management AB | 348 203 | 0 | 31.12.2023 |
0,23072 % | Flatley (Jay T) | 330 327 | 2074 | 31.03.2023 |
0,22688 % | abrdn Inc. | 324 829 | 324 829 | 31.12.2023 |
0,22688 % | Tekla Capital Management LLC_NLE | 324 829 | 0 | 30.06.2023 |
0,22632 % | Barclays Bank PLC | 324 019 | 157 512 | 31.12.2023 |
0,22489 % | Rafferty Asset Management LLC | 321 973 | 92 660 | 31.12.2023 |
0,22070 % | Nuveen LLC | 315 981 | -47 684 | 31.12.2023 |
0,22038 % | Eagle Asset Management, Inc. | 315 520 | 26 387 | 31.12.2023 |
0,21221 % | BlackRock Investment Management, LLC | 303 825 | 2788 | 31.12.2023 |
0,20324 % | UBS Financial Services, Inc. | 290 985 | 181 289 | 31.12.2023 |
0,19180 % | Voya Investment Management LLC | 274 607 | 19 127 | 31.12.2023 |
0,18868 % | Goldman Sachs & Company, Inc. | 270 135 | 108 858 | 31.12.2023 |
0,18201 % | Balyasny Asset Management LP | 260 587 | 260 587 | 31.12.2023 |
0,17677 % | Ho (Carole) | 253 082 | -4189 | 14.02.2024 |
0,17196 % | Mitsubishi UFJ Trust and Banking Corporation | 246 190 | -44 770 | 31.12.2023 |
0,15171 % | Baillie Gifford Overseas Ltd. | 217 209 | 0 | 29.02.2024 |
0,15136 % | Schweizerische Nationalbank | 216 700 | -24 100 | 31.12.2023 |
0,14950 % | Morgan Stanley Smith Barney LLC | 214 042 | -42 259 | 31.12.2023 |
0,14691 % | Newton Investment Management North America, LLC | 210 334 | -72 930 | 31.12.2023 |
0,14573 % | Kentucky Teachers' Retirement System | 208 644 | -9550 | 31.12.2023 |
0,13969 % | ACATIS Investment Kapitalverwaltungsgesellschaft GmbH | 200 000 | 0 | 31.01.2024 |
0,13801 % | Woodline Partners LP | 197 584 | -653 905 | 31.12.2023 |
0,13386 % | BNP Paribas Securities Corp. North America | 191 643 | 28 817 | 31.12.2023 |
0,12302 % | California Public Employees' Retirement System | 176 131 | 0 | 31.12.2023 |
0,12223 % | Hudson Bay Capital Management LP | 175 000 | 175 000 | 31.12.2023 |
0,12169 % | Pier Capital, LLC | 174 219 | 49 139 | 31.12.2023 |
0,11962 % | Qube Research & Technologies Ltd | 171 262 | 157 709 | 31.12.2023 |
0,11648 % | Rhumbline Advisers Ltd. Partnership | 166 763 | -2361 | 31.12.2023 |
0,11572 % | Edmond de Rothschild Asset Management (France) S.A. | 165 680 | 65 800 | 31.12.2023 |
0,11548 % | Jefferies LLC | 165 327 | 152 527 | 31.12.2023 |
0,11311 % | Renaissance Technologies LLC | 161 946 | -305 905 | 31.12.2023 |
0,11003 % | BlackRock Investment Management (UK) Ltd. | 157 534 | -9519 | 31.12.2023 |
0,10756 % | Schroder Investment Management Ltd. (SIM) | 154 000 | 154 000 | 31.12.2023 |
0,10756 % | International Biotechnology Trust PLC | 154 000 | -34 000 | 30.09.2023 |
0,10405 % | Jane Street Capital, L.L.C. | 148 965 | 110 226 | 31.12.2023 |
0,10321 % | Parametric Portfolio Associates LLC | 147 769 | 52 705 | 31.12.2023 |
0,10090 % | Neuberger Berman, LLC | 144 461 | 144 461 | 31.12.2023 |
0,09868 % | Citi Investment Research (US) | 141 276 | 2967 | 31.12.2023 |
0,09776 % | AllianceBernstein L.P. | 139 960 | 3200 | 31.12.2023 |
0,09541 % | New Jersey Division of Investment | 136 600 | 29 511 | 31.12.2023 |
0,09429 % | SELECTRA Management Company S.A. | 135 000 | 0 | 30.06.2023 |
0,09080 % | Soleus Capital Management, L.P. | 130 000 | 130 000 | 31.12.2023 |
0,08659 % | New York State Common Retirement Fund | 123 974 | -5879 | 31.12.2023 |
0,08197 % | California State Teachers Retirement System | 117 351 | -5553 | 31.12.2023 |
0,07827 % | Sato (Vicki Lee) | 112 057 | -1666 | 15.04.2024 |
0,07786 % | Russell Investments Trust Company | 111 473 | -2585 | 31.12.2023 |
0,07454 % | Legal & General Investment Management Ltd. | 106 713 | 888 | 31.12.2023 |